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1. 发明申请

US20080057489A1 Photolabile Compound and Substrate for Oligomer Probe Array with the Same 失效
标题翻译：用于低聚物探针阵列的光不稳定化合物和底物
公开(公告)号：US20080057489A1
公开(公告)日：2008-03-06
申请号：US11686626
申请日：2007-03-15
申请人： Sung-Min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi , Man-hyoung Ryoo
发明人： Sung-Min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi , Man-hyoung Ryoo
IPC分类号： C12Q1/00 , C07H17/00
CPC分类号： C07H17/00 , B01J19/0046 , B01J2219/00452 , B01J2219/00454 , B01J2219/00527 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00
摘要： Provided is a substrate for an oligomer probe array to which a photolabile material having an acetylene derivative is directly attached or attached via a linker.
摘要翻译：提供了一种用于低聚物探针阵列的基底，具有乙炔衍生物的光不稳定材料通过连接体直接附着或附着于其上。

2. 发明申请

US20090137426A1 MICROARRAY, SUBSTRATE FOR MICROARRAY AND METHODS OF FABRICATING THE SAME 有权
标题翻译：微波炉，微波炉基板及其制造方法
公开(公告)号：US20090137426A1
公开(公告)日：2009-05-28
申请号：US12137608
申请日：2008-06-12
申请人： Sun-Ok Jung , Song-Jun Choi , Man-Hyoung Ryoo , Sung-Min Chi , Jung-Hwan Hah , Kyoung-Seon Kim , Won-Sun Kim
发明人： Sun-Ok Jung , Song-Jun Choi , Man-Hyoung Ryoo , Sung-Min Chi , Jung-Hwan Hah , Kyoung-Seon Kim , Won-Sun Kim
IPC分类号： C40B40/06 , C40B50/08
CPC分类号： C12Q1/6834 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00432 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00711 , B01J2219/00722 , B01L3/5027 , B01L3/502707 , B01L2300/0654 , B01L2300/0867 , B82Y30/00 , C40B50/18 , C40B60/08
摘要： A microarray, a substrate for a microarray and more productive methods of fabricating the microarray and the substrate are provided. The microarray includes a substrate divided into a first region and a second region; a plurality of linkers represented by formula 1 or 2: wherein X is a site coupled to the substrate, R is a hydroxyl, aldehyde, carboxyl, amino, amide, thiol, halo, epoxy, or sulfonate group, m is an integer in the range of 3 to 16, p is an integer in the range of 1 to 30, and q is an integer in the range of 1 to 15,directly coupled to the substrate in the first region but not coupled to the substrate in the second region; anda plurality of probes coupled to the respective linkers.
摘要翻译：提供微阵列，用于微阵列的基底和制备微阵列和基底的更有生产力的方法。微阵列包括分为第一区域和第二区域的衬底; 由式1或2表示的多个接头：其中X是与基底偶联的位点，R是羟基，醛，羧基，氨基，酰胺，硫醇，卤素，环氧基或磺酸酯基，m是范围为3〜16，p为1〜30的整数，q为1〜15的整数，直接与第1区域的基板结合，但不与第2区域的基板结合 ; 以及耦合到各个接头的多个探头。

3. 发明授权

US07994097B2 Microarray, substrate for microarray and methods of fabricating the same 有权
标题翻译：微阵列，微阵列基片及其制造方法
公开(公告)号：US07994097B2
公开(公告)日：2011-08-09
申请号：US12137608
申请日：2008-06-12
申请人： Sun-Ok Jung , Song-Jun Choi , Man-Hyoung Ryoo , Sung-Min Chi , Jung-Hwan Hah , Kyoung-Seon Kim , Won-Sun Kim
发明人： Sun-Ok Jung , Song-Jun Choi , Man-Hyoung Ryoo , Sung-Min Chi , Jung-Hwan Hah , Kyoung-Seon Kim , Won-Sun Kim
IPC分类号： C40B40/00 , C40B40/06 , G01N33/543 , C12Q1/68
CPC分类号： C12Q1/6834 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00432 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00711 , B01J2219/00722 , B01L3/5027 , B01L3/502707 , B01L2300/0654 , B01L2300/0867 , B82Y30/00 , C40B50/18 , C40B60/08
摘要： A microarray, a substrate for a microarray and more productive methods of fabricating the microarray and the substrate are provided. The microarray includes a substrate divided into a first region and a second region; a plurality of linkers represented by formula 1 or 2: wherein X is a site coupled to the substrate, R is a hydroxyl, aldehyde, carboxyl, amino, amide, thiol, halo, epoxy, or sulfonate group, m is an integer in the range of 3 to 16, p is an integer in the range of 1 to 30, and q is an integer in the range of 1 to 15, directly coupled to the substrate in the first region but not coupled to the substrate in the second region; and a plurality of probes coupled to the respective linkers.
摘要翻译：提供微阵列，用于微阵列的基底和制备微阵列和基底的更有生产力的方法。微阵列包括分为第一区域和第二区域的衬底; 由式1或2表示的多个接头：其中X是与基底偶联的位点，R是羟基，醛，羧基，氨基，酰胺，硫醇，卤素，环氧基或磺酸酯基，m是范围为3〜16，p为1〜30的整数，q为1〜15的整数，直接与第1区域的基板结合，但不与第2区域的基板结合 ; 以及耦合到各个接头的多个探头。

4. 发明申请

US20090131635A1 Method for synthesizing polymer on substrate 审中-公开
标题翻译：在基材上合成聚合物的方法
公开(公告)号：US20090131635A1
公开(公告)日：2009-05-21
申请号：US12220923
申请日：2008-07-30
申请人： Sung-Min Chi , Man-Hyoung Ryoo , Jung-Hwan Hah , Kyoung-Seon Kim , Won-Sun Kim , Sun-Ok Jung
发明人： Sung-Min Chi , Man-Hyoung Ryoo , Jung-Hwan Hah , Kyoung-Seon Kim , Won-Sun Kim , Sun-Ok Jung
IPC分类号： C07K1/04 , C07H1/00
CPC分类号： H01L21/6715 , B01J19/0046 , B01J2219/00484 , B01J2219/00493 , B01J2219/00527 , B01J2219/00529 , B01J2219/00612 , B01J2219/00722 , B01J2219/00725 , H01L21/67126
摘要： For synthesizing a polymer, a substrate is placed within a reaction chamber, and a polymer synthesis sample is fed into the reaction chamber for forming the polymer on the substrate. In addition, the reaction chamber is shaken during formation of the polymer on the substrate within the reaction chamber for increased reaction yield. In addition, forming bubbles of the inactive gas in the polymer synthesis sample during formation of the polymer on the substrate further increases reaction yield.
摘要翻译：为了合成聚合物，将基板放置在反应室内，并将聚合物合成样品进料到反应室中，以在基板上形成聚合物。此外，在反应室内的基底上形成聚合物期间，反应室被振动，以提高反应产率。此外，在聚合物合成样品中在基材上形成聚合物期间形成无活性气体的气泡进一步提高了反应产率。

5. 发明申请

US20090093625A1 APPARATUS FOR AND METHOD OF SYNTHESIZING BIOPOLYMER AND METHOD OF RECOVERING REAGENT FOR SYNTHESIZING BIOPOLYMER 审中-公开
标题翻译：合成生物聚合物的方法和方法和用于合成生物聚合物的回收试剂的方法
公开(公告)号：US20090093625A1
公开(公告)日：2009-04-09
申请号：US12238162
申请日：2008-09-25
申请人： Sung-Min Chi , Man-Hyoung Ryoo , Hyeong-Jun Kim , Jung-Hwan Hah , Won-Sun Kim , Sun-Ok Jung
发明人： Sung-Min Chi , Man-Hyoung Ryoo , Hyeong-Jun Kim , Jung-Hwan Hah , Won-Sun Kim , Sun-Ok Jung
IPC分类号： C07H21/04 , B01J19/24
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00389 , B01J2219/00394 , B01J2219/00418 , B01J2219/00423 , B01J2219/00432 , B01J2219/00452 , B01J2219/00484 , B01J2219/00495 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B82Y30/00 , Y02P20/582
摘要： An apparatus for synthesizing a biopolymer includes a reaction chamber, an outlet tube connected to the reaction chamber, a plurality of recovery tanks connected to the outlet tube, and a plurality of recovery valves configured to open or block the passageway between the outlet tube and each of the recovery tanks.
摘要翻译：用于合成生物聚合物的装置包括反应室，连接到反应室的出口管，连接到出口管的多个回收罐，以及多个回收阀，其配置成打开或阻塞出口管与每个的回收罐。

6. 发明申请

US20090117645A1 Biochips and methods of fabricating the same 审中-公开
标题翻译：生物芯片及其制造方法
公开(公告)号：US20090117645A1
公开(公告)日：2009-05-07
申请号：US12229645
申请日：2008-08-26
申请人： Won-Sun Kim , Jung-Hwan Hah , Sung-Min Chi , Sun-Ok Jung , Man-Hyoung Ryoo
发明人： Won-Sun Kim , Jung-Hwan Hah , Sung-Min Chi , Sun-Ok Jung , Man-Hyoung Ryoo
IPC分类号： C12M1/34 , B05D5/00
CPC分类号： G01N33/54373 , B01J19/0046 , B01J2219/00432 , B01J2219/00443 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837
摘要： Biochips for analyzing components of a biological sample using probes and methods of fabricating the same are provided. In some embodiments, a biochip includes a substrate, a plurality of probes immobilized on a top surface of the substrate, and a capping layer formed on a bottom surface of the substrate.
摘要翻译：提供了用于使用探针分析生物样品的组分的生物芯片及其制造方法。在一些实施例中，生物芯片包括衬底，固定在衬底的顶表面上的多个探针和形成在衬底的底表面上的覆盖层。

7. 发明申请

US20080220415A1 Detection Method of Dna Amplification Using Probe Labeled With Intercalating Dye 审中-公开
标题翻译：用插入染料标记的探针的Dna扩增检测方法
公开(公告)号：US20080220415A1
公开(公告)日：2008-09-11
申请号：US10593900
申请日：2005-03-25
申请人： Han Oh Park , Hyun-Bae Kim , Sung-Min Chi
发明人： Han Oh Park , Hyun-Bae Kim , Sung-Min Chi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q1/686 , C12Q2563/173 , C12Q2563/107 , C12Q2561/113
摘要： The present invention relates to a detection method of nucleic acid amplification using probe labeled with intercalating dye. More particularly, the present invention is directed to a real-time detection method of nucleic acid amplification, comprising the steps of i) producing an aqueous buffer which contains a nucleic acid, a pair of primers for amplification of said nucleic acid, a fluorescent probe wherein a fluorescent dye of which intensity of fluorescence is varied when the dye is intercalated into a double-stranded nucleic acid, is connected with an oligonucleotide of which base sequence is complementary with at least a part of said nucleic acid, four (4) kinds of nucleotides and DNA polymerase; ii) denaturing said doublestranded nucleic acid into single strands by heating the aqueous buffer prepared in step i) up to 931 C to 96 C; iii) annealing said pair of primers with said single strand by cooling the solution obtained in step ii) up to 50 C. to 571 C; iv) replicating said single-stranded nucleic acid by heating the solution obtained from step iii) up to 701 C to 74° C.; v) denaturing said replicated nucleic add into single strands by heating the solution obtained in step iv) up to 931 C to 961 C; vi) annealing said fluorescent probe with said single-stranded nucleic acid by cooling the solution obtained in step v up to 501 C to 57 C; vii) measuring an intensity of the fluorescence emitted from the solution obtained in step vi); and viii) repeating more than one steps iv) through vii).
摘要翻译：本发明涉及使用用插层染料标记的探针的核酸扩增检测方法。更具体地，本发明涉及核酸扩增的实时检测方法，包括以下步骤：i）产生含有核酸的水性缓冲液，用于扩增所述核酸的一对引物，荧光探针其中当染料插入双链核酸时荧光强度变化的荧光染料与其碱基序列与所述核酸的至少一部分互补的寡核苷酸连接，四（4）种的核苷酸和DNA聚合酶; ii）通过加热步骤i）中制备的含水缓冲液至931℃至96℃，将所述双链核酸变性为单链; iii）通过将步骤ii）中获得的溶液冷却至50℃至571℃，用所述单链退火所述一对引物; iv）通过将从步骤iii）获得的溶液加热至701℃至74℃来复制所述单链核酸; v）通过将步骤iv）中获得的溶液加热至931℃至961℃，将所述复制的核酸添加到单链中; vi）通过将步骤v中获得的溶液冷却至501℃至57℃，用所述单链核酸退火所述荧光探针; vii）测量从步骤vi）中获得的溶液发射的荧光的强度; 和viii）重复多于一个步骤iv）至vii）。

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