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1. 发明授权

US4100009A Method of and apparatus for producing hollow-cylindrically shaped fibrous articles 失效
标题翻译：中空圆柱形纤维制品的制造方法和设备
公开(公告)号：US4100009A
公开(公告)日：1978-07-11
申请号：US794697
申请日：1977-05-06
申请人： Takayoshi Nakajima , Hiroshi Sonoda , Katsutoshi Sasaki , Teruaki Hane
发明人： Takayoshi Nakajima , Hiroshi Sonoda , Katsutoshi Sasaki , Teruaki Hane
IPC分类号： B01D17/04 , B01D29/00 , B01D39/16 , B29C67/04 , B65H81/00
CPC分类号： B29C67/04 , B01D17/045 , B01D29/111 , B01D29/216 , B01D29/237 , B01D39/083 , B01D39/086 , B01D39/163 , B01D2201/182 , B01D2239/04 , B01D2239/0457 , B01D2239/0478 , B01D2239/065 , B01D2239/0695 , B01D2239/08 , B01D2239/10 , Y10T428/1369
摘要： A method for producing a hollow-cylindrically shaped fibrous article stabilized by hot adhesion and an apparatus suitable to produce the same are provided. Said method comprises passing a web of gathered fiber layer carried on a conveyor belt through a heating zone, heating said web in such a way that a lower-melting component of composite fiber contained in the lower part of said web contacting the conveyor belt is not in the molten state and a lower-melting component contained in the upper part of said web is in the molten state, while separating said web from the conveyor belt, winding up said web on a take-up rod or tube in such a way that the upper surface thereof occupies the inner side of the winding, while heating the web further, cooling the wound up article and drawing out the take-up rod or tube from the shaped product.The production method of the present invention is simple and does not require complicated apparatus and the resultant product is useful for filtration.
摘要翻译：提供一种用于制造通过热粘合而稳定的中空圆柱形纤维制品的方法和适于制造其的装置。所述方法包括将承载在传送带上的收集的纤维层的纤维网通过加热区，加热所述纤维网，使得包含在所述纤维网的下部的复合纤维的较低熔点成分与传送带接触不是在熔融状态下，并且包含在所述幅材的上部中的较低熔点成分处于熔融状态，同时将所述幅材与传送带分离，将所述纸幅卷绕在卷取杆或管上，使得其上表面占据绕组的内侧，同时进一步加热幅材，冷却卷绕物品并从成形产品中拉出卷取杆或管。

2. 发明授权

US4197156A Apparatus for producing hollow-cylindrically shaped fibrous articles 失效
标题翻译：用于生产中空圆柱形纤维制品的装置
公开(公告)号：US4197156A
公开(公告)日：1980-04-08
申请号：US868362
申请日：1978-01-10
申请人： Takayoshi Nakajima , Hiroshi Sonoda , Katsutoshi Sasaki , Teruari Hane
发明人： Takayoshi Nakajima , Hiroshi Sonoda , Katsutoshi Sasaki , Teruari Hane
IPC分类号： B01D17/04 , B01D29/00 , B01D39/16 , B29C67/04 , B65H81/00
CPC分类号： B29C67/04 , B01D17/045 , B01D29/111 , B01D29/216 , B01D29/237 , B01D39/163 , B01D2201/182 , B01D2239/0216 , B01D2239/0407 , B01D2239/0478 , B01D2239/0613 , B01D2239/064 , B01D2239/065 , B01D2239/0668 , B01D2239/0681 , B01D2239/0695 , B01D2239/10
摘要： A method for producing a hollow-cylindrically shaped fibrous article stabilized by hot adhesion and an apparatus suitable to produce the same are provided. Said method comprises passing a web of gathered fiber layer carried on a conveyer belt through a heating zone, heating said web in such a way that a lower-melting component of composite fiber contained in the lower part of said web contacting the conveyer belt is not in the molten state and a lower-melting component contained in the upper part of said web is in the molten state, while separating said web from the conveyer belt, winding up said web on a take-up rod or tube in such a way that the upper surface thereof occupies the inner side of the winding, while heating the web further, cooling the wound up article and drawing out the take-up rod or tube from the shaped product.The production method of the present invention is simple and does not require complicated apparatus and the resultant product is useful for filtration.
摘要翻译：提供一种用于制造通过热粘合而稳定的中空圆柱形纤维制品的方法和适于制造其的装置。所述方法包括将承载在输送带上的聚集的纤维层的纤维网通过加热区，加热所述纤维网，使得包含在所述纤维网的下部的复合纤维的较低熔点成分与传送带接触不接近在熔融状态下，并且包含在所述幅材的上部中的较低熔点成分处于熔融状态，同时将所述幅材与输送带分离，将所述幅材卷绕在卷取杆或管上，使得其上表面占据绕组的内侧，同时进一步加热幅材，冷却卷绕物品并从成形产品中拉出卷取杆或管。本发明的制造方法简单，不需要复杂的装置，所得产物可用于过滤。

3. 发明授权

US07291491B2 Polypeptides 失效
标题翻译：多肽
公开(公告)号：US07291491B2
公开(公告)日：2007-11-06
申请号：US10166098
申请日：2002-06-11
申请人： Minoru Fukuda , Katsutoshi Sasaki , Kazumi Miura , Satoshi Nakagawa , Tatsunari Nishi , Susumu Sekine
发明人： Minoru Fukuda , Katsutoshi Sasaki , Kazumi Miura , Satoshi Nakagawa , Tatsunari Nishi , Susumu Sekine
IPC分类号： C12N9/10 , C07H21/04 , C12P21/06
CPC分类号： C12N9/1051
摘要： The present invention provides pharmaceutical preparations for anti-inflammation, anti-infection, inhibition of cancer metastasis etc., foods such as dairy products etc., and a method for improving proteins, as well as a method for diagnosis of inflammatory diseases and cancer malignancy. According to the present invention, there can be provided a polypeptide having poly-N-acetyllactosamine sugar chains synthesis-related activity, a process for producing the polypeptide, DNA coding for the polypeptide, a process for producing the DNA, a recombinant vector having the DNA integrated therein, a transformant carrying the recombinant vector, an antibody recognizing the polypeptide, a process for producing poly-N-acetyllactosamine sugar chains by use of the DNA or the polypeptide, diagnosis and treatment of diseases such as inflammations, cancers etc. by use of the DNA, the polypeptide or the antibody, determination and immunostaining of the polypeptide of the present invention by use of the antibody, a method for screening a compound varying the expression of a gene coding for the polypeptide, and a method for screening a substance varying the activity of the polypeptide.
摘要翻译：本发明提供抗炎，抗感染，癌转移抑制等药物制剂，乳制品等食品，以及改善蛋白质的方法，以及炎性疾病和癌症恶性肿瘤的诊断方法。根据本发明，可以提供具有聚-N-乙酰乳糖胺糖链合成相关活性的多肽，制备多肽的方法，编码多肽的DNA，制备DNA的方法，具有整合在其中的DNA，携带重组载体的转化体，识别多肽的抗体，使用DNA或多肽产生聚-N-乙酰乳糖胺糖链的方法，诊断和治疗诸如炎症，癌症等疾病，通过使用DNA，多肽或抗体，通过使用抗体测定和免疫染色本发明的多肽，筛选改变编码多肽的基因的表达的化合物的方法，以及筛选方法物质改变多肽的活性。

4. 发明申请

US20060239999A1 Preventive and/or therapeutic drugs for asthma 审中-公开
标题翻译：用于哮喘的预防和/或治疗药物
公开(公告)号：US20060239999A1
公开(公告)日：2006-10-26
申请号：US10525326
申请日：2003-08-22
申请人： Mayumi Saki , Hiromi Nonaka , Hiromasa Miyaji , Naoko Hiura , Haruhiko Manabe , Tsotomu Matsumura , Hitoshi Arai , Katsutoshi Sasaki , Cjoei Kobatake , Kyoichiro Iida , Takeshi Kuboyama
发明人： Mayumi Saki , Hiromi Nonaka , Hiromasa Miyaji , Naoko Hiura , Haruhiko Manabe , Tsotomu Matsumura , Hitoshi Arai , Katsutoshi Sasaki , Cjoei Kobatake , Kyoichiro Iida , Takeshi Kuboyama
IPC分类号： A61K48/00 , A61K39/395 , A61K31/55
CPC分类号： A61K31/519 , A61K31/55 , A61K31/7088 , C07D403/06
摘要： The present invention provides an agent for prevention and/or treatment of asthma comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides an agent for prevention and/or treatment of asthma which comprises a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R1 represents a substituted or unsubstituted lower alkyl, or the like; R2 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; R3 and R4 are the same or different and each represents hydrogen, lower alkyl, or the like; n represents 0 or 1; X represents —(CH2)2—, or the like; and Y represents the formula (II) (wherein W represents CH or a nitrogen atom; Z1 and Z2 are the same or different and each represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; and Z3 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like)] as an active ingredient.
摘要翻译：本发明提供了用于预防和/或治疗哮喘的药剂，其包含能够抑制作为活性成分的GPR4的信号转导所涉及的功能的物质。它还提供了一种预防和/或治疗哮喘的药剂，其包含由式（I）表示的含氮三环化合物或其季铵盐或其药学上可接受的盐; [其中R 1表示取代或未取代的低级烷基等; R 2表示氢，取代或未取代的低级烷基等; R 3和R 4相同或不同，各自表示氢，低级烷基等; n表示0或1; X表示 - （CH 2 2）2 - 等; Y表示式（II）（其中W表示CH或氮原子; Z 1和Z 2相同或不同，各自表示氢，取代或未取代的低级烷基等; Z 3表示氢，取代或未取代的低级烷基等）作为活性成分。

5. 发明授权

US07094530B1 α-1,3-fucosyltransferase 失效
标题翻译： α-1,3-岩藻糖基转移酶
公开(公告)号：US07094530B1
公开(公告)日：2006-08-22
申请号：US08361306
申请日：1994-11-29
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12N15/54 , C12N9/10 , C12P19/18 , C12Q1/68
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译：本发明提供由从动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法，涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。

6. 发明授权

US07005279B1 Process for producing carbohydrates using β 1,3-N-acetyl-glucosaminyltransferase 有权
标题翻译：使用β1,3-N-乙酰基 - 氨基葡萄糖转移酶生产碳水化合物的方法
公开(公告)号：US07005279B1
公开(公告)日：2006-02-28
申请号：US10019735
申请日：2000-06-29
申请人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
发明人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
IPC分类号： C12P19/18 , C12N9/10 , C12N15/54
CPC分类号： C12N9/1051 , A61K38/00 , C07K2319/02 , C12N9/1085
摘要： The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.
摘要翻译：本发明提供了具有β1,3-N-乙酰葡糖胺基转移酶活性的新型多肽; 一种生产该多肽的方法; 编码多肽的DNA; 插入DNA的重组载体; 包含重组载体的转化体; 使用该多肽制备糖链或复合碳水化合物的方法; 使用该转化体生产糖链或复合碳水化合物的方法; 识别多肽的抗体; 用于筛选改变编码多肽的基因表达的物质的方法; 以及筛选改变多肽活性的物质的方法。

7. 发明授权

US06821756B2 Processes for reproducing sugar nucleotides and complex carbohydrates 失效
标题翻译：复制糖核苷酸和复合碳水化合物的方法
公开(公告)号：US06821756B2
公开(公告)日：2004-11-23
申请号：US09068528
申请日：1998-05-13
申请人： Satoshi Koizumi , Katsutoshi Sasaki , Tetsuo Endo , Kazuhiko Tabata , Akio Ozaki
发明人： Satoshi Koizumi , Katsutoshi Sasaki , Tetsuo Endo , Kazuhiko Tabata , Akio Ozaki
IPC分类号： C12P1930
CPC分类号： C12P19/30
摘要： This invention relates to a process for producing a sugar nucleotide, in which a) a culture broth of a microorganism capable of producing NTP from a nucleotide precursor, or a treated product of the culture broth, and b) a culture broth of a microorganism capable of producing a sugar nucleotide from a sugar and NTP, or a treated product of the culture broth, are used as enzyme sources; a process for producing a complex carbohydrate, in which the above-described a) and b) and c) a culture broth of a microorganism, an animal cell or an insect cell capable of producing a complex carbohydrate from a sugar nucleotide and a complex carbohydrate precursor, or a treated product of the culture broth, are used as enzyme sources; a process for producing a complex carbohydrate, in which a culture broth of a microorganism, an animal cell or an insect cell capable of producing a complex carbohydrate from a sugar nucleotide and a complex carbohydrate precursor, or a treated product of the culture broth, is as an enzyme source; and a process for producing N-acetylglucosamine-1-phosphate, in which a culture broth of a microorganism having strong galactokinase activity, or a treated product of the culture broth, is used as the enzyme source.
摘要翻译：本发明涉及一种制备糖核苷酸的方法，其中a）从核苷酸前体产生NTP的微生物的培养液或培养液的处理产物，和b）能够培养的微生物的培养液从糖和NTP生产糖核苷酸或培养液的处理产物用作酶源; 复合碳水化合物的制造方法，其中上述a）和b）和c）能够从糖核苷酸和复合碳水化合物生产复合碳水化合物的微生物，动物细胞或昆虫细胞的培养液前体或培养液的处理产物用作酶源; 复合碳水化合物的制造方法，其中可以从糖核苷酸和复合碳水化合物前体生产复合碳水化合物的微生物，动物细胞或昆虫细胞的培养液或培养液的处理产物是作为酶源; 使用其中具有强烈的半乳糖激酶活性的微生物的培养液或培养液的处理产物的N-乙酰葡糖胺-1-磷酸的生产方法作为酶源。

8. 发明授权

US08865731B2 Inhibitor of analgesic tolerance 有权
标题翻译：止痛耐受抑制剂
公开(公告)号：US08865731B2
公开(公告)日：2014-10-21
申请号：US12994923
申请日：2009-05-29
申请人： Jun Ouchi , Shunji Kunori , Yozo Kojima , Katsumi Shinoda , Katsutoshi Sasaki , Shiro Shirakura
发明人： Jun Ouchi , Shunji Kunori , Yozo Kojima , Katsumi Shinoda , Katsutoshi Sasaki , Shiro Shirakura
IPC分类号： A01N43/90 , A61K31/522 , A61K31/52 , A01N43/64 , A61K31/41 , A01N43/78 , A61K31/425 , A01N43/54 , A61K31/517 , A61K31/519 , C07D471/04 , C07D471/22 , C07D487/04 , C07D473/00 , C07D273/00 , C07D239/02 , C07D249/16 , C07D403/00 , A61K31/4439 , C07D473/34 , C07D473/06 , C07D487/14 , C07D417/04 , C07D417/14 , A61K31/506 , A61K45/06 , A61K31/343 , A61K31/427 , A61K31/485
CPC分类号： C07D417/14 , A61K31/343 , A61K31/427 , A61K31/4439 , A61K31/485 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/522 , A61K45/06 , C07D417/04 , C07D473/06 , C07D473/34 , C07D487/04 , C07D487/14 , A61K2300/00
摘要： Provided are: an agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), which comprises a compound having adenosine A2A receptor antagonistic activity or a pharmaceutically acceptable salt thereof as an active ingredient; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance or constipation; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance; and the like.
摘要翻译：提供：包含具有腺苷A 2A受体拮抗作用的化合物或其药学上可接受的盐作为活性成分的阿片类止痛剂（阿片样物质）的不良作用的药剂。用于抑制阿片样镇痛药（阿片样物质）的不良作用的药剂，其中阿片类镇痛药（阿片样物质）的不良作用是镇痛耐受性或便秘性; 用于抑制阿片样镇痛药（阿片样物质）的不良作用的药剂，其中阿片类镇痛药（阿片样物质）的不良作用是止痛耐受性; 等等。

9. 发明授权

US07709234B2 α-1,3-fucosyltransferase 失效
标题翻译： α-1,3-岩藻糖基转移酶
公开(公告)号：US07709234B2
公开(公告)日：2010-05-04
申请号：US11276029
申请日：2006-02-10
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12N9/10 , C12N15/54 , C12P19/18
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译：本发明提供由动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法，涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。

10. 发明申请

US20070037178A1 Endocrine cell lines and method of using the same 审中-公开
标题翻译：内分泌细胞系及其使用方法
公开(公告)号：US20070037178A1
公开(公告)日：2007-02-15
申请号：US11332785
申请日：2006-01-17
申请人： Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
发明人： Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
IPC分类号： C12Q1/68 , A01K67/027 , C12P21/06 , C12N5/06
CPC分类号： C12Q1/6897
摘要： In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or evaluating a substance capable of acting on the cells using the cell line, (4) a method of screening or isolating a useful gene or useful peptide using the cell line and (5) a highly-sensitive and simple assay system for GPCR ligand used in the above expression cloning system.
摘要翻译：根据本发明，提供了（1）衍生自哺乳动物的下丘脑和朗格汉斯胰岛的各种细胞系，（2）使用细胞系作为宿主的活性肽的生产方法和活性肽前体基因的表达克隆系统（3）使用细胞系筛选或评价能够作用于细胞的物质的方法，（4）使用细胞系筛选或分离有用基因或有用肽的方法，和（5）高度敏感的和用于上述表达克隆系统的GPCR配体的简单测定系统。

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