专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5677305A Oxopyridinylquinoxaline derivative 失效
标题翻译：氧吡嗪基喹喔啉衍生物
公开(公告)号：US5677305A
公开(公告)日：1997-10-14
申请号：US418196
申请日：1995-04-07
申请人： Susumu Takada , Nobuo Chomei , Makoto Adachi , Masami Eigyo , Kazuo Kawasaki
发明人： Susumu Takada , Nobuo Chomei , Makoto Adachi , Masami Eigyo , Kazuo Kawasaki
IPC分类号： C07D401/04 , C07D241/36 , A01N43/60 , C07D241/38
CPC分类号： C07D401/04
摘要： An oxopyridinylquinoxaline derivative represented by the following Formula I or pharmaceutically acceptable salts thereof: ##STR1## wherein R.sup.1 is hydrogen, halogen, nitro, or trihalomethyl; R.sup.2 is hydrogen, halogen, nitro, cyano, trihalomethyl, carbamoyl, carbamoyl substituted with lower alkyl, sulfamoyl, or sulfamoyl substituted with lower alkyl; R.sup.3 is hydrogen, nitro, or halogen; R.sup.4 is hydrogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, or substituted lower cycloalkyl; R.sup.5 's are substituents independently selected from the group consisting of halogen, nitro, cyano, lower alkyl, carbamoyl, and carbamoyl substituted with lower alkyl; and n is an integer of 0 to 4. The derivative works as an antagonistic agent against both the NMDA receptors and the AMPA receptors, so that it is effective as a therapeutic agent for neurological disorders caused by excitatory amino acids binding to the receptors.
摘要翻译：由下式I表示的氧代吡啶基喹喔啉衍生物或其药学上可接受的盐：其中R 1是氢，卤素，硝基或三卤代甲基; R2是氢，卤素，硝基，氰基，三卤甲基，氨基甲酰基，被低级烷基取代的氨基甲酰基，氨磺酰基或被低级烷基取代的氨磺酰基; R3是氢，硝基或卤素; R4是氢，低级烷基，取代的低级烷基，低级环烷基或取代的低级环烷基; R 5是独立地选自卤素，硝基，氰基，低级烷基，氨基甲酰基和被低级烷基取代的氨基甲酰基的取代基。并且n为0至4的整数。该衍生物作为对NMDA受体和AMPA受体的拮抗剂起作用，因此其作为由与受体结合的兴奋性氨基酸引起的神经障碍的治疗剂是有效的。

2. 发明授权

US5410058A Tetrahydropyridine derivatives 失效
标题翻译：四氢吡啶衍生物
公开(公告)号：US5410058A
公开(公告)日：1995-04-25
申请号：US202554
申请日：1994-02-28
申请人： Hiromu Matsumura , Toshisada Yano , Hiroshi Hashizume , Akira Matsushita , Masami Eigyo
发明人： Hiromu Matsumura , Toshisada Yano , Hiroshi Hashizume , Akira Matsushita , Masami Eigyo
IPC分类号： C07D211/70 , C07D211/76 , C07D401/12 , C07D409/14 , C07D401/06
CPC分类号： C07D401/12 , C07D211/70 , C07D211/76 , C07D409/14
摘要： The compounds of the present invention relates to tetrahydropyridine derivatives and have high affinity and specificity to .sigma. receptors, whereby these are thought to be effective for some psychoses.
摘要翻译：本发明的化合物涉及四氢吡啶衍生物，并且对σ受体具有高亲和力和特异性，因此认为这些对某些精神病有效。

3. 发明授权

US4940714A 2-substituted carbonylimidazo[4,5-c]quinolines 失效
标题翻译： 2-取代的羰基咪唑并[4,5-c]喹啉
公开(公告)号：US4940714A
公开(公告)日：1990-07-10
申请号：US309868
申请日：1989-02-14
申请人： Susumu Takada , Toshio Fujishita , Takashi Sasatani , Akira Matsushita , Masami Eigyo
发明人： Susumu Takada , Toshio Fujishita , Takashi Sasatani , Akira Matsushita , Masami Eigyo
IPC分类号： A61K31/435 , A61K31/44 , A61P25/00 , A61P25/20 , A61P25/26 , C07D471/04
CPC分类号： C07D471/04
摘要： 2-Substituted carbonylimidazo[4,5-c]quinolines of formula: ##STR1## having a high affinity for benzodiazepin receptor and showing an excellent psychostimulating action orally at a dose of 0.1-500 mg are provided through several routes.
摘要翻译：通过几条途径提供2-取代的对苯并二氮杂受体具有高亲和力的式（I）的羰基咪唑并[4,5-c]喹啉，并以0.1-500mg的剂量口服显示极好的精神刺激作用。

4. 发明授权

US4690930A Pyrazolo[4,3-c]quinoline-3-one and imidazo[4,3-c]cinnolin-3-one derivatives and their use as psychotropic agents 失效
标题翻译：吡唑并[4,3-c]喹啉-3-酮和咪唑并[4,3-c]噌啉-3-酮衍生物及其作为精神药物的用途
公开(公告)号：US4690930A
公开(公告)日：1987-09-01
申请号：US795168
申请日：1985-11-05
申请人： Susumu Takada , Takashi Sasatani , Hirohisa Shindo , Akira Matsushita , Masami Eigyo
发明人： Susumu Takada , Takashi Sasatani , Hirohisa Shindo , Akira Matsushita , Masami Eigyo
IPC分类号： A61K31/47 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D333/36 , C07D409/12 , C07D471/04 , C07D487/04 , A61K31/415 , C07D237/28
CPC分类号： C07D409/12 , C07D333/36 , C07D471/04 , C07D487/04
摘要： Compounds of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 each is hydrogen, alkyl, alkoxycarbonyl, carboxy, halogen, nitro or trifluoromethyl, or R.sup.1 and R.sup.2 taken together may form alkylene; R.sup.3 is hydrogen, alkyl, alkanoyl or alkylsulfonyl; R.sup.4 is hydrogen, alkoxycarbonyl, carboxy or halogen; X is hydrogen, alkyl, alkoxy, halogen or hydroxy; and Y is methine or nitrogen or salts thereof are provided. The compounds (I) show potent psychotropic activity.
摘要翻译：式（I）的化合物：其中R 1和R 2各自为氢，烷基，烷氧基羰基，羧基，卤素，硝基或三氟甲基，或者R 1和R 2一起可以形成亚烷基; R3是氢，烷基，烷酰基或烷基磺酰基; R4是氢，烷氧基羰基，羧基或卤素; X是氢，烷基，烷氧基，卤素或羟基; 并且Y是次甲基或氮或其盐。化合物（I）显示出有效的精神活性。

5. 发明授权

US5149817A Teirahydropyridine derivatives 失效
标题翻译：噻吩衍生物
公开(公告)号：US5149817A
公开(公告)日：1992-09-22
申请号：US655585
申请日：1991-02-15
申请人： Hiromu Matsumura , Toshisada Yano , Hiroshi Hashizume , Akira Matsushita , Masami Eigyo
发明人： Hiromu Matsumura , Toshisada Yano , Hiroshi Hashizume , Akira Matsushita , Masami Eigyo
IPC分类号： C07D211/70 , C07D211/76 , C07D401/12 , C07D409/14
CPC分类号： C07D401/12 , C07D211/70 , C07D211/76 , C07D409/14
摘要： The present invention relates to tetrahydropyridine derivatives which have high affinity and specificity to .sigma. receptors, whereby these compounds are thought to be effective for treatment of some psychoses.

6. 发明授权

US5120733A Carbamoylpyrrolidone derivatives and drugs for senile dementia 失效
标题翻译：卡铂类吡咯烷酮衍生物和药物用于先天性
公开(公告)号：US5120733A
公开(公告)日：1992-06-09
申请号：US571402
申请日：1990-08-23
申请人： Hiromu Matsumura , Toshisada Yano , Akira Matsushita , Masami Eigyo
发明人： Hiromu Matsumura , Toshisada Yano , Akira Matsushita , Masami Eigyo
IPC分类号： C07D207/26 , C07D207/263 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/10
CPC分类号： C07D207/27 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/10
摘要： A compound of the formula: ##STR1## (wherein R is phenoxy optionally substituted by a halogen, methoxy, or methyl group, ##STR2## one of A and B is ##STR3## and the other is >CH.sub.2 ;R.sup.1 is hydrogen or C.sub.1 -C.sub.5 alkyl;Z.sup.1 is phenyl, benzyl, or isoxazolyl each optionally substituted by a halogen, methoxy, or methyl group; Z.sup.2 is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, or phenyl optionally mono-, di-, or tri-substituted by a halogen, methoxy, or methyl group; or Z.sup.1 and Z.sup.2 taken together with the adjacent nitrogen atom may form 5-membered heterocyclic group; Z.sup.3 is C.sub.1 -C.sub.5 hydroxyalkyl, di(C.sub.1 -C.sub.5 alkyl) sulfamoyl, 6-membered heterocyclic group, phenyl, benzyl, or phenylsulfonyl each phenyl moiety of the last three members being optionally substituted by a halogen, methoxy, or methyl group; Z.sup.4 is phenyl optionally substituted by a halogen, methoxy, or methyl group or 5- or 6-membered heterocyclic group which is optionally substituted by a halogen, methoxy, or methyl group and which can be optionally condensed with a benzene ring; Z.sup.5 is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; Z.sup.6 is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; m is an integer from 0 to 2; n is an integer from 2 to 3)or its pharmaceutical acceptable acid addition salt being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.

7. 发明授权

US4560684A 1,4-Benzodiazepine derivatives 失效
标题翻译： 1,4-苯并二氮杂衍生物
公开(公告)号：US4560684A
公开(公告)日：1985-12-24
申请号：US560994
申请日：1983-12-13
申请人： Tsutomu Sugasawa , Makoto Adachi , Kazuyuki Sasakura , Akira Matsushita , Masami Eigyo
发明人： Tsutomu Sugasawa , Makoto Adachi , Kazuyuki Sasakura , Akira Matsushita , Masami Eigyo
IPC分类号： C07D243/14 , A61K31/55 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D207/12 , C07D207/14 , C07D209/00 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/72 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07F7/18
CPC分类号： C07D401/04 , C07D207/12 , C07D207/14 , C07D211/42 , C07D211/58 , C07D211/72 , C07D401/12 , C07D403/04 , C07D403/12
摘要： 1,4-Benzodiazepine derivatives of the formula: ##STR1## (in which R.sup.1 is pyrrolidinyl or piperidinyl each optionally substituted by C.sub.1-3 alkyl, phenyl-C.sub.1-3 alkyl, C.sub.1-5 alkanoyl, or C.sub.2-5 alkoxycarbonyl,R.sup.2 is hydrogen, hydroxy, or acetoxy,R.sup.3 is C.sub.1-3 alkyl, phenyl-C.sub.1-3 alkyl, or phenyl optionally substituted by one or two halogens,X is hydrogen, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, nitro, trifluoromethyl, or di-C.sub.1-3 alkyl-amino, andn is 1 or 2)or pharmaceutically acceptable acid addition salts thereof, which are useful as a psychotropic agent such as anti-depressant or anxiolytic agent can be prepared from several routes.
摘要翻译：下式的1,4-苯并二氮杂衍生物（其中R 1为吡咯烷基或哌啶基，各自任选被C 1-3烷基，苯基-C 1-3烷基，C 1-5烷酰基或C 2-5烷氧基羰基取代，R 2为氢，羟基或乙酰氧基，R 3是C 1-3烷基，苯基-C 1-3烷基或任选被一个或两个卤素取代的苯基，X是氢，卤素，C 1-3烷基，C 1-3烷氧基，硝基，三氟甲基，或二-C 1-3烷基 - 氨基，n为1或2）或其药学上可接受的酸加成盐，其可用作精神药物如抗抑郁药或抗焦虑剂，可以从多种途径制备。

8. 发明授权

US5243051A Tetrahydropyridine derivatives 失效
标题翻译：四氢吡啶衍生物
公开(公告)号：US5243051A
公开(公告)日：1993-09-07
申请号：US903924
申请日：1992-06-26
申请人： Hiromu Matsumura , Toshisada Yano , Hiroshi Hashizume , Akira Matsushita , Masami Eigyo
发明人： Hiromu Matsumura , Toshisada Yano , Hiroshi Hashizume , Akira Matsushita , Masami Eigyo
IPC分类号： C07D211/70 , C07D211/76 , C07D401/12 , C07D409/14
CPC分类号： C07D401/12 , C07D211/70 , C07D211/76 , C07D409/14
摘要： The present invention relates to tetrahydropyridine derivatives which have high affinity and specificity to .sigma. receptors, whereby these compounds are thought to be effective for treatment of some psychoses.
摘要翻译：本发明涉及对σ受体具有高亲和力和特异性的四氢吡啶衍生物，由此认为这些化合物对治疗某些精神病有效。

9. 发明授权

US5242915A Formulation useful for the inhibition of massive release of cerebral glutamate 失效
标题翻译：抑制谷氨酸盐大量释放的配方
公开(公告)号：US5242915A
公开(公告)日：1993-09-07
申请号：US885864
申请日：1992-05-20
申请人： Motohiko Ueda , Takefumi Gemba , Masami Eigyo , Ikuo Adachi
发明人： Motohiko Ueda , Takefumi Gemba , Masami Eigyo , Ikuo Adachi
IPC分类号： A61K31/435 , A61K31/44 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/28 , C07D495/04
CPC分类号： A61K31/44
摘要： A method useful for the treatment or prevention of diseases caused by a massive release of cerebral glutamate, in particular epilepsy and dementia, and pharmaceutical formulations therefor, which comprise, as an active ingredient, a therapeutically effective amount of methyl (+)-(4S)-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate (S-312-d).

10. 发明授权

US5202345A Carbamoylpyrrolidone derivatives and drugs for senile dementia 失效
标题翻译：氨基甲酰吡咯烷酮衍生物和老年痴呆药物
公开(公告)号：US5202345A
公开(公告)日：1993-04-13
申请号：US832407
申请日：1992-02-07
申请人： Hiromu Matsumura , Toshisada Yano , Akira Matsushita , Masami Eigyo
发明人： Hiromu Matsumura , Toshisada Yano , Akira Matsushita , Masami Eigyo
IPC分类号： C07D207/26 , C07D207/263 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/10
CPC分类号： C07D207/27 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/10 , C07D417/12 , C07D471/10
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is hydrogen, or C.sub.1 14 C.sub.6 alkyl; n is an integer of from 2 to 3; Z.sup.1 is phenyl, benzyl, or isoxazolyl and each is optionally substituted by a halogen, a methoxy, or a methyl group; Z.sup.2 is hydrogen, C.sub.1 -C.sub.5 alkyl, allyl, unsubstituted phenyl, or phenyl substituted by halogen, methyl, or methoxy; orZ.sub.1 and Z.sub.2 are taken together with the adjacent nitrogen atom to form triazolyl, imidazolyl or pyrazolyl; or a pharmaceutically acceptable acid addition salt thereof.
摘要翻译：下式的化合物：其中R 1是氢或C 11-14烷基; n为2〜3的整数， Z 1是苯基，苄基或异恶唑基，并且各自任选被卤素，甲氧基或甲基取代; Z2为氢，C1-C5烷基，烯丙基，未取代的苯基或被卤素，甲基或甲氧基取代的苯基; 或Z 1和Z 2与相邻的氮原子一起形成三唑基，咪唑基或吡唑基; 或其药学上可接受的酸加成盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式