专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070010469A1 Gene products differentially expressed in cancerous cells III 失效
标题翻译：在癌细胞中差异表达的基因产物III
公开(公告)号：US20070010469A1
公开(公告)日：2007-01-11
申请号：US10948737
申请日：2004-09-22
申请人： Vivien Chan , Jaime Escobedo , Pablo Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia Kennedy , George Lamson , Edward Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien Chan , Jaime Escobedo , Pablo Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia Kennedy , George Lamson , Edward Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： A61K48/00 , A61K39/395 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

2. 发明申请

US20050227917A1 Gene products differentially expressed in cancerous cells and their methods of use II 有权
标题翻译：在癌细胞中差异表达的基因产物及其使用方法II
公开(公告)号：US20050227917A1
公开(公告)日：2005-10-13
申请号：US10779543
申请日：2004-02-12
申请人： Lewis Williams , Jaime Escobedo , Michael Innis , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia Kennedy , David Pot , Altaf Kassam , George Lamson , Zhijun He , Elizabeth Scott , Guozhong Zhang , Theresa May , Doreen Sakamoto , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee Jones , Birgit Stache-Crain
发明人： Lewis Williams , Jaime Escobedo , Michael Innis , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia Kennedy , David Pot , Altaf Kassam , George Lamson , Zhijun He , Elizabeth Scott , Guozhong Zhang , Theresa May , Doreen Sakamoto , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee Jones , Birgit Stache-Crain
IPC分类号： A61K38/17 , C07H21/04 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： A61K38/1709 , C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/574
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

3. 发明申请

US20070243176A1 Human genes and gene expression products 审中-公开
标题翻译：人类基因和基因表达产物
公开(公告)号：US20070243176A1
公开(公告)日：2007-10-18
申请号：US10615618
申请日：2003-07-07
申请人： Jaime Escobedo , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Filippo Randazzo , George Lamson , Elizabeth Scott , Guozhong Zhang , Altaf Kassam , David Pot , Radoje Drmanac , Ivan Labat , Birgit Stache-Crain
发明人： Jaime Escobedo , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Filippo Randazzo , George Lamson , Elizabeth Scott , Guozhong Zhang , Altaf Kassam , David Pot , Radoje Drmanac , Ivan Labat , Birgit Stache-Crain
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/18 , C12N15/85 , C12N5/10 , C12P21/00 , C12Q1/68
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

4. 发明申请

US20060234246A1 Gene products differentially expressed in cancerous cells 审中-公开
标题翻译：在癌细胞中差异表达的基因产物
公开(公告)号：US20060234246A1
公开(公告)日：2006-10-19
申请号：US10934842
申请日：2004-09-02
申请人： Elizabeth Scott , George Lamson , Altaf Kassam , Guozhong Zhang , Doreen Sakamoto , Pablo Garcia , Theresa May , Giulia Kennedy , Sanmao Kang , Christoph Reinhard , Ann Jefferson
发明人： Elizabeth Scott , George Lamson , Altaf Kassam , Guozhong Zhang , Doreen Sakamoto , Pablo Garcia , Theresa May , Giulia Kennedy , Sanmao Kang , Christoph Reinhard , Ann Jefferson
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

5. 发明申请

US20060275747A1 Endogenous retrovirus up-regulated in prostate cancer 审中-公开
标题翻译：内源性逆转录病毒在前列腺癌中上调
公开(公告)号：US20060275747A1
公开(公告)日：2006-12-07
申请号：US10498033
申请日：2002-12-09
申请人： Stephen Hardy , Pablo Garcia , Lewis Williams , Jaime Escobedo
发明人： Stephen Hardy , Pablo Garcia , Lewis Williams , Jaime Escobedo
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/702 , C12Q2600/136 , C12Q2600/158 , G01N33/57434
摘要： A specific member of the HERV-K family located in chromosome 22 at 20.428 megabases (22q11.2) has been found to be preferentially and significantly up-regulated in prostate tumors. The invention provides methods for diagnosing prostate cancer, comprising the step of detecting in a patient sample the presence or absence of an expression product of the virus. The virus has five features not seen in other HERV-K members: (1) its own specific nucleotide sequence, and consequently amino acid sequences; (2) tandem 5′ LTRs; (3) a fragmented 3′ LTR; (4) an env gene interrupted by an alu insertion; and (5) unique gag sequences.
摘要翻译：已经发现，在20.428兆比特（22q11.2）位于22号染色体上的HERV-K家族的特异成员在前列腺肿瘤中优先显着上调。本发明提供了诊断前列腺癌的方法，包括在患者样品中检测病毒表达产物的存在或不存在的步骤。该病毒在其他HERV-K成员中没有看到五个特征：（1）其自身的特异核苷酸序列，因此是氨基酸序列; （2）串联5'LTR; （3）碎片3'LTR; （4）由alu插入中断的env基因; 和（5）独特的gag序列。

6. 发明申请

US20070037147A1 Endogenous retrovirus polypeptides linked to oncogenic transformation 审中-公开
标题翻译：与致癌转化相关的内源性逆转录病毒多肽
公开(公告)号：US20070037147A1
公开(公告)日：2007-02-15
申请号：US10497786
申请日：2002-12-09
申请人： Pablo Garcia , Stephen Hardy , Lewis Williams , Jaime Escobedo
发明人： Pablo Garcia , Stephen Hardy , Lewis Williams , Jaime Escobedo
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/10021 , C12N2740/10022 , C12Q1/6886 , C12Q1/702 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N2333/15
摘要： HERV-K human endogenous retroviruses show up-regulated expression in tumors. In particular, splicing events in the env region generate a series of transcripts which utilise the +2 reading frame, relative to the env reading frame. The proteins show activity typical of transcriptional regulators, and they also have oncogenic potential. Two related proteins, PCAP2 and PCAP3, are strongly associated with breast cancer and prostate cancer, respectively. PCAP4 stimulates cell division. These proteins can be used in cancer diagnosis and therapy, and are also drug target e.g. for adjuvant therapy. The identification of these splice products is remarkable because full sequence information has been available for HERV-K viruses since 1986.
摘要翻译： HERV-K人内源性逆转录病毒在肿瘤中表达上调。特别地，env区域中的拼接事件产生一系列相对于env阅读框使用+2阅读框的抄本。蛋白质表现出转录调节因子的典型活性，并且具有致癌潜力。两种相关蛋白，PCAP2和PCAP3分别与乳腺癌和前列腺癌密切相关。 PCAP4刺激细胞分裂。这些蛋白质可用于癌症诊断和治疗，也是药物靶标。用于辅助治疗。鉴于这些拼接产品是非常显着的，因为自1986年以来，全序列信息已经可用于HERV-K病毒。

7. 发明申请

US20080233046A1 Trefoil Factor 3 (Tff3) as a Target for Anti-Cancer Therapy 审中-公开
标题翻译：作为抗癌治疗目标的三叶因子3（Tff3）
公开(公告)号：US20080233046A1
公开(公告)日：2008-09-25
申请号：US10567330
申请日：2004-08-05
申请人： Mary J. Janatpour , Pablo Garcia , Christoph Reinhard
发明人： Mary J. Janatpour , Pablo Garcia , Christoph Reinhard
IPC分类号： A61K51/04 , A61K31/7088 , A61K39/395 , G01N33/53 , C07H21/04 , C07K17/02 , C12N5/00 , C12P21/04 , C07K7/06 , C12N9/00 , C07K16/18 , A61K51/10 , G01N33/574 , A61P35/04
CPC分类号： C12N15/1136 , C07K14/575 , C07K16/26 , C07K2317/34 , C07K2317/73 , C12N2310/11
摘要： The present invention is directed to methods of treating and preventing cancer, such as cancer characterized by differential expression of trefoil factor 3 (TFF3). The methods include administering to a patient an agent that modulates TFF3 activity or expression. The present invention is further directed to reducing the physiological effects of TFF3 expression in cells, including inhibiting cell motility and resistance to apoptosis. Oligonucleotides and antibodies that can modulate expression or activity of TFF3 are also provided.
摘要翻译：本发明涉及治疗和预防癌症的方法，例如以三叶因子3（TFF3）的差异表达为特征的癌症。所述方法包括向患者施用调节TFF3活性或表达的试剂。本发明进一步涉及减少TFF3在细胞中的表达的生理作用，包括抑制细胞运动性和抗细胞凋亡。还提供了可调节TFF3的表达或活性的寡核苷酸和抗体。

8. 发明申请

US20050186212A1 Trefoil factor 3 (TFF3) as a target for anti-cancer therapy 审中-公开
标题翻译：三叶因子3（TFF3）作为抗癌治疗的靶标
公开(公告)号：US20050186212A1
公开(公告)日：2005-08-25
申请号：US10913685
申请日：2004-08-05
申请人： Mary Janatpour , Pablo Garcia , Christoph Reinhard
发明人： Mary Janatpour , Pablo Garcia , Christoph Reinhard
IPC分类号： A61B20060101 , A61K39/395 , A61K48/00 , C07K14/575 , C07K16/26 , C12N15/113
CPC分类号： C12N15/1136 , C07K14/575 , C07K16/26 , C07K2317/34 , C07K2317/73 , C12N2310/11
摘要： The present invention is directed to methods of treating and preventing cancer, such as cancer characterized by differential expression of trefoil factor 3 (TFF3). The methods include administering to a patient an agent that modulates TFF3 activity or expression. The present invention is further directed to reducing the physiological effects of TFF3 expression in cells, including inhibiting cell motility and resistance to apoptosis. Oligonucleotides and antibodies that can modulate expression or activity of TFF3 are also provided.
摘要翻译：本发明涉及治疗和预防癌症的方法，例如以三叶因子3（TFF3）的差异表达为特征的癌症。所述方法包括向患者施用调节TFF3活性或表达的试剂。本发明进一步涉及减少TFF3在细胞中的表达的生理作用，包括抑制细胞运动性和抗细胞凋亡。还提供了可调节TFF3的表达或活性的寡核苷酸和抗体。

9. 发明申请

US20110062948A1 System and Method for Measuring Movement of a Component from Rings Magnetized in a Magnetically Hard Layer 有权
标题翻译：用于测量在磁性硬层中磁化的环的组分的运动的系统和方法
公开(公告)号：US20110062948A1
公开(公告)日：2011-03-17
申请号：US12953919
申请日：2010-11-24
申请人： Donald C. Arns, JR. , Pablo Garcia
发明人： Donald C. Arns, JR. , Pablo Garcia
IPC分类号： G01B7/14
CPC分类号： F15B15/2861 , F15B15/2846 , G01D5/00 , G01D5/24423 , G01D5/24438 , G01D5/24447 , G01D5/24476
摘要： A position-sensing system includes a first component (e.g., a cylinder) and a second component (e.g., a piston rod) movably coupled to the first component for movement with respect thereto. A magnetically hard layer on the second component provides a recording medium. Regions of the magnetically hard layer are magnetized as magnetized rings around the second component. Magnetic-field sensors are coupled to the first component in proximity of the magnetically hard layer on the second component to sense the rings of magnetized regions. Each of the magnetic field sensors senses flux from each of the rings of magnetized regions as the second component is moving with respect to the first component and, in response to sensing the rings of magnetized regions, generates signals used to determine position of the second component.
摘要翻译：位置感测系统包括可移动地联接到第一部件以相对于其移动的第一部件（例如，气缸）和第二部件（例如，活塞杆）。第二组件上的磁性硬层提供记录介质。磁性硬层的区域被磁化为围绕第二组分的磁化环。磁场传感器在第二部件上的磁性硬层附近耦合到第一部件以感测磁化区域的环。当第二部件相对于第一部件移动时，每个磁场传感器感测来自磁化区域的每个环的磁通，并且响应于感测磁化区域的环，产生用于确定第二部件的位置的信号。

10. 发明授权

US07755350B2 System and method of perpendicularly magnetizing position information in a magnetically hard layer of a moving component 有权
标题翻译：在运动部件的磁性硬层中垂直磁化位置信息的系统和方法
公开(公告)号：US07755350B2
公开(公告)日：2010-07-13
申请号：US12252342
申请日：2008-10-15
申请人： Donald C. Arns, Jr. , Pablo Garcia
发明人： Donald C. Arns, Jr. , Pablo Garcia
IPC分类号： G01B7/14
CPC分类号： F15B15/2861 , F15B15/2846 , G01D5/00 , G01D5/24423 , G01D5/24438 , G01D5/24447 , G01D5/24476
摘要： A position-sensing system magnetically senses the position of a piston rod moving with respect to a cylinder. A magnetically hard layer on the piston rod provides a recording medium. Information is perpendicularly magnetized in regions of the magnetically hard layer. These regions provide an encoding scheme for determining the position of the piston rod. Magnetic-field sensors are positioned over redundant tracks of magnetically recorded regions. Each magnetic-field sensor positioned over a given track senses the same magnetized regions while the piston rod moves with respect to the cylinder. Other magnetic-field sensors can sense ambient fields for use in performing common-mode rejection. A write head can dynamically repair damaged or erased regions detected by the magnetic-field sensors. Energized by a battery-backup power source, the magnetic-field sensors and associated circuitry can continue to track movement of the piston rod when the machinery is off.
摘要翻译：位置感测系统磁性地感测相对于气缸移动的活塞杆的位置。活塞杆上的磁性硬层提供了一种记录介质。信息在磁性硬层的区域中垂直磁化。这些区域提供用于确定活塞杆的位置的编码方案。磁场传感器位于磁记录区域的冗余轨道上。位于给定轨道上方的每个磁场传感器在活塞杆相对于气缸移动时感测相同的磁化区域。其他磁场传感器可以感测用于执行共模抑制的环境场。写头可以动态修复由磁场传感器检测到的损坏或擦除的区域。由电池备用电源供电，当机械关闭时，磁场传感器和相关电路可以继续跟踪活塞杆的运动。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式