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1. 发明申请

US20050021013A1 Photoacoustic removal of occlusions from blood vessels 审中-公开
标题翻译：光声消除血管闭塞
公开(公告)号：US20050021013A1
公开(公告)日：2005-01-27
申请号：US10241741
申请日：2002-09-10
申请人： Steven Visuri , Luiz Da Silva , Peter Celliers , Richard London , Duncan Maitland , Victor Esch
发明人： Steven Visuri , Luiz Da Silva , Peter Celliers , Richard London , Duncan Maitland , Victor Esch
IPC分类号： A61B17/22 , A61B18/20 , A61B18/22 , A61B18/24 , A61N5/06 , A61B18/18
CPC分类号： A61B18/245 , A61B2018/20359 , A61B2018/2211
摘要： Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamic flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombi and emboli) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photoacoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamic flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.
摘要翻译：通过将光纤阵列定位在通道中并沿着纤维一次一个地引导处理辐射脉冲来去除人体内的流体通道的部分或完全闭塞，以产生冲击波和流体动力学流动，其冲击和乳化闭塞。优选的应用是从小脑血管移除血块（血栓和栓塞）以逆转缺血性卒中的作用。选择操作参数和技术以最小化在该光声处理期间发生的脆弱的脑血管壁的加热量。一种这样的技术是当期望发生流体动力学流动产生蒸汽气泡的存在并且阻止沿着不产生这种气泡的光纤传播的发热脉冲时的光学监测。

2. 发明授权

US06379325B1 Opto-acoustic transducer for medical applications 失效
标题翻译：用于医疗应用的光学传感器
公开(公告)号：US06379325B1
公开(公告)日：2002-04-30
申请号：US09350494
申请日：1999-07-09
申请人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
发明人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
IPC分类号： A61B1720
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00106 , A61B2017/22084 , A61B2090/378
摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.
摘要翻译：本发明是用于在生物介质中产生声振动的光学激活换能器。传感器位于可以位于导管内的光纤的端部。用于操作换能器的能量由通过光纤传输到换能器的激光光学地提供。脉冲激光被吸收在换能器的工作流体中，以产生热压力并随之导致换能器头部的绝热膨胀，使其对环境介质起作用。传感器通过热冷却过程返回到其原始状态。传感器在环境介质中的运动将声能耦合到介质中。通过以高重复率脉冲激光（其可以从CW变化到100kHz），可以在介质中局部地建立超声辐射场。这种生产超声波振动的方法可以在体内用于治疗人类中风相关病症，特别是用于溶解血栓。导管还可以掺入抗血栓溶解药物治疗作为辅助治疗，并且其可以与用于成像和反馈控制的超声波检测设备结合操作。

3. 发明授权

US06022309A Opto-acoustic thrombolysis 失效
公开(公告)号：US06022309A
公开(公告)日：2000-02-08
申请号：US639017
申请日：1996-04-24
申请人： Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Pat Fitch
发明人： Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Pat Fitch
IPC分类号： A61B17/22 , A61B17/00 , A61B18/00 , A61B18/26 , A61B19/00 , A61B17/36
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00022 , A61B2017/22084 , A61B2090/378
摘要： This invention is a catheter-based device for generating an ultrasound excitation in biological tissue. Pulsed laser light is guided through an optical fiber to provide the energy for producing the acoustic vibrations. The optical energy is deposited in a water-based absorbing fluid, e.g. saline, thrombolytic agent, blood or thrombus, and generates an acoustic impulse in the fluid through thermoelastic and/or thermodynamic mechanisms. By pulsing the laser at a repetition rate (which may vary from 10 Hz to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus or treating vasospasm. The catheter can also incorporate thrombolytic drug treatments as an adjunct therapy and it can be operated in conjunction with ultrasonic detection equipment for imaging and feedback control and with optical sensors for characterization of thrombus type and consistency.

4. 发明授权

US5944687A Opto-acoustic transducer for medical applications 失效
公开(公告)号：US5944687A
公开(公告)日：1999-08-31
申请号：US639018
申请日：1996-04-24
申请人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
发明人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
IPC分类号： A61B17/22 , A61B17/00 , A61B18/00 , A61B18/26 , A61B19/00 , A61B17/20
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00106 , A61B2017/22084 , A61B2090/378
摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

5. 发明申请

US20050113654A1 Body function monitoring mouth guard 审中-公开
标题翻译：身体功能监控口罩
公开(公告)号：US20050113654A1
公开(公告)日：2005-05-26
申请号：US10916787
申请日：2004-08-11
申请人： Paul Weber , Luiz Da Silva , John Wooldridge
发明人： Paul Weber , Luiz Da Silva , John Wooldridge
IPC分类号： A61B5/00 , A61B5/01 , A63B71/08
CPC分类号： A61B5/01 , A61B5/02055 , A61B5/02438 , A61B5/14532 , A61B5/1455 , A61B5/14551 , A61B5/682 , A61B2503/10 , A63B71/085 , A63B2071/088 , A63B2230/50
摘要： A device is described that can be easily used to warn an athlete of potential risk of hyperthermia due to an elevated core body temperature. The mouth guard device continually monitors the users internal or core body temperature and emits an alarm signal when body temperature exceeds a preset value. This invention can protect the physical well being of an athlete as well as improve overall team performance.
摘要翻译：描述了一种可以容易地用于警告运动员由于核心体温升高而引起的高热潜在风险的装置。口罩设备持续监控用户内部或核心体温，并在体温超过预设值时发出报警信号。本发明可以保护运动员的身体健康以及提高团队的整体表现。

6. 发明授权

US06484052B1 Optically generated ultrasound for enhanced drug delivery 失效
标题翻译：光学产生的超声波用于增强药物输送
公开(公告)号：US06484052B1
公开(公告)日：2002-11-19
申请号：US09281371
申请日：1999-03-30
申请人： Steven R. Visuri , Heather L. Campbell , Luiz Da Silva
发明人： Steven R. Visuri , Heather L. Campbell , Luiz Da Silva
IPC分类号： A61N130
CPC分类号： A61M37/0092 , A61B2018/263 , A61M2037/0007
摘要： High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.
摘要翻译：类似于超声的高频声波可以增强治疗性化合物递送到细胞中。所递送的化合物可以是化疗药物，抗生素，光动力药物或基因疗法。治疗性化合物系统地或优选局部施用于靶向部位。取决于进入路线的位置，可以通过针头，插管或通过各种血管导管实现局部输送。为了增强治疗化合物的全身或局部递送，在靶位点局部产生高频声波，优选在化合物给药部位附近产生高频声波。声波通过与吸收介质的激光辐射相互作用产生，并且可以通过热弹性膨胀，热力学蒸发，材料消融或等离子体形成来产生。声波具有临时透化局部细胞膜的作用，增加治疗化合物向细胞的扩散，允许减少全身剂量，减少副作用，并使新疗法成为可能。

7. 发明授权

US06466713B2 Optical fiber head for providing lateral viewing 有权
公开(公告)号：US06466713B2
公开(公告)日：2002-10-15
申请号：US09883513
申请日：2001-06-18
申请人： Matthew J. Everett , Billy W. Colston , Dale L. James , Steve Brown , Luiz Da Silva
发明人： Matthew J. Everett , Billy W. Colston , Dale L. James , Steve Brown , Luiz Da Silva
IPC分类号： G02B626
CPC分类号： G02B6/241 , A61B5/0066 , A61B5/0084 , G02B6/262
摘要： The head of an optical fiber comprising the sensing probe of an optical heterodyne sensing device includes a planar surface that intersects the perpendicular to axial centerline of the fiber at a polishing angle &thgr;. The planar surface is coated with a reflective material so that light traveling axially through the fiber is reflected transverse to the fiber's axial centerline, and is emitted laterally through the side of the fiber. Alternatively, the planar surface can be left uncoated. The polishing angle &thgr; must be no greater than 39° or must be at least 51°. The emitted light is reflected from adjacent biological tissue, collected by the head, and then processed to provide real-time images of the tissue. The method for forming the planar surface includes shearing the end of the optical fiber and applying the reflective material before removing the buffer that circumscribes the cladding and the core.

8. 发明申请

US20100087806A1 Automated Cryogenic Skin Treatment 审中-公开
公开(公告)号：US20100087806A1
公开(公告)日：2010-04-08
申请号：US12575370
申请日：2009-10-07
申请人： Luiz Da Silva , Donald Cohen , Marc Lieberman
发明人： Luiz Da Silva , Donald Cohen , Marc Lieberman
IPC分类号： A61B18/02
CPC分类号： A61B18/0218 , A61B90/361 , A61B2017/00084 , A61B2017/00747
摘要： An apparatus and methods for treating lesions on skin are presented. The apparatus collects information about a lesion and can automatically determine a course of treatment for the lesion. The device can include a controller that positions the nozzle proximate to a surface region of the lesion and automatically dispenses a pulse of the cryogenic fluid from the nozzle. The controller then positions the nozzle proximate to another surface region of the lesion and automatically dispenses a pulse of the cryogenic fluid from the nozzle.

9. 发明申请

US20060184024A1 Tissue thickness measurement device 审中-公开
标题翻译：组织厚度测量装置
公开(公告)号：US20060184024A1
公开(公告)日：2006-08-17
申请号：US11302039
申请日：2005-12-12
申请人： Luiz Da Silva , George Choi , Igor Kochemasov
发明人： Luiz Da Silva , George Choi , Igor Kochemasov
IPC分类号： A61B8/00
CPC分类号： A61B8/0858 , A61B8/4281
摘要： A device is described that can be easily used to accurately measure and monitor tissue thickness using ultrasound. The device comprises a remote control and data processing unit, a handheld ultrasound transducer, a display monitor and means for effectively coupling ultrasound to tissue.
摘要翻译：描述了可以容易地使用超声波来精确地测量和监测组织厚度的装置。该装置包括遥控和数据处理单元，手持超声波换能器，显示监视器和用于有效地将超声波耦合到组织的装置。

10. 发明申请

US20050261568A1 Multisensor probe for tissue identification 审中-公开
标题翻译：用于组织鉴定的多传感器探针
公开(公告)号：US20050261568A1
公开(公告)日：2005-11-24
申请号：US11139904
申请日：2005-05-26
申请人： Richard Hular , Luiz Da Silva , Charles Chase
发明人： Richard Hular , Luiz Da Silva , Charles Chase
IPC分类号： G01N21/17 , A61B5/00 , A61B5/01 , A61B5/05 , A61B5/145 , A61B5/1459 , A61B10/00 , A61B17/00 , A61B19/00 , G01N21/27
CPC分类号： A61B5/6848 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/061 , A61B5/145 , A61B5/6885 , A61B2017/00796 , A61B2090/062 , A61B2562/0242
摘要： A multisensor probe for continuous real-time tissue identification. The multisensor probe includes a tissue penetrating needle, a plurality of sensors useful in characterizing tissue and a position sensor to measure the depth of the needle into the tissue being diagnosed. The sensors include but are not limited to an optical scattering and absorption spectroscopy sensor, an optical coherence domain reflectometry sensor, an electrical impedance sensor, a temperature sensor, a pO2 sensor, a chemical sensor and other sensors useful in identifying tissue. The sensors may take the form of a plurality of optical fibers extending through said needle. A retractable sheath may be disposed around the distal section of the needle to protect the needle when not in use. The sheath retracts when the probe is inserted into tissue and the position of the sheath relative to the needle may be measured to determine the needle's depth. Systems and methods for tissue identification are also provided.
摘要翻译：用于连续实时组织鉴定的多传感器探头。多传感器探针包括组织穿刺针，用于表征组织的多个传感器和位置传感器，以测量针进入被诊断的组织的深度。这些传感器包括但不限于光学散射和吸收光谱传感器，光学相干畴反射测量传感器，电阻抗传感器，温度传感器，pO 2传感器，化学传感器和其它传感器用于鉴定组织。传感器可以采用延伸穿过所述针的多根光纤的形式。可伸缩护套可以设置在针的远端部分周围，以在不使用时保护针头。当探头插入组织中时，护套缩回，并且可以测量护套相对于针的位置以确定针的深度。还提供了用于组织鉴定的系统和方法。

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