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1. 发明授权

US06683300B2 Method and apparatus for mass spectrometry analysis of common analyte solutions 失效
标题翻译：普通分析物溶液质谱分析方法和装置
公开(公告)号：US06683300B2
公开(公告)日：2004-01-27
申请号：US09953403
申请日：2001-09-17
申请人： Vladimir M. Doroshenko , Victor V. Laiko , Mikhail Yakshin , Coorg R. Prasad , Hyo Sang Lee
发明人： Vladimir M. Doroshenko , Victor V. Laiko , Mikhail Yakshin , Coorg R. Prasad , Hyo Sang Lee
IPC分类号： H01J4916
CPC分类号： H01J49/04
摘要： A method, system, and apparatus for mass spectroscopic analysis of an analyte solution in which a liquid volume of the analyte solution is irradiated with a light source resulting in desorption of solution-specific ions into a surrounding gas to produce gas-phase ions, the gas-phase ions are transferred to an inlet port of a mass analyzer, and the gas-phase ions are mass analyzed. More specifically, the apparatus may include a laser configured to pulse irradiate a surface of the analyte solution, a mass spectrometer configured to mass-analyze the gas-phase ions according to the mass-to-charge ratio, and a transfer mechanism configured to transfer the gas-phase ions to an inlet port of the mass spectrometer.
摘要翻译：分析物溶液的质谱分析的方法，系统和装置，其中用光源照射分析物溶液的液体体积，导致溶液特异性离子解吸到周围气体中以产生气相离子，将气相离子转移到质量分析器的入口，并对气相离子进行质量分析。更具体地，该装置可以包括被配置为脉冲照射分析物溶液的表面的激光器，配置成根据质荷比对气相离子进行质量分析的质谱仪，以及被配置为转移气相离子到质谱仪的入口。

2. 发明申请

US20100006760A1 Ultraviolet lidar for detection of biological warfare agents 失效
标题翻译：用于检测生物战剂的紫外线激光雷达
公开(公告)号：US20100006760A1
公开(公告)日：2010-01-14
申请号：US11104505
申请日：2005-04-13
申请人： Hyo Sang Lee , Coorg R. Prasad
发明人： Hyo Sang Lee , Coorg R. Prasad
IPC分类号： G01N21/00 , G01J1/42
CPC分类号： G01N21/6456 , G01N21/3504 , G01N21/47 , G01N21/6408 , G01N21/645 , G01N2021/1793 , G01N2021/3513 , G01N2021/4709 , G01N2021/6463 , G01N2021/6495
摘要： A system and method for detecting airborne agents. The system includes a semiconductor ultraviolet optical source configured to emit an ultraviolet light, a controller configured to generate a pseudo-random code for emission of the ultraviolet light modulated at the pseudo-random code, a telescope configured to focus the ultraviolet light to a distance from the source and to receive elastically backscattered signals and fluorescence signals from the distance, and a sensor configured to detect the elastically backscattered and fluorescence signals. The method generates a pseudo-random code and emits at least one wavelength of ultraviolet light modulated at the pseudo-random code, transmits the modulated ultraviolet light pulses to a distance from the source, receives elastically backscattered signals and fluorescence signals from the distance, and detects the elastically backscattered and fluorescence signals.
摘要翻译：一种用于检测空气传播剂的系统和方法。该系统包括被配置为发射紫外光的半导体紫外光源，被配置为产生用于发射以伪随机码调制的紫外光的伪随机码的控制器，配置成将紫外光聚焦到一定距离的望远镜并且从该距离接收弹性背散射信号和荧光信号，以及被配置为检测弹性背散射和荧光信号的传感器。该方法产生伪随机码并且发射以伪随机码调制的紫外光的至少一个波长，将经调制的紫外光脉冲发射到距离源一段距离，从该距离接收弹性反向散射信号和荧光信号，以及检测弹性背散射和荧光信号。

3. 发明授权

US06593582B2 Portable digital lidar system 失效
公开(公告)号：US06593582B2
公开(公告)日：2003-07-15
申请号：US09852782
申请日：2001-05-11
申请人： Hyo Sang Lee , In Heon Hwang , Coorg R. Prasad
发明人： Hyo Sang Lee , In Heon Hwang , Coorg R. Prasad
IPC分类号： G01N2117
CPC分类号： G01N21/6486 , G01N21/3504 , G01N21/39 , G01N21/6402 , G01S7/4972 , G01S17/95 , Y02A90/19
摘要： A light detecting and ranging system and method for detecting airborne agents in which the system includes a laser which provides laser pulses of at least two wavelengths, a transmitter which transmits the laser pulses, a receiver which receives both elastically backscattered signals from airborne agents and fluorescence signals from the airborne agents, a common telescope which both focuses a laser beam transmission of the laser pulse from the transmitter to a far field and receives the elastically backscattered signals and the fluorescence signals from the far field, a digital detection system having at least one of a backscatter optical detector which detects the elastically backscattered signals and a fluorescence optical detector which detects the fluorescence signals from the airborne agents.

4. 发明授权

US07741618B2 Enhanced portable digital lidar system 失效
标题翻译：增强便携式数字激光雷达系统
公开(公告)号：US07741618B2
公开(公告)日：2010-06-22
申请号：US11281621
申请日：2005-11-18
申请人： Hyo Sang Lee , In Heon Hwang , Coorg R. Prasad
发明人： Hyo Sang Lee , In Heon Hwang , Coorg R. Prasad
IPC分类号： G01J1/58
CPC分类号： G01S17/95 , G01N21/645 , G01N21/6486 , G01N2021/1793 , G01N2021/4709 , G01N2021/6476 , G01S7/481 , G01S7/4815 , G01S7/4817 , G01S17/88 , Y02A90/19
摘要： A system for detecting airborne agents. The system can include a laser source that provides laser pulses of at least two wavelengths, a transmitter that transmits the laser pulses, and a coupling mechanism configured to remotely couple the laser pulses between the laser source and the transmitter. The system can include a receiver receives both elastically backscattered signals from airborne agents and fluorescence signals from the airborne agents. The system can include a telescope both transmits a collimated laser beam of the laser pulse from the transmitter to a far field and receives the elastically backscattered signals and the fluorescence signals from the far field. The system can include a detection system having at least one of a backscatter optical detector that detects the elastically backscattered signals and one or more fluorescence optical detectors that detect the fluorescence signals in selected spectral band(s) from the airborne agents.
摘要翻译：一种用于检测空气传播剂的系统。该系统可以包括提供至少两个波长的激光脉冲的激光源，传递激光脉冲的发射器，以及配置成远程耦合激光源和发射器之间的激光脉冲的耦合机构。该系统可以包括一个接收器接收来自空气传播剂的弹性反向散射信号和来自空气传播剂的荧光信号。该系统可以包括望远镜将激光脉冲的准直激光束从发射器传输到远场，并且接收来自远场的弹性反向散射信号和荧光信号。该系统可以包括检测系统，该检测系统具有检测弹性反向散射信号的反向散射光学检测器和检测来自空气传播剂的所选频谱带中的荧光信号的一个或多个荧光光学检测器中的至少一个。

5. 发明授权

US06683894B1 Tunable IR laser source for MALDI 失效
标题翻译：可调谐的红外激光源用于MALDI
公开(公告)号：US06683894B1
公开(公告)日：2004-01-27
申请号：US09552579
申请日：2000-04-19
申请人： Hyo Sang Lee , Coorg R. Prasad , Jun Zhang
发明人： Hyo Sang Lee , Coorg R. Prasad , Jun Zhang
IPC分类号： H01S310
CPC分类号： H01J49/164 , H01S3/0612 , H01S3/09408 , H01S3/09415 , H01S3/117 , H01S3/1618 , H01S3/1643
摘要： A diode pumped solid state laser/OPO system widely tunable in mid infrared spectrum for infrared matrix assisted laser desorption/ionization (MALDI) mass spectroscopy is disclosed. Up to a few tens of milli-Joule, short pulse, tunable near infrared laser pulse is generated from an all solid state laser at a high pulse repetition rate up to one kHz. The tunable near-infrared laser pumps a Quasi-Phase Matching (QPM) OPO system to further shift the wavelength to the mid-IR range and to broaden the tuning range to as much as 3 &mgr;m to effectively generate a widely tunable spectral output. The wide range tuning of the infrared output is accomplished by a narrow range tuning of the pump laser. The pump laser output is generated by a diode pumped tunable solid state laser module using either a Yb:YAG crystal or any other efficient tunable laser crystals. The wavelength range (2-5 &mgr;m) covered by the solid state laser system is optimum for MALDI applications. This wavelength range is especially beneficial for large mass DNA analysis. A light detection and ranging system is also disclosed.
摘要翻译：公开了用于红外矩阵辅助激光解吸/电离（MALDI）质谱的中红外光谱广泛可调谐的二极管泵浦固态激光器/ OPO系统。高达几十毫焦耳，短脉冲，可调谐的近红外激光脉冲从全固态激光器以高达1kHz的高脉冲重复频率产生。可调谐近红外激光泵浦准相位匹配（QPM）OPO系统，以进一步将波长转移到中红外范围，并将调谐范围扩展到3um以有效地产生广泛可调谐的光谱输出。通过泵浦激光器的窄范围调谐来实现红外输出的宽范围调谐。泵浦激光器输出由使用Yb：YAG晶体或任何其他有效的可调谐激光晶体的二极管泵浦可调谐固态激光器模块产生。由固体激光系统覆盖的波长范围（2-5μm）对于MALDI应用是最佳的。该波长范围对于大质量DNA分析特别有益。还公开了光检测和测距系统。

6. 发明授权

US08024135B2 Ultraviolet lidar for detection of biological warfare agents 失效
标题翻译：用于检测生物战剂的紫外线激光雷达
公开(公告)号：US08024135B2
公开(公告)日：2011-09-20
申请号：US11104505
申请日：2005-04-13
申请人： Hyo Sang Lee , Coorg R. Prasad
发明人： Hyo Sang Lee , Coorg R. Prasad
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , G01N21/3504 , G01N21/47 , G01N21/6408 , G01N21/645 , G01N2021/1793 , G01N2021/3513 , G01N2021/4709 , G01N2021/6463 , G01N2021/6495
摘要： A system and method for detecting airborne agents. The system includes a semiconductor ultraviolet optical source configured to emit an ultraviolet light, a controller configured to generate a pseudo-random code for emission of the ultraviolet light modulated at the pseudo-random code, a telescope configured to focus the ultraviolet light to a distance from the source and to receive elastically backscattered signals and fluorescence signals from the distance, and a sensor configured to detect the elastically backscattered and fluorescence signals. The method generates a pseudo-random code and emits at least one wavelength of ultraviolet light modulated at the pseudo-random code, transmits the modulated ultraviolet light pulses to a distance from the source, receives elastically backscattered signals and fluorescence signals from the distance, and detects the elastically backscattered and fluorescence signals.
摘要翻译：一种用于检测空气传播剂的系统和方法。该系统包括被配置为发射紫外光的半导体紫外光源，被配置为产生用于发射以伪随机码调制的紫外光的伪随机码的控制器，配置成将紫外光聚焦到一定距离的望远镜并且从该距离接收弹性背散射信号和荧光信号，以及被配置为检测弹性背散射和荧光信号的传感器。该方法产生伪随机码并且发射以伪随机码调制的紫外光的至少一个波长，将经调制的紫外光脉冲发射到距离源一段距离，从该距离接收弹性反向散射信号和荧光信号，以及检测弹性背散射和荧光信号。

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