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1. 发明申请

US20050227917A1 Gene products differentially expressed in cancerous cells and their methods of use II 有权
标题翻译：在癌细胞中差异表达的基因产物及其使用方法II
公开(公告)号：US20050227917A1
公开(公告)日：2005-10-13
申请号：US10779543
申请日：2004-02-12
申请人： Lewis Williams , Jaime Escobedo , Michael Innis , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia Kennedy , David Pot , Altaf Kassam , George Lamson , Zhijun He , Elizabeth Scott , Guozhong Zhang , Theresa May , Doreen Sakamoto , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee Jones , Birgit Stache-Crain
发明人： Lewis Williams , Jaime Escobedo , Michael Innis , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia Kennedy , David Pot , Altaf Kassam , George Lamson , Zhijun He , Elizabeth Scott , Guozhong Zhang , Theresa May , Doreen Sakamoto , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee Jones , Birgit Stache-Crain
IPC分类号： A61K38/17 , C07H21/04 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： A61K38/1709 , C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/574
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

2. 发明申请

US20070037147A1 Endogenous retrovirus polypeptides linked to oncogenic transformation 审中-公开
标题翻译：与致癌转化相关的内源性逆转录病毒多肽
公开(公告)号：US20070037147A1
公开(公告)日：2007-02-15
申请号：US10497786
申请日：2002-12-09
申请人： Pablo Garcia , Stephen Hardy , Lewis Williams , Jaime Escobedo
发明人： Pablo Garcia , Stephen Hardy , Lewis Williams , Jaime Escobedo
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/10021 , C12N2740/10022 , C12Q1/6886 , C12Q1/702 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N2333/15
摘要： HERV-K human endogenous retroviruses show up-regulated expression in tumors. In particular, splicing events in the env region generate a series of transcripts which utilise the +2 reading frame, relative to the env reading frame. The proteins show activity typical of transcriptional regulators, and they also have oncogenic potential. Two related proteins, PCAP2 and PCAP3, are strongly associated with breast cancer and prostate cancer, respectively. PCAP4 stimulates cell division. These proteins can be used in cancer diagnosis and therapy, and are also drug target e.g. for adjuvant therapy. The identification of these splice products is remarkable because full sequence information has been available for HERV-K viruses since 1986.
摘要翻译： HERV-K人内源性逆转录病毒在肿瘤中表达上调。特别地，env区域中的拼接事件产生一系列相对于env阅读框使用+2阅读框的抄本。蛋白质表现出转录调节因子的典型活性，并且具有致癌潜力。两种相关蛋白，PCAP2和PCAP3分别与乳腺癌和前列腺癌密切相关。 PCAP4刺激细胞分裂。这些蛋白质可用于癌症诊断和治疗，也是药物靶标。用于辅助治疗。鉴于这些拼接产品是非常显着的，因为自1986年以来，全序列信息已经可用于HERV-K病毒。

3. 发明申请

US20060275747A1 Endogenous retrovirus up-regulated in prostate cancer 审中-公开
标题翻译：内源性逆转录病毒在前列腺癌中上调
公开(公告)号：US20060275747A1
公开(公告)日：2006-12-07
申请号：US10498033
申请日：2002-12-09
申请人： Stephen Hardy , Pablo Garcia , Lewis Williams , Jaime Escobedo
发明人： Stephen Hardy , Pablo Garcia , Lewis Williams , Jaime Escobedo
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/702 , C12Q2600/136 , C12Q2600/158 , G01N33/57434
摘要： A specific member of the HERV-K family located in chromosome 22 at 20.428 megabases (22q11.2) has been found to be preferentially and significantly up-regulated in prostate tumors. The invention provides methods for diagnosing prostate cancer, comprising the step of detecting in a patient sample the presence or absence of an expression product of the virus. The virus has five features not seen in other HERV-K members: (1) its own specific nucleotide sequence, and consequently amino acid sequences; (2) tandem 5′ LTRs; (3) a fragmented 3′ LTR; (4) an env gene interrupted by an alu insertion; and (5) unique gag sequences.
摘要翻译：已经发现，在20.428兆比特（22q11.2）位于22号染色体上的HERV-K家族的特异成员在前列腺肿瘤中优先显着上调。本发明提供了诊断前列腺癌的方法，包括在患者样品中检测病毒表达产物的存在或不存在的步骤。该病毒在其他HERV-K成员中没有看到五个特征：（1）其自身的特异核苷酸序列，因此是氨基酸序列; （2）串联5'LTR; （3）碎片3'LTR; （4）由alu插入中断的env基因; 和（5）独特的gag序列。

4. 发明申请

US20070178527A1 Human platelet-derived growth factor receptors 审中-公开
标题翻译：人血小板衍生生长因子受体
公开(公告)号：US20070178527A1
公开(公告)日：2007-08-02
申请号：US11495096
申请日：2006-07-28
申请人： Lewis Williams , Jaime Escobedo
发明人： Lewis Williams , Jaime Escobedo
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/71
CPC分类号： C07K14/71 , G01N33/74 , G01N2333/49
摘要： DNA sequences encoding human platelet-derived growth factor receptors (hPDGF-R), and expression constructs comprising sequences which encode a receptor that can be secreted or incorporated into the membrane of a mammalian cell. Peptide fragments with functions equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor are provided. The constructs can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity. Soluble fragments comprising PDGF receptor sequences are also provided, including important intracellular kinase insert sequences which interact with intracellular proteins.
摘要翻译：编码人血小板衍生生长因子受体（hPDGF-R）的DNA序列和包含编码可以分泌或并入哺乳动物细胞膜的受体的序列的表达构建体。提供了功能相当于野生型受体的肽片段，赋予缺乏受体的细胞对PDGF敏感的促有丝分裂反应。该构建体可用于增强细胞的PDGF应答，确定与PDGF结合相关的转导信号所涉及的区域，提供突变的类似物并评估药物的生理活性。还提供了包含PDGF受体序列的可溶性片段，包括与细胞内蛋白质相互作用的重要细胞内激酶插入序列。

5. 发明申请

US20120274954A1 PRINTING DEVICE HAVING INTERNAL GRAPHIC USER INTERFACE DISPLAY 有权
标题翻译：具有内部图形用户界面显示的打印设备
公开(公告)号：US20120274954A1
公开(公告)日：2012-11-01
申请号：US13094017
申请日：2011-04-26
申请人： Gareth Andrew Dobinson , Nicholas Baxter , Alexandria Jayne Dobinson , Lewis Williams
发明人： Gareth Andrew Dobinson , Nicholas Baxter , Alexandria Jayne Dobinson , Lewis Williams
IPC分类号： G06F15/00
CPC分类号： B41J3/46 , G03G15/5016 , G03G21/1633
摘要： A printing apparatus includes non-transparent doors and/or drawers on a body of the printing apparatus. The non-transparent doors and drawers allow access to internal areas of the body of the printing apparatus. A processor is within the body of the printing apparatus, and the processor controls actions of the printing apparatus. Also, at least one internal graphic user interface display is within the body of the printing apparatus. The internal graphic user interface display is operatively connected to the processor, and the internal graphic user interface display is positioned to be observable only when the non-transparent doors and drawers are open.
摘要翻译：打印设备包括在打印设备的主体上的非透明门和/或抽屉。不透明的门和抽屉允许进入打印设备的主体的内部区域。处理器在打印设备的主体内，并且处理器控制打印设备的动作。此外，至少一个内部图形用户界面显示在打印装置的主体内。内部图形用户界面显示器可操作地连接到处理器，并且只有当非透明门和抽屉打开时，内部图形用户界面显示器被定位成才可观察到。

6. 发明申请

US20070258949A1 Human Cdna Clones Comprising Polynucleotides Encoding Polypeptides and Methods of Their Use 审中-公开
标题翻译：包含编码多肽的多核苷酸的人Cdna克隆及其使用方法
公开(公告)号：US20070258949A1
公开(公告)日：2007-11-08
申请号：US10591451
申请日：2005-03-01
申请人： Ernestine Lee , Kevin Hestir , Keting Chu , Lewis Williams
发明人： Ernestine Lee , Kevin Hestir , Keting Chu , Lewis Williams
IPC分类号： A61K38/00 , A61K48/00 , C07H21/04 , C07K14/00 , C07K16/18 , C12N15/00 , C12N15/87 , C12N5/06 , C12P1/04 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/4702 , A61K38/00
摘要： The invention provides novel polynucleotides, related polypeptides related nucleic acid and polypeptide compositions corresponding to novel human cDNA clones, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译：本发明提供了新的多核苷酸，与新的人cDNA克隆相应的相关多肽相关的核酸和多肽组合物，以及相关的调节剂，例如抗体和小分子调节剂。本发明还提供了制备和使用这些多核苷酸，多肽，相关组合物和调节剂的方法。这些方法包括诊断，预防和治疗应用。本发明的组合物和方法可用于治疗增殖性疾病，例如癌症，炎症，免疫，细菌和病毒性疾病。

7. 发明授权

US08626003B2 Printing device having internal graphic user interface display 有权
标题翻译：具有内部图形用户界面显示的打印设备
公开(公告)号：US08626003B2
公开(公告)日：2014-01-07
申请号：US13094017
申请日：2011-04-26
申请人： Gareth Andrew Dobinson , Nicholas Baxter , Alexandria Jayne Dobinson , Lewis Williams
发明人： Gareth Andrew Dobinson , Nicholas Baxter , Alexandria Jayne Dobinson , Lewis Williams
IPC分类号： G03G15/00
CPC分类号： B41J3/46 , G03G15/5016 , G03G21/1633
摘要： A printing apparatus includes non-transparent doors and/or drawers on a body of the printing apparatus. The non-transparent doors and drawers allow access to internal areas of the body of the printing apparatus. A processor is within the body of the printing apparatus, and the processor controls actions of the printing apparatus. Also, at least one internal graphic user interface display is within the body of the printing apparatus. The internal graphic user interface display is operatively connected to the processor, and the internal graphic user interface display is positioned to be observable only when the non-transparent doors and drawers are open.
摘要翻译：打印设备包括在打印设备的主体上的非透明门和/或抽屉。不透明的门和抽屉允许进入打印设备的主体的内部区域。处理器在打印设备的主体内，并且处理器控制打印设备的动作。此外，至少一个内部图形用户界面显示在打印装置的主体内。内部图形用户界面显示器可操作地连接到处理器，并且只有当非透明门和抽屉打开时，内部图形用户界面显示器被定位成才可观察到。

8. 发明申请

US20050282766A1 Compositions and methods for treating neoplastic disease using chemotherapy and radiation sensitizers 审中-公开
公开(公告)号：US20050282766A1
公开(公告)日：2005-12-22
申请号：US11177138
申请日：2005-07-08
申请人： Bin Wu , Todd Seeley , Lewis Williams
发明人： Bin Wu , Todd Seeley , Lewis Williams
IPC分类号： C12N15/09 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K38/55 , A61K39/395 , A61K48/00 , A61P35/00 , A61P43/00 , C12N9/12 , C12N9/99 , C12N15/113 , C07H21/04 , C07K16/40
CPC分类号： C12N15/1137 , A61K38/00 , C12N9/1205 , C12N2310/11 , C12Y207/01037
摘要： Inhibitors of KIAA0175 are provided that reduce the expression or biological activities of KIAA0175, p53 and/or p21 in a mammalian cell. KIAA0175 inhibitors include anti-sense molecules, ribozymes, antibodies and antibody fragments, proteins and polypeptides as well as small molecules. KIAA0175 inhibitors find use in compositions and methods for decreasing KIAA0175, p53 and/or p21 gene expression as well as methods for increasing the chemo and/or radiosensitivity of mammalian cells, including tumor cells, methods for decreasing the side effects of cancer therapy and methods for treating neoplastic diseases.

9. 发明授权

US4774455A Method for automatic guard selection in automatic test equipment 失效
标题翻译：自动检测设备自动防护选择方法
公开(公告)号：US4774455A
公开(公告)日：1988-09-27
申请号：US840297
申请日：1986-03-14
申请人： Lewis Williams
发明人： Lewis Williams
IPC分类号： G01R31/28
CPC分类号： G01R31/2813
摘要： During the testing of circuit boards with Automatic Test Equipment in some circuit configurations the performance of a component may not be as expected even though it is sound due to the influence of surrounding components. In such a situation guards may be placed, that is further signals via probes contacting nodes other than those to which the component is connected, so that such disruption may be minimized. A method for defining guards during the operation of automatic test equipment so that a selected component of a circuit may be tested includes establishing a measurement of the selected component in a known to be good circuit of the type to be tested. A circuit node associated with the selected component is identified and a guard is applied to the node. A second measurement is established with the selected guard in place. If the guard results in an improvement, it is retained during subsequent automatic testing.
摘要翻译：在具有自动测试设备的电路板的测试中，在某些电路配置中，由于周围组件的影响，组件的性能可能不是预期的，即使它是健全的。在这种情况下，可以放置保护装置，这是通过探头接触除了与其连接的那些节点之外的节点的信号，使得这种中断可能被最小化。一种用于在自动测试设备的操作期间定义防护装置的方法，使得可以测试电路的选定部件可以包括以已知为被测试类型的良好电路来建立所选择的部件的测量。识别与所选择的组件相关联的电路节点，并且将保护应用于该节点。第二个测量是与所选择的守卫建立在一起的。如果防护结果有所改善，则在随后的自动测试中保留。

10. 发明申请

US20120105924A1 SELF-CLEANING DOCUMENT HANDLER WITH VIBRATING CLEANER ELEMENTS 审中-公开
标题翻译：自清洁文件处理与振动清洁元件
公开(公告)号：US20120105924A1
公开(公告)日：2012-05-03
申请号：US12938566
申请日：2010-11-03
申请人： Gareth Andrew Dobinson , Nicholas Baxter , Alexandria Jayne Dobinson , Lewis Williams
发明人： Gareth Andrew Dobinson , Nicholas Baxter , Alexandria Jayne Dobinson , Lewis Williams
IPC分类号： H04N1/04
CPC分类号： H04N1/00909 , H04N1/00013 , H04N1/00037 , H04N1/0005 , H04N1/00055 , H04N1/00063 , H04N1/00084 , H04N1/1013 , H04N1/121 , H04N1/193 , H04N2201/0081
摘要： Scanning devices include a sheet feeder moving sheets of media. A transparent scanning surface (e.g., platen) is positioned adjacent the sheet feeder. The sheet feeder supplies the sheets of media to the transparent scanning surface and moves the sheets of media across the transparent scanning surface. Additionally, an optical scanner is positioned adjacent the transparent scanning surface. The optical scanner detects contrasting markings on the sheets of media through the transparent scanning surface. Vibrating elements are connected to the transparent scanning surface.
摘要翻译：扫描装置包括一个送纸器移动的介质片。透明扫描表面（例如，压板）被定位成邻近送纸器。纸张馈送器将介质片供应到透明扫描表面，并且将介质片移动穿过透明扫描表面。另外，光学扫描器位于透明扫描表面附近。光学扫描仪通过透明扫描表面检测介质片上的对比标记。振动元件连接到透明扫描表面。

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