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    • 8. 发明授权
    • Oxopyridinylquinoxaline derivative
    • 氧吡嗪基喹喔啉衍生物
    • US5677305A
    • 1997-10-14
    • US418196
    • 1995-04-07
    • Susumu TakadaNobuo ChomeiMakoto AdachiMasami EigyoKazuo Kawasaki
    • Susumu TakadaNobuo ChomeiMakoto AdachiMasami EigyoKazuo Kawasaki
    • C07D401/04C07D241/36A01N43/60C07D241/38
    • C07D401/04
    • An oxopyridinylquinoxaline derivative represented by the following Formula I or pharmaceutically acceptable salts thereof: ##STR1## wherein R.sup.1 is hydrogen, halogen, nitro, or trihalomethyl; R.sup.2 is hydrogen, halogen, nitro, cyano, trihalomethyl, carbamoyl, carbamoyl substituted with lower alkyl, sulfamoyl, or sulfamoyl substituted with lower alkyl; R.sup.3 is hydrogen, nitro, or halogen; R.sup.4 is hydrogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, or substituted lower cycloalkyl; R.sup.5 's are substituents independently selected from the group consisting of halogen, nitro, cyano, lower alkyl, carbamoyl, and carbamoyl substituted with lower alkyl; and n is an integer of 0 to 4. The derivative works as an antagonistic agent against both the NMDA receptors and the AMPA receptors, so that it is effective as a therapeutic agent for neurological disorders caused by excitatory amino acids binding to the receptors.
    • 由下式I表示的氧代吡啶基喹喔啉衍生物或其药学上可接受的盐:其中R 1是氢,卤素,硝基或三卤代甲基; R2是氢,卤素,硝基,氰基,三卤甲基,氨基甲酰基,被低级烷基取代的氨基甲酰基,氨磺酰基或被低级烷基取代的氨磺酰基; R3是氢,硝基或卤素; R4是氢,低级烷基,取代的低级烷基,低级环烷基或取代的低级环烷基; R 5是独立地选自卤素,硝基,氰基,低级烷基,氨基甲酰基和被低级烷基取代的氨基甲酰基的取代基。 并且n为0至4的整数。该衍生物作为对NMDA受体和AMPA受体的拮抗剂起作用,因此其作为由与受体结合的兴奋性氨基酸引起的神经障碍的治疗剂是有效的。
    • 10. 发明申请
    • Surface light source device and display
    • 表面光源装置和显示屏
    • US20060274551A1
    • 2006-12-07
    • US11440018
    • 2006-05-25
    • Susumu Takada
    • Susumu Takada
    • F21V7/04
    • G02B6/0055G02B6/0068
    • Emission of a surface light source device is prevented from having brightness-unevenness, having a uniformalized brightness. A plurality of LEDs are disposed opposite to an incidence face of a light guide plate. A reflection sheet is disposed along a back face of the light guide plate while a cover member for the LEDs is disposed on an emission face in the vicinity incidence face. A light diffusion member, first and second light control members are laminated disposed along a part of the emission face which is not covered by the cover member. A top of the reflection sheet is secluded a predetermined distance L from the incidence face to provided a part which is not covered by the reflection sheet in the vicinity of the incidence face. The predetermined distance L may be given, for example, by L=2h·tan θ (where h=thickness of light guide plate at incidence face, θ=critical angle at an interface between light guide plate and air.
    • 防止表面光源装置的发光具有均匀亮度的亮度不均匀。 多个LED布置成与导光板的入射面相对。 反射片沿着导光板的背面设置,而用于LED的盖构件设置在附近入射面的发射面上。 光漫射构件,第一和第二光控制构件沿着未被盖构件覆盖的发射面的一部分层叠。 反射片的顶部从入射面偏离预定距离L,以设置在入射面附近未被反射片覆盖的部分。 预定距离L可以例如通过L =2h.tanθ(其中h =入射面处的导光板的厚度,θ=导光板和空气之间的界面处的临界角)。