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    • 9. 发明授权
    • Polypeptides
    • 多肽
    • US07291491B2
    • 2007-11-06
    • US10166098
    • 2002-06-11
    • Minoru FukudaKatsutoshi SasakiKazumi MiuraSatoshi NakagawaTatsunari NishiSusumu Sekine
    • Minoru FukudaKatsutoshi SasakiKazumi MiuraSatoshi NakagawaTatsunari NishiSusumu Sekine
    • C12N9/10C07H21/04C12P21/06
    • C12N9/1051
    • The present invention provides pharmaceutical preparations for anti-inflammation, anti-infection, inhibition of cancer metastasis etc., foods such as dairy products etc., and a method for improving proteins, as well as a method for diagnosis of inflammatory diseases and cancer malignancy. According to the present invention, there can be provided a polypeptide having poly-N-acetyllactosamine sugar chains synthesis-related activity, a process for producing the polypeptide, DNA coding for the polypeptide, a process for producing the DNA, a recombinant vector having the DNA integrated therein, a transformant carrying the recombinant vector, an antibody recognizing the polypeptide, a process for producing poly-N-acetyllactosamine sugar chains by use of the DNA or the polypeptide, diagnosis and treatment of diseases such as inflammations, cancers etc. by use of the DNA, the polypeptide or the antibody, determination and immunostaining of the polypeptide of the present invention by use of the antibody, a method for screening a compound varying the expression of a gene coding for the polypeptide, and a method for screening a substance varying the activity of the polypeptide.
    • 本发明提供抗炎,抗感染,癌转移抑制等药物制剂,乳制品等食品,以及改善蛋白质的方法,以及炎性疾病和癌症恶性肿瘤的诊断方法 。 根据本发明,可以提供具有聚-N-乙酰乳糖胺糖链合成相关活性的多肽,制备多肽的方法,编码多肽的DNA,制备DNA的方法,具有 整合在其中的DNA,携带重组载体的转化体,识别多肽的抗体,使用DNA或多肽产生聚-N-乙酰乳糖胺糖链的方法,诊断和治疗诸如炎症,癌症等疾病,通过 使用DNA,多肽或抗体,通过使用抗体测定和免疫染色本发明的多肽,筛选改变编码多肽的基因的表达的化合物的方法,以及筛选方法 物质改变多肽的活性。