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1. 发明申请

WO0028574A2 MASS SPECTROMETER INCLUDING MULTIPLE MASS ANALYSIS STAGES AND METHOD OF OPERATION, TO GIVE IMPROVED RESOLUTION 审中-公开
标题翻译：质谱仪包括多个质量分析阶段和操作方法，以提供改进的分辨率
公开(公告)号：WO0028574A2
公开(公告)日：2000-05-18
申请号：PCT/CA9901062
申请日：1999-11-09
申请人： UNIV BRITISH COLUMBIA , DOUGLAS DONALD J , ZHAOHUI DU , COLLINGS BRUCE A
发明人： DOUGLAS DONALD J , DU ZHAOHUI , COLLINGS BRUCE A
IPC分类号： H01J49/42
CPC分类号： H01J49/421 , H01J49/004 , H01J49/288 , H01J49/429
摘要： A method is provided of operating a mass spectrometer apparatus comprising a pair of quadrupole rod sets. Each quadrupole rod set is operated in a mass resolving mode. They may be operated in the same or different stability regions. The rod sets are operated to select essentially ions of the same mass to charge ratio, and are operated such that the combined resolution of the two rod sets is greater than the resolution of either rod set. The rod sets can be operated at relatively low resolution, with the combined peak shape from the two rod sets showing high resolution. This can make up for mechanical imperfections in the rod sets, losses due to high gas pressures, etc. A mass shift can be provided to give the desired resolution. The rod sets can be close coupled, and for this purpose neutralizing capacitors can be provided to prevent electrical interference between adjacent rod sets. The rod sets can be provided with the same frequency signal, which preferably is a phase locked and shifted, to give enhanced sensitivity.
摘要翻译：提供了一种操作包括一对四极杆组的质谱仪装置的方法。每个四极杆组以质量分辨模式运行。它们可以在相同或不同的稳定性区域中操作。操作杆组以选择基本上具有相同质荷比的离子，并且操作使得两个杆组的组合分辨率大于任一杆组的分辨率。杆组可以相对较低的分辨率操作，两个组合的组合峰形显示高分辨率。这可以弥补棒组中的机械缺陷，由于气体压力高导致的损失等。可以提供质量偏移以给出所需的分辨率。杆组可以紧密连接，为此，可以提供中和电容器以防止相邻杆组之间的电气干扰。杆组可以设置有相同的频率信号，其优选地是锁相和偏移的，以提供增强的灵敏度。

2. 发明申请

WO0033350A3 METHOD AND APPARATUS FOR MULTIPLE STAGES OF MASS SPECTROMETRY 审中-公开
标题翻译：方法和装置用于大量光谱的多个阶段
公开(公告)号：WO0033350A3
公开(公告)日：2000-10-26
申请号：PCT/CA9901142
申请日：1999-11-30
申请人： UNIV BRITISH COLUMBIA , DOUGLAS DONALD , CAMPBELL JENNIFER , COLLINGS BRUCE A
发明人： DOUGLAS DONALD , CAMPBELL JENNIFER , COLLINGS BRUCE A
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/004
摘要： A method of and apparatus for analyzing a stream of ions first subjects astream of ions to a first mass analysis step, to select ions having a mass-to-charge ratio in a first desired range; this enables a mass analyzer with highresolution to be used. The selected ions are then passed into a radiofrequency linear ion trap containing a gas. The trapped ions are caused to collide with the gas, either by being injected with a high axial energy or by application of external excitation to cause fragmentation. Fragment ions of a given mass-to-charge ratio can then be isolated and excited to produce fragments of fragments. This process can be repeated to give multiple steps of mass spectrometry, MS . The fragment ions, and undissociated precursorions are then passed out of the linear ion trap and subjected to a further mass analysis step, for example in a time of flight device, to determine the mass spectrum of the ions.
摘要翻译：用于分析离子流的方法和装置首先使离子流进入第一质量分析步骤，以选择质量与电荷比在第一期望范围内的离子; 这使得能够使用具有高分辨率的质量分析器。然后将选定的离子通入含有气体的射频线性离子阱。被捕获的离子通过注入高轴向能量或通过施加外部激发而引起碎片而与气体碰撞。然后可以分离并激发给定质荷比的片段离子以产生碎片片段。这个过程可以重复进行质谱分析MS MS。然后将片段离子和未解离的前体从线性离子阱中通过，并进行进一步的质量分析步骤，例如在飞行时间装置中，以确定离子的质谱。

3. 发明申请

WO2006076228A3 METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER 审中-公开
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：WO2006076228A3
公开(公告)日：2007-06-21
申请号：PCT/US2006000492
申请日：2006-01-05
申请人： APPLERA CORP , MDS INC , LOBODA ALEXANDRE V , COLLINGS BRUCE A , COVEY THOMAS R , GUNA MIRCEA , JAVAHERI HASSAN , SCHNEIDER BRADLEY B , THOMSON BRUCE A
发明人： COLLINGS BRUCE A , COVEY THOMAS R , GUNA MIRCEA , JAVAHERI HASSAN , SCHNEIDER BRADLEY B , THOMSON BRUCE A
IPC分类号： H01J49/04 , B01D59/44 , H01J49/10
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

4. 发明申请

WO2009085081A2 METHOD AND APPARATUS FOR REDUCING SPACE CHARGE IN AN ION TRAP 审中-公开
标题翻译：用于减少离子阱中空隙电荷的方法和装置
公开(公告)号：WO2009085081A2
公开(公告)日：2009-07-09
申请号：PCT/US2008012910
申请日：2008-11-19
申请人： MDS ANALYTICAL TECH BU MDS INC , APPLIED BIOSYSTEMS LLC , COLLINGS BRUCE A
发明人： COLLINGS BRUCE A
IPC分类号： H01J49/26 , H01J3/40 , H01J49/02
CPC分类号： H01J49/4225 , H01J49/4265
摘要： Ion trap apparatus and methods for efficiently addressing the effects of charge space caused by ion trap overfilling, useful in linear ion traps of mass spectrometers.
摘要翻译：用于有效解决由离子阱过度填充引起的电荷空间影响的离子阱设备和方法，可用于质谱仪的线性离子阱。

5. 发明专利

DE69940216D1 未知
公开(公告)号：DE69940216D1
公开(公告)日：2009-02-12
申请号：DE69940216
申请日：1999-11-30
申请人： UNIV BRITISH COLUMBIA
发明人： DOUGLAS DONALD , CAMPBELL JENNIFER , COLLINGS BRUCE A
IPC分类号： H01J49/42
摘要： A method of and apparatus for analyzing a stream of ions first subjects astream of ions to a first mass analysis step, to select ions having a mass-to-charge ratio in a first desired range; this enables a mass analyzer with highresolution to be used. The selected ions are then passed into a radiofrequency linear ion trap containing a gas. The trapped ions are caused to collide with the gas, either by being injected with a high axial energy or by application of external excitation to cause fragmentation. Fragment ions of a given mass-to-charge ratio can then be isolated and excited to produce fragments of fragments. This process can be repeated to give multiple steps of mass spectrometry, MS . The fragment ions, and undissociated precursorions are then passed out of the linear ion trap and subjected to a further mass analysis step, for example in a time of flight device, to determine the mass spectrum of the ions.

6. 发明专利

AU1025200A Mass spectrometer including multiple mass analysis stages and method of operation, to give improved resolution 未知
公开(公告)号：AU1025200A
公开(公告)日：2000-05-29
申请号：AU1025200
申请日：1999-11-09
申请人： UNIV BRITISH COLUMBIA
发明人： DOUGLAS DONALD J , DU ZHAOHUI , COLLINGS BRUCE A
IPC分类号： H01J49/42

7. 发明专利

CA2350568A1 MASS SPECTROMETER INCLUDING MULTIPLE MASS ANALYSIS STAGES AND METHOD OF OPERATION, TO GIVE IMPROVED RESOLUTION 未知
公开(公告)号：CA2350568A1
公开(公告)日：2000-05-18
申请号：CA2350568
申请日：1999-11-09
申请人： UNIV BRITISH COLUMBIA
发明人： COLLINGS BRUCE A , DU ZHAOHUI , DOUGLAS DONALD J
IPC分类号： H01J49/42 , H01J49/28
摘要： A method is provided of operating a mass spectrometer apparatus comprising a pair of quadrupole rod sets. Each quadrupole rod set is operated in a mass resolving mode. They may be operated in the same or different stability regions. The rod sets are operated to select essentially ions of the same ma ss to charge ratio, and are operated such that the combined resolution of the t wo rod sets is greater than the resolution of either rod set. The rod sets can be operated at relatively low resolution, with the combined peak shape from the two rod sets showing high resolution. This can make up for mechanical imperfections in the rod sets, losses due to high gas pressures, etc. A mass shift can be provided to give the desired resolution. The rod sets can be close coupled, and for this purpose neutralizing capacitors can be provided to prevent electrical interference between adjacent rod sets. The rod sets can be provided with the same frequency signal, which preferably is a phase locked and shifted, to give enhanced sensitivity.

8. 发明专利

AU1329899A Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap 未知
公开(公告)号：AU1329899A
公开(公告)日：1999-06-28
申请号：AU1329899
申请日：1998-12-03
申请人： UNIV BRITISH COLUMBIA
发明人： DOUGLAS DONALD J , CAMPBELL JENNIFER M , COLLINGS BRUCE A
IPC分类号： G01N27/62 , H01J49/40 , H01J49/42

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