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    • 1. 发明授权
    • Method of artifact rejection for noninvasive blood-pressure measurement
by prediction and adjustment of blood-pressure data
    • 通过预测和调整血压数据进行无创血压测量的人工制品排除方法
    • US4949710A
    • 1990-08-21
    • US254204
    • 1988-10-06
    • Thomas J. DorsettCharles L. Davis
    • Thomas J. DorsettCharles L. Davis
    • A61B5/0225
    • A61B5/02225A61B5/02116A61B5/0225A61B5/7207
    • For use in performing non-invasive blood-pressure measurement (NIBP), an artifact rejection method for predicting expected data values from acquired data, and for adjusting previously acquired data based on the relationship of actually measured data values to their corresponding predicted values. The method is practiced in a system comprising an inflatable, occluding cuff, a pump and a valve coupled to the cuff, and monitoring apparatus coupled to the cuff adapted to measure cuff pressure and recurring blood-pressure pulsations occurring in the cuff that are caused by each heart contraction occurring in a measurement cycle. Cuff pressure is raised to a level above the patient's systolic pressure, and progressively reduced in a stepwise fashion to an ending cuff pressure. A fixed number of pulsations are measured and processed at a first and second cuff-pressure step, and a generally lesser number of pulsations are measured and processed at a third and subsequent cuff-pressure steps. The method includes, at the second cuff-pressure step, generating a prediction curve for predicting a next, expected-to-be-stored pulsation data value for a next, lower cuff-pressure step. The method also includes repeatedly smoothing the prediction curve based on the difference between a pulsations's calculated data value and its respective predicted data value. A final, smoothed curve is generated reflecting a final pulsation data value for each cuff-pressure step. From the final curve, the desired blood pressure parameters are derived and displayed in the form of arabic numerals by means of an LCD read-out.
    • 用于执行非侵入性血压测量(NIBP),用于从所获取的数据预测预期数据值的伪影拒绝方法,以及用于基于实际测量的数据值与其对应的预测值的关系来调整先前获取的数据。 该方法在包括可膨胀,闭塞的袖带,泵和耦合到袖带的阀的系统中实现,以及耦合到袖带的监测装置,其适于测量袖带中产生的袖带压力和重复出现的血压脉动,其由 每个心脏收缩发生在测量周期。 袖带压力提高到高于患者收缩压的水平,并逐步地逐渐减小到最终袖带压力。 在第一和第二袖带压步骤测量和处理固定数量的脉动,并且在第三和随后的袖带压力步骤测量和处理通常较少数量的脉动。 该方法包括:在第二袖带压步骤中,生成用于预测下一个较低袖带压步骤的下一个预期存储脉动数据值的预测曲线。 该方法还包括基于脉动计算的数据值与其各自的预测数据值之间的差异反复平滑预测曲线。 产生最终平滑的曲线,反映每个袖带压步骤的最终脉动数据值。 从最终曲线中,通过LCD读出导出所需血压参数并以阿拉伯数字显示。
    • 2. 发明授权
    • Method for noninvasive blood-pressure measurement by evaluation of
waveform-specific area data
    • US4889133A
    • 1989-12-26
    • US198468
    • 1988-05-25
    • Craig H. NelsonThomas J. DorsettCharles L. Davis
    • Craig H. NelsonThomas J. DorsettCharles L. Davis
    • A61B5/0225
    • A61B5/02225A61B5/0225
    • A microprocessor-controlled, oscillometric method for determining a patient's systolic, diastolic, and mean arterial pressure, practiced in a system comprising an inflatable, occluding cuff, a pump and a valve coupled to the cuff, and monitoring apparatus coupled to the cuff adapted to measure cuff pressure and recurring blood-pressure pulsations occurring in the cuff that are caused by each heart contraction occurring in a measurement cycle. Cuff pressure is raised to a level above the patinet's systolic pressure, and progressively reduced in a stepwise fashion to an ending cuff pressure. A fixed number of pulsations are measured and processed at a first and second cuff-pressure step, and a generally lesser number of oscillations are measured and processed at a third and subsequent cuff-pressure steps. The method includes a first artifact rejection technique used to check for false data relative to the formation of each blood-pressure pulsation. Further, the method includes calculating, for each blood-pressure pulsation, the impulse of a force that is exerted upon the patinet's blood from, and during, each heart contraction that occurs in the measurement cycle. An impulse value is stored relative to each pulsation. A second artifact rejection technique is used, beginning at the second cuff-pressure step, to generate a prediction curve for predicting a next, expected-to-be-stored pulsation impulse value for a next, lower cuff-pressure step. The second artifact rejection technique is also used to repeatedly smooth the prediction curve based on the difference between a pulsation's calculated impulse value and its respective predicted impulse value. A final, smoothed curve is generated reflecting a final impulse value for each cuff-pressure step. From the final curve, the desired blood pressure parameters are derived and displayed in the form of arabic numerals by means of an LCD readout.
    • 3. 发明授权
    • Noninvasive method of measuring blood density and hematocrit
    • 非侵入性测量血液密度和血细胞比容的方法
    • US07011631B2
    • 2006-03-14
    • US10760625
    • 2004-01-20
    • Charles L. DavisPatrick D. HarrisonJohn E. Bronson
    • Charles L. DavisPatrick D. HarrisonJohn E. Bronson
    • A61B5/00
    • A61B5/14535A61B5/02125A61B5/0535
    • Apparatus and methods for noninvasively measuring blood density and hematocrit in a human subject can include an appliance for applying pressure around a segment of a subject's limb or appendage that includes a pressure sensing means and encloses an array of impedance sensing devices applied to the subject's skin for independent fluid volume measurements. While applying pressure to the limb segment by the pressure appliance, measurements of blood pressure, blood pulse wave velocity, and limb segment impedance are recorded. The measurements are subsequently processed to yield changes of arterial blood volume during pulse wave passage. Then pressure, wave velocity, and derived volume data are combined to yield the density of the blood. Blood density is converted to hematocrit by means of a linear relationship between the two. Independent of the blood hematocrit, such apparatus and means may also be used to measure the density of enclosed fluid in other pulsed flow non-rigid wall vessel systems.
    • 用于非侵入性地测量人类受试者血液密度和血细胞比容的装置和方法可以包括用于在受试者肢体或附属部分周围施加压力的装置,所述装置包括压力感测装置并且包围应用于受试者皮肤的阻抗感测装置的阵列 独立液体体积测量。 在通过压力器具对肢段施加压力的同时,记录血压,血压波速度和肢体阻抗的测量值。 随后进行测量以产生脉搏通过期间动脉血容量的变化。 然后将压力,波速和导出的体积数据组合以产生血液的密度。 通过两者之间的线性关系将血液密度转化为血细胞比容。 独立于血液血细胞比容,这种装置和装置也可用于测量其它脉冲流非刚性壁容器系统中封闭流体的密度。
    • 5. 发明授权
    • Digital timing signal generator and voltage regulation circuit
    • 数字定时信号发生器和电压调节电路
    • US5077488A
    • 1991-12-31
    • US319883
    • 1989-03-03
    • Charles L. Davis
    • Charles L. Davis
    • G05F1/46H03K3/01H03K5/13
    • G05F1/466
    • A digital circuit both provides multiphasic timing signals and regulates the operating voltage of a non-ideal power source. In one embodiment, a delay line is provided whose delay characteristics vary inversely with operating voltage. Control gates are connected to selected outputs of the delay line to receive at differing times a control signal propagated through the delay line. In a preferred embodiment the control gates generate output signals the duration of which are determined by the delay characteristics of the delay line (and thus by the level of the operating voltage), such that the output signal duration increases in response to increases in operating voltage. The output signals activate current sinks or loads which increase the current drain on the non-ideal power source, thereby depressing its voltage. Regulation is optimized when the power source comprises a power supply having a significant output impedance at normal operating current levels, or the a power source is derived from a remote power supply coupled to said remote power supply by a high impedance or lossy coupling.
    • 数字电路都提供多相定时信号并调节非理想电源的工作电压。 在一个实施例中,提供延迟线,其延迟特性与工作电压成反比变化。 控制栅极连接到延迟线的选定输出,以在不同时间接收通过延迟线传播的控制信号。 在优选实施例中,控制门产生输出信号,其持续时间由延迟线的延迟特性(以及因此通过工作电压的电平)确定,使得输出信号持续时间响应于工作电压的增加而增加 。 输出信号激活电流吸收器或负载,从而增加非理想电源上的电流消耗,从而降低其电压。 当电源包括在正常工作电流水平下具有显着输出阻抗的电源时,或者通过高阻抗或有损耦合从与所述远程电源耦合的远程电源导出电源,从而对电压进行优化。
    • 6. 发明授权
    • Door retainer
    • 门保持架
    • US4747181A
    • 1988-05-31
    • US63452
    • 1987-06-18
    • Charles L. Davis
    • Charles L. Davis
    • E05C19/00E05F5/00
    • E05C19/003Y10S292/15Y10T16/61
    • A door retainer for removably mounting on the folding steps of a recreational vehicle to prevent the door from opening, which door retainer is characterized by a flat step plate designed to fit on the top step of the folding steps and provided with a downwardly-extending rear plate for engaging the rear edge of the top step. A post is upward-standing from the step plate in close proximity to the door, in order to prevent the door from opening when the step plate and the rear plate are installed on the steps in functional position. A latch bracket projects downwardly from fixed attachment to the step plate and a tab slot is provided in the rear plate opposite the latch bracket for receiving a tab located on one end of a keeper plate. The opposite end of the keeper plate is fitted with a keeper bracket for engaging the latch bracket on the step plate and receiving the hasp of a padlock to secure the step plate and the rear plate in functional configuration on the folding steps of the recreational vehicle.
    • 一种用于可拆卸地安装在休闲车辆的折叠台阶上以防止门打开的门保持器,该门保持器的特征在于平板踏板,其设计成适合折叠台阶的顶部台阶并设置有向下延伸的后部 用于接合顶部步骤的后边缘的板。 一个立柱从靠近门的踏板向上竖立,以便当台阶板和后板安装在功能位置的台阶上时,防止门打开。 闩锁支架从固定附件向下突出到台阶板,并且在后板中设置有与闩锁支架相对的突片槽,用于接收位于保持板一端的突片。 保持板的相对端配有保持架支架,用于与踏板上的闩锁支架接合,并接收挂锁的搭扣,以将踏板和后板固定在休闲车辆的折叠台阶上的功能构型上。
    • 7. 发明授权
    • Apparatus and method for adjusting a curie effect temperature sensing
system
    • 用于调节居里效应温度感测系统的装置和方法
    • US4610142A
    • 1986-09-09
    • US662875
    • 1984-10-19
    • Charles L. Davis
    • Charles L. Davis
    • H01H37/50G01K7/38G05D23/19G05D23/26H01H37/58H01H51/00G05D23/00
    • H01H37/585G05D23/1902G05D23/26
    • An apparatus and method for controlling the operating temperatures and differential temperature of a curie effect temperature sensing switch is disclosed. The temperature switch is adapted to provide temperature control of a cold plate in a reagent refrigerator. The temperature switch activates cold plate cooling devices when the cold plate temperature is above a first operating temperature and deactivates the cold plate cooling devices when the cold plate temperature is below a second operating temperature. An electromagnet is fixed external of and relative to the temperature switch so that the strength of the external magnetic field sets the operating temperatures of the temperature switch. A potentiometer is used to incrementally vary the current supplied to the electromagnet to thereby incrementally adjust the strength of the external magnetic field and the operating temperatures. A microprocessor may be provided to adjust the voltage supply of the potentiometer, which allows remote control of the operating temperatures. A second potentiometer is connected to the electromagnet so that it incrementally adjusts the current passed to the electromagnet as a function of whether the temperature switch is open or closed. Incremental adjustment of the second potentiometer provides incremental adjustment of the temperature differential. A monitor provides a warning signal if the temperature switch does not open and close within a predetermined time interval.
    • 公开了一种用于控制居里效应温度感测开关的操作温度和差温的装置和方法。 温度开关适于提供试剂冰箱中的冷板的温度控制。 当冷板温度高于第一工作温度时,温度开关激活冷板冷却装置,并且当冷板温度低于第二工作温度时,冷却板冷却装置停用。 电磁铁固定在温度开关的外部并相对于温度开关,外部磁场的强度设定温度开关的工作温度。 电位计用于递增地改变提供给电磁体的电流,从而逐渐调节外部磁场的强度和工作温度。 可以提供微处理器来调节电位器的电压供应,其允许远程控制工作温度。 第二电位器连接到电磁体,以便根据温度开关是打开还是闭合来递增地调节传递到电磁体的电流。 第二个电位计的增量调整提供了温差的增量调整。 如果温度开关在预定的时间间隔内没有打开和关闭,则显示器提供警告信号。