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1. 发明授权

US3535309A Antibiotics and their production 失效
标题翻译：抗生素及其生产
公开(公告)号：US3535309A
公开(公告)日：1970-10-20
申请号：US3535309D
申请日：1967-09-01
申请人： KITASATO INST , TOYO JOZO KK
发明人： HATA TOJU , MATSUMAE AKIHIRO , OMURA SATOSHI , ABE JINNOSUKE , WATANABE TETSUO
IPC分类号： C07H17/08 , C07C47/18
CPC分类号： C07H17/08 , Y10S435/886

2. 发明授权

US3630846A Antibiotic production using streptomyces kitasatoensis 失效
标题翻译：抗生素生产使用STRATTOMYCES KITASATOENSIS
公开(公告)号：US3630846A
公开(公告)日：1971-12-28
申请号：US3630846D
申请日：1969-10-07
申请人： KITASATO INST AND TOYO JOZO KK
发明人： HATA TOJU , MATSUMAE AKIHIRO , OMURA SATOSHI , ABE JINNOSUKE , WATANABE TETSUO
IPC分类号： C07H17/08 , C12D9/00
CPC分类号： C07H17/08 , Y10S435/803 , Y10S435/886
摘要： Manufacture of new antibiotic substances by the cultivation of a micro-organism belonging to Streptomyces kitasatoensis. The antibiotic of the invention has the general structural formula:

WHEREIN WHEN R1 represents hydrogen, R2 represents acetyl, propionyl, butyryl or where when R1 represents acetyl, R2 represents acetyl, propionyl, butyryl or isovaleryl.

3. 发明专利

DE1617585A1 未知
公开(公告)号：DE1617585A1
公开(公告)日：1971-02-25
申请号：DEK0063272
申请日：1967-09-04
申请人： KITASATO INST , TOYO JOZO KK
发明人： HATA TOJU , MATSUMAE AKIHIRO , OMURA SATOSHI , ABE JINNOSUKE , WATANABE TETSUO
IPC分类号： C07H17/08

4. 发明专利

CA874952A PROCESS FOR THE MANUFACTURE OF NEW ANTIBIOTICS 未知
公开(公告)号：CA874952A
公开(公告)日：1971-07-06
申请号：CA874952D
申请人： KITASATO INST , TOYO JOZO KK
发明人： WATANABE TETSUO , HATA TOJU , ABE JINNOSUKE , MATSUMAE AKIHIRO , OMURA SATOSHI

5. 发明专利

DE1202935B 未知
公开(公告)号：DE1202935B
公开(公告)日：1965-10-14
申请号：DEK0052190
申请日：1964-02-24
申请人： KITASATO INST
发明人： HATA TOJU , SANO YOSHIMOTO , MATSUMAE AKIHIRO , HOSHINO MASUO , MONURA SETSUZO
IPC分类号： C12P1/06

6. 发明专利

FR1479218A 未知
公开(公告)号：FR1479218A
公开(公告)日：1967-05-05
申请号：FR975858
申请日：1964-05-26
申请人： KITASATO INST
发明人： HATA TOJU , SANO YOSHIMOTO , MATSUMAE AKIHIRO , HOSHINO MASUO , NOMURA SETSUZO
IPC分类号： C12P1/06

7. 发明专利

GB1033856A A new anti-tumour antibiotic iyomycin 未知
公开(公告)号：GB1033856A
公开(公告)日：1966-06-22
申请号：GB1079564
申请日：1964-03-13
申请人： KITASATO INST
发明人： HATA TOJU , SANA YOSHIMOTO , MATSUMAE AKIHIRO , HOSHINO MASUO , NOMURA SETSUZO
IPC分类号： C12P1/06
摘要： The invention relates to an anti-tumour antibiotic, Iyomycin complex, containing an acidic polypeptide as a major component A and a basic substance as a minor component B, and having the following properties: ultra-violet absorption spectrum showing a (Fig. 1, not shown); infrared spectrum having absorption maxima at 2.95 m and 6.05 m (Fig. 2); elementary analysis C = 47.64%, H = 6.15%, N = 9.4%, ash 8.3%, total N 8.8-9.1%; positive reactions to ninhydrin, xanthoprotein, Folin and Pauli reagents and negative to Millon, Molisch, Tollens, Benedict, Elson-Morgan, biuret, Adamkiewitz, Liebermann, Sakaguchi and nitroprusside reagents; on acid hydrolysis produces glutamic acid, aspartic acid, serine, threonine, proline, glycine, alanine, valine, leucine, phenylalanine, tyrosine, cysteine and lysine. Iyomycin is produced by cultivating Streptomyces phaeoverticillatus nov. spec., especially NRRL 3021, in an aqueous nutrient medium containing a source of assimilable carbon, nitrogen and inorganic salts, e.g. aqueous solution containing meat extract, sodium chloride, calcium carbonate, soyabean oil, peptone, and glucose. Iyomycin complex is obtained from the clarified broth by (A) treatment with 1% magnesium sulphate or passage through cation exchange resin in sodium form to remove impurities, (B) precipitation by adjusting to pH 3.6 (isoelectric point) or adding a salting-out agent such as ammonium sulphate, magnesium sulphate, a salt of a heavy metal, e.g. zinc chloride, lead acetate, cupric sulphate or ferrous sulphate, aluminium hydroxide, or 6,9-diamino-2-ethoxyacridine lactate, (C) treating precipitate (B) with water, dilute alkali or phosphate buffer and removing inorganic ions by dialysis. Further purification is by passage through column of "Sephadex G25" (Registered Trade Mark).

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