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1. 发明授权

US06379325B1 Opto-acoustic transducer for medical applications 失效
标题翻译：用于医疗应用的光学传感器
公开(公告)号：US06379325B1
公开(公告)日：2002-04-30
申请号：US09350494
申请日：1999-07-09
申请人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
发明人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
IPC分类号： A61B1720
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00106 , A61B2017/22084 , A61B2090/378
摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.
摘要翻译：本发明是用于在生物介质中产生声振动的光学激活换能器。传感器位于可以位于导管内的光纤的端部。用于操作换能器的能量由通过光纤传输到换能器的激光光学地提供。脉冲激光被吸收在换能器的工作流体中，以产生热压力并随之导致换能器头部的绝热膨胀，使其对环境介质起作用。传感器通过热冷却过程返回到其原始状态。传感器在环境介质中的运动将声能耦合到介质中。通过以高重复率脉冲激光（其可以从CW变化到100kHz），可以在介质中局部地建立超声辐射场。这种生产超声波振动的方法可以在体内用于治疗人类中风相关病症，特别是用于溶解血栓。导管还可以掺入抗血栓溶解药物治疗作为辅助治疗，并且其可以与用于成像和反馈控制的超声波检测设备结合操作。

2. 发明授权

US5944687A Opto-acoustic transducer for medical applications 失效
公开(公告)号：US5944687A
公开(公告)日：1999-08-31
申请号：US639018
申请日：1996-04-24
申请人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
发明人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
IPC分类号： A61B17/22 , A61B17/00 , A61B18/00 , A61B18/26 , A61B19/00 , A61B17/20
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00106 , A61B2017/22084 , A61B2090/378
摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

3. 发明授权

US06022309A Opto-acoustic thrombolysis 失效
公开(公告)号：US06022309A
公开(公告)日：2000-02-08
申请号：US639017
申请日：1996-04-24
申请人： Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Pat Fitch
发明人： Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Pat Fitch
IPC分类号： A61B17/22 , A61B17/00 , A61B18/00 , A61B18/26 , A61B19/00 , A61B17/36
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00022 , A61B2017/22084 , A61B2090/378
摘要： This invention is a catheter-based device for generating an ultrasound excitation in biological tissue. Pulsed laser light is guided through an optical fiber to provide the energy for producing the acoustic vibrations. The optical energy is deposited in a water-based absorbing fluid, e.g. saline, thrombolytic agent, blood or thrombus, and generates an acoustic impulse in the fluid through thermoelastic and/or thermodynamic mechanisms. By pulsing the laser at a repetition rate (which may vary from 10 Hz to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus or treating vasospasm. The catheter can also incorporate thrombolytic drug treatments as an adjunct therapy and it can be operated in conjunction with ultrasonic detection equipment for imaging and feedback control and with optical sensors for characterization of thrombus type and consistency.

4. 发明授权

US5827265A Intraluminal tissue welding for anastomosis 失效
标题翻译：管腔内组织焊接吻合
公开(公告)号：US5827265A
公开(公告)日：1998-10-27
申请号：US801224
申请日：1997-02-19
申请人： Michael Glinsky , Richard London , George Zimmerman , Steven Jacques
发明人： Michael Glinsky , Richard London , George Zimmerman , Steven Jacques
IPC分类号： A61B17/00 , A61B17/11 , A61F2/00 , A61F2/06 , A61F2/84 , A61B17/36
CPC分类号： A61F2/958 , A61B17/11 , A61B17/1114 , A61B2017/00004 , A61B2017/00508 , A61B2017/1107 , A61F2002/30454 , A61F2220/0058
摘要： A method and device are provided for performing intraluminal tissue welding for anastomosis of a hollow organ. A retractable catheter assembly is delivered through the hollow organ and consists of a catheter connected to an optical fiber, an inflatable balloon, and a biocompatible patch mounted on the balloon. The disconnected ends of the hollow organ are brought together on the catheter assembly, and upon inflation of the balloon, the free ends are held together on the balloon to form a continuous channel while the patch is deployed against the inner wall of the hollow organ. The ends are joined or "welded" using laser radiation transmitted through the optical fiber to the patch. A thin layer of a light-absorbing dye on the patch can provide a target for welding. The patch may also contain a bonding agent to strengthen the bond. The laser radiation delivered has a pulse profile to minimize tissue damage.
摘要翻译：提供了一种用于进行腔内组织焊接以中空器官吻合的方法和装置。可伸缩导管组件通过中空器官输送，并且由连接到光纤，可充气气囊和安装在气囊上的生物相容性贴片的导管组成。中空器官的断开的端部在导管组件上聚集在一起，并且在球囊膨胀时，将自由端保持在球囊上一起形成连续通道，同时将贴片部署在中空器官的内壁上。使用通过光纤传输的激光辐射将端部连接或“焊接”到贴片。贴片上的光吸收染料的薄层可以提供焊接目标。贴剂还可以含有粘合剂以加强粘合。所传送的激光辐射具有脉冲分布，以最小化组织损伤。

5. 发明申请

US20070276901A1 Method and system for providing a graphical workbench environment with intelligent plug-ins 审中-公开
标题翻译：用智能插件提供图形工作台环境的方法和系统
公开(公告)号：US20070276901A1
公开(公告)日：2007-11-29
申请号：US11439111
申请日：2006-05-23
申请人： Michael Glinsky , Gilbert Hansen
发明人： Michael Glinsky , Gilbert Hansen
IPC分类号： G06F15/16
CPC分类号： G06F9/485 , G06F9/541 , G06F9/546 , G06F2209/482 , G06F2209/547
摘要： An apparatus and a method for analysis of point-gathered data. The apparatus and method provide a platform that includes a workbench providing a graphical working environment for a user to view and perform operations on point-gathered data and to interact with the platform, one or more plug-ins that operate on the point-gathered data, including plug-ins that receive inputs from a user through workbench and issue commands as messages and that actively save their state by passing the state as a message, and a message framework that receives all messages from producer plug-ins and passes the messages to an intended consumer. The platform actively saves the workbench state and plug-in states as messages passed to the message framework.
摘要翻译：一种用于分析点收集数据的装置和方法。该装置和方法提供了一种平台，该平台包括提供图形工作环境的工作台，用于用户查看和执行点收集数据的操作并与平台交互，对点聚集数据进行操作的一个或多个插件，包括通过工作台接收来自用户的输入和作为消息发出命令并通过将状态作为消息主动保存其状态的插件以及从生成器插件接收所有消息并将消息传递到的消息框架一个预期的消费者。该平台主动将工作台状态和插件状态保存为传递到消息框架的消息。

6. 发明申请

US20070277115A1 Method and system for providing a graphical workbench environment with intelligent plug-ins for processing and/or analyzing sub-surface data 审中-公开
标题翻译：用于为图形工作台环境提供智能插件以处理和/或分析子表面数据的方法和系统
公开(公告)号：US20070277115A1
公开(公告)日：2007-11-29
申请号：US11439082
申请日：2006-05-23
申请人： Michael Glinsky , Gilbert Hansen
发明人： Michael Glinsky , Gilbert Hansen
IPC分类号： G06F3/00
CPC分类号： G01V1/34
摘要： A system and method for performing processing and/or analysis of sub-surface data in a graphical working environment. The system and method may provide a platform that includes a workbench that provides a graphical working environment for a user to interact with and operate a plurality of components. The plurality of components include one or more commanders that receive inputs from the user through the workbench, issue commands and receive responses and one or more self-commanders that receive inputs from the user through the workbench, issue and receive commands, and issue and receive responses. Each commander includes state-saving, state-restoring and message passing capabilities and the one or more commanders include one or more sub-surface data commanders that process and/or analyze sub-surface data. The one or more self-commanders include one or more viewers that display sub-surface data and results of processing and/or analysis of sub-surface data performed by sub-surface data commanders. The platform also includes a message framework that receives the commands and responses as messages from a producer component and passes the messages to an intended consumer component. The platform actively saves component and workbench state as a message passed to the message framework.
摘要翻译：一种用于在图形工作环境中执行处理和/或分析子表面数据的系统和方法。该系统和方法可以提供一个平台，该平台包括提供图形工作环境的工作台，用于使用户与多个组件交互并操作多个组件。多个组件包括一个或多个命令器，其通过工作台接收来自用户的输入，发出命令和接收响应，以及一个或多个自我指挥者，其通过工作台接收来自用户的输入，发出和接收命令，以及发出和接收回应。每个指挥员包括状态保存，状态恢复和消息传递能力，并且一个或多个指挥员包括处理和/或分析子表面数据的一个或多个子表面数据命令器。一个或多个自我指挥者包括一个或多个观察者，其显示子表面数据以及由子表面数据指挥员执行的子表面数据的处理和/或分析结果。该平台还包括一个消息框架，它接收作为来自生产者组件的消息的命令和响应，并将消息传递给预期的消费者组件。该平台主动将组件和工作台状态保存为传递到消息框架的消息。

7. 发明授权

US06948887B1 Transport container having compartments that can be individually pressurized 有权
标题翻译：运输容器具有可单独加压的隔间
公开(公告)号：US06948887B1
公开(公告)日：2005-09-27
申请号：US10422517
申请日：2003-04-24
申请人： Bryan Yielding , David Turner , Michael Glinsky , David A. Bechtold , Brian Polgrean
发明人： Bryan Yielding , David Turner , Michael Glinsky , David A. Bechtold , Brian Polgrean
IPC分类号： B60P1/60 , B60P3/22 , B60P3/24 , B65G53/36
CPC分类号： B65G53/36 , B60P1/60 , B60P3/2245 , B60P3/243
摘要： A container for use in transporting particulate materials includes a plurality of product compartments, with each such compartment having a material outlet in communication therewith through which particulate material in the compartment may be discharged. The container also includes a gas-tight bulkhead separating a pair of adjacent product compartments, and an unloading system that is adapted for removal of particulate materials from the product compartments. The unloading system includes a source for supplying a pressurizing gas, and one or more top air conduits connecting the pressurizing gas source to the product compartments for conveying pressurizing gas to the product compartments. The unloading system also includes a material conveying conduit that is in fluid communication with one or more of the material outlets and which includes a discharge end through which particulate material may be unloaded. The unloading system is adapted for selectively pressurizing one or more of the product compartments so that particulate material may be discharged through the material outlet of a product compartment that is pressurized. The unloading system is also adapted for entraining material that is discharged through a material outlet in the material conveying conduit and conveying such material to the discharge end of the conduit.
摘要翻译：用于运输颗粒材料的容器包括多个产品隔室，每个这样的隔室具有与其连通的材料出口，隔室中的颗粒材料可以通过该出口隔离。容器还包括分隔一对相邻产品隔室的气密隔板和适于从产品隔室中去除颗粒材料的卸载系统。卸载系统包括用于供应加压气体的源和连接加压气体源到产品室的一个或多个顶部空气管道，用于将加压气体输送到产品隔间。卸载系统还包括与一个或多个材料出口流体连通并且包括排放端的材料输送管道，通过该排出端可以卸载颗粒材料。卸载系统适于选择性地加压一个或多个产品隔室，使得颗粒材料可以通过加压的产品隔室的材料出口排出。卸载系统还适于夹带通过材料输送管道中的材料出口排出的材料，并将这种材料输送到管道的排放端。

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