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1. 发明授权

US06791080B2 Method and apparatus for efficient transfer of ions into a mass spectrometer 有权
标题翻译：将离子有效转移到质谱仪中的方法和装置
公开(公告)号：US06791080B2
公开(公告)日：2004-09-14
申请号：US10367917
申请日：2003-02-19
申请人： Vladimir M. Doroshenko , Victor V. Laiko , Phillip V. Tan
发明人： Vladimir M. Doroshenko , Victor V. Laiko , Phillip V. Tan
IPC分类号： H01J4904
CPC分类号： H01J49/403
摘要： An apparatus and a method which produce a pulse of ions, generate a transient electric field correlated in time with a duration of the pulse of ions, receive the pulse of ions into the transient electric field, and collect the ions from an ion drift region of the transient electric field into a gas dynamic flow region of the mass analyzer. As such, an apparatus for transferring ions into a mass analyzer includes an ion source configured to generate the pulse of ions, a transient electric field device configured to receive the pulse of ions and generate the transient electric field, and an ion collector configured to collect the ions from the ion drift region and transfer the ions into the mass analyzer.
摘要翻译：产生离子脉冲的装置和方法产生时间上与离子脉冲持续时间相关的瞬时电场，将离子脉冲接收到瞬态电场中，并从离子漂移区域瞬态电场进入质量分析仪的气体动态流动区域。因此，用于将离子转移到质量分析器中的装置包括被配置为产生离子脉冲的离子源，被配置为接收离子脉冲并产生瞬态电场的瞬态电场装置，以及被配置为收集离子的离子收集器来自离子漂移区域的离子并将离子转移到质谱仪中。

2. 发明授权

US07122789B2 Method and apparatus to increase ionization efficiency in an ion source 有权
标题翻译：提高离子源电离效率的方法和装置
公开(公告)号：US07122789B2
公开(公告)日：2006-10-17
申请号：US10842481
申请日：2004-05-11
申请人： Phillip V. Tan , Victor V. Laiko , Vadym Berkout , Vladimir M. Doroshenko
发明人： Phillip V. Tan , Victor V. Laiko , Vadym Berkout , Vladimir M. Doroshenko
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/164 , H01J49/0404
摘要： A method and an apparatus for collecting ions in which ions are produced from a sample in an ion source. An electric field is provided that is more uniform in an area adjacent the sample than in an area adjacent an inlet to the ion transfer device or that is larger in field strength at the sample than at a point removed from the sample towards the inlet of the ion transfer device. Ions are received into the electric field and transferred through the ion transfer device to a sampling orifice of the mass spectrometer. The apparatus includes an ion transfer device coupled to a sampling orifice of a mass spectrometer. The ion transfer device has an inlet with a surface that extends in a direction from an axis of the ion transfer device. The ion transfer device can extend a distance of at least 10 times an inner diameter of a sampling orifice of the mass spectrometer.
摘要翻译：用于收集离子的方法和装置，其中离子源中的样品产生离子。提供电场，其在靠近样品的区域中比邻近离子转移装置的入口的区域更均匀，或者在样品处的场强大于在从样品朝向所述样品的入口移除的点离子转移装置。离子被接收到电场中并通过离子传递装置传送到质谱仪的采样孔。该装置包括耦合到质谱仪的采样孔的离子传递装置。离子转移装置具有从离子转移装置的轴线方向延伸的表面的入口。离子转移装置可以延伸质谱仪的采样孔的内径的至少10倍的距离。

3. 发明授权

US06683300B2 Method and apparatus for mass spectrometry analysis of common analyte solutions 失效
标题翻译：普通分析物溶液质谱分析方法和装置
公开(公告)号：US06683300B2
公开(公告)日：2004-01-27
申请号：US09953403
申请日：2001-09-17
申请人： Vladimir M. Doroshenko , Victor V. Laiko , Mikhail Yakshin , Coorg R. Prasad , Hyo Sang Lee
发明人： Vladimir M. Doroshenko , Victor V. Laiko , Mikhail Yakshin , Coorg R. Prasad , Hyo Sang Lee
IPC分类号： H01J4916
CPC分类号： H01J49/04
摘要： A method, system, and apparatus for mass spectroscopic analysis of an analyte solution in which a liquid volume of the analyte solution is irradiated with a light source resulting in desorption of solution-specific ions into a surrounding gas to produce gas-phase ions, the gas-phase ions are transferred to an inlet port of a mass analyzer, and the gas-phase ions are mass analyzed. More specifically, the apparatus may include a laser configured to pulse irradiate a surface of the analyte solution, a mass spectrometer configured to mass-analyze the gas-phase ions according to the mass-to-charge ratio, and a transfer mechanism configured to transfer the gas-phase ions to an inlet port of the mass spectrometer.
摘要翻译：分析物溶液的质谱分析的方法，系统和装置，其中用光源照射分析物溶液的液体体积，导致溶液特异性离子解吸到周围气体中以产生气相离子，将气相离子转移到质量分析器的入口，并对气相离子进行质量分析。更具体地，该装置可以包括被配置为脉冲照射分析物溶液的表面的激光器，配置成根据质荷比对气相离子进行质量分析的质谱仪，以及被配置为转移气相离子到质谱仪的入口。

4. 发明授权

US08471199B1 Portable mass spectrometer with atmospheric pressure interface 有权
标题翻译：便携式质谱仪，带有大气压力界面
公开(公告)号：US08471199B1
公开(公告)日：2013-06-25
申请号：US13441532
申请日：2012-04-06
申请人： Vladimir M. Doroshenko , Victor V. Laiko , Alexander S. Misharin
发明人： Vladimir M. Doroshenko , Victor V. Laiko , Alexander S. Misharin
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0013
摘要： A portable mass spectrometer having an atmospheric pressure interface for introducing ions generated at ambient pressure gas conditions into a vacuum of the mass spectrometer. The mass spectrometer has a vacuum chamber having at least one vacuum section and at least one gas inlet for directing the ambient pressure gas including the ions into the at least one vacuum section. The at least one gas inlet has a gas passage channel of a length L and a limiting cross section S with a ratio of L/S being less than 20,000 cm−1. The mass spectrometer has a radio frequency (RF) ion guide in the at least one vacuum section positioned for collecting the ions from the at least one gas inlet and transmitting the ions further to a mass analyzer for analyzing the ions transmitted from the ion guide.
摘要翻译：一种便携式质谱仪，具有用于将在环境压力气体条件下产生的离子引入质谱仪真空的大气压界面。质谱仪具有至少一个真空部分的真空室和至少一个气体入口，用于将包括离子的环境压力气体引导到至少一个真空部分中。至少一个气体入口具有长度为L的气体通道通道和L / S的比例小于20,000cm -1的限制横截面S. 所述质谱仪在所述至少一个真空部分中具有射频（RF）离子引导件，定位成用于从所述至少一个气体入口收集离子，并将所述离子进一步传输到质量分析器，以分析从所述离子导向器传输的离子。

5. 发明授权

US06943346B2 Method and apparatus for mass spectrometry analysis of aerosol particles at atmospheric pressure 失效
公开(公告)号：US06943346B2
公开(公告)日：2005-09-13
申请号：US10639508
申请日：2003-08-13
申请人： Phillip V. Tan , Vladimir M. Doroshenko
发明人： Phillip V. Tan , Vladimir M. Doroshenko
IPC分类号： H01J49/04 , H01J49/16 , H01J49/40 , B01D54/44
CPC分类号： H01J49/164 , H01J49/0445
摘要： An apparatus and method for generating ions from an aerosol and transferring the ions into a mass analyzer. In the apparatus and method, an aerosol beam is generated, the aerosol beam is directed to a spatial volume outside the mass analyzer, particles in the aerosol beam are ionized to produce the ions, and the ions are collected into the mass analyzer. As such the apparatus includes respectively an aerosol beam generator, an ion source generator, and an ion collector.

6. 发明授权

US07397029B2 Method and apparatus for ion fragmentation in mass spectrometry 失效
标题翻译：离子质谱分离方法和装置
公开(公告)号：US07397029B2
公开(公告)日：2008-07-08
申请号：US11620504
申请日：2007-01-05
申请人： Vadym D. Berkout , Vladimir M. Doroshenko
发明人： Vadym D. Berkout , Vladimir M. Doroshenko
IPC分类号： B01D59/44
CPC分类号： H01J49/0045
摘要： An apparatus for mass analyzing molecules includes a mass spectrometer configured to select precursor ions having a mass to charge ratio range, a metastable species generator configured to generate a metastable species for introduction into the mass spectrometer, and a mass detector configured to detect a mass of the product ions. The apparatus also includes interaction region in the mass spectrometer where the precursor ions are converted into product ions via interaction of the precursor ions with the metastable species. The mass spectrometer includes at least one of a three-dimensional ion trap, a linear ion trap, or an ion guide. The interaction region is located inside the three-dimensional ion trap, the linear trap, or the ion guide; and at least one of the precursor ions or at least one of the product ions are excited by an alternating electric field or collisionally activated to produce additional product ions.
摘要翻译：用于质量分析分子的装置包括：质谱仪，其被配置为选择具有质荷比范围的前体离子;构造成产生用于引入质谱仪的亚稳态物质的亚稳态物质发生器;以及质量检测器，产品离子。该装置还包括质谱仪中的相互作用区域，其中前体离子通过前体离子与亚稳态物质的相互作用转化成产物离子。质谱仪包括三维离子阱，线性离子阱或离子导体中的至少一种。相互作用区域位于三维离子阱，线性阱或离子导向器内; 并且至少一种前体离子或至少一种产物离子被交变电场激发或者被碰撞激活以产生另外的产物离子。

7. 发明授权

US08825413B2 Spectral deconvolution in ion cyclotron resonance mass spectrometry 有权
标题翻译：离子回旋共振质谱中的光谱去卷积
公开(公告)号：US08825413B2
公开(公告)日：2014-09-02
申请号：US12755977
申请日：2010-04-07
申请人： Alexander Misharin , Konstantin Novoselov , Vladimir M. Doroshenko
发明人： Alexander Misharin , Konstantin Novoselov , Vladimir M. Doroshenko
IPC分类号： G01N31/00 , H01J49/38 , H01J49/00 , H03F1/26
CPC分类号： H01J49/0036 , H01J49/38
摘要： A method and system for deconvolution of a frequency spectrum obtained in an ICR mass spectrometer based on a detection of ion oscillation overtones of the M-th order (where the integer M>1). A plurality of frequency peaks is collected within the frequency spectrum corresponding respectively to oscillations of different groups of ions, and associates at least one of the frequency peaks having a frequency f and a measured amplitude A with a particular group of the ions. The method and system identify whether the frequency peak is related to one of an overtone frequency, a subharmonic frequency, a higher harmonic frequency, or a side-shifted frequency of the oscillations of the different group of ions. The method and system derive calculated amplitudes of the overtone frequency peaks associated with the groups of ions by incorporating measured amplitudes of the frequency peaks related to the subharmonic frequency, the higher harmonic frequency, or the side-shifted frequency associated with the groups of ions into the calculated amplitudes of the overtone frequency peaks. The method and system generate a deconvoluted frequency spectrum including the overtone frequency peaks associated with the different groups of ions.
摘要翻译：基于对M阶离子振荡泛音（其中整数M> 1）的检测，在ICR质谱仪中获得的频谱的去卷积方法和系统。在分别对应于不同离子组的振荡的频谱内收集多个频率峰值，并且将具有频率f和测量幅度A的频率峰值中的至少一个与特定的一组离子相关联。该方法和系统识别频率峰值是否与不同离子组的振荡的泛音频率，次谐波频率，高次谐波频率或侧移频率之一相关。该方法和系统通过将与次谐波频率，高次谐波频率或与离子组相关联的侧移频率相关的频率峰值的测量幅度并入到离子组相关的泛音频率峰值中来计算振幅计算的泛音频率峰值的幅度。该方法和系统产生包括与不同离子组相关的泛音频率峰值的解卷积频谱。

8. 发明申请

US20120326026A1 PORTABLE ION TRAP MASS SPECTROMETER WITH METAL HYDRIDE CONTAINER AS SOURCE OF HYDROGEN BUFFER GAS 有权
标题翻译：具有金属氢化物容器的便携式离子质谱仪作为氢气缓冲气体源
公开(公告)号：US20120326026A1
公开(公告)日：2012-12-27
申请号：US13168690
申请日：2011-06-24
申请人： Alexander MISHARIN , Vladimir M. Doroshenko
发明人： Alexander MISHARIN , Vladimir M. Doroshenko
IPC分类号： H01J49/34 , H01J49/26
CPC分类号： H01J49/424 , H01J49/0013 , H01J49/0081 , H01J49/0481 , H01J49/422
摘要： A mass spectrometry (MS) method which includes generating in a vicinity of the quadrupole ion trap hydrogen molecules, directing at least part of the hydrogen molecules into the quadrupole ion trap cell, applying AC and DC voltages to quadrupole ion trap cell electrodes to create a combined AC/DC trapping field, placing sample ions inside the quadrupole ion trap cell, cooling at least part of said ions using said hydrogen molecules as a buffer gas, changing the combined AC/DC trapping field to eject the ions from the quadrupole ion trap cell, and detecting the ejected ions
摘要翻译：一种质谱（MS）方法，其包括在四极离子阱附近产生氢分子，将至少部分氢分子引入四极离子阱电池中，向四极离子阱电池电极施加AC和DC电压，以产生组合的AC / DC捕获场，将样品离子放置在四极离子阱单元内，使用所述氢分子作为缓冲气体冷却至少部分所述离子，改变组合的AC / DC捕获场以从四极离子阱中排出离子电池，并检测被排出的离子

9. 发明授权

US08188423B2 Method and apparatus for ion fragmentation in mass spectrometry 失效
标题翻译：离子质谱分离方法和装置
公开(公告)号：US08188423B2
公开(公告)日：2012-05-29
申请号：US12784532
申请日：2010-05-21
申请人： Vladimir M. Doroshenko , Vadym D. Berkout , Andrey Vilkov
发明人： Vladimir M. Doroshenko , Vadym D. Berkout , Andrey Vilkov
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/0045
摘要： A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.
摘要翻译：用于质谱分析的分析物离子的碎裂方法和用于质谱的系统。该方法产生气相分析物离子，与分析物离子分开产生含气相奇异电子物质，并在基本大气压条件下将气相分析离子和含奇异电子的物质混合，以在引入质谱仪。该系统包括气相分析物离子源，与气相分析物离子源分离的气相奇电子物质源，气相分析物离子和含奇异电子的物质混合的混合区域在基本上大气压下产生分析物离子的碎片离子，质谱仪具有入口，其中至少一部分碎片离子被引入质谱仪的真空中，以及质谱仪中的检测器，电荷比分析碎片离子。

10. 发明申请

US20100288920A1 METHOD AND APPARATUS FOR ION FRAGMENTATION IN MASS SPECTROMETRY 失效
标题翻译：用于离子质谱分析的方法和装置
公开(公告)号：US20100288920A1
公开(公告)日：2010-11-18
申请号：US12784532
申请日：2010-05-21
申请人： Vladimir M. Doroshenko , Vadym D. Berkout , Andrey Vilkov
发明人： Vladimir M. Doroshenko , Vadym D. Berkout , Andrey Vilkov
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/0045
摘要： A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.
摘要翻译：用于质谱分析的分析物离子的碎裂方法和用于质谱的系统。该方法产生气相分析物离子，与分析物离子分开产生含气相奇异电子物质，并在基本大气压条件下将气相分析离子和含奇异电子的物质混合，以在引入质谱仪。该系统包括气相分析物离子源，与气相分析物离子源分离的气相奇电子物质源，气相分析物离子和含奇异电子的物质混合的混合区域在基本上大气压下产生分析物离子的碎片离子，质谱仪具有入口，其中至少一部分碎片离子被引入质谱仪的真空中，以及质谱仪中的检测器，电荷比分析碎片离子。

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