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1. 发明授权

US3594367A Process for production of penicillin 失效
标题翻译：生菜素的方法
公开(公告)号：US3594367A
公开(公告)日：1971-07-20
申请号：US3594367D
申请日：1968-11-29
申请人： TOYO JOZO KK
发明人： ABE JINNOSUKE , WATANABE TETSUO , TAKE TERUO , FUJIMOTO KENTARO , FUJII TADASHIRO , KURAMOTO MASASHI , KOBARI SADAMI
IPC分类号： C07D499/00 , C07D499/12 , C07D499/60 , C07D99/16
CPC分类号： C07D499/00 , Y02P20/582
摘要： A-PHENOXYALKYL PENICILLIN AND SALTS THEREOF ARE PRODUCED BY REACTING 6-AMINOPENICILLANIC ACID OR SALTS THEREOF WITH A NOVEL N, N-DIACYL COMPOUND OF THE FORMULA

PHENYL-O-C(-R1)(-R2)-CO-N(-R)-CO-AR

IN WHICH R IS ALKYL, CYCLOALKYL, ARYL, SUBSTITUTED ARYL, ARALKYL, SUBSTITUTED ARALKYL OR PHENYLALKENYL, AR IS PHENYL, PHENOXYALKYL, OR SUBSTITUTED PHENYL, AND R1 AND R2 ARE HYDROGEN OR LOWER ALKYL.

2. 发明授权

US3668200A Process for the production of isoxazolyl penicillins 失效
标题翻译：生产ISOXAZOLYL PENICILLINS的方法
公开(公告)号：US3668200A
公开(公告)日：1972-06-06
申请号：US3668200D
申请日：1969-09-24
申请人： TOYO JOZO KK
发明人： ABE JINNOSUKE , WATANABE TETSUO , TAKE TERUO , FUJIMOTO KENTARO , FUJII TADASHIRO , TAKEMURA KAZUNARI , NISHIIE KAZUYOSHI , SATOH SAKAE , KOIDE TADASHI , HOTTA YASUE
IPC分类号： C07D499/00 , C07D499/76 , C07D99/16
CPC分类号： C07D499/00 , Y02P20/55
摘要： WHEREIN R1, R2 and R'' are as defined above; then subjecting the compound of Formula V to dephenylacetylation; and eliminating R'' when R'' is a said easily eliminated group.

A chemical process for the production of isoxazolyl penicillins and nontoxic salts and lower alkyl esters thereof having the formula REQUIRES NO MICROBIOLOGICAL DEACYLATION OR FERMENTATION TO PRODUCE 6-AMINOPENICILLANIC ACID, BUT INSTEAD COMPRISES REACTING A PENICILLIN G ester having the formula WHEREIN R'' is a protective group for carboxyl group and is selected from the group consisting of lower alkyl and a group which, when subjected to an elimination reaction, can be easily eliminated without having any detrimental effect on the structure of penicillin, which a chlorinating agent in the presence of a tertiary organic base to obtain an imide chloride groupincorporated compound having the formula WHEREIN R'' is as defined above; reacting the compound of Formula III with an isoxazol carboxylate having the formula WHEREIN M is a metal atom, and R1 and R2 are as defined above, to obtain a diacyl penicillin ester having the formula
摘要翻译：用于生产具有下式的异恶唑青霉素及其无毒盐及其低级烷基酯的化学方法不需要微生物学脱水或发酵生产6-氨基苯甲酸，而是包含反应式PENICILLIN G的酯，其具有式WHEREIN R'是保护性的羧基组，并且选自低级烷基和基团，当进行消除反应时，可以容易地除去，而不会对青霉素的结构产生任何有害影响，青霉素的存在下，氯化剂叔有机碱，得到具有式WHEREIN R'如上定义的酰亚胺氯化物引入的化合物; 使式III的化合物与式WHEREIN M是金属原子的异恶唑羧酸酯反应，并且R 1和R 2如上所定义，得到具有式WHEREIN R 1，R 2和R'如上定义的二酰基青霉素酯; 然后使式V的化合物进行苯基乙酰化; 并且当R'是所述容易消除的组时，消除R'。

3. 发明授权

US3658792A Diacyl penicillins and methods for their production 失效
标题翻译： DIACYL PENICILLINS及其生产方法
公开(公告)号：US3658792A
公开(公告)日：1972-04-25
申请号：US3658792D
申请日：1970-04-07
申请人： TOYO JOZO KK
发明人： ABE JINNOSUKE , WATANABE TETSUO , TAKE TERUO , FUJIMOTO KENTARO , FUJII TADASHIRO , TAKEMURA KAZUNARI , NISHII KAZUYOSHI
IPC分类号： C07D499/00 , C07D499/76 , C07D99/16
CPC分类号： C07D499/00
摘要： NOVEL DIACYL PENICILLINS OF THE FORMULA

2-(R-OOC-),3,3-DI(CH3-),6-((3-(R1,R2-PHENYL),5-CH3-

ISOXAZOL-4-YL)-CO-N(-CO-CH2-C6H5)-)PENAM

WHEREIN R IS A PROTECTIVE GROUP FOR THE CARBOXYL GROUP, AND R1 AND R2 ARE INDIVIDUALLY HYDROGEN OR HALOGEN, ARE PRODUCED BY REACTING A BENZL PENICILLIN ESTER OF THE FORMULA

2-(R-OOC-),3,3-DI(CH3-),6-(PHENYL-CH2-CO-NH-)PENAM

WHEREIN R IS AS DEFINED ABOVE, WITH A CHLORINATING AGENT IN THE PRESENCE OF A TERTIARY ORGANIC BASE TO OBTAIN AN IMIDE CHLORIDE GROUP-INCORPORATED COMPOUND OF THE FORMULA

2-(R-OOC-),3,3-DI(CH3-),6-(PHENYL-CH2-C(-CL)=N-)PENAM

AND THEN REACTING THE COMPOUND OF THE LAST-NAMED FORMULA WITH AN ISOXAZOL CARBOXYLATE OF THE FORMULA

3-(R1,R2-PHENYL),4-(M-OOC-),5-CH3-ISOXAZOLE

WHEREIN M IS A METAL ATOM, AND R1 AND R2 ARE AS DEFINED ABOVE.

4. 发明专利

HU185000B PROCESS FOR PREPARING ANTIBIOTIC DERIVATIVES OF NEPLANOCINE 未知
公开(公告)号：HU185000B
公开(公告)日：1984-11-28
申请号：HU361879
申请日：1979-04-12
申请人： TOYO JOZO KK
发明人： OTANI MASARU , YAGINUMA SATOSHI , TSUJINO MASATOSHI , MUTO NAOKI , SAITO TETSU , FUJII TADASHIRO
IPC分类号： C07D473/30 , C07D235/00 , C07D471/04 , C07D473/36 , C07D473/38 , C07D473/40 , C12P17/18 , C12R1/01

5. 发明专利

CH641804A5 ANTIBIOTISCHE NEPLANOCINE. 未知
公开(公告)号：CH641804A5
公开(公告)日：1984-03-15
申请号：CH490879
申请日：1979-05-25
申请人： TOYO JOZO KK
发明人： OTANI MASARU , YAGINUMA SATOSHI , TSUJINO MASATOSHI , MUTO NAOKI , SAITO TETSU , FUJII TADASHIRO
IPC分类号： C12P1/06 , C07D473/00 , C07H19/16 , C12P19/40 , C07D473/26 , C07D473/40 , C12P17/18

6. 发明专利

CA1154756A ANTIBIOTICS PLANOTHIOCINS 未知
公开(公告)号：CA1154756A
公开(公告)日：1983-10-04
申请号：CA357917
申请日：1980-08-08
申请人： TOYO JOZO KK
发明人： FUJII TADASHIRO , YAGINUMA SATOSHI , MUTO NAOKI , HAYASHI MITSUO
IPC分类号： A23K1/18 , A23K20/195 , C12P1/06 , C07C103/52 , C12P21/00
摘要： The present invention as disclosed provides sulfur-containing antibiotics known generically by the name planothiocin. The following variants are described: planothiocin-A, planothiocin-B, and planothiocins -C, -D, -E, .-F and -G. These substances are useful as feed additives to provide a growth-promoting effect in livestock, poultry or fish.

7. 发明专利

DE3028594A1 未知
公开(公告)号：DE3028594A1
公开(公告)日：1981-02-26
申请号：DE3028594
申请日：1980-07-28
申请人： TOYO JOZO KK
发明人： FUJII TADASHIRO , YAGINUMA SATOSHI , MUTO NAOKI , HAYASHI MITSUO
IPC分类号： A23K1/18 , A23K20/195 , C12P1/06 , C07G11/00 , C12N1/20 , C12P1/04 , A61K35/74
摘要： A group of sulfur-containing antibiotics, planothiocin-A, -B, -C, -D, -E, -F and -G, are produced by culturing Actinoplanes sp. A12526 in a nutrient medium, and separating the thus-produced planothiocins therefrom. The novel antibiotics have utility in therapeutic or prophylactic antibacterial compositions or feed additives for livestock, poultry or fish.

8. 发明专利

DE2709505A1 未知
公开(公告)号：DE2709505A1
公开(公告)日：1977-09-08
申请号：DE2709505
申请日：1977-03-04
申请人： SAGAMI CHEM RES , TOYO JOZO KK
发明人： TSUCHIHASHI GENICHI , OGURA KATSUYUKI , YASO MASAO , SAGAMIHARA KANAGAWA , KURAMOTO MASASHI , FUJII TADASHIRO , WATANABE TETSUO
IPC分类号： C07D501/34 , A61K31/545 , A61K31/546 , A61P31/04 , C07D307/54 , C07D333/24 , C07D501/24 , C07D501/36 , C07D501/38
摘要： Cephalosporins having a sulfur-containing functional group of the formula present at the carbon atom directly bonded to the thienyl or furyl group in the side chain of the 7-position of cephem derivatives. These compounds are useful as anti-bacterial agents against Gram-positive and Gram-negative bacteria.

9. 发明专利

CA986440A ENZYMATIC PRODUCTION OF CEPHALEXIN 未知
公开(公告)号：CA986440A
公开(公告)日：1976-03-30
申请号：CA150260
申请日：1972-08-18
申请人： TOYO JOZO KK
发明人： FUJII TADASHIRO , MATSUMOTO KUNIO , SHIBUYA YUZO , HANAMITSU KAZUMI , YAMAGUCHI TSUTOMU , ABE JINNOSUKE , WATANABE TETSUO
IPC分类号： C07D501/22 , C12P35/04

10. 发明专利

DE2502706A1 未知
公开(公告)号：DE2502706A1
公开(公告)日：1975-09-25
申请号：DE2502706
申请日：1975-01-23
申请人： TOYO JOZO KK
发明人： SHIBUYA YUZO , FUJII TADASHIRO , YAMAGUCHI TSUTOMU , MATSUDA TETSUO , TUKUSHIMA MITSURU , MATSUMOTO KUNIO , MORISHITA MASATAKA
IPC分类号： C07D501/18 , C12P35/02
摘要： 7-Amino-cephem compounds are produced from 7-substituted-cephem compounds by the enzymatic action of microorganisms Comamonas sp. SY-77-1 FERM-P 2410 or Pseudomonas ovalis ATCC 950.

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