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    • 1. 发明授权
    • Oxopyridinylquinoxaline derivative
    • 氧吡嗪基喹喔啉衍生物
    • US5677305A
    • 1997-10-14
    • US418196
    • 1995-04-07
    • Susumu TakadaNobuo ChomeiMakoto AdachiMasami EigyoKazuo Kawasaki
    • Susumu TakadaNobuo ChomeiMakoto AdachiMasami EigyoKazuo Kawasaki
    • C07D401/04C07D241/36A01N43/60C07D241/38
    • C07D401/04
    • An oxopyridinylquinoxaline derivative represented by the following Formula I or pharmaceutically acceptable salts thereof: ##STR1## wherein R.sup.1 is hydrogen, halogen, nitro, or trihalomethyl; R.sup.2 is hydrogen, halogen, nitro, cyano, trihalomethyl, carbamoyl, carbamoyl substituted with lower alkyl, sulfamoyl, or sulfamoyl substituted with lower alkyl; R.sup.3 is hydrogen, nitro, or halogen; R.sup.4 is hydrogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, or substituted lower cycloalkyl; R.sup.5 's are substituents independently selected from the group consisting of halogen, nitro, cyano, lower alkyl, carbamoyl, and carbamoyl substituted with lower alkyl; and n is an integer of 0 to 4. The derivative works as an antagonistic agent against both the NMDA receptors and the AMPA receptors, so that it is effective as a therapeutic agent for neurological disorders caused by excitatory amino acids binding to the receptors.
    • 由下式I表示的氧代吡啶基喹喔啉衍生物或其药学上可接受的盐:其中R 1是氢,卤素,硝基或三卤代甲基; R2是氢,卤素,硝基,氰基,三卤甲基,氨基甲酰基,被低级烷基取代的氨基甲酰基,氨磺酰基或被低级烷基取代的氨磺酰基; R3是氢,硝基或卤素; R4是氢,低级烷基,取代的低级烷基,低级环烷基或取代的低级环烷基; R 5是独立地选自卤素,硝基,氰基,低级烷基,氨基甲酰基和被低级烷基取代的氨基甲酰基的取代基。 并且n为0至4的整数。该衍生物作为对NMDA受体和AMPA受体的拮抗剂起作用,因此其作为由与受体结合的兴奋性氨基酸引起的神经障碍的治疗剂是有效的。
    • 8. 发明授权
    • Combined transceiver and radio unit
    • 组合收发器和无线电单元
    • US4045739A
    • 1977-08-30
    • US694602
    • 1976-06-10
    • Kazuo Kawasaki
    • Kazuo Kawasaki
    • H04B1/38F16H35/18
    • H04B1/3805
    • The unit incorporates a transceiver, having a channel changing mechanism, and a radio, having a tuner, a tone control and a balance control, together with a volume control in a common housing having a front wall, for conjoint mounting of the unit in an automobile or the like. The front wall is formed with an opening therethrough adjacent one end thereof and with a slot therethrough adjacent the opposite end thereof. Coaxial shafts for the radio tuner, tone control and balance controls extend through the opening adjacent one end of the front wall, and have respective operating knobs secured to their outer ends whereby the radio controls are grouped adjacent the one end of the front wall. A volume control shaft is connected to the volume control, and a channel control shaft is connected to the channel changing mechanism. A tubular outer shaft extends through the slot and is connected by gears to the channel control shaft. An inner shaft extends coaxially through the tubular outer shaft and is connected, by a double universal joint, to the volume control shaft. Respective operating knobs are secured to the outer ends of the coaxial tubular and inner shafts, whereby the transceiver channel control and the volume control are conveniently grouped adjacent such opposite ends of the front wall. The coaxial tubular and inner shafts are adjustable, as a unit, along the slot to adapt to different mounting conditions, and the gears provide play for this adjustment.