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1. 发明申请

US20070243176A1 Human genes and gene expression products 审中-公开
标题翻译：人类基因和基因表达产物
公开(公告)号：US20070243176A1
公开(公告)日：2007-10-18
申请号：US10615618
申请日：2003-07-07
申请人： Jaime Escobedo , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Filippo Randazzo , George Lamson , Elizabeth Scott , Guozhong Zhang , Altaf Kassam , David Pot , Radoje Drmanac , Ivan Labat , Birgit Stache-Crain
发明人： Jaime Escobedo , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Filippo Randazzo , George Lamson , Elizabeth Scott , Guozhong Zhang , Altaf Kassam , David Pot , Radoje Drmanac , Ivan Labat , Birgit Stache-Crain
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/18 , C12N15/85 , C12N5/10 , C12P21/00 , C12Q1/68
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

2. 发明申请

US20050227917A1 Gene products differentially expressed in cancerous cells and their methods of use II 有权
标题翻译：在癌细胞中差异表达的基因产物及其使用方法II
公开(公告)号：US20050227917A1
公开(公告)日：2005-10-13
申请号：US10779543
申请日：2004-02-12
申请人： Lewis Williams , Jaime Escobedo , Michael Innis , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia Kennedy , David Pot , Altaf Kassam , George Lamson , Zhijun He , Elizabeth Scott , Guozhong Zhang , Theresa May , Doreen Sakamoto , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee Jones , Birgit Stache-Crain
发明人： Lewis Williams , Jaime Escobedo , Michael Innis , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia Kennedy , David Pot , Altaf Kassam , George Lamson , Zhijun He , Elizabeth Scott , Guozhong Zhang , Theresa May , Doreen Sakamoto , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee Jones , Birgit Stache-Crain
IPC分类号： A61K38/17 , C07H21/04 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： A61K38/1709 , C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/574
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

3. 发明授权

US07122373B1 Human genes and gene expression products V 有权
标题翻译：人类基因和基因表达产物V
公开(公告)号：US07122373B1
公开(公告)日：2006-10-17
申请号：US09313292
申请日：1999-05-13
申请人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
发明人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
IPC分类号： C12N5/10 , C12N15/63 , C12N15/11
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

4. 发明授权

US06964868B1 Human genes and gene expression products II 失效
标题翻译：人类基因和基因表达产物二
公开(公告)号：US06964868B1
公开(公告)日：2005-11-15
申请号：US09297648
申请日：1999-01-28
申请人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
发明人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
IPC分类号： C07K14/47 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/63
CPC分类号： C07K14/4748
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

5. 发明授权

US06492112B1 Mitogen-activated protein kinase kinase 7 (MKK7) 失效
标题翻译：丝裂原活化蛋白激酶激酶7（MKK7）
公开(公告)号：US06492112B1
公开(公告)日：2002-12-10
申请号：US09206166
申请日：1998-12-07
申请人： Christoph Reinhard , Altaf Kassam , David Pot
发明人： Christoph Reinhard , Altaf Kassam , David Pot
IPC分类号： C12Q148
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： A human gene encoding a novel mitogen-activated (MAP) kinase kinase, MKK7, provides methods and reagents for treating a variety of MKK7-mediated disorders, such as ischemic heart disease, kidney failure, oxidative liver damage, respiratory distress syndrome, heat and radiation burns, septic shock, autoimmune disorders, and inflammatory diseases. MKK7 reagents can also be used to induce or prevent apoptosis.
摘要翻译：编码新的丝裂原活化（MAP）激酶激酶MKK7的人基因提供了用于治疗各种MKK7介导的疾病如心肌缺血，肾衰竭，氧化性肝损伤，呼吸窘迫综合征，热和放射性灼伤，败血性休克，自身免疫性疾病和炎性疾病。 MKK7试剂也可用于诱导或预防凋亡。

6. 发明授权

US06432668B1 Polynucleotides encoding human cyclin-dependent kinase (hPFTAIRE) 失效
标题翻译：编码人细胞周期蛋白依赖性激酶（hPFTAIRE）的多核苷酸
公开(公告)号：US06432668B1
公开(公告)日：2002-08-13
申请号：US09206344
申请日：1998-12-07
申请人： Christoph Reinhard , David Pot , Altaf Kassam , Tasha Marenbach , Lewis T. Williams
发明人： Christoph Reinhard , David Pot , Altaf Kassam , Tasha Marenbach , Lewis T. Williams
IPC分类号： C12P2106
CPC分类号： C12N9/1205 , A61K38/00 , C07K2319/00 , C12Y207/11022 , Y02A90/24 , Y02A90/26
摘要： A human gene encoding a novel cyclin-dependent kinase termed hPFTAIRE and its expression products can be used to provide reagents and methods for detecting migrating or metastasizing cells. Compositions and methods for treating proliferative disorders and neoplasia are also provided.
摘要翻译：编码称为hPFTAIRE的新型细胞周期蛋白依赖性激酶的人基因及其表达产物可用于提供用于检测迁移或转移细胞的试剂和方法。还提供了治疗增殖性疾病和瘤形成的组合物和方法。

7. 发明授权

US06077701A Ikk.beta. regulates transcription factors 失效
标题翻译： Ikk beta调节转录因子
公开(公告)号：US06077701A
公开(公告)日：2000-06-20
申请号：US222734
申请日：1998-12-29
申请人： Keting Chu , David Pot
发明人： Keting Chu , David Pot
IPC分类号： A61K38/00 , A61P29/00 , C12N1/21 , C12N9/12 , C12N15/12 , C12N15/54 , C12N5/10
CPC分类号： C12N9/1205 , A61K38/00 , C07K2319/00
摘要： A novel kinase has been identified which phosphorylates I.kappa.B. Reagents which inhibit this kinase can be used as therapeutic tools to inhibit inflammation. The kinase can also be used as a target for drug screening to identify anti-inflammatory compounds.
摘要翻译：已经鉴定出了使κκB磷酸化的新型激酶。抑制该激酶的试剂可用作抑制炎症的治疗工具。该激酶也可以用作药物筛选的目标，以鉴定抗炎化合物。

8. 发明授权

US6090621A Signaling inositol polyphosphate 5-phosphatases (SIPs) 失效
标题翻译：信号多聚磷酸肌醇5磷酸酶（SIPs）
公开(公告)号：US6090621A
公开(公告)日：2000-07-18
申请号：US195868
申请日：1998-11-19
申请人： W. Michael Kavanaugh , David Pot , Lewis T. Williams
发明人： W. Michael Kavanaugh , David Pot , Lewis T. Williams
IPC分类号： A61K38/00 , C07K16/40 , C12N9/16 , C12N15/55 , C12N5/06
CPC分类号： C12N9/16 , C07K16/40 , A61K38/00
摘要： Novel polypeptides called signaling inositol polyphosphate 5-phosphatases are described called SIP-130, SIP-125, and SIP-N. SIP-130 is capable of binding to aPTB domain of SH2 and collagen containing protein (SHC). Also provided are polynucleotide sequences encoding the novel polypeptides, as well as vectors and host cells containing the polynucleotides. Further provided are modulators including agonists and antagonists of the novel polypeptides for use as therapeutics, including antibodies, polypeptides, small molecules, and polynucleotides and methods of using the therapeutics in treatment of diseases associated with abnormal cell growth. Methods of making the polypeptides, polynucleotides, vectors, host cells, antibodies, and small molecules are also provided. Gene delivery vehicles including SIP and SIP activity-modulating polynucleotides are described.
摘要翻译：称为信号多聚磷酸肌醇5磷酸酶的新型多肽被称为SIP-130，SIP-125和SIP-N。 SIP-130能够结合到SH2和含胶原蛋白（SHC）的aPTB结构域。还提供了编码新多肽的多核苷酸序列以及含有多核苷酸的载体和宿主细胞。还提供了包括用作治疗剂的新型多肽的激动剂和拮抗剂的调节剂，包括抗体，多肽，小分子和多核苷酸以及使用治疗剂治疗与异常细胞生长有关的疾病的方法。还提供了制备多肽，多核苷酸，载体，宿主细胞，抗体和小分子的方法。描述了包括SIP和SIP活性调节多核苷酸的基因递送载体。

9. 发明授权

US6030834A Human IKK-beta DNA constructs and cells 失效
标题翻译：人类IKK-βDNA构建体和细胞
公开(公告)号：US6030834A
公开(公告)日：2000-02-29
申请号：US215131
申请日：1998-12-18
申请人： Keting Chu , David Pot
发明人： Keting Chu , David Pot
IPC分类号： A61K38/00 , A61P29/00 , C12N1/21 , C12N9/12 , C12N15/12 , C12N15/54 , C12N15/85 , C07H21/04 , C12N15/63
CPC分类号： C12N9/1205 , A61K38/00 , C07K2319/00
摘要： A novel kinase has been identified which phosphorylates I.kappa.B. Reagents which inhibit this kinase can be used as therapeutic tools to inhibit inflammation. The kinase can also be used as a target for drug screening to identify anti-inflammatory compounds.
摘要翻译：已经鉴定出了使κκB磷酸化的新型激酶。抑制该激酶的试剂可用作抑制炎症的治疗工具。该激酶也可以用作药物筛选的目标，以鉴定抗炎化合物。

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