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1. 发明申请

US20060146322A1 Raman probe and Raman spectrum measuring apparatus utilizing the same 失效
标题翻译：拉曼探头和拉曼光谱测量装置
公开(公告)号：US20060146322A1
公开(公告)日：2006-07-06
申请号：US10807328
申请日：2004-03-24
申请人： Yuichi Komachi , Hideo Tashiro , Hidetoshi Sato , Katsuo Aizawa
发明人： Yuichi Komachi , Hideo Tashiro , Hidetoshi Sato , Katsuo Aizawa
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： A61B5/02007 , A61B5/0075 , A61B5/0084 , G01J3/44 , G01N21/65 , G01N2021/6484
摘要： A Raman probe that can be used with high-intensity excitation light without producing light that interferes with the measurement of Raman scattering. A receiving-end filter is doughnut-shaped, with an exciting-end filter disposed at the center thereof. A light-blocking structure is provided between the exciting-end filter and the receiving-end filter such that the excitation end and the receiving end are completely separated.
摘要翻译：拉曼探头可用于高强度激发光，而不会产生干扰拉曼散射测量的光。接收端滤波器是环形的，其中心处设置有激励端滤波器。在激励端过滤器和接收端过滤器之间设置有阻光结构，使得激发端和接收端完全分离。

2. 发明授权

US07184142B2 Raman probe and Raman spectrum measuring apparatus utilizing the same 失效
标题翻译：拉曼探头和拉曼光谱测量装置
公开(公告)号：US07184142B2
公开(公告)日：2007-02-27
申请号：US10807328
申请日：2004-03-24
申请人： Yuichi Komachi , Hideo Tashiro , Hidetoshi Sato , Katsuo Aizawa
发明人： Yuichi Komachi , Hideo Tashiro , Hidetoshi Sato , Katsuo Aizawa
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： A61B5/02007 , A61B5/0075 , A61B5/0084 , G01J3/44 , G01N21/65 , G01N2021/6484
摘要： A Raman probe for measuring Raman spectrum includes an exciting-end light guiding path for guiding excitation light from a light source to a sample; a receiving light-guide path for guiding a light signal from said sample to a detector; a band-pass filter for passing said excitation light and blocking Raman-scattered light produced from said exciting-end light guiding path; a pipe for securing said band-pass filter inside said pipe, said pipe being mounted on a light-outgoing end of said exciting-end light guiding path; and an edge filter mounted on a light-incident end of said receiving light-guide path, said edge filter passing Raman-scattered light from said sample while blocking the excitation light. The edge filter is a short-wavelength transmitting filter that permits passage of wavelengths shorter than the excitation wavelength.
摘要翻译：用于测量拉曼光谱的拉曼探针包括用于将来自光源的激发光引导到样品的激光端导光路径; 用于将来自所述样品的光信号引导到检测器的接收光导路径; 用于使所述激发光通过并阻挡从所述激光端导光路径产生的拉曼散射光的带通滤波器; 用于将所述带通过滤器固定在所述管内的管，所述管安装在所述激光端导光路径的出光端; 以及安装在所述接收导光路的光入射端的边缘滤波器，所述边缘滤波器在阻挡激发光的同时通过来自所述样品的拉曼散射光。边缘滤波器是允许通过比激发波长短的波长的短波长透射滤波器。

3. 发明申请

US20060276699A1 Spectral probe for blood vessel diagnosis 审中-公开
标题翻译：用于血管诊断的光谱探针
公开(公告)号：US20060276699A1
公开(公告)日：2006-12-07
申请号：US11378311
申请日：2006-03-20
申请人： Yuichi Komachi , Hidetoshi Sato , Hideo Tashiro
发明人： Yuichi Komachi , Hidetoshi Sato , Hideo Tashiro
IPC分类号： A61B5/00
CPC分类号： A61B5/0075 , A61B1/00082 , A61B1/07 , A61B1/3137 , A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/6852 , A61B5/6853 , A61B8/12
摘要： A spectral probe for blood vessel diagnosis that can be used for diagnosing blood vessels with high reliability, without imposing an excessive burden on patients. A Raman spectrum measuring probe and either an endoscope or an ultrasonic probe are integrated. A mechanism is provided for bringing the tip of the Raman probe into contact with an affected area so as to eliminate the influence of blood when measuring. An endoscope has a forward-looking view in the blood vessel, while the Raman probe is of the lateral-view type for facilitating the measurement of blood vessel walls. A fixing balloon is provided at the probe tip portion that is inserted into a blood vessel, and a window for the Raman probe is provided on the opposite side of the balloon. As the fixing balloon is inflated, part of it comes into contact with the internal wall of a blood vessel and fixes the probe, while leaving a gap between the internal wall of the blood vessel and the probe. The window comes into contact with the affected area. Because the blood is allowed to flow through the gap, the blood stream is not stopped even when the balloon is inflated.
摘要翻译：用于血管诊断的光谱探针，可用于诊断血管，可靠性高，不会对患者造成过重负担。一个拉曼光谱测量探头，一个内窥镜或一个超声波探头是集成的。提供了用于使拉曼探针的尖端与受影响区域接触的机构，以便在测量时消除血液的影响。内窥镜在血管中具有前视图，而拉曼探针是侧视型，便于测量血管壁。在插入血管的探针末端部分设置有固定球囊，并且在气球的相反侧设置有用于拉曼探针的窗口。当定影气囊膨胀时，其一部分与血管的内壁接触并固定探针，同时在血管的内壁和探针之间留下间隙。窗户与受影响的地区接触。因为允许血液流过间隙，所以即使气囊膨胀也不会停止血流。

4. 发明授权

US07541195B2 Substrate for biomolecule microarray, biomolecule microarray, device and method of promoting interaction, and method of detecting interaction 失效
标题翻译：用于生物分子微阵列的基质，生物分子微阵列，促进相互作用的装置和方法以及检测相互作用的方法
公开(公告)号：US07541195B2
公开(公告)日：2009-06-02
申请号：US10560584
申请日：2004-06-09
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Satoru Hatakeyama
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Satoru Hatakeyama
IPC分类号： G01N33/543
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , C40B40/06 , C40B40/10 , G01N21/253 , G01N21/6428 , G01N33/5438 , G01N2021/6482
摘要： The substrate for biomolecule microarray has one or more spots for immobilizing a biomolecule. The spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, at least the surface of the substrate around the protruding spot part, the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. Alternatively, the spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, the protruding spot parts adjacent each other border through the lateral surface of the protruding spot part, and at least the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. The biomolecule microarray comprises the above substrate and a biomolecule and the biomolecule is immobilized on at least the flat surface for spotting on the substrate. The device of promoting interaction between biomolecules comprises a biomolecule microarray having one or more biomolecule-immobilized spots on a substrate, an electrode provided so as to face the surface having the biomolecule-immobilized spots of the microarray, and a power source for applying an electric field between the microarray and the electrode. The method of promoting interaction between biomolecules employing the above device. The method of detecting interaction between biomolecules. Provided are a substrate having biomolecule immobilization regions of prescribed shape on a biomolecule microarray, and means by which the interaction of biomolecules is rapidly conducted, the interaction of trace quantities of sample is promoted, and the interaction is detected and analyzed rapidly and with high sensitivity.
摘要翻译：用于生物分子微阵列的底物具有用于固定生物分子的一个或多个斑点。用于固定生物分子的点从基板的表面突出，并且具有用于在其顶部上点样的平坦表面，至少在突出的点部分周围的基板的表面，突出的点部分的侧表面和平坦表面用于点样由导电物质组成。或者，用于固定生物分子的斑点从基板的表面突出，并且具有用于在其顶部上斑点的平坦表面，突出的点部分彼此相邻，通过突出的斑点部分的侧表面，并且至少横向突出点部分的表面和用于点样的平坦表面由导电物质组成。生物分子微阵列包括上述底物和生物分子，生物分子至少固定在平坦表面上以便在基底上进行点样。促进生物分子之间的相互作用的装置包括在基底上具有一个或多个生物分子固定斑点的生物分子微阵列，设置成面对具有微阵列的生物分子固定点的表面的电极，以及用于施加电微阵列和电极之间的场。促进使用上述装置的生物分子之间相互作用的方法。检测生物分子之间相互作用的方法。提供了一种在生物分子微阵列上具有规定形状的生物分子固定区的底物，以及快速进行生物分子相互作用的手段，促进了微量样品的相互作用，并快速，高灵敏度地检测和分析了相互作用。

5. 发明申请

US20070178463A1 Micro-array substrate for biopolymer, hybridization device, and hybridization method 审中-公开
标题翻译：用于生物聚合物的微阵列底物，杂交装置和杂交方法
公开(公告)号：US20070178463A1
公开(公告)日：2007-08-02
申请号：US10590455
申请日：2005-02-17
申请人： Takeo Tanaami , Hideo Tashiro
发明人： Takeo Tanaami , Hideo Tashiro
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： G01N27/447 , C12Q1/6837
摘要： The invention provides a substrate for biopolymer hybridization, a biopolymer hybridization device, and a biopolymer hybridization method capable of: speeding up hybridization of a biopolymer, by means of dielectrophoresis or electrophoresis by applying an alternating voltage or a direct voltage to a planar electrode, so as to generate an electric field; and reading the hybridized biopolymer by means of a laser or the like.
摘要翻译：本发明提供用于生物聚合物杂交的底物，生物聚合物杂交装置和生物聚合物杂交方法，其能够通过介电电泳或电泳加速生物聚合物的杂交，通过向平面电极施加交流电压或直流电压，因此以产生电场; 并通过激光等读取杂化的生物聚合物。

6. 发明授权

US06937630B2 Laser oscillation method and laser device 失效
标题翻译：激光振荡法和激光装置
公开(公告)号：US06937630B2
公开(公告)日：2005-08-30
申请号：US10237678
申请日：2002-09-10
申请人： Satoshi Wada , Takayo Ogawa , Hideo Tashiro , Hiroshi Machida , Mikio Higuchi , Kohei Kodaira , Tomohiro Shonai
发明人： Satoshi Wada , Takayo Ogawa , Hideo Tashiro , Hiroshi Machida , Mikio Higuchi , Kohei Kodaira , Tomohiro Shonai
IPC分类号： H01S3/092 , H01S3/093 , H01S3/16 , H01S3/14
CPC分类号： H01S3/0621 , H01S3/0606 , H01S3/094038 , H01S3/09415 , H01S3/1611 , H01S3/1671
摘要： To provide a laser oscillation method and a laser device, which use a laser medium such as an Nd:GdVO4 crystal to which neodymium is doped in high concentration exceeding 1% in atomicity ratio, the laser medium comprised of the gadolinium-vanadate crystal to which neodymium as laser active ion is doped by a floating zone method such that concentration becomes exceeding 1% in atomicity ratio.
摘要翻译：为了提供激光振荡方法和激光装置，其使用Nd：GdVO 4晶体的激光介质，其中掺杂有钕以高浓度超过1％的原子比，激光介质包括的通过浮选法掺杂钕作为激光活性离子的钆 - 钒酸盐晶体，使得浓度以原子比率超过1％。

7. 发明授权

US06605257B1 Micro array manufacturing apparatus 失效
标题翻译：微阵列制造装置
公开(公告)号：US06605257B1
公开(公告)日：2003-08-12
申请号：US09634875
申请日：2000-08-07
申请人： Touji Nakazawa , Akihiro Iimura , Hideo Tashiro , Tokuji Kitsunai , Yoshihide Hayashizaki
发明人： Touji Nakazawa , Akihiro Iimura , Hideo Tashiro , Tokuji Kitsunai , Yoshihide Hayashizaki
IPC分类号： B01L302
CPC分类号： B01L3/0251 , B01J19/0046 , B01J2219/00364 , B01J2219/00369 , B01J2219/00376 , B01J2219/00387 , B01J2219/00527 , B01J2219/00533 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00677 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00722 , B01L3/0244 , B01L3/0255 , B82Y30/00 , C40B60/14 , G01N2035/1037 , Y10T436/2575
摘要： A present micro array manufacturing apparatus includes a substrate placement portion 11 on which a plurality of substrates can be arranged, a tighter plate 12 for storing a solution including a living body sample, a solution storing member 52 for taking in the solution from the tighter plate 12 and storing the solution therein, and a needle 51 which can be inserted into the solution storing member 52 to allow the solution stored in the solution storing member 52 to adhere onto each of the substrates by a given quantity, wherein the solution storing member 52 and needle 51 are moved in directions where they approach and part away from the substrates to thereby form spots on the substrates. And, the individual operations of the solution storing member 52 and needle 51 are carried out by single drive means 32.
摘要翻译：本发明的微阵列制造装置包括：基板配置部11，能够配置多个基板的基板配置部11;用于存储包含生物体样品的溶液的更紧密的板12;从更紧的板取出溶液的溶液存储部件52 12，将溶液保存在其中，将针51插入到溶液收容部件52中，使存储在溶液储存部件52中的溶液以规定量附着在各基板上，其中，溶液收容部件52 并且针51在它们接近并远离基板的方向上移动，从而在基板上形成点。并且，溶液储存构件52和针51的各个操作由单个驱动装置32执行。

8. 发明授权

US5936981A Wavelength selectable laser oscillator in wavelength tunable laser 失效
标题翻译：波长可选激光振荡器在波长可调激光器中
公开(公告)号：US5936981A
公开(公告)日：1999-08-10
申请号：US848218
申请日：1997-04-29
申请人： Satoshi Wada , Kazuyuki Akagawa , Hideo Tashiro
发明人： Satoshi Wada , Kazuyuki Akagawa , Hideo Tashiro
IPC分类号： G02F1/35 , G02F1/11 , H01S3/094 , H01S3/106 , H01S3/108 , H01S3/16 , H01S3/10
CPC分类号： H01S3/1068 , G02F1/116 , H01S3/094038 , H01S3/1625 , H01S3/1636
摘要： An object of the present invention is to provide a wavelength selectable laser oscillator in wavelength tunable laser by which the rate of repetitive pulse oscillation of laser beam in a laser resonator can be markedly increased in comparison with that of conventional ones, besides excitation input can be decreased, and in addition, speed-up of wavelength tuning speed can be achieved, whereby flexibility is remarkably elevated in case of practicing the wavelength selectable laser oscillator. The wavelength selectable laser oscillator in wavelength tunable laser comprises a laser resonator composed of opposed mirrors each having a prescribed reflectivity; a wavelength tunable laser medium disposed in the laser resonator and capable of laser oscillation in a wavelength zone of a prescribed range; an acousto-optical crystal disposed in the laser oscillator and to which is inputted the outgoing light from the wavelength tunable laser medium; an acoustic wave inputting means mounted on the acousto-optical crystal and for inputting an acoustic wave to the acousto-optical crystal; an optical element disposed in the laser resonator and for correcting dispersion of the diffracted light outputted from the acousto-optical crystal; and a pulse excitation laser for inputting excitation laser beam into the laser resonator.
摘要翻译：本发明的目的是提供一种波长可调激光器中的波长可选激光振荡器，其中激光谐振器中的激光束的重复脉冲振荡速率可以与常规激光振荡器相比显着增加，除了激励输入可以降低，另外，可以实现波长调谐速度的加快，从而在实施波长可选激光振荡器的情况下，柔性显着提高。波长可调激光器中的波长可选激光振荡器包括由相对的反射镜组成的激光谐振器，每个反射镜具有规定的反射率; 设置在所述激光谐振器中并能够在规定范围的波长区域内进行激光振荡的波长可调激光介质; 设置在激光振荡器中的声光晶体，并从波长可调激光介质输入出射光; 声波输入装置，安装在声光晶体上，并将声波输入声光晶体; 设置在所述激光谐振器中并用于校正从所述声光晶体输出的衍射光的色散的光学元件; 以及用于将激发激光束输入激光谐振器的脉冲激励激光器。

9. 发明授权

US5734666A Method for selecting wavelength in wavelength-tunable lasers and laser oscillators capable of selecting wavelengths in wavelength-tunable lasers 失效
标题翻译：在波长可调激光器中选择波长的方法和能够选择波长可调激光器中的波长的激光振荡器
公开(公告)号：US5734666A
公开(公告)日：1998-03-31
申请号：US552515
申请日：1995-11-09
申请人： Satoshi Wada , Kouichi Toyoda , Hideo Tashiro
发明人： Satoshi Wada , Kouichi Toyoda , Hideo Tashiro
IPC分类号： H01S3/10 , H01S3/106
CPC分类号： H01S3/1068
摘要： In order to eliminate a mechanically movable section, such as a rotation mechanism of a diffraction grating, to achieve a compact fabrication of the whole apparatus, and to realize stable action for selecting a wavelength, a laser oscillator selecting a wavelength in a wavelength-tunable laser is composed of a laser resonator consisting of a mirror on the input side and a mirror on the output side; a laser medium which is placed in the laser resonator and can oscillate in a predetermined range of wavelengths; a crystal to which is piezoelectric element is attached, the crystal receiving acoustic waves from the piezoelectric element in accordance with a desired wavelength; and a polarizing plate which is placed in the laser resonator and transmits only the output light beam having a prescribed plane of polarization or having a prescribed direction of light propagation among the output light beams from the laser medium. The apparatus thereby outputs only the desired wavelength.
摘要翻译：为了消除诸如衍射光栅的旋转机构的机械可移动部分，为了实现整个装置的紧凑的制造，并且为了实现选择波长的稳定动作，选择波长可调谐波长的激光振荡器激光器由在输入侧的反射镜和输出侧的反射镜组成的激光谐振器组成; 激光介质，其被放置在激光谐振器中并且可以在预定波长范围内振荡; 安装有晶体的压电元件，所述晶体从所述压电元件接收根据期望波长的声波; 以及偏振板，其被放置在激光谐振器中，并且仅在来自激光介质的输出光束中仅透射具有规定的偏振面或具有规定的光传播方向的输出光束。因此该装置仅输出期望的波长。

10. 发明授权

US07378636B2 Method of evaluating non-linear optical crystal and device therefor and wavelength conversion method and device therefor 有权
标题翻译：评估非线性光学晶体的方法及其装置及其波长转换方法及其装置
公开(公告)号：US07378636B2
公开(公告)日：2008-05-27
申请号：US10504290
申请日：2003-02-13
申请人： Satoshi Wada , Hideo Tashiro , Masataka Morita
发明人： Satoshi Wada , Hideo Tashiro , Masataka Morita
IPC分类号： G02B23/04 , G02F2/02
CPC分类号： G01N21/636 , G01M11/00 , G02F1/3501 , G02F1/37
摘要： A method of evaluating a non-linear optical crystal used for non-linear wavelength conversion of laser beam which enables the non-linear optical crystal to be evaluated before the crystal is actually used as a wavelength conversion element in order for the crystal to be constantly used for an extended time with a high conversion efficiency retained and without lowering in output when non-linear optical crystals for various non-linear wavelength conversions such as a CLBO crystal are used to convert laser beams, wherein the non-linear optical crystal is moved to changed a laser beam incident position to detect the output of a laser beam emitted from the non-linear optical crystal for each changing position.
摘要翻译：一种评估用于激光束的非线性波长转换的非线性光学晶体的方法，其使得在晶体实际用作波长转换元件之前能够评估非线性光学晶体以使晶体恒定用于延长的时间，保持高的转换效率，并且当用于各种非线性波长转换的非线性光学晶体（例如CLBO晶体）用于转换激光束时，输出不降低，其中非线性光学晶体被移动以改变激光束入射位置，以检测对于每个改变位置从非线性光学晶体发射的激光束的输出。

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