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1. 发明授权

US4410716A Dibenzo[a,d]cycloheptene derivatives and process for production thereof 失效
标题翻译：二苯并[a，d]环庚烯衍生物及其制备方法
公开(公告)号：US4410716A
公开(公告)日：1983-10-18
申请号：US190270
申请日：1980-09-24
申请人： Tetsutaro Hayasaka , Kuniro Saito , Sen-ichi Narita , Takao Goto , Shin-ichi Yamada , Teruo Saito , Kazuyoshi Okutani
发明人： Tetsutaro Hayasaka , Kuniro Saito , Sen-ichi Narita , Takao Goto , Shin-ichi Yamada , Teruo Saito , Kazuyoshi Okutani
IPC分类号： C07C69/73 , A61K31/19 , A61K31/215 , A61K31/22 , A61P25/04 , A61P29/00 , C07C29/14 , C07C29/143 , C07C45/46 , C07C51/00 , C07C57/38 , C07C57/58 , C07C57/72 , C07C59/42 , C07C59/72 , C07C59/74 , C07C59/76 , C07C59/86 , C07C59/88 , C07C67/00 , C07C69/612 , C07C69/708 , C07C69/716 , C07C69/734 , C07C69/738 , C07C69/76
CPC分类号： C07C255/00 , C07C29/14 , C07C29/143 , C07C45/46 , C07C57/38 , C07C57/58 , C07C57/72 , C07C59/72 , C07C59/86 , C07C59/88
摘要： Novel compounds, dibenzo[a,d]cycloheptene derivatives, of the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom or a lower alkyl group, R.sub.2 and R.sub.3 each represent a hydrogen atom or a lower alkyl group, and Z represents a group of the formula ##STR2## These novel compounds are useful as non-steroidal anti-inflammatory agents free from gastrointestinal lesions. The compounds of formula (I) can be prepared, for example, by cyclizing a compound of the general formula ##STR3## wherein R.sub.1 and R.sub.2 are as defined above, X represents a hydroxyl group or a halogen atom, one Y represents a group of the formula --CH.sub.2 COX and the other Y represents a hydrogen atom; optionally hydrolyzing the cyclized product; and optionally esterifying the product, and/or etherifying its enol group.
摘要翻译：新的化合物，二苯并[a，d]环庚烯衍生物，其通式为其中R 1表示氢原子，卤原子或低级烷基，R 2和R 3各自表示氢原子或低级烷基基团，Z表示下式的基团。这些新化合物可用作不含胃肠道损伤的非甾体抗炎剂。式（I）化合物可以例如通过使通式（II）的化合物环化，其中R 1和R 2如上定义，X表示羟基或卤素原子，一个Y代表式-CH 2 COX基团，另一个Y代表氢原子; 任选地水解环化产物; 并任选地酯化产物，和/或醚化其烯醇基团。

2. 发明授权

US5117037A Cis-bicyclo[4,3.0]non-2-end derivatives 失效
标题翻译： CIS-BICYCLO（4,3.0）非2-D衍生物
公开(公告)号：US5117037A
公开(公告)日：1992-05-26
申请号：US622471
申请日：1990-12-05
申请人： Masakatsu Shibasaki , Takahashi Atsuo , Tuyoshi Aoki , Hiroyasu Sato , Shin-ichi Yamada , Michiko Kudo , Takaji Yamaguchi , Kentaro Kogi , Sen-ichi Narita
发明人： Masakatsu Shibasaki , Takahashi Atsuo , Tuyoshi Aoki , Hiroyasu Sato , Shin-ichi Yamada , Michiko Kudo , Takaji Yamaguchi , Kentaro Kogi , Sen-ichi Narita
IPC分类号： C07C59/46 , C07C59/62 , C07C69/712 , C07C69/732 , C07C69/738 , C07C405/00
CPC分类号： C07C69/738 , C07C405/0083 , C07C59/46 , C07C59/62 , C07C69/712 , C07C69/732 , Y02P20/55
摘要： A cis-bicyclo[4.3.0]non-2-ene derivative of the formula: ##STR1## wherein R is a hydrogen atom, or a protecting group for a hydroxyl group, R.sup.1 is a hydrogen atom, A C.sub.1 -C.sub.12 straight or branched chain alkyl group, a substituted or unsubstituted phenyl group, a C.sub.6 -C.sub.12 aralkyl group containing a condensed aromatic ring or an aromatic hetero ring, or 1 equivalent of a cation, A is --CH.dbd.CH--CH.sub.2 --, or --CH.sub.2 --CH.sub.2 --O--, R.sup.2 is a C.sub.3 -C.sub.10 straight or branched chain alkyl group, a C.sub.1 -C.sub.3 alkyl group substituted by an aryloxy group which may be substituted, a C.sub.3 -C.sub.12 straight or branched chain alkenyl group, a C.sub.3 -C.sub.8 straight or branched chain alkynyl group, a C.sub.1 -C.sub.3 alkyl group substituted by a phenyl or phenoxy group which may be substituted, by a C.sub.1 -C.sub.6 alkoxy group or by a C.sub.5 -C.sub.8 cycloalkyl group, R.sup.3 is a hydrogen atom, a methyl group, or a vinyl group, and X is a halogen atom.

3. 发明授权

US5728835A Substituted cyclic amine compound, production process thereof and pharmaceutical composition for circulatory organ use containing the same 失效
标题翻译：取代的环胺化合物，其制备方法和含有其的循环器官用途的药物组合物
公开(公告)号：US5728835A
公开(公告)日：1998-03-17
申请号：US575062
申请日：1995-12-19
申请人： Tsuyoshi Aoki , Atsuo Takahashi , Hiroyasu Sato , Eiji Shimanuki , Kaoru Gengyou , Toyoki Nishimata , Sachiko Ishigami , Shin-ichi Yamada , Takahiro Yamaguchi , Yoichi Manome , Isamu Sato , Kentaro Kogi , Sen-ichi Narita
发明人： Tsuyoshi Aoki , Atsuo Takahashi , Hiroyasu Sato , Eiji Shimanuki , Kaoru Gengyou , Toyoki Nishimata , Sachiko Ishigami , Shin-ichi Yamada , Takahiro Yamaguchi , Yoichi Manome , Isamu Sato , Kentaro Kogi , Sen-ichi Narita
IPC分类号： A61K31/445 , C07D211/32
CPC分类号： A61K31/445 , C07D211/32
摘要： A substituted cyclic amine compound represented by the following general formula (1) ##STR1## wherein each of R.sup.1 to R.sup.5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or the like, A represents a carbonyl group or a sulfonyl group, B represents a methine moiety or a nitrogen atom, D represents a methine moiety, a nitrogen atom or .dbd.N(.fwdarw.O)-- and n is an integer of 2 to 3; and synthetic methods thereof. The inventive compound is useful in preventing and treating circulatory organ-related diseases such as hypertension, ischemic heart disease, cerebrovascular disease, peripheral circulatory disease and the like.
摘要翻译：由下列通式（1）表示的取代环胺化合物其中R 1至R 5各自表示氢原子，卤素原子，低级烷基，低级烷氧基等，A表示羰基或磺酰基，B表示次甲基部分或氮原子，D表示次甲基部分，氮原子或= N（ - O） - ，n为2〜3的整数。及其合成方法。本发明化合物可用于预防和治疗诸如高血压，缺血性心脏病，脑血管病，外周血循环疾病等循环器官相关疾病。

4. 发明授权

US4874760A 4,7-dihydroisothiazolo(5,4-b)pyridine derivatives and cardiovascular treating agents containing said derivatives 失效
标题翻译： 4,7-二氢异噻唑（5,4-b）吡啶衍生物和含有所述衍生物的心血管治疗剂
公开(公告)号：US4874760A
公开(公告)日：1989-10-17
申请号：US140999
申请日：1988-01-05
申请人： Shin-ichi Yamada , Takao Goto , Toshihisa Mashiko , Kentaro Kogi , Yukiko Oguchi , Senichi Narita
发明人： Shin-ichi Yamada , Takao Goto , Toshihisa Mashiko , Kentaro Kogi , Yukiko Oguchi , Senichi Narita
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： A 4,7-dihydroisothiazole[5,4-b]pyridine derivative represented by the general formula ##STR1## wherein R.sup.1 represents an alkyl group which may be substituted,R.sup.2 represents a hydrogen atom, a hydroxyl group, a benzyloxy group, a lower alkoxy group, a group of the formula ##STR2## in which R.sup.3 and R.sup.4 are identical or different and each represents a hydrogen atom, a lower alkyl group, an aralkyl group, an aralkynyl group, an aryloxyalkyl group, an arylaminoalkyl group, a pyridylalkyl group or a benzazolylalkyl group, or R.sup.3 and R.sup.4 form a ring and represent a group of the formula ##STR3## where X represents a methine group, a nitrogen atom or an oxygen atom, n is an integer of 1 or 2, and when X is a methine group or a nitrogen atom, R.sup.5 represents a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group, an aryl group, an aryloxy group, an aralkyl group, a furoyl group, a pyridyl group or a diphenylmethane group each of which group may be substituted, andm is an integer of 1 to 3,or an acid addition salt thereof. Processes for producing said derivative and a cardiovascular treating agent comprising said derivative as an active ingredient are also provided.

5. 发明授权

US5149702A Cycloheptenopyridine derivatives, process for preparation thereof and antiulcer agents containing the same 失效
标题翻译：环庚烯并吡啶衍生物，其制备方法和含有它们的抗溃疡剂
公开(公告)号：US5149702A
公开(公告)日：1992-09-22
申请号：US618943
申请日：1990-11-27
申请人： Shin-ichi Yamada , Takao Goto , Rie Yorita , Eizi Shimanuki , Takaji Yamaguchi , Kentaro Kogi , Senichi Narita
发明人： Shin-ichi Yamada , Takao Goto , Rie Yorita , Eizi Shimanuki , Takaji Yamaguchi , Kentaro Kogi , Senichi Narita
IPC分类号： C07D401/12 , C07D471/04
CPC分类号： C07D401/12 , C07D471/04 , Y02P20/55 , Y10S514/926 , Y10S514/927
摘要： Provided are cycloheptenopyridine derivatives represented by the general formula ##STR1## [wherein R represents a hydrogen atom or lower alkyl group; R.sup.1 represents a hydrogen atom, halogen atom, lower cycloalkoxy group, amido group, substituted phenoxy group, substituted benzyloxy group, lower alkoxy group optionally containing halogen atoms(s), nitro group, hydroxyl group, lower alkenyloxy group, lower alkylthio group, or a group--NR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 may be the same or different and each represent a hydrogen atom or lower alkyl group, or R.sup.4 and R.sup.5 mutually combine together with the nitrogen atom adjacent thereto to form a 5- or 6-membered heterocyclic group); R.sup.2 represents a hydrogen atom, halogen atom, lower alkyl group optionally containing a halogen atom, lower alkoxy group optionally containing a halogen atom, hydroxyl group, acyl group, lower alkoxycarbonyl group, nitro group or amino group; R.sup.3 represents a hydrogen atom, a lower alkyl group, lower alkoxymethyl group, lower alkylcarbonyl group, lower alkoxycarbonyl group, carbamoyl group, lower alkylcarbamoyl group, lower alkylcarbonylmethyl group, lower alkoxycarbonyl group, lower acyloxymethyl group, lower alkylsulfonyl group, or physiologically acceptable protective group eliminatable in an acid medium or under a physiological condition; n represents 0 or 1; and A represents a methine carbon or nitrogen atom] or their salts. These derivatives and their salts are useful as antiulcer agents.
摘要翻译：提供由通式[IMAGE] [I]表示的环庚烯并吡啶衍生物[其中R表示氢原子或低级烷基; R1表示氢原子，卤素原子，低级环烷氧基，酰胺基，取代苯氧基，取代的苄氧基，任选含有卤原子的低级烷氧基，硝基，羟基，低级链烯氧基，低级烷硫基，或基团-NR 4 R 5（其中R 4和R 5可以相同或不同，各自表示氢原子或低级烷基，或者R 4和R 5与与其相邻的氮原子相互结合形成5-或6-元杂环基）; R2表示氢原子，卤素原子，任选含有卤原子的低级烷基，任选含有卤素原子的低级烷氧基，羟基，酰基，低级烷氧基羰基，硝基或氨基; R3表示氢原子，低级烷基，低级烷氧基甲基，低级烷基羰基，低级烷氧基羰基，氨基甲酰基，低级烷基氨基甲酰基，低级烷基羰基甲基，低级烷氧基羰基，低级酰氧基甲基，低级烷基磺酰基或生理上可接受的保护性组在酸性培养基中或在生理条件下可消除; n表示0或1; A表示次甲基碳或氮原子]或其盐。这些衍生物及其盐可用作抗溃疡剂。

6. 发明授权

US06258829B1 Cycloalka[b]pyridine-3-carbonylguanidine derivatives, process for producing the same, and drugs containing the same 有权
标题翻译：环烷基[b]吡啶-3-羰基胍衍生物，其制备方法和含有它们的药物
公开(公告)号：US06258829B1
公开(公告)日：2001-07-10
申请号：US09367873
申请日：1999-09-03
申请人： Atsuo Takahashi , Kaoru Genkyou , Sachiko Yoneyama , Kazuyuki Aihara , Takashi Satoh , Fumiya Yoneyama , Jun Sasamori , Shin-ichi Yamada , Tetsuo Kimura , Kentaro Kogi
发明人： Atsuo Takahashi , Kaoru Genkyou , Sachiko Yoneyama , Kazuyuki Aihara , Takashi Satoh , Fumiya Yoneyama , Jun Sasamori , Shin-ichi Yamada , Tetsuo Kimura , Kentaro Kogi
IPC分类号： A61K31435
CPC分类号： C07D221/04 , C07D215/54 , C07D215/60 , C07D401/04 , C07D401/06 , C07D401/12 , C07D409/06 , C07D491/04 , C07D491/10 , C07F7/1804
摘要： This invention relates to a cycloalka[b]pyridine-3-carbonylguanidine derivative represented by the following general formula (1): and a salt thereof, which can provide a drug having sodium/proton (Na+/H+) exchange transport inhibitory action.
摘要翻译：本发明涉及可以提供具有钠/质子（Na + / H +）交换转运抑制作用的药物的由以下通式（1）表示的环烷并[b]吡啶-3-羰基胍衍生物及其盐。

7. 发明授权

US6011762A Optical disk apparatus 失效
标题翻译：光盘装置
公开(公告)号：US6011762A
公开(公告)日：2000-01-04
申请号：US688294
申请日：1996-07-29
申请人： Katsuya Watanabe , Mitsurou Moriya , Shin-ichi Yamada , Yasuaki Edahiro , Takeharu Yamamoto
发明人： Katsuya Watanabe , Mitsurou Moriya , Shin-ichi Yamada , Yasuaki Edahiro , Takeharu Yamamoto
IPC分类号： G11B7/00 , G11B7/085 , G11B7/09
CPC分类号： G11B7/0945 , G11B7/08511 , G11B2007/0006 , G11B2007/0013
摘要： An optical disk apparatus comprises a focusing means for focusing a light beam on a recording medium having first and second information faces; means for moving a focal point of the light beam in a direction substantially perpendicular to the information faces of the recording medium; means for detecting a focus condition of the light beam on the basis of an output signal from the reflected light detecting means; a focus control means for driving the focal point moving means on the basis of an output signal from the focus condition detecting means, and controlling the light beam so that the focus condition of the light beam becomes a prescribed focus condition; and a focus jumping means for moving the focal point of the light beam from the first information face to the second information face by driving the focal point moving means.
摘要翻译：光盘装置包括用于将光束聚焦在具有第一和第二信息面的记录介质上的聚焦装置; 用于沿着与记录介质的信息面大致垂直的方向移动光束的焦点的装置; 用于根据来自反射光检测装置的输出信号检测光束的聚焦条件的装置; 焦点控制装置，用于根据来自聚焦条件检测装置的输出信号驱动焦点移动装置，并控制光束使得光束的聚焦条件成为规定的聚焦条件; 以及聚焦跳跃装置，用于通过驱动焦点移动装置将光束的焦点从第一信息面移动到第二信息面。

8. 发明授权

US5818898A X-ray imaging apparatus using X-ray planar detector 失效
标题翻译： X射线成像装置使用X射线平面检测器
公开(公告)号：US5818898A
公开(公告)日：1998-10-06
申请号：US744937
申请日：1996-11-06
申请人： Akira Tsukamoto , Masayuki Nishiki , Seiichiro Nagai , Koichiro Nabuchi , Tohru Saisu , Shin-ichi Yamada , Takayuki Tomisaki , Manabu Tanaka
发明人： Akira Tsukamoto , Masayuki Nishiki , Seiichiro Nagai , Koichiro Nabuchi , Tohru Saisu , Shin-ichi Yamada , Takayuki Tomisaki , Manabu Tanaka
IPC分类号： H04N5/32 , A61B6/03
CPC分类号： H04N5/361 , H04N5/32
摘要： An X-ray imaging apparatus comprises an X-ray emission unit for emitting X-rays onto a human body under examination, an X-ray emission control unit for outputting an X-ray emission signal to direct the X-ray emission unit to emit X-rays, a flat panel X-ray detector having a two-dimensional array of detector elements in rows (lines) and columns, each of the detector elements converting incident X-rays passed through the human body under examination into an electric charge signal and storing it, a resetting unit for placing each line of the detector elements in the readout state in sequence, thereby discharging electric charge stored on each of the detector elements, a storage unit for placing all the lines of the detector elements in the readout state to thereby allow each of the detector elements to store an electric charge signal, and a readout unit for placing each line of the detector elements in the readout state in sequence to thereby read an electric charge signal from each of the detector elements.
摘要翻译：一种X射线成像装置，包括：X射线发射单元，用于将X射线发射到被检查的人体上; X射线发射控制单元，用于输出X射线发射信号以引导X射线发射单元发射 X射线，具有行（行）和列的检测器元件的二维阵列的平板X射线检测器，每个检测器元件将经检查的人体的入射X射线转换为电荷信号并将其存储起来;复位单元，用于将检测器元件的每一行依次放置在读出状态，从而放电存储在每个检测器元件上的电荷;存储单元，用于将检测器元件的所有线放置在读出状态从而允许每个检测器元件存储电荷信号，以及读取单元，用于依次将放置检测器元件的每一行放置在读出状态，从而读取每个检测器元件的电荷信号 e检测器元件。

9. 发明授权

US5732051A Focusing control apparatus using dynamic target value in relation to land/groove 失效
标题翻译：使用相对于陆/沟的动态目标值对焦控制装置
公开(公告)号：US5732051A
公开(公告)日：1998-03-24
申请号：US413489
申请日：1995-03-30
申请人： Hiroyuki Yamaguchi , Mitsuro Moriya , Osamu Yamaguchi , Shin-ichi Yamada , Toshiyuki Kinou , Yoshihiro Kanda
发明人： Hiroyuki Yamaguchi , Mitsuro Moriya , Osamu Yamaguchi , Shin-ichi Yamada , Toshiyuki Kinou , Yoshihiro Kanda
IPC分类号： G11B7/007 , G11B7/09 , G11B7/00
CPC分类号： G11B7/00718 , G11B7/0908
摘要： A focusing control apparatus is provided for controlling focusing of a light beam on a recording medium. The apparatus includes a control mechanism for maintaining the focusing state of the light beam on the recording medium by moving a focus mechanism based on a comparison between an output signal indicative of the focusing state and a target value. The apparatus further includes a target value setting circuit for setting the target value at a first level when the light beam is irradiated on the land track portions of the recording medium; and for setting the target value at a second level when the light beam is irradiated on the groove track portions.
摘要翻译：提供了一种聚焦控制装置，用于控制光束在记录介质上的聚焦。该装置包括控制机构，用于通过基于指示聚焦状态的输出信号与目标值之间的比较来移动聚焦机构来保持光束在记录介质上的聚焦状态。该装置还包括目标值设置电路，用于当光束照射在记录介质的脊迹部分上时，将目标值设置在第一水平; 并且当光束照射在凹槽轨道部分上时将目标值设置在第二水平。

10. 发明授权

US08094532B2 Interlayer movement apparatus, and integrated circuit for interlayer movement apparatus 有权
标题翻译：层间移动装置和层间移动装置用集成电路
公开(公告)号：US08094532B2
公开(公告)日：2012-01-10
申请号：US12810970
申请日：2008-12-25
申请人： Shin-ichi Yamada , Masaya Kuwahara , Yu Okada
发明人： Shin-ichi Yamada , Masaya Kuwahara , Yu Okada
IPC分类号： G11B7/00
CPC分类号： G11B7/08511 , G11B7/0941 , G11B7/0945 , G11B7/13925 , G11B2007/0013
摘要： In an interlayer movement apparatus for moving the focal point of the laser light to an arbitrary layer, there are provided an objective lens which collects the laser light from an optical source, a focus actuator which makes the objective lens move in its optical axis direction, a focus error detection means for detecting the convergent state of the laser light on the information layer of the optical disc, and an interlayer movement control system for making the focal point of the laser light move to an information layer two or more layers apart by controlling the focus actuator according to a relative speed between the information layer of the optical disc and the focal point which was calculated using the time required for the focal point of the laser light passing through the respective layers which was measured on the basis of the output signal of the focus error detection means and the respective interlayer distances which are specified by the optical disc specifications.
摘要翻译：在将激光焦点移动到任意层的层间移动装置中，设置有从光源收集激光的物镜，使物镜沿其光轴方向移动的聚焦致动器，用于检测激光在光盘的信息层上的会聚状态的聚焦误差检测装置，以及通过控制使激光的焦点移动到两层或更多层的信息层的层间移动控制系统所述聚焦致动器根据所述光盘的信息层和所述焦点之间的相对速度，所述相对速度是使用根据所述输出信号测量的通过各个层的激光的焦点所需的时间计算的的焦点误差检测装置和由光盘规格指定的各层间距离。

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