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1. 发明授权

US06022309A Opto-acoustic thrombolysis 失效
公开(公告)号：US06022309A
公开(公告)日：2000-02-08
申请号：US639017
申请日：1996-04-24
申请人： Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Pat Fitch
发明人： Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Pat Fitch
IPC分类号： A61B17/22 , A61B17/00 , A61B18/00 , A61B18/26 , A61B19/00 , A61B17/36
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00022 , A61B2017/22084 , A61B2090/378
摘要： This invention is a catheter-based device for generating an ultrasound excitation in biological tissue. Pulsed laser light is guided through an optical fiber to provide the energy for producing the acoustic vibrations. The optical energy is deposited in a water-based absorbing fluid, e.g. saline, thrombolytic agent, blood or thrombus, and generates an acoustic impulse in the fluid through thermoelastic and/or thermodynamic mechanisms. By pulsing the laser at a repetition rate (which may vary from 10 Hz to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus or treating vasospasm. The catheter can also incorporate thrombolytic drug treatments as an adjunct therapy and it can be operated in conjunction with ultrasonic detection equipment for imaging and feedback control and with optical sensors for characterization of thrombus type and consistency.

2. 发明授权

US06379325B1 Opto-acoustic transducer for medical applications 失效
标题翻译：用于医疗应用的光学传感器
公开(公告)号：US06379325B1
公开(公告)日：2002-04-30
申请号：US09350494
申请日：1999-07-09
申请人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
发明人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
IPC分类号： A61B1720
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00106 , A61B2017/22084 , A61B2090/378
摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.
摘要翻译：本发明是用于在生物介质中产生声振动的光学激活换能器。传感器位于可以位于导管内的光纤的端部。用于操作换能器的能量由通过光纤传输到换能器的激光光学地提供。脉冲激光被吸收在换能器的工作流体中，以产生热压力并随之导致换能器头部的绝热膨胀，使其对环境介质起作用。传感器通过热冷却过程返回到其原始状态。传感器在环境介质中的运动将声能耦合到介质中。通过以高重复率脉冲激光（其可以从CW变化到100kHz），可以在介质中局部地建立超声辐射场。这种生产超声波振动的方法可以在体内用于治疗人类中风相关病症，特别是用于溶解血栓。导管还可以掺入抗血栓溶解药物治疗作为辅助治疗，并且其可以与用于成像和反馈控制的超声波检测设备结合操作。

3. 发明授权

US5944687A Opto-acoustic transducer for medical applications 失效
公开(公告)号：US5944687A
公开(公告)日：1999-08-31
申请号：US639018
申请日：1996-04-24
申请人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
发明人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
IPC分类号： A61B17/22 , A61B17/00 , A61B18/00 , A61B18/26 , A61B19/00 , A61B17/20
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00106 , A61B2017/22084 , A61B2090/378
摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

4. 发明申请

US20050021013A1 Photoacoustic removal of occlusions from blood vessels 审中-公开
标题翻译：光声消除血管闭塞
公开(公告)号：US20050021013A1
公开(公告)日：2005-01-27
申请号：US10241741
申请日：2002-09-10
申请人： Steven Visuri , Luiz Da Silva , Peter Celliers , Richard London , Duncan Maitland , Victor Esch
发明人： Steven Visuri , Luiz Da Silva , Peter Celliers , Richard London , Duncan Maitland , Victor Esch
IPC分类号： A61B17/22 , A61B18/20 , A61B18/22 , A61B18/24 , A61N5/06 , A61B18/18
CPC分类号： A61B18/245 , A61B2018/20359 , A61B2018/2211
摘要： Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamic flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombi and emboli) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photoacoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamic flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.
摘要翻译：通过将光纤阵列定位在通道中并沿着纤维一次一个地引导处理辐射脉冲来去除人体内的流体通道的部分或完全闭塞，以产生冲击波和流体动力学流动，其冲击和乳化闭塞。优选的应用是从小脑血管移除血块（血栓和栓塞）以逆转缺血性卒中的作用。选择操作参数和技术以最小化在该光声处理期间发生的脆弱的脑血管壁的加热量。一种这样的技术是当期望发生流体动力学流动产生蒸汽气泡的存在并且阻止沿着不产生这种气泡的光纤传播的发热脉冲时的光学监测。

5. 发明授权

US5827265A Intraluminal tissue welding for anastomosis 失效
标题翻译：管腔内组织焊接吻合
公开(公告)号：US5827265A
公开(公告)日：1998-10-27
申请号：US801224
申请日：1997-02-19
申请人： Michael Glinsky , Richard London , George Zimmerman , Steven Jacques
发明人： Michael Glinsky , Richard London , George Zimmerman , Steven Jacques
IPC分类号： A61B17/00 , A61B17/11 , A61F2/00 , A61F2/06 , A61F2/84 , A61B17/36
CPC分类号： A61F2/958 , A61B17/11 , A61B17/1114 , A61B2017/00004 , A61B2017/00508 , A61B2017/1107 , A61F2002/30454 , A61F2220/0058
摘要： A method and device are provided for performing intraluminal tissue welding for anastomosis of a hollow organ. A retractable catheter assembly is delivered through the hollow organ and consists of a catheter connected to an optical fiber, an inflatable balloon, and a biocompatible patch mounted on the balloon. The disconnected ends of the hollow organ are brought together on the catheter assembly, and upon inflation of the balloon, the free ends are held together on the balloon to form a continuous channel while the patch is deployed against the inner wall of the hollow organ. The ends are joined or "welded" using laser radiation transmitted through the optical fiber to the patch. A thin layer of a light-absorbing dye on the patch can provide a target for welding. The patch may also contain a bonding agent to strengthen the bond. The laser radiation delivered has a pulse profile to minimize tissue damage.
摘要翻译：提供了一种用于进行腔内组织焊接以中空器官吻合的方法和装置。可伸缩导管组件通过中空器官输送，并且由连接到光纤，可充气气囊和安装在气囊上的生物相容性贴片的导管组成。中空器官的断开的端部在导管组件上聚集在一起，并且在球囊膨胀时，将自由端保持在球囊上一起形成连续通道，同时将贴片部署在中空器官的内壁上。使用通过光纤传输的激光辐射将端部连接或“焊接”到贴片。贴片上的光吸收染料的薄层可以提供焊接目标。贴剂还可以含有粘合剂以加强粘合。所传送的激光辐射具有脉冲分布，以最小化组织损伤。

6. 发明授权

US07261514B2 Sealing arrangement, in particular for the blade segments of gas turbines 有权
标题翻译：密封装置，特别是用于燃气轮机的叶片段
公开(公告)号：US07261514B2
公开(公告)日：2007-08-28
申请号：US11400793
申请日：2006-04-10
申请人： Richard London , Peter Marx
发明人： Richard London , Peter Marx
IPC分类号： F01D11/08
CPC分类号： F01D11/006 , F01D5/225 , F01D11/008 , F05D2240/11 , F05D2240/57 , F05D2250/182 , F05D2260/30 , F16J15/061 , F16J15/0887
摘要： A sealing arrangement has two bodies with two end faces which extend along a longitudinal axis, adjoin one another while forming a gap, the width of which can vary between zero and a maximum width. The gap is covered by a sealing strip which lies transversely to the gap, extends along the longitudinal axis and is mounted with clearance in two opposite grooves of a predetermined depth. In such a sealing arrangement, an increased maximum width of the gap is made possible by the sealing strip having a basic width transversely to the longitudinal axis, this basic width being less than or equal to twice the depth of the grooves, and by the sealing strip is constructed to prevent the sealing strip from slipping out of the grooves if the sum of the maximum width of the gap and the depth of the grooves is greater than or equal to the basic width of the sealing strip.
摘要翻译：密封装置具有两个主体，两个主体具有沿着纵向轴线延伸的两个端面，彼此相邻，同时形成间隙，其宽度可以在零和最大宽度之间变化。间隙由横向于间隙的密封条覆盖，沿着纵向轴线延伸并且以预定深度的两个相对的凹槽中的间隙安装。在这种密封装置中，通过具有横向于纵向轴线的基本宽度的密封条，使间隙增大的最大宽度成为可能，该基本宽度小于或等于凹槽深度的两倍，并且通过密封如果间隙的最大宽度和凹槽的深度之和大于或等于密封条的基本宽度，则条带被构造成防止密封条从凹槽中滑出。

7. 发明申请

US20060263204A1 Sealing arrangement, in particular for the blade segments of gas turbines 有权
标题翻译：密封装置，特别是用于燃气轮机的叶片段
公开(公告)号：US20060263204A1
公开(公告)日：2006-11-23
申请号：US11400793
申请日：2006-04-10
申请人： Richard London , Peter Marx
发明人： Richard London , Peter Marx
IPC分类号： F01D25/26
CPC分类号： F01D11/006 , F01D5/225 , F01D11/008 , F05D2240/11 , F05D2240/57 , F05D2250/182 , F05D2260/30 , F16J15/061 , F16J15/0887
摘要： In a sealing arrangement, in particular for the blade segments of gas turbines, two bodies, with two end faces which extend along a longitudinal axis, adjoin one another while forming a gap, the width of which can vary between zero and a maximum width. The gap is covered by a sealing strip which lies transversely to the gap, extends along the longitudinal axis and is mounted with clearance in two opposite grooves of a predetermined depth. In such a sealing arrangement, an increased maximum width of the gap is made possible by the sealing strip having a basic width transversely to the longitudinal axis, this basic width being less than or equal to twice the depth of the grooves, and by the sealing strip having additional means which prevent the sealing strip from slipping out of the grooves if the sum of the maximum width of the gap and the depth of the grooves is greater than or equal to the basic width of the sealing strip.
摘要翻译：在密封装置中，特别是对于燃气涡轮机的叶片段，两个具有沿着纵向轴线延伸的两个端面的主体彼此相邻，同时形成间隙，其宽度可以在零和最大宽度之间变化。间隙由横向于间隙的密封条覆盖，沿着纵向轴线延伸并且以预定深度的两个相对的凹槽中的间隙安装。在这种密封装置中，通过具有横向于纵向轴线的基本宽度的密封条，使间隙增大的最大宽度成为可能，该基本宽度小于或等于凹槽深度的两倍，并且通过密封如果间隙的最大宽度和凹槽的深度之和大于或等于密封条的基本宽度，则带材具有防止密封条从凹槽中滑出的附加装置。

8. 发明申请

US20060182624A1 Sealing arrangement, in particular for the blade segments of gas turbines 审中-公开
公开(公告)号：US20060182624A1
公开(公告)日：2006-08-17
申请号：US11206824
申请日：2005-08-19
申请人： Richard London , Peter Marx
发明人： Richard London , Peter Marx
IPC分类号： F04D29/08
CPC分类号： F01D11/006 , F01D5/225 , F01D11/008 , F05D2240/11 , F05D2240/57 , F05D2250/182 , F05D2260/30 , F16J15/061 , F16J15/0887
摘要： In a sealing arrangement, in particular for the blade segments of gas turbines, two bodies, with two end faces which extend along a longitudinal axis, adjoin one another while forming a gap, the width of which can vary between zero and a maximum width. The gap is covered by a sealing strip which lies transversely to the gap, extends along the longitudinal axis and is mounted with clearance in two opposite grooves of a predetermined depth. In such a sealing arrangement, an increased maximum width of the gap is made possible by the sealing strip having a basic width transversely to the longitudinal axis, this basic width being less than or equal to twice the depth of the grooves, and by the sealing strip having additional means which prevent the sealing strip from slipping out of the grooves if the sum of the maximum width of the gap and the depth of the grooves is greater than or equal to the basic width of the sealing strip.

9. 发明申请

US20050276370A1 Tamper to delay motion and decrease ionization of a sample during short pulse x-ray imaging 失效
标题翻译：篡改在短脉冲X射线成像期间延迟运动并减少样品的电离
公开(公告)号：US20050276370A1
公开(公告)日：2005-12-15
申请号：US11134207
申请日：2005-05-17
申请人： Richard London , Abraham Szoke , Stefan Hau-Riege , Henry Chapman
发明人： Richard London , Abraham Szoke , Stefan Hau-Riege , Henry Chapman
IPC分类号： G01N23/00 , G01N23/10 , G01T1/00
CPC分类号： G01N23/10
摘要： A system for x-ray imaging of a small sample comprising positioning a tamper so that it is operatively connected to the sample, directing short intense x-ray pulses onto the tamper and the sample, and detecting an image from the sample. The tamper delays the explosive motion of the sample during irradiation by the short intense x-ray pulses, thereby extending the time to obtain an x-ray image of the original structure of the sample.
摘要翻译：一种用于小样品的x射线成像的系统，包括定位捣固器，使得其可操作地连接到样品，将短的强烈X射线脉冲引导到篡改和样品上，并且检测来自样品的图像。篡改在短时间强烈的X射线脉冲照射期间延迟了样品的爆炸运动，从而延长了获得样品原始结构的X射线图像的时间。

10. 发明授权

US06647624B2 Method of fitting an impingement plate 有权
标题翻译：碰撞板的安装方法
公开(公告)号：US06647624B2
公开(公告)日：2003-11-18
申请号：US10187004
申请日：2002-07-02
申请人： Reinhard Fried , Richard London , Peter Marx
发明人： Reinhard Fried , Richard London , Peter Marx
IPC分类号： B23P1500
CPC分类号： B23K11/002 , Y10T29/4932 , Y10T29/49778 , Y10T29/49895
摘要： A method of fitting an impingement plate to a platform of a guide blade of a gas turbine. The impingement plate is first fastened at individual spots by spot welds to at least one supporting surface of the platform and is then brazed at the supporting surface to the platform. The impingement plate is prefabricated with recesses and the spot welds are executed at the recesses.
摘要翻译：一种将冲击板装配到燃气轮机的引导叶片的平台上的方法。冲击板首先通过点焊在单个点处紧固到平台的至少一个支撑表面上，然后在支撑表面上钎焊到平台。冲击板预制有凹槽，点焊在凹槽处执行。

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