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1. 发明授权

US3668200A Process for the production of isoxazolyl penicillins 失效
标题翻译：生产ISOXAZOLYL PENICILLINS的方法
公开(公告)号：US3668200A
公开(公告)日：1972-06-06
申请号：US3668200D
申请日：1969-09-24
申请人： TOYO JOZO KK
发明人： ABE JINNOSUKE , WATANABE TETSUO , TAKE TERUO , FUJIMOTO KENTARO , FUJII TADASHIRO , TAKEMURA KAZUNARI , NISHIIE KAZUYOSHI , SATOH SAKAE , KOIDE TADASHI , HOTTA YASUE
IPC分类号： C07D499/00 , C07D499/76 , C07D99/16
CPC分类号： C07D499/00 , Y02P20/55
摘要： WHEREIN R1, R2 and R'' are as defined above; then subjecting the compound of Formula V to dephenylacetylation; and eliminating R'' when R'' is a said easily eliminated group.

A chemical process for the production of isoxazolyl penicillins and nontoxic salts and lower alkyl esters thereof having the formula REQUIRES NO MICROBIOLOGICAL DEACYLATION OR FERMENTATION TO PRODUCE 6-AMINOPENICILLANIC ACID, BUT INSTEAD COMPRISES REACTING A PENICILLIN G ester having the formula WHEREIN R'' is a protective group for carboxyl group and is selected from the group consisting of lower alkyl and a group which, when subjected to an elimination reaction, can be easily eliminated without having any detrimental effect on the structure of penicillin, which a chlorinating agent in the presence of a tertiary organic base to obtain an imide chloride groupincorporated compound having the formula WHEREIN R'' is as defined above; reacting the compound of Formula III with an isoxazol carboxylate having the formula WHEREIN M is a metal atom, and R1 and R2 are as defined above, to obtain a diacyl penicillin ester having the formula
摘要翻译：用于生产具有下式的异恶唑青霉素及其无毒盐及其低级烷基酯的化学方法不需要微生物学脱水或发酵生产6-氨基苯甲酸，而是包含反应式PENICILLIN G的酯，其具有式WHEREIN R'是保护性的羧基组，并且选自低级烷基和基团，当进行消除反应时，可以容易地除去，而不会对青霉素的结构产生任何有害影响，青霉素的存在下，氯化剂叔有机碱，得到具有式WHEREIN R'如上定义的酰亚胺氯化物引入的化合物; 使式III的化合物与式WHEREIN M是金属原子的异恶唑羧酸酯反应，并且R 1和R 2如上所定义，得到具有式WHEREIN R 1，R 2和R'如上定义的二酰基青霉素酯; 然后使式V的化合物进行苯基乙酰化; 并且当R'是所述容易消除的组时，消除R'。

2. 发明授权

US3594367A Process for production of penicillin 失效
标题翻译：生菜素的方法
公开(公告)号：US3594367A
公开(公告)日：1971-07-20
申请号：US3594367D
申请日：1968-11-29
申请人： TOYO JOZO KK
发明人： ABE JINNOSUKE , WATANABE TETSUO , TAKE TERUO , FUJIMOTO KENTARO , FUJII TADASHIRO , KURAMOTO MASASHI , KOBARI SADAMI
IPC分类号： C07D499/00 , C07D499/12 , C07D499/60 , C07D99/16
CPC分类号： C07D499/00 , Y02P20/582
摘要： A-PHENOXYALKYL PENICILLIN AND SALTS THEREOF ARE PRODUCED BY REACTING 6-AMINOPENICILLANIC ACID OR SALTS THEREOF WITH A NOVEL N, N-DIACYL COMPOUND OF THE FORMULA

PHENYL-O-C(-R1)(-R2)-CO-N(-R)-CO-AR

IN WHICH R IS ALKYL, CYCLOALKYL, ARYL, SUBSTITUTED ARYL, ARALKYL, SUBSTITUTED ARALKYL OR PHENYLALKENYL, AR IS PHENYL, PHENOXYALKYL, OR SUBSTITUTED PHENYL, AND R1 AND R2 ARE HYDROGEN OR LOWER ALKYL.

3. 发明授权

US3535309A Antibiotics and their production 失效
标题翻译：抗生素及其生产
公开(公告)号：US3535309A
公开(公告)日：1970-10-20
申请号：US3535309D
申请日：1967-09-01
申请人： KITASATO INST , TOYO JOZO KK
发明人： HATA TOJU , MATSUMAE AKIHIRO , OMURA SATOSHI , ABE JINNOSUKE , WATANABE TETSUO
IPC分类号： C07H17/08 , C07C47/18
CPC分类号： C07H17/08 , Y10S435/886

4. 发明授权

US3892732A Antibiotic tuberactinomycin-N and process for production thereof 失效
标题翻译：抗生素结核菌素N及其生产方法
公开(公告)号：US3892732A
公开(公告)日：1975-07-01
申请号：US15848871
申请日：1971-06-30
申请人： TOYO JOZO KK
发明人： ABE JINNOSUKE , WATANABE TETSUO , NAGATA AKIHO , ANDO TAKUJI , TAKE TERUO , IZUMI ROKURO , NODA TOSHIHARU , MATSUURA KAZUO
IPC分类号： C12P21/04 , A61K36/06 , A61K38/00 , A61P31/04 , A61P31/06 , C07D239/12 , C07D403/04 , C07K7/56 , C07K14/195 , C07K14/41 , C12P1/06 , C12R1/465 , C07D57/00 , C07C103/52
CPC分类号： C07D403/04 , A61K38/00 , C07D239/12 , C07K7/56 , Y10S435/886 , Y10S514/924
摘要： A new antibiotic of basic peptide Tuberactinomycin-N and process for production thereof which comprises the steps of: cultivating Streptomyces griseoverticillatus var. tuberacticus No. N 6-130 FERM P-619 in a nutrient culture medium; cultivating the said culture medium aerobically until substantial antibiotic activity is imparted to said medium; isolating the said antibiotic from the culture medium; obtaining the said antibiotic in its essentially crystalline powder having an antituberculosis activity.
摘要翻译：一种新型的基础肽丁香霉素-N的抗生素及其制备方法，其特征在于包括以下步骤：培养灰霉链霉菌（Streptomyces griseoverticillatus var。 tuberamicus No. N 6-130 FERM P-619在营养培养基中; 有氧地培养所述培养基，直到向所述培养基施加显着的抗生素活性; 从培养基中分离所述抗生素; 在其具有抗结核活性的基本上结晶的粉末中获得所述抗生素。

5. 发明授权

US3880823A Process for preparing peptides using N-hydroxy succinimide mono-and dichloroacetate esters 失效
标题翻译：使用N-羟基琥珀酰亚胺单 - 和二氯乙酸酯制备肽的方法
公开(公告)号：US3880823A
公开(公告)日：1975-04-29
申请号：US6661370
申请日：1970-08-24
申请人： TOYO JOZO KK
发明人： HAGITANI AKIRA , MURAMATSU ICHIRO , SAKAKIBARA SHUMPEI , ABE JINNOSUKE , WATANABE TETSUO
IPC分类号： C07D499/00 , C07K1/08 , C07K5/06 , C07K5/103 , C07C103/52 , C07G7/00 , C08H1/00
CPC分类号： C07K5/1013 , C07D499/00 , C07K1/084 , C07K5/06043 , Y10S930/15
摘要： 1. A group of new compounds having a general formula:
摘要翻译： 1.一组具有以下通式的新化合物：R2-CO-NH-R3，其中R2和R3表示本文公开的并适用于药物的各种基团。

6. 发明授权

US3630846A Antibiotic production using streptomyces kitasatoensis 失效
标题翻译：抗生素生产使用STRATTOMYCES KITASATOENSIS
公开(公告)号：US3630846A
公开(公告)日：1971-12-28
申请号：US3630846D
申请日：1969-10-07
申请人： KITASATO INST AND TOYO JOZO KK
发明人： HATA TOJU , MATSUMAE AKIHIRO , OMURA SATOSHI , ABE JINNOSUKE , WATANABE TETSUO
IPC分类号： C07H17/08 , C12D9/00
CPC分类号： C07H17/08 , Y10S435/803 , Y10S435/886
摘要： Manufacture of new antibiotic substances by the cultivation of a micro-organism belonging to Streptomyces kitasatoensis. The antibiotic of the invention has the general structural formula:

WHEREIN WHEN R1 represents hydrogen, R2 represents acetyl, propionyl, butyryl or where when R1 represents acetyl, R2 represents acetyl, propionyl, butyryl or isovaleryl.

7. 发明授权

US3658792A Diacyl penicillins and methods for their production 失效
标题翻译： DIACYL PENICILLINS及其生产方法
公开(公告)号：US3658792A
公开(公告)日：1972-04-25
申请号：US3658792D
申请日：1970-04-07
申请人： TOYO JOZO KK
发明人： ABE JINNOSUKE , WATANABE TETSUO , TAKE TERUO , FUJIMOTO KENTARO , FUJII TADASHIRO , TAKEMURA KAZUNARI , NISHII KAZUYOSHI
IPC分类号： C07D499/00 , C07D499/76 , C07D99/16
CPC分类号： C07D499/00
摘要： NOVEL DIACYL PENICILLINS OF THE FORMULA

2-(R-OOC-),3,3-DI(CH3-),6-((3-(R1,R2-PHENYL),5-CH3-

ISOXAZOL-4-YL)-CO-N(-CO-CH2-C6H5)-)PENAM

WHEREIN R IS A PROTECTIVE GROUP FOR THE CARBOXYL GROUP, AND R1 AND R2 ARE INDIVIDUALLY HYDROGEN OR HALOGEN, ARE PRODUCED BY REACTING A BENZL PENICILLIN ESTER OF THE FORMULA

2-(R-OOC-),3,3-DI(CH3-),6-(PHENYL-CH2-CO-NH-)PENAM

WHEREIN R IS AS DEFINED ABOVE, WITH A CHLORINATING AGENT IN THE PRESENCE OF A TERTIARY ORGANIC BASE TO OBTAIN AN IMIDE CHLORIDE GROUP-INCORPORATED COMPOUND OF THE FORMULA

2-(R-OOC-),3,3-DI(CH3-),6-(PHENYL-CH2-C(-CL)=N-)PENAM

AND THEN REACTING THE COMPOUND OF THE LAST-NAMED FORMULA WITH AN ISOXAZOL CARBOXYLATE OF THE FORMULA

3-(R1,R2-PHENYL),4-(M-OOC-),5-CH3-ISOXAZOLE

WHEREIN M IS A METAL ATOM, AND R1 AND R2 ARE AS DEFINED ABOVE.

8. 发明授权

US3649455A Production of lipase 失效
标题翻译：生产脂肪
公开(公告)号：US3649455A
公开(公告)日：1972-03-14
申请号：US83865869
申请日：1969-07-02
申请人： TOYO JOZO KK
发明人： ABE JINNOSUKE , WATANABE TETSUO , MIYAUCHI KANGO , YAMAGUCHI TSUTOMU , NITO TOSHIHARU , MUROYA NORIYUKI
IPC分类号： C12N9/20 , C07G7/028
CPC分类号： C12N9/20 , Y10S435/814 , Y10S435/822
摘要： A PROCESS FOR THE PRODUCTION OF ENZYME LIPASE IN WHICH A MICROORGANISM OF GENUS CHROMOBACTERIUM IS CULTIVATED IN A CULURE MEDIUM CONTAINING A SOURCE OF ASSIMIABLE CARBON AND NITROGEN, AND THE ENZYME PRODUCED IS THEN SEPARATED FROM THE CULTURED MEDIUM. THE ENZYME LIPASE THUS PRODUCED IS CHARACTERIZED BY GOOD STABILITY AND ACTIVITY. A NEW MICOORGANISM IS USEFUL IN THIS PROCESS, NAMELY, CHROMOBACTERIUM VISCOSUM VAD. PARALIPOLYTICUM KO HATSU KEN KIN KI NO. 137 OF THE FERMENTAION RESEARCH INSTITUTE OF JAPAN.

9. 发明授权

US3541084A Process for synthesizing semisynthetic penicillins using n-hydroxy succinimide mono-and dichloroacetate esters 失效
标题翻译：使用N-羟基琥珀酰亚胺单和二氯酸酯酯合成半胱氨酸的方法
公开(公告)号：US3541084A
公开(公告)日：1970-11-17
申请号：US3541084D
申请日：1967-09-14
申请人： TOYO JOZO KK
发明人： HAGITANI AKIRA , MURAMATSU ICHIRO , SAKAKIBARA SHUNPEI , ABE JINNOSUKE , WATANABE TETSUO
IPC分类号： C07D499/00 , C07D499/12 , C07K5/06 , C07K5/065 , C07C103/04 , C07D27/10 , C07D99/22
CPC分类号： C07D499/00 , C07K5/06026 , C07K5/06078

10. 发明专利

CA1008067A PREPARATION OF CEPHALOSPORIN DERIVATIVE 未知
公开(公告)号：CA1008067A
公开(公告)日：1977-04-05
申请号：CA170017
申请日：1973-04-18
申请人： TOYO JOZO KK
发明人： FUJII TADASHIRO , KOIDE TADASHI , ISHIMURA FUMIHIRO , WATANABE TETSUO , ABE JINNOSUKE
IPC分类号： C07D20060101 , C07D501/10

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