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1. 发明申请

US20110257215A1 NOVEL CO-CRYSTAL OF TIOTROPIUM BROMIDE 审中-公开
标题翻译：新戊酰胆碱的新晶体
公开(公告)号：US20110257215A1
公开(公告)日：2011-10-20
申请号：US12515220
申请日：2007-11-13
申请人： Stephen Watt , Alexander R. Eberlin
发明人： Stephen Watt , Alexander R. Eberlin
IPC分类号： A61K31/439 , A61P11/00 , C07D491/18 , A61P11/06
CPC分类号： C07D451/10
摘要： The invention relates to a new crystalline form of tiotropium bromide, processes for preparing it and its use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
摘要翻译：本发明涉及噻托溴铵的新结晶形式，其制备方法及其用于制备用于治疗呼吸道疾病，特别是用于治疗COPD（慢性阻塞性肺疾病）和哮喘的药物组合物的用途。

2. 发明授权

US09012495B2 Crystalline forms of genistein 有权
标题翻译：结晶形式的染料木素
公开(公告)号：US09012495B2
公开(公告)日：2015-04-21
申请号：US13133085
申请日：2009-12-11
申请人： Anders Berkenstam , Stefan Rehnmark , Michael-Robin Witt , Keith Lorimer , Stephen Watt
发明人： Anders Berkenstam , Stefan Rehnmark , Michael-Robin Witt , Keith Lorimer , Stephen Watt
IPC分类号： A61K31/352 , C07D311/74 , C07D311/22
CPC分类号： A61K31/353 , A61K31/352 , C07B2200/13 , C07D311/22
摘要： The disclosure relates to new crystalline forms of genistein. The disclosed crystalline forms include crystalline genistein sodium salt dihydrate; crystalline genistein potassium salt dihydrate; crystalline genistein calcium salt; crystalline genistein magnesium salt; crystalline genistein L-lysine salt; crystalline genistein N-methylglucamine salt; crystalline genistein N-ethylglucamine salt; crystalline genistein diethylamine salt; and crystalline genistein monohydrate. The disclosure also relates to the novel genistein salts represented by these crystalline forms. Therapeutic compositions containing at least one of these crystalline forms of genistein and/or a genistein salt and a pharmaceutically acceptable carrier are described. The disclosure also relates to methods of treating cancer comprising the step of administering to a patient in need thereof a therapeutically effective amount of a therapeutic composition containing the compounds of the disclosure, of a crystalline form of genistein, or of a genistein salt.
摘要翻译：本公开涉及染料木素的新结晶形式。所公开的结晶形式包括结晶染料木黄酮钠盐二水合物; 结晶染料木黄酮钾盐二水合物; 结晶染料木素钙盐; 结晶染料木素镁盐; 结晶染料木素L-赖氨酸盐; 结晶染料木素N-甲基葡糖胺盐; 结晶染料木素N-乙基葡糖胺盐; 结晶染料木素二乙胺盐; 和结晶染料木素一水合物。本公开还涉及由这些结晶形式表示的新型染料木素盐。描述了含有染料木素和/或染料木黄酮盐和药学上可接受的载体的这些结晶形式中的至少一种的治疗组合物。本公开还涉及治疗癌症的方法，其包括向有需要的患者施用治疗有效量的含有本发明化合物的染料木素结晶形式或染料木黄酮盐的治疗组合物的步骤。

3. 发明申请

US20070225967A1 Cadence management of translated multi-speaker conversations using pause marker relationship models 失效
标题翻译：使用暂停标记关系模型对翻译的多扬声器对话进行Cadence管理
公开(公告)号：US20070225967A1
公开(公告)日：2007-09-27
申请号：US11388015
申请日：2006-03-23
申请人： Rhonda Childress , Stewart Hyman , David Kumhyr , Stephen Watt
发明人： Rhonda Childress , Stewart Hyman , David Kumhyr , Stephen Watt
IPC分类号： G06F17/27
CPC分类号： G10L13/00
摘要： A system, method, and medium for cadence management of translated multi-speaker conversations including a demultiplexer for separating a multi-speaker audio source into time-related single-speaker audio tracks, each track containing first language audio snippets; and a pause relationship model generator and manager that determines the time relationships between the single-speaker snippets using pause markers to denote beginnings and endings of mutual silence pauses, collects a translated language audio track for each of single-speaker track, transforms the original pause relationship model of the snippets, and controls a multiplexer to producing a multi-speaker audio output including the translated snippets in a manner such that they are related in time according to the transformed pause relationship model.
摘要翻译：一种用于演绎多扬声器对话的节奏管理的系统，方法和媒体，包括用于将多扬声器音频源分离成时间相关的单个扬声器音频轨道的解复用器，每个轨道包含第一语言音频片段; 以及暂停关系模型生成器和管理器，其使用暂停标记来确定单个扬声器片段之间的时间关系，以表示相互静音暂停的开始和结束，为每个单个扬声器轨道收集翻译的语音音轨，转换原始暂停并且控制多路复用器以使得它们根据转换的暂停关系模型在时间上相关联的方式产生包括转换的片段的多扬声器音频输出。

4. 发明授权

US07863325B2 Crystalline genistein sodium salt dihydrate 有权
标题翻译：结晶染料木黄酮钠盐二水合物
公开(公告)号：US07863325B2
公开(公告)日：2011-01-04
申请号：US12636395
申请日：2009-12-11
申请人： Anders Berkenstam , Stefan Rehnmark , Michael-Robin Witt , Stephen Watt
发明人： Anders Berkenstam , Stefan Rehnmark , Michael-Robin Witt , Stephen Watt
IPC分类号： A61K31/352 , C07D311/30
CPC分类号： C07D311/30 , A61K31/352
摘要： The disclosure relates to a new crystalline form of genistein. The disclosed crystalline form is crystalline genistein sodium salt dihydrate. The disclosure also relates to the novel genistein salt composition represented by this crystalline form. Therapeutic compositions containing crystalline genistein sodium salt and a pharmaceutically acceptable carrier are described. The disclosure also relates to therapeutic methods comprising the step of administering to a patient in need thereof a therapeutically effective amount of a therapeutic composition containing the crystalline form of the disclosure or crystalline genistein sodium salt dihydrate.
摘要翻译：本公开涉及染料木素的新结晶形式。所公开的结晶形式是结晶染料木黄酮钠盐二水合物。本公开还涉及由该结晶形式表示的新颖的染料木黄酮盐组合物。描述了含有结晶染料木素钠盐和药学上可接受的载体的治疗组合物。本公开还涉及治疗方法，其包括向有需要的患者施用治疗有效量的含有本发明的结晶形式或结晶染料木黄酮钠盐二水合物的治疗组合物的步骤。

5. 发明申请

US20050138208A1 Service oriented integration server architecture 失效
标题翻译：面向服务的集成服务器架构
公开(公告)号：US20050138208A1
公开(公告)日：2005-06-23
申请号：US10738713
申请日：2003-12-17
申请人： Stephen Watt
发明人： Stephen Watt
IPC分类号： G06F15/16 , H04L29/06
CPC分类号： H04L29/06 , H04L69/08
摘要： An integration server architecture (ISA) that facilitates communication between processes that do not share a common message format or use a common communication protocol. The ISA comprises a combination of adapters and a Queuing and Translation Engine (QTE). Every process that uses the ISA must have an adapter designed to understand that process's native message format. The adapter forwards the message to the QTE. The QTE places the forwarded message in an incoming message queue (IMQ). The QTE then retrieves messages from the IMQ in the order they arrive, identifies the sender, and locates an entry for the sender in a Configuration Database (CDB). The CDB entry designates a translation map that enables the QTE to properly translate messages into the receiving process's native format. The QTE uses the map to translate the messages into the receiving process's native format, and then forwards the translated message to the appropriate adapter.
摘要翻译：集成服务器体系结构（ISA），促进不共享公共消息格式或使用通用通信协议的进程之间的通信。 ISA包括适配器和排队和翻译引擎（QTE）的组合。使用ISA的每个进程都必须有一个适配器，用于理解该进程的本机消息格式。适配器将消息转发到QTE。 QTE将转发的消息放置在传入消息队列（IMQ）中。然后，QTE按照它们到达的顺序从IMQ检索消息，识别发送方，并在配置数据库（CDB）中找到发件人的条目。 CDB条目指定一个翻译地图，使得QTE可以将消息正确地转换为接收进程的本机格式。 QTE使用映射将消息转换为接收进程的本机格式，然后将转换的消息转发到适当的适配器。

6. 发明申请

US20120035253A1 CRYSTALLINE FORMS OF GENISTEIN 有权
标题翻译：基因组的结晶形式
公开(公告)号：US20120035253A1
公开(公告)日：2012-02-09
申请号：US13133085
申请日：2009-12-11
申请人： Anders Berkenstam , Stefan Rehnmark , Michael-Robin Witt , Keith Lorimer , Stephen Watt
发明人： Anders Berkenstam , Stefan Rehnmark , Michael-Robin Witt , Keith Lorimer , Stephen Watt
IPC分类号： A61K31/352 , A61P35/00 , A61P31/00 , A61P43/00 , A61P11/00 , C07D311/36 , A61P29/00
CPC分类号： A61K31/353 , A61K31/352 , C07B2200/13 , C07D311/22
摘要： The disclosure relates to new crystalline forms of genistein. The disclosed crystalline forms include crystalline genistein sodium salt dihydrate; crystalline genistein potassium salt dihydrate; crystalline genistein calcium salt; crystalline genistein magnesium salt; crystalline genistein L-lysine salt; crystalline genistein N-methylglucamine salt; crystalline genistein N-ethylglucamine salt; crystalline genistein diethylamine salt; and crystalline genistein monohydrate. The disclosure also relates to the novel genistein salts represented by these crystalline forms. Therapeutic compositions containing at least one of these crystalline forms of genistein and/or a genistein salt and a pharmaceutically acceptable carrier are described. The disclosure also relates to methods of treating cancer comprising the step of administering to a patient in need thereof a therapeutically effective amount of a therapeutic composition containing the compounds of the disclosure, of a crystalline form of genistein, or of a genistein salt.
摘要翻译：本公开涉及染料木素的新结晶形式。所公开的结晶形式包括结晶染料木黄酮钠盐二水合物; 结晶染料木黄酮钾盐二水合物; 结晶染料木素钙盐; 结晶染料木素镁盐; 结晶染料木素L-赖氨酸盐; 结晶染料木素N-甲基葡糖胺盐; 结晶染料木素N-乙基葡糖胺盐; 结晶染料木素二乙胺盐; 和结晶染料木素一水合物。本公开还涉及由这些结晶形式表示的新型染料木素盐。描述了含有染料木素和/或染料木黄酮盐和药学上可接受的载体的这些结晶形式中的至少一种的治疗组合物。本公开还涉及治疗癌症的方法，其包括向有需要的患者施用治疗有效量的含有本发明化合物的染料木素结晶形式或染料木黄酮盐的治疗组合物的步骤。

7. 发明申请

US20100243561A1 LOCAL SEWAGE PROCESSING UNIT, SEWAGE TREATMENT SYSTEM, METHOD OF LOCALLY PROCESSING SEWAGE AND SEWAGE TREATMENT PROCESS 有权
标题翻译：地方加工单位，地下水处理系统，地下水处理方法及污水处理工艺
公开(公告)号：US20100243561A1
公开(公告)日：2010-09-30
申请号：US12707645
申请日：2010-02-17
申请人： Alan CREFFIELD , Andrew Moore , Stephen Watt
发明人： Alan CREFFIELD , Andrew Moore , Stephen Watt
IPC分类号： C02F3/30 , C02F11/12 , C02F3/28 , C02F3/02
CPC分类号： C02F9/00 , C02F1/44 , C02F3/208 , C02F3/30 , C02F2303/16 , C02F2307/08 , Y02W10/15 , Y10S210/92
摘要： A local sewage processing unit is provided that receives sewage from a local source of sewage, extracts water from the received sewage that is suitable for re-use and includes a pump that is configured to pump sewage from a receiving section of the local sewage processing unit into a pressure sewer network, as required.
摘要翻译：提供一种从当地污水源接收污水的当地污水处理单元，从接收到的适合重复使用的污水中提取水，并包括一个泵，其配置为从当地污水处理单元的接收部分抽取污水根据需要进入压力下水道网络。

8. 发明申请

US20070203110A1 17-Allylamino-17-demethoxygeldanamycin polymorphs and formulations 失效
标题翻译： 17-烯丙基氨基-17-去甲氧基格尔德霉素多晶型物和制剂
公开(公告)号：US20070203110A1
公开(公告)日：2007-08-30
申请号：US11595005
申请日：2006-11-08
申请人： Peter Licari , Timothy Leaf , Ruchir Desai , Jorge Galazzo , Greg Buchanan , Stephen Watt , Alexander Eberlin , Robert Arslanian
发明人： Peter Licari , Timothy Leaf , Ruchir Desai , Jorge Galazzo , Greg Buchanan , Stephen Watt , Alexander Eberlin , Robert Arslanian
IPC分类号： A61K31/395 , C07D225/04
CPC分类号： C07D225/04
摘要： Polymorphs and pharmaceutical formulations of 17-allylamino-17-demethoxygeldanamycin (17-AAG).
摘要翻译： 17-烯丙基氨基-17-去甲氧基格尔德霉素（17-AAG）的多晶型物和药物制剂。

9. 发明申请

US20130336987A1 Identification of Therapeutic Targets in Cutaneous SCC 审中-公开
标题翻译：皮肤SCC中治疗靶标的鉴定
公开(公告)号：US20130336987A1
公开(公告)日：2013-12-19
申请号：US13878387
申请日：2011-10-07
申请人： Andrew South , Celine Pourreyron , Stephen Watt , John Foerster
发明人： Andrew South , Celine Pourreyron , Stephen Watt , John Foerster
IPC分类号： C12Q1/68 , C12N15/113
CPC分类号： C12Q1/6886 , C07K14/47 , C12N15/113 , C12N2310/14 , C12N2320/12 , C12Q2600/158
摘要： The present invention discloses a series of genes and/or proteins associated with cutaneous squamous cell carcinoma (cSCC) and provides polynucleotides and/or polypeptides for use in the treatment and/or prevention of cSCC. The invention further relates to methods of diagnosing cSCC and provides oligonucleotides/polypeptide probes and primers.
摘要翻译：本发明公开了一系列与皮肤鳞状细胞癌（cSCC）相关的基因和/或蛋白质，并提供用于治疗和/或预防cSCC的多核苷酸和/或多肽。本发明还涉及诊断cSCC并提供寡核苷酸/多肽探针和引物的方法。

10. 发明授权

US08840789B2 Local sewage processing unit, sewage treatment system, method of locally processing sewage and sewage treatment process 有权
标题翻译：当地污水处理单位，污水处理系统，污水处理过程当地处理方法
公开(公告)号：US08840789B2
公开(公告)日：2014-09-23
申请号：US12707645
申请日：2010-02-17
申请人： Alan Creffield , Andrew Moore , Stephen Watt
发明人： Alan Creffield , Andrew Moore , Stephen Watt
IPC分类号： C02F3/30 , C02F9/00 , C02F3/20 , C02F1/44
CPC分类号： C02F9/00 , C02F1/44 , C02F3/208 , C02F3/30 , C02F2303/16 , C02F2307/08 , Y02W10/15 , Y10S210/92
摘要： A local sewage processing unit is provided that receives sewage from a local source of sewage, extracts water from the received sewage that is suitable for re-use and includes a pump that is configured to pump sewage from a receiving section of the local sewage processing unit into a pressure sewer network, as required.
摘要翻译：提供一种从当地污水源接收污水的当地污水处理单元，从接收到的适合重复使用的污水中提取水，并包括一个泵，其配置为从当地污水处理单元的接收部分抽取污水根据需要进入压力下水道网络。

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