专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070105096A1 Endocrine cell lines and methods of using same 审中-公开
标题翻译：内分泌细胞系及其使用方法
公开(公告)号：US20070105096A1
公开(公告)日：2007-05-10
申请号：US10511341
申请日：2003-04-16
申请人： Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
发明人： Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
IPC分类号： C40B30/06 , C12Q1/68 , C07H21/02 , C12N5/06 , C40B40/08
CPC分类号： G01N33/507 , C12N2510/04 , C12N2830/002 , G01N33/5008 , G01N33/5023 , G01N33/5026 , G01N33/5044 , G01N33/74 , G01N2500/10
摘要： In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or evaluating a substance capable of acting on the cells using the cell line, (4) a method of screening or isolating a useful gene or useful peptide using the cell line and (5) a highly-sensitive and simple assay system for GPCR ligand used in the above expression cloning system.
摘要翻译：根据本发明，提供了（1）衍生自哺乳动物的下丘脑和朗格汉斯胰岛的各种细胞系，（2）使用细胞系作为宿主的活性肽的生产方法和活性肽前体基因的表达克隆系统（3）使用细胞系筛选或评价能够作用于细胞的物质的方法，（4）使用细胞系筛选或分离有用基因或有用肽的方法，和（5）高度敏感的和用于上述表达克隆系统的GPCR配体的简单测定系统。

2. 发明申请

US20070037178A1 Endocrine cell lines and method of using the same 审中-公开
标题翻译：内分泌细胞系及其使用方法
公开(公告)号：US20070037178A1
公开(公告)日：2007-02-15
申请号：US11332785
申请日：2006-01-17
申请人： Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
发明人： Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
IPC分类号： C12Q1/68 , A01K67/027 , C12P21/06 , C12N5/06
CPC分类号： C12Q1/6897
摘要： In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or evaluating a substance capable of acting on the cells using the cell line, (4) a method of screening or isolating a useful gene or useful peptide using the cell line and (5) a highly-sensitive and simple assay system for GPCR ligand used in the above expression cloning system.
摘要翻译：根据本发明，提供了（1）衍生自哺乳动物的下丘脑和朗格汉斯胰岛的各种细胞系，（2）使用细胞系作为宿主的活性肽的生产方法和活性肽前体基因的表达克隆系统（3）使用细胞系筛选或评价能够作用于细胞的物质的方法，（4）使用细胞系筛选或分离有用基因或有用肽的方法，和（5）高度敏感的和用于上述表达克隆系统的GPCR配体的简单测定系统。

3. 发明授权

US07709234B2 α-1,3-fucosyltransferase 失效
标题翻译： α-1,3-岩藻糖基转移酶
公开(公告)号：US07709234B2
公开(公告)日：2010-05-04
申请号：US11276029
申请日：2006-02-10
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12N9/10 , C12N15/54 , C12P19/18
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译：本发明提供由动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法，涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。

4. 发明授权

US06596523B1 &agr;,2,8-sialyltransferase 失效
标题翻译： α，2,8-唾液酸转移酶
公开(公告)号：US06596523B1
公开(公告)日：2003-07-22
申请号：US08361304
申请日：1994-11-29
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12N910
CPC分类号： C12N9/1081
摘要： The invention provides a novel &agr;-2,8-sialyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the &agr;-2,8-sialyltransferase, a method of detecting, or suppressing the production of &agr;-2,8-sialyltransferase by using the cDNA, a recombinant vector containing the DNA as an insert and cells harboring the recombinant vector as well as methods of preparing same. The &agr;-2,8-sialyltransferase of the invention is useful, for example, in the production of carbohydrate chains having a useful physiological activity, for example the ganglioside GD3, and modifications thereof.
摘要翻译：本发明提供由从动物细胞克隆的基因表达的新型α-2,8-唾液酸转移酶，编码α-2,8-唾液酸转移酶的cDNA，检测或抑制α-2,8-唾液酸转移酶的产生的方法，唾液酸转移酶，使用含有DNA作为插入片段的重组载体和携带重组载体的细胞以及其制备方法。本发明的α-2,8-唾液酸转移酶可用于例如生产具有有用生理活性的糖链，例如神经节苷脂GD3及其修饰。

5. 发明授权

US06420149B1 Polypeptides 失效
标题翻译：多肽
公开(公告)号：US06420149B1
公开(公告)日：2002-07-16
申请号：US09182450
申请日：1998-10-30
申请人： Minoru Fukuda , Katsutoshi Sasaki , Kazumi Miura , Satoshi Nakagawa , Tatsunari Nishi , Susumu Sekine
发明人： Minoru Fukuda , Katsutoshi Sasaki , Kazumi Miura , Satoshi Nakagawa , Tatsunari Nishi , Susumu Sekine
IPC分类号： C12N900
CPC分类号： C12N9/1051
摘要： The present invention provides pharmaceutical preparations for anti-inflammation, anti-infection, inhibition of cancer metastasis etc., foods such as dairy products etc., and a method for improving proteins, as well as a method for diagnosis of inflammatory diseases and cancer malignancy. According to the present invention, there can be provided a polypeptide having poly-N-acetyllactosamine sugar chains synthesis-related activity, a process for producing the polypeptide, DNA coding for the polypeptide, a process for producing the DNA, a recombinant vector having the DNA integrated therein, a transformant carrying the recombinant vector, an antibody recognizing the polypeptide, a process for producing poly-N-acetyllactosamine sugar chains by use of the DNA or the polypeptide, diagnosis and treatment of diseases such as inflammations, cancers etc. by use of the DNA, the polypeptide or the antibody, determination and immunostaining of the polypeptide of the present invention by use of the antibody, a method for screening a compound varying the expression of a gene coding for the polypeptide, and a method for screening a substance varying the activity of the polypeptide.
摘要翻译：本发明提供抗炎，抗感染，癌转移抑制等药物制剂，乳制品等食品，以及改善蛋白质的方法，以及炎性疾病和癌症恶性肿瘤的诊断方法。根据本发明，可以提供具有聚-N-乙酰乳糖胺糖链合成相关活性的多肽，制备多肽的方法，编码多肽的DNA，制备DNA的方法，具有整合在其中的DNA，携带重组载体的转化体，识别多肽的抗体，使用DNA或多肽产生聚-N-乙酰乳糖胺糖链的方法，诊断和治疗诸如炎症，癌症等疾病，通过使用DNA，多肽或抗体，通过使用抗体测定和免疫染色本发明的多肽，筛选改变编码多肽的基因的表达的化合物的方法，以及筛选方法物质改变多肽的活性。

6. 发明授权

US07291491B2 Polypeptides 失效
标题翻译：多肽
公开(公告)号：US07291491B2
公开(公告)日：2007-11-06
申请号：US10166098
申请日：2002-06-11
申请人： Minoru Fukuda , Katsutoshi Sasaki , Kazumi Miura , Satoshi Nakagawa , Tatsunari Nishi , Susumu Sekine
发明人： Minoru Fukuda , Katsutoshi Sasaki , Kazumi Miura , Satoshi Nakagawa , Tatsunari Nishi , Susumu Sekine
IPC分类号： C12N9/10 , C07H21/04 , C12P21/06
CPC分类号： C12N9/1051
摘要： The present invention provides pharmaceutical preparations for anti-inflammation, anti-infection, inhibition of cancer metastasis etc., foods such as dairy products etc., and a method for improving proteins, as well as a method for diagnosis of inflammatory diseases and cancer malignancy. According to the present invention, there can be provided a polypeptide having poly-N-acetyllactosamine sugar chains synthesis-related activity, a process for producing the polypeptide, DNA coding for the polypeptide, a process for producing the DNA, a recombinant vector having the DNA integrated therein, a transformant carrying the recombinant vector, an antibody recognizing the polypeptide, a process for producing poly-N-acetyllactosamine sugar chains by use of the DNA or the polypeptide, diagnosis and treatment of diseases such as inflammations, cancers etc. by use of the DNA, the polypeptide or the antibody, determination and immunostaining of the polypeptide of the present invention by use of the antibody, a method for screening a compound varying the expression of a gene coding for the polypeptide, and a method for screening a substance varying the activity of the polypeptide.
摘要翻译：本发明提供抗炎，抗感染，癌转移抑制等药物制剂，乳制品等食品，以及改善蛋白质的方法，以及炎性疾病和癌症恶性肿瘤的诊断方法。根据本发明，可以提供具有聚-N-乙酰乳糖胺糖链合成相关活性的多肽，制备多肽的方法，编码多肽的DNA，制备DNA的方法，具有整合在其中的DNA，携带重组载体的转化体，识别多肽的抗体，使用DNA或多肽产生聚-N-乙酰乳糖胺糖链的方法，诊断和治疗诸如炎症，癌症等疾病，通过使用DNA，多肽或抗体，通过使用抗体测定和免疫染色本发明的多肽，筛选改变编码多肽的基因的表达的化合物的方法，以及筛选方法物质改变多肽的活性。

7. 发明授权

US07094530B1 α-1,3-fucosyltransferase 失效
标题翻译： α-1,3-岩藻糖基转移酶
公开(公告)号：US07094530B1
公开(公告)日：2006-08-22
申请号：US08361306
申请日：1994-11-29
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12N15/54 , C12N9/10 , C12P19/18 , C12Q1/68
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译：本发明提供由从动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法，涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。

8. 发明申请

US20060246468A1 ALPHA-1,3-FUCOSYLTRANSFERASE 失效
公开(公告)号：US20060246468A1
公开(公告)日：2006-11-02
申请号：US11276029
申请日：2006-02-10
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12Q1/68 , C07H21/04 , C08B37/00 , C12P21/06 , C12N9/10 , C12N15/74 , C12N1/21
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译：本发明提供由从动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法，涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。

9. 发明授权

US07163791B2 α,2,8-sialyltransferase 失效
标题翻译： α，2,8-唾液酸转移酶
公开(公告)号：US07163791B2
公开(公告)日：2007-01-16
申请号：US10430325
申请日：2003-05-07
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12N15/54 , C12N15/63 , C12N1/21 , C12Q1/68 , C12N9/10
CPC分类号： C12N9/1081
摘要： The invention provides a novel α-2,8-sialyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-2,8-sialyltransferase, a method of detecting, or suppressing the production of α-2,8-sialyltransferase by using the cDNA, a recombinant vector containing the DNA as an insert and cells harboring the recombinant vector as well as methods of preparing same. The α-2,8-sialyltransferase of the invention is useful, for example, in the production of carbohydrate chains having a useful physiological activity, for example the ganglioside GD3, and modifications thereof.
摘要翻译：本发明提供由从动物细胞克隆的基因表达的新型α-2,8-唾液酸转移酶，编码α-2,8-唾液酸转移酶的cDNA，检测或抑制α-2,8-唾液酸转移酶的产生的方法，唾液酸转移酶，使用含有DNA作为插入片段的重组载体和携带重组载体的细胞以及其制备方法。本发明的α-2,8-唾液酸转移酶可用于例如生产具有有用生理活性的糖链，例如神经节苷脂GD3及其修饰。

10. 发明授权

US5494790A .alpha.-3 sialyltransferase 失效
标题翻译： α-3唾液酸转移酶
公开(公告)号：US5494790A
公开(公告)日：1996-02-27
申请号：US309985
申请日：1994-09-20
申请人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
发明人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
IPC分类号： C12N1/21 , C12N9/10 , C12N15/54 , C12Q1/68
CPC分类号： C12N9/1081
摘要： There are provided a novel .alpha.2.fwdarw.3 sialyltransferase expressed by a cloned gene from animal cells, a cDNA encoding the .alpha.2.fwdarw.3 sialyltransferase, a method for detecting or suppressing the expression of an .alpha.2.fwdarw.3 sialyltransferase by use of said cDNA, a recombinant vector containing said cDNA, a cell containing said vector, and their production processes.
摘要翻译：提供了由动物细胞克隆的基因表达的新型α2-> 3唾液酸转移酶，编码α2-> 3唾液酸转移酶的cDNA，通过使用α2-> 3唾液酸转移酶检测或抑制α2-> 3唾液酸转移酶的表达的方法所述cDNA是含有所述cDNA的重组载体，含有所述载体的细胞及其制备方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式