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1. 发明申请

US20060275747A1 Endogenous retrovirus up-regulated in prostate cancer 审中-公开
标题翻译：内源性逆转录病毒在前列腺癌中上调
公开(公告)号：US20060275747A1
公开(公告)日：2006-12-07
申请号：US10498033
申请日：2002-12-09
申请人： Stephen Hardy , Pablo Garcia , Lewis Williams , Jaime Escobedo
发明人： Stephen Hardy , Pablo Garcia , Lewis Williams , Jaime Escobedo
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/702 , C12Q2600/136 , C12Q2600/158 , G01N33/57434
摘要： A specific member of the HERV-K family located in chromosome 22 at 20.428 megabases (22q11.2) has been found to be preferentially and significantly up-regulated in prostate tumors. The invention provides methods for diagnosing prostate cancer, comprising the step of detecting in a patient sample the presence or absence of an expression product of the virus. The virus has five features not seen in other HERV-K members: (1) its own specific nucleotide sequence, and consequently amino acid sequences; (2) tandem 5′ LTRs; (3) a fragmented 3′ LTR; (4) an env gene interrupted by an alu insertion; and (5) unique gag sequences.
摘要翻译：已经发现，在20.428兆比特（22q11.2）位于22号染色体上的HERV-K家族的特异成员在前列腺肿瘤中优先显着上调。本发明提供了诊断前列腺癌的方法，包括在患者样品中检测病毒表达产物的存在或不存在的步骤。该病毒在其他HERV-K成员中没有看到五个特征：（1）其自身的特异核苷酸序列，因此是氨基酸序列; （2）串联5'LTR; （3）碎片3'LTR; （4）由alu插入中断的env基因; 和（5）独特的gag序列。

2. 发明申请

US20070037147A1 Endogenous retrovirus polypeptides linked to oncogenic transformation 审中-公开
标题翻译：与致癌转化相关的内源性逆转录病毒多肽
公开(公告)号：US20070037147A1
公开(公告)日：2007-02-15
申请号：US10497786
申请日：2002-12-09
申请人： Pablo Garcia , Stephen Hardy , Lewis Williams , Jaime Escobedo
发明人： Pablo Garcia , Stephen Hardy , Lewis Williams , Jaime Escobedo
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/10021 , C12N2740/10022 , C12Q1/6886 , C12Q1/702 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N2333/15
摘要： HERV-K human endogenous retroviruses show up-regulated expression in tumors. In particular, splicing events in the env region generate a series of transcripts which utilise the +2 reading frame, relative to the env reading frame. The proteins show activity typical of transcriptional regulators, and they also have oncogenic potential. Two related proteins, PCAP2 and PCAP3, are strongly associated with breast cancer and prostate cancer, respectively. PCAP4 stimulates cell division. These proteins can be used in cancer diagnosis and therapy, and are also drug target e.g. for adjuvant therapy. The identification of these splice products is remarkable because full sequence information has been available for HERV-K viruses since 1986.
摘要翻译： HERV-K人内源性逆转录病毒在肿瘤中表达上调。特别地，env区域中的拼接事件产生一系列相对于env阅读框使用+2阅读框的抄本。蛋白质表现出转录调节因子的典型活性，并且具有致癌潜力。两种相关蛋白，PCAP2和PCAP3分别与乳腺癌和前列腺癌密切相关。 PCAP4刺激细胞分裂。这些蛋白质可用于癌症诊断和治疗，也是药物靶标。用于辅助治疗。鉴于这些拼接产品是非常显着的，因为自1986年以来，全序列信息已经可用于HERV-K病毒。

3. 发明申请

US20050227917A1 Gene products differentially expressed in cancerous cells and their methods of use II 有权
标题翻译：在癌细胞中差异表达的基因产物及其使用方法II
公开(公告)号：US20050227917A1
公开(公告)日：2005-10-13
申请号：US10779543
申请日：2004-02-12
申请人： Lewis Williams , Jaime Escobedo , Michael Innis , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia Kennedy , David Pot , Altaf Kassam , George Lamson , Zhijun He , Elizabeth Scott , Guozhong Zhang , Theresa May , Doreen Sakamoto , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee Jones , Birgit Stache-Crain
发明人： Lewis Williams , Jaime Escobedo , Michael Innis , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia Kennedy , David Pot , Altaf Kassam , George Lamson , Zhijun He , Elizabeth Scott , Guozhong Zhang , Theresa May , Doreen Sakamoto , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee Jones , Birgit Stache-Crain
IPC分类号： A61K38/17 , C07H21/04 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： A61K38/1709 , C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/574
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

4. 发明申请

US20070243176A1 Human genes and gene expression products 审中-公开
标题翻译：人类基因和基因表达产物
公开(公告)号：US20070243176A1
公开(公告)日：2007-10-18
申请号：US10615618
申请日：2003-07-07
申请人： Jaime Escobedo , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Filippo Randazzo , George Lamson , Elizabeth Scott , Guozhong Zhang , Altaf Kassam , David Pot , Radoje Drmanac , Ivan Labat , Birgit Stache-Crain
发明人： Jaime Escobedo , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Filippo Randazzo , George Lamson , Elizabeth Scott , Guozhong Zhang , Altaf Kassam , David Pot , Radoje Drmanac , Ivan Labat , Birgit Stache-Crain
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/18 , C12N15/85 , C12N5/10 , C12P21/00 , C12Q1/68
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

5. 发明申请

US20070010469A1 Gene products differentially expressed in cancerous cells III 失效
标题翻译：在癌细胞中差异表达的基因产物III
公开(公告)号：US20070010469A1
公开(公告)日：2007-01-11
申请号：US10948737
申请日：2004-09-22
申请人： Vivien Chan , Jaime Escobedo , Pablo Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia Kennedy , George Lamson , Edward Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien Chan , Jaime Escobedo , Pablo Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia Kennedy , George Lamson , Edward Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： A61K48/00 , A61K39/395 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

6. 发明申请

US20110062948A1 System and Method for Measuring Movement of a Component from Rings Magnetized in a Magnetically Hard Layer 有权
标题翻译：用于测量在磁性硬层中磁化的环的组分的运动的系统和方法
公开(公告)号：US20110062948A1
公开(公告)日：2011-03-17
申请号：US12953919
申请日：2010-11-24
申请人： Donald C. Arns, JR. , Pablo Garcia
发明人： Donald C. Arns, JR. , Pablo Garcia
IPC分类号： G01B7/14
CPC分类号： F15B15/2861 , F15B15/2846 , G01D5/00 , G01D5/24423 , G01D5/24438 , G01D5/24447 , G01D5/24476
摘要： A position-sensing system includes a first component (e.g., a cylinder) and a second component (e.g., a piston rod) movably coupled to the first component for movement with respect thereto. A magnetically hard layer on the second component provides a recording medium. Regions of the magnetically hard layer are magnetized as magnetized rings around the second component. Magnetic-field sensors are coupled to the first component in proximity of the magnetically hard layer on the second component to sense the rings of magnetized regions. Each of the magnetic field sensors senses flux from each of the rings of magnetized regions as the second component is moving with respect to the first component and, in response to sensing the rings of magnetized regions, generates signals used to determine position of the second component.
摘要翻译：位置感测系统包括可移动地联接到第一部件以相对于其移动的第一部件（例如，气缸）和第二部件（例如，活塞杆）。第二组件上的磁性硬层提供记录介质。磁性硬层的区域被磁化为围绕第二组分的磁化环。磁场传感器在第二部件上的磁性硬层附近耦合到第一部件以感测磁化区域的环。当第二部件相对于第一部件移动时，每个磁场传感器感测来自磁化区域的每个环的磁通，并且响应于感测磁化区域的环，产生用于确定第二部件的位置的信号。

7. 发明授权

US07755350B2 System and method of perpendicularly magnetizing position information in a magnetically hard layer of a moving component 有权
标题翻译：在运动部件的磁性硬层中垂直磁化位置信息的系统和方法
公开(公告)号：US07755350B2
公开(公告)日：2010-07-13
申请号：US12252342
申请日：2008-10-15
申请人： Donald C. Arns, Jr. , Pablo Garcia
发明人： Donald C. Arns, Jr. , Pablo Garcia
IPC分类号： G01B7/14
CPC分类号： F15B15/2861 , F15B15/2846 , G01D5/00 , G01D5/24423 , G01D5/24438 , G01D5/24447 , G01D5/24476
摘要： A position-sensing system magnetically senses the position of a piston rod moving with respect to a cylinder. A magnetically hard layer on the piston rod provides a recording medium. Information is perpendicularly magnetized in regions of the magnetically hard layer. These regions provide an encoding scheme for determining the position of the piston rod. Magnetic-field sensors are positioned over redundant tracks of magnetically recorded regions. Each magnetic-field sensor positioned over a given track senses the same magnetized regions while the piston rod moves with respect to the cylinder. Other magnetic-field sensors can sense ambient fields for use in performing common-mode rejection. A write head can dynamically repair damaged or erased regions detected by the magnetic-field sensors. Energized by a battery-backup power source, the magnetic-field sensors and associated circuitry can continue to track movement of the piston rod when the machinery is off.
摘要翻译：位置感测系统磁性地感测相对于气缸移动的活塞杆的位置。活塞杆上的磁性硬层提供了一种记录介质。信息在磁性硬层的区域中垂直磁化。这些区域提供用于确定活塞杆的位置的编码方案。磁场传感器位于磁记录区域的冗余轨道上。位于给定轨道上方的每个磁场传感器在活塞杆相对于气缸移动时感测相同的磁化区域。其他磁场传感器可以感测用于执行共模抑制的环境场。写头可以动态修复由磁场传感器检测到的损坏或擦除的区域。由电池备用电源供电，当机械关闭时，磁场传感器和相关电路可以继续跟踪活塞杆的运动。

8. 发明申请

US20070262770A1 SYSTEM AND METHOD OF MAGNETICALLY SENSING POSITION OF A MOVING COMPONENT 有权
标题翻译：移动组件的磁感测位置的系统和方法
公开(公告)号：US20070262770A1
公开(公告)日：2007-11-15
申请号：US11782005
申请日：2007-07-24
申请人： Donald Arns , Pablo Garcia
发明人： Donald Arns , Pablo Garcia
IPC分类号： G01B7/14
CPC分类号： F15B15/2861 , F15B15/2846 , G01D5/00 , G01D5/24423 , G01D5/24438 , G01D5/24447 , G01D5/24476
摘要： A position-sensing system magnetically senses the position of a first component moving with respect to a second component. A magnetically hard layer on the first component provides a recording medium. Information is magnetically recorded in regions of the magnetically hard layer. These regions provide a relative encoding scheme for determining the position of the first component. Magnetic-field sensors are positioned over redundant tracks of magnetically recorded regions. Each magnetic-field sensor positioned over a given track senses the same magnetized regions while the first component moves with respect to the second component. Other magnetic-field sensors can sense ambient fields for use in performing common-mode rejection. A write head can dynamically repair damaged or erased regions detected by the magnetic-field sensors. Energized by a battery-backup power source, the magnetic-field sensors and associated circuitry can continue to track movement of the first component when the machinery is off.
摘要翻译：位置感测系统磁性地感测相对于第二部件移动的第一部件的位置。第一组件上的磁性硬层提供记录介质。信息被磁记录在磁性硬层的区域中。这些区域提供用于确定第一部件的位置的相对编码方案。磁场传感器位于磁记录区域的冗余轨道上。位于给定轨道上方的每个磁场传感器在第一部件相对于第二部件移动时感测相同的磁化区域。其他磁场传感器可以感测用于执行共模抑制的环境场。写头可以动态修复由磁场传感器检测到的损坏或擦除的区域。由电池备用电源供电，当机械关闭时，磁场传感器和相关电路可以继续跟踪第一部件的运动。

9. 发明申请

US20060238066A1 Electroactive polymer generators 有权
公开(公告)号：US20060238066A1
公开(公告)日：2006-10-26
申请号：US11339078
申请日：2006-01-24
申请人： Ronald Pelrine , Roy Kornbluh , Pablo Garcia , Joseph Eckerle
发明人： Ronald Pelrine , Roy Kornbluh , Pablo Garcia , Joseph Eckerle
IPC分类号： H04R25/00 , H02N1/00
CPC分类号： H02N11/006 , F02G1/043 , F02G2243/52 , F04B35/00 , F04B35/045 , F04B43/043 , F05C2225/08 , F25B9/14 , H01L41/094 , H01L41/0973 , H01L41/0986 , H01L41/1138 , H01L41/193 , H02N2/023 , H04R19/02 , H04R23/00 , Y10S310/80
摘要： The present invention relates to transducers, their use and fabrication. The transducers convert between mechanical and electrical energy. Some transducers of the present invention include a pre-strained polymer. The pre-strain improves the conversion between electrical and mechanical energy. The present invention also relates to devices including an electroactive polymer to convert between electrical and mechanical energy. The present invention further relates to compliant electrodes that conform to the shape of a polymer included in a transducer. The present invention provides methods for fabricating electromechanical devices including one or more electroactive polymers.

10. 发明授权

US08822497B2 PIM kinase inhibitors and methods of their use 有权
标题翻译： PIM激酶抑制剂及其使用方法
公开(公告)号：US08822497B2
公开(公告)日：2014-09-02
申请号：US12449701
申请日：2008-03-03
申请人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, Jr. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
发明人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, Jr. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
IPC分类号： A61K31/4545 , C07D401/14
CPC分类号： C07D401/12 , C07D213/78 , C07D239/28
摘要： New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译：提供了在人或动物受试者中抑制与肿瘤发生相关的激酶活性的新化合物，组合物和方法。在某些实施方案中，化合物和组合物有效地抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用，用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症，例如癌症。

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