专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07138228B2 Protein O-sulfonation 有权
标题翻译：蛋白O-磺化
公开(公告)号：US07138228B2
公开(公告)日：2006-11-21
申请号：US10657027
申请日：2003-09-05
申请人： Alma L. Burlingame , Katalin F. Medzihradszky , Zsuzsanna Darula , Eran Perlson , Michael Fainzilber , Robert J. Chalkley , Darren Tyson , Ralph A. Bradshaw
发明人： Alma L. Burlingame , Katalin F. Medzihradszky , Zsuzsanna Darula , Eran Perlson , Michael Fainzilber , Robert J. Chalkley , Darren Tyson , Ralph A. Bradshaw
IPC分类号： C12Q1/00 , C12Q1/48 , C12Q1/44 , C12P21/04 , G01N33/53
CPC分类号： G01N33/6842 , C07K16/44 , C07K2317/21 , C07K2317/622 , G01N33/6803
摘要： Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.
摘要翻译：检测蛋白质丝氨酸或苏氨酸残基的翻译后O-磺化，任选比较，其中在第一生理条件下检测到检测到的O-磺化，并与在第二生理条件下检测到的对照O-磺化进行比较，并且检测到和控制的O-磺化物之间的差异表示第一和第二生理条件之间的差异。使用生理条件的预定变化来推测O-磺化的具体变化。通过在蛋白质的丝氨酸或苏氨酸残基处引入O-磺化的预定变化，并任选地检测所得到的O-磺化变化来修饰蛋白质。这些方法包括引入或增加O-磺化，消除或降低O-磺化; 并衍生化或取代O-磺化。

2. 发明授权

US07741021B2 Protein O-sulfonation 失效
标题翻译：蛋白O-磺化
公开(公告)号：US07741021B2
公开(公告)日：2010-06-22
申请号：US11595319
申请日：2006-11-09
申请人： Alma L. Burlingame , Katalin F. Medzihradszky , Zsuzsanna Darula , Eran Perlson , Michael Fainzilber , Robert J. Chalkley , Darren Tyson , Ralph A. Bradshaw
发明人： Alma L. Burlingame , Katalin F. Medzihradszky , Zsuzsanna Darula , Eran Perlson , Michael Fainzilber , Robert J. Chalkley , Darren Tyson , Ralph A. Bradshaw
IPC分类号： C12Q1/00 , C12Q1/48 , C12Q1/37
CPC分类号： G01N33/6842 , C07K16/44 , C07K2317/21 , C07K2317/622 , G01N33/6803
摘要： Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions.Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.
摘要翻译：检测蛋白质丝氨酸或苏氨酸残基的翻译后O-磺化，任选比较，其中在第一生理条件下检测到检测到的O-磺化，并与在第二生理条件下检测到的对照O-磺化进行比较，并且检测到和控制的O-磺化物之间的差异表示第一和第二生理条件之间的差异。使用生理条件的预定变化来推测O-磺化的具体变化。通过在蛋白质的丝氨酸或苏氨酸残基处引入O-磺化的预定变化，并任选地检测所得到的O-磺化变化来修饰蛋白质。这些方法包括引入或增加O-磺化，消除或减少O-磺化; 并衍生化或取代O-磺化。

3. 发明授权

US06624288B1 Gamma-conopeptides 有权
标题翻译：伽玛肽
公开(公告)号：US06624288B1
公开(公告)日：2003-09-23
申请号：US09210952
申请日：1998-12-15
申请人： Michael Fainzilber , Karel S. Kits , Alma L. Burlingame , Baldomero M. Olivera , Craig Walker , Maren Watkins , Reshma Shetty , Lourdes J. Cruz , Julita Imperial , Clark Colledge
发明人： Michael Fainzilber , Karel S. Kits , Alma L. Burlingame , Baldomero M. Olivera , Craig Walker , Maren Watkins , Reshma Shetty , Lourdes J. Cruz , Julita Imperial , Clark Colledge
IPC分类号： C07K500
CPC分类号： C07K14/43504 , A61K38/00
摘要： This invention relates to relatively short peptides about 25-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include three cyclizing disulfide linkages and one or more &ggr;-carboxyglutamate residues. More specifically, the present invention is directed to &ggr;-conopeptides having the general formula I: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Cys-Xaa6-Cys-Xaa7 (SEQ ID NO:1), as described herein; or having the general formula II: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Cys-Xaa7-Cys-Xaa8 (SEQ ID NO:2), as defined herein; or having the general formula III: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa2-Cys-Xaa7 (SEQ ID NO:3), as described herein; or having the general formula IV: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7 (SEQ ID NO:4), as described herein; or having the general formula V: Xaa1-Xaa2-Cys-Xaa3-Xaa4-Phe-Xaa5-Cys-Thr-Xaa6-Ser-Xaa7-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr-Cys-Xaa8-Leu-Xaa9 (SEQ ID NO:5), as described herein. The invention further relates to specific &ggr;-conopeptides, specific pro-&ggr;-conopeptides and nucleic acids encoding the pro-&ggr;-conopeptides. The invention also includes pharmaceutically acceptable salts of the conopeptides. These conopeptides are useful as agonists of neuronal pacemaker calcium channels.
摘要翻译：本发明涉及长度约25-40个残基的相对较短的肽，其在锥形蜗牛的毒液中或天然存在的肽的类似物中天然可用量少，并且其包括三个环化二硫键和一个或多个γ- 羧基谷氨酸残基。更具体地，本发明涉及具有通式I的X射线衍生肽：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Cys-Xaa6-Cys-Xaa7（SEQ ID NO：1），如本文所述; 或具有如本文所定义的通式II：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Cys-Xaa7-Cys-Xaa8（SEQ ID NO：2）或具有通式III：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa2-Cys-Xaa7（SEQ ID NO：3）在这里或具有通式IV：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7（SEQ ID NO：4）在这里或具有通式V：Xaa1-Xaa2-Cys-Xaa3-Xaa4-Phe-Xaa5-Cys-Thr-Xaa6-Ser-Xaa7-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr -Cys-Xaa8-Leu-Xaa9（SEQ ID NO：5），如本文所述。本发明进一步涉及具体的γ-配体肽，特异性前-γ-肽和编码前γ-多肽的核酸。本发明还包括肽的药学上可接受的盐。这些肽可用作神经元起搏器钙通道的激动剂。

4. 发明申请

US20090181988A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof 审中-公开
标题翻译：吡唑并嘧啶衍生物及其使用方法
公开(公告)号：US20090181988A1
公开(公告)日：2009-07-16
申请号：US12194469
申请日：2008-08-19
申请人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
发明人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
IPC分类号： A61K31/522 , C12Q1/02 , C07D473/34 , A61K31/519 , C07D473/30 , A61K31/52 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.
摘要翻译：本发明一般涉及用作特别是NAD（P）（H）依赖性氧化还原酶的短链脱氢酶/还原酶（SDR）家族的抑制剂的吡唑并嘧啶衍生物。更具体地，本发明涉及吡唑并嘧啶衍生物，包括SDR抑制剂的衍生物和类似物，含有SDR抑制剂的衍生物和类似物的药物组合物，制备SDR抑制剂的衍生物和类似物的方法及其使用方法。

5. 发明授权

US07429596B2 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof 有权
标题翻译： 1H-吡咯并[2,3-D]嘧啶衍生物及其使用方法
公开(公告)号：US07429596B2
公开(公告)日：2008-09-30
申请号：US10871732
申请日：2004-06-18
申请人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
发明人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
IPC分类号： C07D487/04 , C07D413/06 , A61K31/519 , A61K31/675 , A61K31/662 , A61K31/497 , A61K31/5355 , C07F9/38 , A61P35/04 , A61P35/02
CPC分类号： C07D487/04
摘要： This invention generally relates to pyrazolo pyrimidine derivatives useful as inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. The invention further relates to pharmaceutical compositions and methods of preventing or treating disease with 1H-Pyrrolo[2.3-d]pyrimidine derivatives. More specifically, the invention relates to a 1H-Pyrrolo[2.3-d]pyrimidine which is a compound of Formula I or II: or a pharmaceutically-acceptable salt or prodrug thereof; wherein: Y is N or CR5; Z is NR3R4, halo, H, OH, alkyl, alkyloxy, or haloalkyl; and R1a is indolyl, thiazolyl, benzyl, biphenylyl, thiophenyl, pyrrolyl, or phenyl, wherein said phenyl is substituted with at least one of OH, —NR3R4, —C(═O)NR6R7, —CN, NO2—C(═O)OH, —C(═O)O-alkyl, (C1-C4)alkyl, halo, haloalkyl or haloaryl; and wherein said indolyl, thiazolyl, benzyl, biphenylyl, thiophenyl, or pyrrolyl is optionally substituted with OH, —NR3R4, —C(═O)NR6R7, —CN, NO2, —C(═O)O—R3, (C1-C4)alkyl, halo, haloalkyl or haloaryl.
摘要翻译：本发明一般涉及可用作NAD（P）（H）依赖性氧化还原酶的短链脱氢酶/还原酶（SDR）家族的抑制剂的吡唑并嘧啶衍生物。本发明还涉及用1H-吡咯并[2,3-d]嘧啶衍生物预防或治疗疾病的药物组合物和方法。更具体地，本发明涉及作为式I或II化合物的1H-吡咯并[2,3-d]嘧啶或其药学上可接受的盐或前药; 其中：Y是N或CR 5; Z是NR 3 R 4，卤素，H，OH，烷基，烷氧基或卤代烷基; 并且R 1a是吲哚基，噻唑基，苄基，联苯基，噻吩基，吡咯基或苯基，其中所述苯基被OH，-NR 3 R 3中的至少一个取代， -C（-O）NR 6 R 7，-CN，NO 2 -C（-O（O））OH，-C（-O）O-烷基，（C 1 -C 4 -C 4）烷基，卤素，卤代烷基或卤代芳基; 并且其中所述吲哚基，噻唑基，苄基，联苯基，噻吩基或吡咯基任选被OH，-NR 3 R 4，-C（ - ）NR -C（O）OR 3，-C（-O）OR 3，（C 1 -C 6） C 1 -C 4烷基，卤素，卤代烷基或卤代芳基。

6. 发明授权

US5962294A Compositions and methods for the identification and synthesis of sialyltransferases 失效
标题翻译：用于鉴定和合成唾液酸转移酶的组合物和方法
公开(公告)号：US5962294A
公开(公告)日：1999-10-05
申请号：US102385
申请日：1993-08-04
申请人： James C. Paulson , Xiaohong Wen , Brian Livingston , William Gillespie , Sorge Kelm , Alma L. Burlingame , Katalin Medzihradszky
发明人： James C. Paulson , Xiaohong Wen , Brian Livingston , William Gillespie , Sorge Kelm , Alma L. Burlingame , Katalin Medzihradszky
IPC分类号： C12N15/09 , C07H21/04 , C12N5/10 , C12N9/10 , C12N15/54 , C12P21/02 , C12Q1/68
CPC分类号： C12N9/1081 , C07K2319/02
摘要： DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of sialyltransferase.
摘要翻译：提供了编码含有同源性保守区域的唾液酸转移酶的DNA分离物以及获得这种DNA的方法以及用于重组产生唾液酸转移酶的表达系统。

7. 发明授权

US5858751A Compositions and methods for producing sialyltransferases 失效
标题翻译：唾液酸转移酶的组合物和方法
公开(公告)号：US5858751A
公开(公告)日：1999-01-12
申请号：US446875
申请日：1995-07-12
申请人： James C. Paulson , Xiaohong Wen , Brian Livingston , Alma L. Burlingame , Katalin Medzihradszky , Sorge Kelm , William Gillespie
发明人： James C. Paulson , Xiaohong Wen , Brian Livingston , Alma L. Burlingame , Katalin Medzihradszky , Sorge Kelm , William Gillespie
IPC分类号： C12N9/10 , C07H21/04 , C12N1/20 , C12P21/06
CPC分类号： C12N9/1081 , C07K2319/02
摘要： DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the various sialyltransferases.
摘要翻译： PCT No.PCT / US94 / 08516 371日期：1995年7月12日 102（e）日期1995年7月12日PCT 1994年7月27日PCT公布。出版物WO95 / 04816 日期1995年2月16日提供了编码含有同源性保守区域的唾液酸转移酶的DNA分离物以及获得这种DNA的方法，以及用于重组生产各种唾液酸转移酶的表达系统。

8. 发明申请

US20120065154A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof 审中-公开
标题翻译：吡唑并嘧啶衍生物及其使用方法
公开(公告)号：US20120065154A1
公开(公告)日：2012-03-15
申请号：US13016957
申请日：2011-01-28
申请人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
发明人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
IPC分类号： A61K31/704 , A61K31/519 , A61K31/52 , A61P35/00 , C12Q1/18 , A61P29/00 , A61P3/00 , A61P3/10 , A61P3/04 , C07D487/04 , A61P35/02
CPC分类号： C07D487/04
摘要： This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.
摘要翻译：本发明一般涉及用作特别是NAD（P）（H）依赖性氧化还原酶的短链脱氢酶/还原酶（SDR）家族的抑制剂的吡唑并嘧啶衍生物。更具体地，本发明涉及吡唑并嘧啶衍生物，包括SDR抑制剂的衍生物和类似物，含有SDR抑制剂的衍生物和类似物的药物组合物，制备SDR抑制剂的衍生物和类似物的方法及其使用方法。

9. 发明授权

US5965884A Atmospheric pressure matrix assisted laser desorption 失效
标题翻译：大气压矩阵辅助激光解吸
公开(公告)号：US5965884A
公开(公告)日：1999-10-12
申请号：US90764
申请日：1998-06-04
申请人： Victor V. Laiko , Alma L. Burlingame
发明人： Victor V. Laiko , Alma L. Burlingame
IPC分类号： H01J49/10 , H01J49/04 , H01J49/16
CPC分类号： H01J49/164
摘要： An Atmospheric Pressure Matrix-Assisted Laser Desorption Ionization (AP-MALDI) apparatus is for connecting to a mass spectrometer. This apparatus provides an ion source using matrix-assisted laser desorption and ionization at or near atmospheric pressure. The apparatus has non-destructive ion source having the characteristics of versatility, simplicity.
摘要翻译：大气压矩阵辅助激光解吸电离（AP-MALDI）装置用于连接质谱仪。该装置在大气压或接近大气压下提供使用基质辅助激光解吸和离子化的离子源。该设备具有无损离子源，具有通用性，简便性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式