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1. 发明授权

US4556057A Cancer diagnosis device utilizing laser beam pulses 失效
标题翻译：癌症诊断装置利用激光束脉冲
公开(公告)号：US4556057A
公开(公告)日：1985-12-03
申请号：US474302
申请日：1983-03-11
申请人： Teruo Hiruma , Atsushi Honma , Tooru Hirano , Yutaka Tsuchiya , Yoshihiro Hayata , Katsuo Aizawa , Harubumi Kato , Keiji Kainuma
发明人： Teruo Hiruma , Atsushi Honma , Tooru Hirano , Yutaka Tsuchiya , Yoshihiro Hayata , Katsuo Aizawa , Harubumi Kato , Keiji Kainuma
IPC分类号： A61B1/04 , A61B5/00 , A61B18/20 , A61N5/06 , G01J3/12 , G01N21/64 , A61B6/08
CPC分类号： A61B1/043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61N5/0601 , A61N5/062 , G01N21/6456 , G01N2021/6417
摘要： Cancer diagnosis device contains an endoscope comprising a light pipe used to transmit light beams from respective light sources and an image guide used to observe the flesh of the organism during both diagnosis and treatment. The tip of the endoscope faces toward the focuses where a photosensitive material having an affinity to the focuses of cancer has been absorbed so that a treatment for cancer can be performed by exposing the organism affected by cancer to the laser beam. The attainable the laser beam within a focus is thus increased by the use of the laser beam pulse from a first laser beam pulse source. In addition to the above, the cancer diagnosis device contains a second laser beam pulse source used to transmit a light beam to the focuses through the light pipe for making a diagnosis, a selector used to selectively pick up the light beam from the first laser beam pulse source or the second laser beam pulse source, a spectroscope used to obtain the spectral response from emission of light led through the image guide used for observation from the flesh of the organism where fluorescence occurs, an imaging device used to pick up the spectral response, a graphic display used to graphically display the processed spectra picked up by the imaging device, and a controller used to control emission of light from the second laser beam pulse source and also to make the operation of the imaging device synchronize with the second laser beam pulse source.
摘要翻译：癌症诊断装置包括内窥镜，其包括用于透射来自各个光源的光束的光管和用于在诊断和治疗期间观察生物体的肉体的图像引导件。内窥镜的尖端朝向焦点，其中已经吸收了对癌症焦点具有亲和力的感光材料，从而可以通过将受癌症影响的生物体暴露于激光束来进行癌症治疗。因此，可以通过使用来自第一激光束脉冲源的激光束脉冲来增加聚焦内的可达到的激光束。除了上述之外，癌症诊断装置包含第二激光束脉冲源，用于通过光管将光束传输到焦点进行诊断，选择器用于选择性地拾取来自第一激光束的光束脉冲源或第二激光束脉冲源，用于获得从发射的光的光谱响应的光谱仪，其通过用于从发生荧光的生物体的肉体观察的图像引导件，用于拾取光谱响应的成像装置，用于图形显示由成像装置拾取的处理光谱的图形显示器，以及用于控制来自第二激光束脉冲源的光的发射的控制器，并且还使成像装置的操作与第二激光束同步脉冲源。

2. 发明授权

US06383175B1 Medical laser apparatus and diagnostic/treatment apparatus using the medical laser apparatus 有权
标题翻译：医用激光装置及使用医疗用激光装置的诊断·治疗装置
公开(公告)号：US06383175B1
公开(公告)日：2002-05-07
申请号：US09406734
申请日：1999-09-28
申请人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
发明人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
IPC分类号： A61B1822
CPC分类号： A61N5/062 , A61N2005/0644 , A61N2005/067
摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.
摘要翻译：在光动力学诊断和光动力学治疗中，来自光源的激光的振荡波长适合于多种不同种类的光敏剂和激发条件。此外，使用单个光源实现诊断和治疗。治疗期间同时诊断也得到实现。半导体激光器产生具有可变的振荡波长的激光，半波长的半峰全宽。光传输线引导照射的激光附近的焦点，图像传输线观察其焦点和周围，荧光提取装置仅提取由照射的激光激发的光敏剂发射的荧光，图像提取/分析装置拾取并分析所提取的荧光的图像，并且图像显示装置显示分析结果。

3. 发明授权

US07016718B2 Medical laser apparatus and diagnostic/treatment apparatus using the medical laser apparatus 失效
公开(公告)号：US07016718B2
公开(公告)日：2006-03-21
申请号：US10097259
申请日：2002-03-15
申请人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
发明人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
IPC分类号： A61F9/008
CPC分类号： A61N5/062 , A61N2005/0644 , A61N2005/067
摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

4. 发明授权

US06214033B1 Medical laser apparatus and diagnostic/treatment apparatus using the medical laser apparatus 失效
标题翻译：医用激光装置及使用医疗用激光装置的诊断·治疗装置
公开(公告)号：US06214033B1
公开(公告)日：2001-04-10
申请号：US08545101
申请日：1995-10-19
申请人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
发明人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
IPC分类号： A61N506
CPC分类号： A61N5/062 , A61N2005/0644 , A61N2005/067
摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.
摘要翻译：在光动力学诊断和光动力学治疗中，来自光源的激光的振荡波长适合于多种不同种类的光敏剂和激发条件。此外，使用单个光源实现诊断和治疗。治疗期间同时诊断也得到实现。半导体激光器产生具有可变的振荡波长的激光，半波长的半峰全宽。光传输线将照射的激光引导到焦点附近，图像传输线观察其焦点和周围，荧光提取装置仅提取由照射的激光激发的光敏剂发射的荧光，图像拾取/分析装置拾取并分析提取的荧光的图像，并且图像显示装置显示分析结果。

5. 发明申请

US20070173725A1 Method of measuring superficial chemical species and apparatus for measuring the same 有权
标题翻译：测量表面化学物质的方法及其测量装置
公开(公告)号：US20070173725A1
公开(公告)日：2007-07-26
申请号：US10590407
申请日：2005-02-22
申请人： Takayuki Souta , Katsuo Aizawa , Atsushi Nakamura , Satoshi Kageyama , Shinya Ohtsubo , Fumihiko Ichikawa
发明人： Takayuki Souta , Katsuo Aizawa , Atsushi Nakamura , Satoshi Kageyama , Shinya Ohtsubo , Fumihiko Ichikawa
IPC分类号： A61B5/00
CPC分类号： A61B5/444 , A61B5/0059 , A61B5/0075
摘要： A method of processing skin surface observation measuring data able to address various sicknesses and reduce an error in sickness detection, and a measuring apparatus requiring no filter with a simple structure. The measuring apparatus comprises a means of applying a white light to a biological surface as a sample, a means of detecting the spectra of the white light reflected off a plurality of positions on the biological surface, a means of plotting the absorbances of the above spectra to a light spectrum multi-dimensional space, a means of subjecting data in the spectrum multi-dimension space obtained from the plurality of positions to multivariate analysis to determine the eigenvectors of at least first, second and third principal components, and a means of projecting data at respective positions in respective eigenvector directions to display their magnitudes on a two-dimension display screen on a gray scale or in colors corresponding to the magnitudes; and a measuring method by the apparatus.
摘要翻译：一种处理皮肤表面观察测量数据的方法，能够解决各种疾病并减少疾病检测中的误差，以及不需要具有简单结构的过滤器的测量装置。测量装置包括将白光作为样品施加到生物表面的手段，检测从生物表面上的多个位置反射的白光的光谱的方法，绘制上述光谱的吸光度的方法对于光谱多维空间，将从多个位置获得的光谱多维空间中的数据进行多变量分析的装置，以确定至少第一，第二和第三主要分量的特征向量，以及投影装置在各个特征向量方向的各个位置处的数据在灰度或二维显示画面上显示其对应于幅度的颜色的幅度; 以及该装置的测量方法。

6. 发明授权

US06653337B2 Therapy of auto-immune disease by a photochemotherapeutical method 有权
公开(公告)号：US06653337B2
公开(公告)日：2003-11-25
申请号：US10056410
申请日：2002-01-23
申请人： Yukari Kuroiwa , Minako Araake , Hiroshi Suwa , Katsuo Aizawa
发明人： Yukari Kuroiwa , Minako Araake , Hiroshi Suwa , Katsuo Aizawa
IPC分类号： A61K3140
CPC分类号： C07D487/22 , A61K31/40 , A61K31/409 , A61K41/0071
摘要： As a novel photochemotherapeutical method for the treatment or prevention of an auto-immune disease, there is provided a method for treating an auto-immune disease, which comprises administering to the patient mono-L-aspartyl chlorin e6 or mono-L-glutamyl chlorin e6 or a pharmacologically acceptable salt thereof, followed by subjecting the blood vessel blood of the patient containing the administered compound to exposure with an ultraviolet ray or a laser light, thereby to excite said compound photochemically. This method is effective to decrease the level of auto-antibody in the blood of the patient and is also of high safety.

7. 发明授权

US4965064A Pheophorbide derivatives 失效
标题翻译：氢硼酸衍生物
公开(公告)号：US4965064A
公开(公告)日：1990-10-23
申请号：US285106
申请日：1988-12-15
申请人： Michito Karasawa , Mari Uchimoto , Hirofumi Kawabe , Takuzo Otani , Katsuo Aizawa
发明人： Michito Karasawa , Mari Uchimoto , Hirofumi Kawabe , Takuzo Otani , Katsuo Aizawa
IPC分类号： G01N33/50 , A61K31/40 , A61K41/00 , A61K51/00 , A61P35/00 , C07D487/22
CPC分类号： C07D487/22 , A61K41/0071
摘要： Novel pheophorbide derivatives of the general formula: ##STR1## [wherein Z is O or NH; n is an integer of 1 to 6; Y is NR'R" or ##STR2## wherein R', R" and R'" are the same or different or each represents a C.sub.1 to C.sub.4 lower alkyl group; X.sup.- is a halogen or organic acid ion); R.sub.1 is an ethenyl group; C.sub.1 to C.sub.4 lower alkyl group or ##STR3## (wherein m is an integer of 0 to 6; R.sub.6 is H or a C.sub.1 to C.sub.4 lower alkyl group); R.sub.2 is CH.sub.3, CHO or CH.sub.2 OH; either of R.sub.3 and R.sub.4 is H, with the other being OH, or both of them combine to represent .dbd.O; R.sub.5 is H or CO.sub.2 CH.sub.3) are provided.When administered to a cancer-carrying animal, the derivatives accumulate specifically in cancer tissues and emit characteristic fluorescent spectrum under irradiation of light, which enables one to detect the cancer tissues.

8. 发明授权

US07184142B2 Raman probe and Raman spectrum measuring apparatus utilizing the same 失效
标题翻译：拉曼探头和拉曼光谱测量装置
公开(公告)号：US07184142B2
公开(公告)日：2007-02-27
申请号：US10807328
申请日：2004-03-24
申请人： Yuichi Komachi , Hideo Tashiro , Hidetoshi Sato , Katsuo Aizawa
发明人： Yuichi Komachi , Hideo Tashiro , Hidetoshi Sato , Katsuo Aizawa
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： A61B5/02007 , A61B5/0075 , A61B5/0084 , G01J3/44 , G01N21/65 , G01N2021/6484
摘要： A Raman probe for measuring Raman spectrum includes an exciting-end light guiding path for guiding excitation light from a light source to a sample; a receiving light-guide path for guiding a light signal from said sample to a detector; a band-pass filter for passing said excitation light and blocking Raman-scattered light produced from said exciting-end light guiding path; a pipe for securing said band-pass filter inside said pipe, said pipe being mounted on a light-outgoing end of said exciting-end light guiding path; and an edge filter mounted on a light-incident end of said receiving light-guide path, said edge filter passing Raman-scattered light from said sample while blocking the excitation light. The edge filter is a short-wavelength transmitting filter that permits passage of wavelengths shorter than the excitation wavelength.
摘要翻译：用于测量拉曼光谱的拉曼探针包括用于将来自光源的激发光引导到样品的激光端导光路径; 用于将来自所述样品的光信号引导到检测器的接收光导路径; 用于使所述激发光通过并阻挡从所述激光端导光路径产生的拉曼散射光的带通滤波器; 用于将所述带通过滤器固定在所述管内的管，所述管安装在所述激光端导光路径的出光端; 以及安装在所述接收导光路的光入射端的边缘滤波器，所述边缘滤波器在阻挡激发光的同时通过来自所述样品的拉曼散射光。边缘滤波器是允许通过比激发波长短的波长的短波长透射滤波器。

9. 发明授权

US06970736B2 Analysis system of matter adhered to inside wall of vessel 失效
标题翻译：物质分析系统粘附在船舶内壁
公开(公告)号：US06970736B2
公开(公告)日：2005-11-29
申请号：US10045866
申请日：2001-10-29
申请人： Yuichi Komachi , Katsuo Aizawa , Atsushi Utsumi
发明人： Yuichi Komachi , Katsuo Aizawa , Atsushi Utsumi
IPC分类号： G01N21/65 , A61B1/00 , A61B5/00 , A61B10/00 , A61B5/02 , A61B6/00 , G02B6/04
CPC分类号： A61B5/0084 , A61B5/0075
摘要： An analysis system comprises an endoscope 10 insertable into the vessel and a Raman analysis apparatus 40. An insert cable 54 of the Raman analysis apparatus 40 is inserted into a channel 10a of the endoscope 10. An excitation optical fiber 60 and a bundle 70A of a plural number of light receivingoptical fibers 70 are received in the insert cable 54. A transparent small piece 63 having a film-like excitation optical filter 64 is abutted against the distal end of the fiber 60. A transparent plate 71 having a film-like light reciving optical filter 72 is abutted against the distal end of fibers bundle 70A. The plate 71 has a center hole 71a and the piece 63 is fitted into the hole 71a.
摘要翻译：分析系统包括可插入容器的内窥镜10和拉曼分析装置40.拉曼分析装置40的插入电缆54插入到内窥镜10的通道10a中。激发光纤60和束70A 多个光接收光纤70被容纳在插入电缆54中。具有膜状激发光学滤光器64的透明小片63与光纤60的远端抵接。具有膜状光的透明板71 收纳光学过滤器72抵靠纤维束70A的远端。板71具有中心孔71a，并且片63装配到孔71a中。

10. 发明授权

US06735369B2 Hollow optical fiber and method for manufacturing the same 失效
标题翻译：中空光纤及其制造方法
公开(公告)号：US06735369B2
公开(公告)日：2004-05-11
申请号：US10139424
申请日：2002-05-06
申请人： Yuichi Komachi , Katsuo Aizawa
发明人： Yuichi Komachi , Katsuo Aizawa
IPC分类号： G02B620
CPC分类号： G02B6/032 , C03B37/014 , C03B37/0756 , C03B2201/82 , C03B2203/16 , C03C13/008 , G02B6/102
摘要： A hollow optical fiber 10 has an intermed ate dielectric layer 12 interposed between an inner periphery side dielectric layer 11 facing a hollow core portion 10a and a metal layer 13. The inner periphery side dielectric layer 11 is formed of calcium fluoride. The intermediate dielectric layer 12 is formed of yttrium fluoride. Metal of the metal layer 13 can be prevented from dispersing into the dielectric layers 12, 11 by the intermediate dielectric layer 12 formed of yttrium fluoride. The hollow optical fiber 10 is manufactured by vapor depositing calcium fluoride on an outer peripheral surface of an acid-soluble glass tube 20 (base material), then vapor depositing yttrium fluoride on its outer peripheral surface, then vapor depositing a metal layer formed of silver, gold or the like on its outer peripheral surface, and thereafter, dissolving the glass tube 20 with acid.
摘要翻译：中空光纤10具有插入在面向中空芯部10a的内周侧电介质层11和金属层13之间的中间电介质层12.内周侧电介质层11由氟化钙形成。中间介电层12由氟化钇形成。可以通过由氟化钇形成的中间介电层12防止金属层13的金属分散到电介质层12,11中。中空光纤10通过在酸溶性玻璃管20（基材）的外周面上蒸镀氟化钙，然后在其外周面上蒸镀氟化钇，然后气相沉积由银形成的金属层，金等在其外周面上，然后用酸溶解玻璃管20。

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