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1. 发明授权

US06245190B1 Plasma processing system and plasma processing method 失效
标题翻译：等离子体处理系统和等离子体处理方法
公开(公告)号：US06245190B1
公开(公告)日：2001-06-12
申请号：US09048075
申请日：1998-03-26
申请人： Toshio Masuda , Katsuhiko Mitani , Tetsunori Kaji , Jun'ichi Tanaka , Katsuya Watanabe , Shigeru Shirayone , Toru Otsubo , Ichiro Sasaki , Hideshi Fukumoto , Makoto Koizumi
发明人： Toshio Masuda , Katsuhiko Mitani , Tetsunori Kaji , Jun'ichi Tanaka , Katsuya Watanabe , Shigeru Shirayone , Toru Otsubo , Ichiro Sasaki , Hideshi Fukumoto , Makoto Koizumi
IPC分类号： H05H146
CPC分类号： H01J37/32091 , H01J37/32082 , H01J37/32165 , H01J37/32623 , H01J37/3266 , H01J37/32678
摘要： A plasma processing apparatus and a method therefor which can achieve a preferred process rate, a fine pattern process capability, a selectivity and uniformity of processing at the same time compatibly for a large size wafer, which effects are achieved by controlling the plasma state and the dissociation state of etching gas through control of the electron resonance through application of a magnetic field thereto. A high frequency power at 20-300 MHz is applied across a pair of electrodes in a vacuum process chamber, and a magnetic field is formed parallel to the plane of the electrodes in the space between the electrodes. By controlling the intensity of the magnetic field in a range of 100 gauss or smaller, formation of electron cyclotron resonance and electron sheath resonance occurring from interaction between the electrical field and the magnetic field in the electrode sheath portion is controlled. Thereby, the plasma state, i.e., the electron density, electron energy distribution and dissociation state of the process gas in the plasma, can be controlled. The magnetic field is generated by a plurality of coils, an outer shield, and pendant yoke to form magnetic field parallel to the plane of the electrodes in the space between the upper and the bottom electrodes.
摘要翻译：一种等离子体处理装置及其方法，其能够通过控制等离子体状态和等离子体状态来实现对于大尺寸晶片同时实现优选的处理速率，精细图案处理能力，同时处理的选择性和均匀性，通过对其施加磁场来控制电子共振来蚀刻气体的解离状态。在真空处理室中的一对电极上施加20-300MHz的高频功率，并且在电极之间的空间中形成平行于电极平面的磁场。通过控制100高斯或更小范围内的磁场的强度，控制由电场鞘部分中的电场和磁场之间的相互作用产生的电子回旋共振和电子鞘共振的形成。由此，可以控制等离子体状态，即等离子体中的处理气体的电子密度，电子能量分布和解离状态。磁场由多个线圈，外屏蔽和悬挂磁轭产生，以在上电极和下电极之间的空间中形成平行于电极平面的磁场。

2. 发明授权

US09885036B2 Double-stranded polynucleotide 有权
公开(公告)号：US09885036B2
公开(公告)日：2018-02-06
申请号：US13001714
申请日：2009-06-30
申请人： Makoto Koizumi , Yasuhide Hirota
发明人： Makoto Koizumi , Yasuhide Hirota
IPC分类号： C12N15/11 , A61K31/713
CPC分类号： C12N15/111 , A61K31/713 , C12N2310/14 , C12N2310/321 , C12N2310/343 , C12N2320/51 , C12N2310/3521
摘要： It is intended to provide a double-stranded polynucleotide that is resistant to RNase and has RNA interference effect, etc. The present invention provides a double-stranded polynucleotide comprising sense and antisense strands comprising polynucleotides comprising a nucleotide unit of DNAs and 2′-O-methyl RNAs alternately combined.

3. 发明申请

US20140316123A1 ENA NUCLEIC ACID PHARMACEUTICALS CAPABLE OF MODIFYING SPLICING OF mRNA PRECURSORS 有权
标题翻译：能够修饰mRNA前体分离的ENA核酸药物
公开(公告)号：US20140316123A1
公开(公告)日：2014-10-23
申请号：US14258663
申请日：2014-04-22
申请人： Masafumi Matsuo , Yasuhiro Takeshima , DAIICHI SANKYO COMPANY, LIMITED , Makoto Koizumi , Orphan Disease Treatment Institute Co., Ltd.
发明人： Masafumi Matsuo , Yasuhiro Takeshima , Makoto Koizumi
IPC分类号： C12N15/113
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C12N15/113 , C12N2310/11 , C12N2310/3231 , C12N2320/33
摘要： Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucleotides.
摘要翻译：具有与核苷酸序列互补的核苷酸序列的寡核苷酸，例如抗肌萎缩蛋白cDNA（Gene Bank登录号NM_004006）的2571-2607,2578-2592,2571-2592,2573-2592,2578-2596,2578-2601或2575-2592。 1）和包含这种寡核苷酸的肌营养不良的治疗剂。

4. 发明申请

US20130090465A1 ENA NUCLEIC ACID PHARMACEUTICALS CAPABLE OF MODIFYING SPLICING OF mRNA PRECURSORS 有权
标题翻译：能够修饰mRNA前体分离的ENA核酸药物
公开(公告)号：US20130090465A1
公开(公告)日：2013-04-11
申请号：US13673466
申请日：2012-11-09
申请人： Masafumi MATSUO , Yasuhiro Takeshima , Makoto Koizumi
发明人： Masafumi MATSUO , Yasuhiro Takeshima , Makoto Koizumi
IPC分类号： C07H21/04
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C12N15/113 , C12N2310/11 , C12N2310/3231 , C12N2320/33
摘要： Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucleotides.
摘要翻译：具有与核苷酸序列互补的核苷酸序列的寡核苷酸，例如抗肌萎缩蛋白cDNA（Gene Bank登录号NM_004006）的2571-2607,2578-2592,2571-2592,2573-2592,2578-2596,2578-2601或2575-2592。 1）和包含这种寡核苷酸的肌营养不良的治疗剂。

5. 发明申请

US20070195286A1 Rear projection display apparatus 审中-公开
标题翻译：背投显示装置
公开(公告)号：US20070195286A1
公开(公告)日：2007-08-23
申请号：US11646453
申请日：2006-12-28
申请人： Yoichi Hiramatsu , Yoshikazu Kidokoro , Kenichiro Utsumi , Makoto Koizumi
发明人： Yoichi Hiramatsu , Yoshikazu Kidokoro , Kenichiro Utsumi , Makoto Koizumi
IPC分类号： G03B21/22 , G03B21/28
CPC分类号： H04N9/3141 , G02B17/0621
摘要： Disclosed herein is a rear projection display apparatus including, a screen, a projection mirror; a video apparatus for projecting a picture, an optical unit including a projection lens, a light source, a drive and control circuit, and a structure body for holding the screen, wherein the projection mirror is adjustably provided on the structure body fitted with the screen or on a structure body holding the screen.
摘要翻译：本文公开了一种背投显示装置，包括：屏幕，投影镜; 用于投影图像的视频设备，包括投影透镜的光学单元，光源，驱动和控制电路以及用于保持屏幕的结构体，其中投影镜可调节地设置在装配有屏幕的结构体上或者在保持屏幕的结构体上。

6. 发明授权

US06262526B1 Color Braun tube 失效
标题翻译：彩色布朗管
公开(公告)号：US06262526B1
公开(公告)日：2001-07-17
申请号：US09492525
申请日：2000-01-27
申请人： Hiroshi Miyazawa , Makoto Koizumi , Mutsumi Maehara , Hidetoshi Kida
发明人： Hiroshi Miyazawa , Makoto Koizumi , Mutsumi Maehara , Hidetoshi Kida
IPC分类号： H01J2946
CPC分类号： H01J29/624 , H01J29/488 , H01J29/51 , H01J2229/4824
摘要： An in-line type color Braun tube having a fluorescent screen and a shield cup at an end of an electron gun, the shield cup including a cylindrical side wall and a bottom having a center electron beam passing hole and two side electron beam passing holes aligned in a horizontal direction. A convergence correcting member including a base and a pair of horizontal plates, the base and horizontal plates being a one piece member, and a bottom member of the base being cross-shaped and including two side electron beam passing holes and a center electron beam passing hole. A pair of horizontal plates sandwiches an electron beam passing through each of the side electron beam passing holes, in a direction vertical to the electron beam. The base is spot-welded to the bottom of the shield cup at an outer side of each of the side electron bottom beam passing holes proximate to a periphery of the bottom of the shield cup or at outer sides of the center electron beam passing hole along a branch of the cross-shaped base of the bottom member.
摘要翻译：一种在电子枪的端部具有荧光屏和屏蔽杯的直列式彩色布朗管，该屏蔽杯包括圆柱形侧壁和具有中心电子束通过孔和两个侧面电子束通过孔对准的底部在水平方向。一种会聚校正构件，包括基座和一对水平板，所述基座和水平板是一体构件，并且所述基座的底部构件是十字形的，并且包括两个侧面电子束通过孔和中心电子束通过孔。一对水平板在垂直于电子束的方向上夹着通过每个侧电子束通过孔的电子束。基座在靠近屏蔽杯底部的周边的每个侧面电子底部梁通过孔的外侧或在中心电子束通过孔的外侧点焊到屏蔽杯的底部底部构件的十字形底座的分支。

7. 发明授权

US5572379A Magnetic recording drive having arrangements for average useful life of magnetorestive effects sensors 失效
标题翻译：磁记录驱动器具有磁悬浮效应传感器的平均使用寿命的布置
公开(公告)号：US5572379A
公开(公告)日：1996-11-05
申请号：US305193
申请日：1994-09-13
申请人： Hajime Aoi , Toshiaki Tsuyoshi , Makoto Koizumi , Nobumasa Nishiyama , Yoshibumi Matsuda , Takuji Ogawa , Kazuhisa Shiraishi
发明人： Hajime Aoi , Toshiaki Tsuyoshi , Makoto Koizumi , Nobumasa Nishiyama , Yoshibumi Matsuda , Takuji Ogawa , Kazuhisa Shiraishi
IPC分类号： G11B5/02 , G11B5/00 , G11B5/012 , G11B5/09 , G11B5/39 , G11B5/40 , G11B5/55 , G11B5/596 , G11B19/02 , G11B19/04 , G11B27/30 , G11B27/36 , G11B5/03 , G11B5/127 , G11B5/33
CPC分类号： G11B19/04 , G11B19/02 , G11B27/3027 , G11B27/36 , G11B5/00 , G11B5/012 , G11B5/40 , G11B5/5547 , G11B2005/0016 , G11B2005/0018 , G11B5/59683
摘要： In a magnetic recording drive having a plurality of magnetic heads each employing a magnetoresistive sensor for the purpose of averaging the time required for sense currents to be caused to flow through the respective magnetoresistive sensors to shorten the longest reproducing time and to suppress the degradation of the characteristics due to the electromigration, thereby improving the reliability of the magnetic recording drive, the magnetic recording drive includes circuits for averaging the useful life depending on the currents caused to flow through the respective magnetoresistive sensors among the plurality of magnetic heads, whereby the time required for the sense current to be caused to flow through one MR reproducing head is greatly shortened. Therefore, the levels of outputs of the MR reproducing heads can be increased without reduction of the reliability and thus the reliability of the magnetic recording drive can be improved.
摘要翻译：在具有多个磁头的磁记录驱动器中，每个磁头采用磁阻传感器，用于平均要使感应电流流过各磁阻传感器所需的时间，以缩短最长再现时间并抑制由于电迁移的特性，从而提高了磁记录驱动器的可靠性，磁记录驱动器包括用于根据流过多个磁头中的相应磁阻传感器的电流来平均使用寿命的电路，由此所需的时间使得通过一个MR再现头流动的感测电流大大缩短。因此，可以在不降低可靠性的情况下增加MR再现头的输出电平，从而可以提高磁记录驱动器的可靠性。

8. 发明申请

US20120220649A1 MODIFIED DOUBLE-STRANDED POLYNUCLEOTIDE 审中-公开
标题翻译：改性双链多核苷酸
公开(公告)号：US20120220649A1
公开(公告)日：2012-08-30
申请号：US13505275
申请日：2010-10-29
申请人： Makoto Koizumi , Yasuhide Hirota
发明人： Makoto Koizumi , Yasuhide Hirota
IPC分类号： A61K31/713 , C07H21/00
CPC分类号： C12N15/1135 , A61K31/713 , C12N15/1136 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2310/3521
摘要： The present invention provides a double-stranded polynucleotide having a sense strand polynucleotide consisting of a nucleotide sequence complementary to a target sequence in a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, wherein an aryl or heteroaryl compound is bound to a phosphate group at the 5′-end of the antisense strand polynucleotide.
摘要翻译：本发明提供了一种双链多核苷酸，其具有由与靶基因中的靶序列互补的核苷酸序列组成的有义链多核苷酸和具有与有义链多核苷酸互补的核苷酸序列的反义链多核苷酸，其中芳基或杂芳基化合物与反义链多核苷酸的5'末端的磷酸基结合。

9. 发明授权

US07906639B2 Oligonucleotides having a 2′-O,4′-C-ethylene nucleotide in the third position of the 3′-end 有权
标题翻译：在3'-末端的第3位具有2'-O，4'-C-亚乙基核苷酸的寡核苷酸
公开(公告)号：US07906639B2
公开(公告)日：2011-03-15
申请号：US10577982
申请日：2004-11-04
申请人： Makoto Koizumi
发明人： Makoto Koizumi
IPC分类号： C07H21/04 , C12P19/34
CPC分类号： C12Q1/6853 , C07H21/04
摘要： The present invention relates to a method for detecting gene polymorphism by PCR, using, as a primer, an oligonucleotide, wherein the third nucleotide from the 3′-end thereof is a 2′-O,4′-C-ethylene nucleotide (ENA) unit, the other oligonucleotides are natural oligonucleotides, the 3′-end position thereof is a nucleotide complementary to the nucleotide of the reference sequence of a polymorphic sequence of a target gene, and the other positions are nucleotides complementary to the nucleotide sequence of the target gene, or an oligonucleotide, wherein the 3′-end of the nucleotide sequence thereof is a polymorphic position, the second nucleotide from the 3′-end thereof is a nucleotide having a base that is not complementary to a gene to be detected, and the third nucleotide from the 3′-end thereof is a 2′-O,4′-C-ethylene nucleotide (ENA) unit; oligonucleotides used in detection of gene polymorphism; and a kit for detecting gene polymorphism, comprising the above oligonucleotides.
摘要翻译：本发明涉及一种利用PCR检测基因多态性的方法，使用寡核苷酸作为引物，其中3'末端的第3个核苷酸为2'-O，4'-C-亚乙基核苷酸（ENA ）单元，其它寡核苷酸是天然寡核苷酸，其3'端位置是与目标基因的多态性序列的参考序列的核苷酸互补的核苷酸，其它位置是与核苷酸序列的核苷酸互补的核苷酸靶基因或寡核苷酸，其核苷酸序列的3'末端为多态性位置，其3'末端的第2个核苷酸为具有与待检测基因不互补的碱基的核苷酸，并且其3'末端的第三个核苷酸是2'-O，4'-C-亚乙基核苷酸（ENA）单元; 用于检测基因多态性的寡核苷酸; 和用于检测基因多态性的试剂盒，其包含上述寡核苷酸。

10. 发明申请

US20070147648A1 Speaker system and video display 失效
标题翻译：扬声器系统和视频显示
公开(公告)号：US20070147648A1
公开(公告)日：2007-06-28
申请号：US11637010
申请日：2006-12-12
申请人： Makoto Koizumi , Hiroyuki Nakamura , Katsuhiro Yamashita
发明人： Makoto Koizumi , Hiroyuki Nakamura , Katsuhiro Yamashita
IPC分类号： H04R25/00
CPC分类号： H04R1/028 , H04R31/006 , H04R2499/15
摘要： Disclosed herein is a speaker system including a speaker unit with a speaker body incorporated therein; and a speaker panel disposed on the front side of the speaker unit; wherein the speaker panel has a multiplicity of fine holes permitting a sound of the speaker body to pass therethrough, and has an opaque part hiding the presence of the speaker unit, and a transparent part in the periphery of the opaque part.
摘要翻译：这里公开了一种扬声器系统，包括扬声器单元，扬声器单元中并入有扬声器主体; 以及布置在所述扬声器单元的前侧的扬声器面板; 其中扬声器面板具有多个允许扬声器主体的声音通过的细孔，并且具有隐藏扬声器单元的存在的不透明部分和不透明部分的周边中的透明部分。

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