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1. 发明申请

US20130336987A1 Identification of Therapeutic Targets in Cutaneous SCC 审中-公开
标题翻译：皮肤SCC中治疗靶标的鉴定
公开(公告)号：US20130336987A1
公开(公告)日：2013-12-19
申请号：US13878387
申请日：2011-10-07
申请人： Andrew South , Celine Pourreyron , Stephen Watt , John Foerster
发明人： Andrew South , Celine Pourreyron , Stephen Watt , John Foerster
IPC分类号： C12Q1/68 , C12N15/113
CPC分类号： C12Q1/6886 , C07K14/47 , C12N15/113 , C12N2310/14 , C12N2320/12 , C12Q2600/158
摘要： The present invention discloses a series of genes and/or proteins associated with cutaneous squamous cell carcinoma (cSCC) and provides polynucleotides and/or polypeptides for use in the treatment and/or prevention of cSCC. The invention further relates to methods of diagnosing cSCC and provides oligonucleotides/polypeptide probes and primers.
摘要翻译：本发明公开了一系列与皮肤鳞状细胞癌（cSCC）相关的基因和/或蛋白质，并提供用于治疗和/或预防cSCC的多核苷酸和/或多肽。本发明还涉及诊断cSCC并提供寡核苷酸/多肽探针和引物的方法。

2. 发明授权

US09155289B2 Methods concerning PPAR delta and antagonists thereof 有权
标题翻译：关于PPARδ及其拮抗剂的方法
公开(公告)号：US09155289B2
公开(公告)日：2015-10-13
申请号：US13057113
申请日：2009-07-31
申请人： Colin Palmer , John Foerster , Nainamalai Sitherswaran
发明人： Colin Palmer , John Foerster , Nainamalai Sitherswaran
IPC分类号： A01K67/00 , A01K67/027 , C07K14/47 , C12N15/85
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2207/20 , A01K2217/00 , A01K2217/052 , A01K2217/203 , A01K2227/105 , A01K2267/0368 , C07K14/4702 , C12N15/8509 , C12N2830/008 , C12N2840/002
摘要： Non-human animals which overexpress PPARd or which express transgenic PPARd are useful as models for inflammatory skin conditions such as psoriasis. Test substances can be screened to assess their suitability for the treatment of inflammatory skin conditions such as psoriasis. Methyl 3-({[2-(methoxy)-4-phenyl]amino}sulfonyl)-2-thiophenecarboxylate can be administered topically for the prevention or treatment of psoriasis.
摘要翻译：过表达PPARd或表达转基因PPARd的非人动物可用作炎性皮肤病症如牛皮癣的模型。可以筛选测试物质以评估其适用于治疗炎症性皮肤病症如银屑病。可以局部施用3 - （{[2-（甲氧基）-4-苯基]氨基}磺酰基）-2-噻吩甲酸甲酯，用于预防或治疗牛皮癣。

3. 发明申请

US20070134654A1 Means for use in treating diseases correlated with or caused by non-physiological levels of microtubule-associated pp2ac 失效
标题翻译：用于治疗与微生物相关的pp2ac的非生理水平相关或引起的疾病的手段
公开(公告)号：US20070134654A1
公开(公告)日：2007-06-14
申请号：US10514542
申请日：2003-05-15
申请人： Susann Schweiger , Hans-Hilger Ropers , Jennifer Winter , Sybille Krauss , Vanessa Suckow , Rainer Schneider , Alexander Trockenbacher , Lars Klimaschewski , John Foerster , Sebastian Haesler
发明人： Susann Schweiger , Hans-Hilger Ropers , Jennifer Winter , Sybille Krauss , Vanessa Suckow , Rainer Schneider , Alexander Trockenbacher , Lars Klimaschewski , John Foerster , Sebastian Haesler
IPC分类号： C12Q1/68 , A61K48/00
CPC分类号： C12Q1/6883 , A61K38/1709 , A61K48/00 , C12Q1/42 , C12Q2600/158 , G01N2500/02
摘要： The present invention relates to a method of preventing or treating a disease correlated with or caused by non-physiologically increased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically effective amount of a protein selected from the group of MID1 or MID2 or a nucleic acid encoding said protein. The invention further relates to a method of preventing or treating a disease correlated with or caused by non-physiologically decreased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically effective amount of a peptidic fragment of MID1 or MID2 wherein said peptidic fragment comprises amino acids 108-165 (preferably 110-165) of MID1, amino acids 108-165 (preferably 110-165) of MID2 or with an effective amount of a fragment of PP2Ac wherein said fragment comprises the binding site to a4 or of a peptide fragment of a4 comprising amino acids 236-279 or with an effective amount of a nucleic acid molecule encoding said peptide fragment or with an effective amount of a molecule interfering with the interaction of MID1 with a4 or with an effective amount of a molecule interfering with the expression or activity of MID1 and/or a 4.
摘要翻译：本发明涉及一种预防或治疗与微管相关蛋白磷酸酶2A（PP2Ac）的催化亚单位的非生理上增加的细胞内水平相关或由其引起的疾病的方法，包括对受所述疾病或危险的受试者施用开发所述疾病的药学有效量的选自MID1或MID2的蛋白质或编码所述蛋白质的核酸。本发明还涉及一种预防或治疗与微管相关蛋白磷酸酶2A（PP2Ac）的催化亚单位的非生理降低的细胞内水平相关或由其引起的疾病的方法，包括对受所述疾病或危险的受试者施用开发所述疾病是药物有效量的MID1或MID2的肽片段，其中所述肽片段包含MID1的氨基酸108-165（优选110-165），MID2的氨基酸108-165（优选110-165），或包含有效量的PP2Ac片段，其中所述片段包含与a4的结合位点或包含氨基酸236-279的a4的肽片段或与有效量的编码所述肽片段的核酸分子或与有效量的一种干扰MID1与a4或与有效量的干扰MID1的表达或活性的分子的相互作用的分子，以及 /或a 4。

4. 发明授权

US08202696B2 Means for use in treating diseases correlated with or caused by non-physiological levels of microtubule-associated PP2Ac 失效
标题翻译：用于治疗与微生物相关性PP2Ac的非生理水平相关或引起的疾病的手段
公开(公告)号：US08202696B2
公开(公告)日：2012-06-19
申请号：US10514542
申请日：2003-05-15
申请人： Susann Schweiger , Hans-Hilger Ropers , Jennifer Winter , Sybille Krauss , Vanessa Suckow , Rainer Schneider , Alexander Trockenbacher , John Foerster
发明人： Susann Schweiger , Hans-Hilger Ropers , Jennifer Winter , Sybille Krauss , Vanessa Suckow , Rainer Schneider , Alexander Trockenbacher , John Foerster
IPC分类号： G01N33/53
CPC分类号： C12Q1/6883 , A61K38/1709 , A61K48/00 , C12Q1/42 , C12Q2600/158 , G01N2500/02
摘要： The present invention relates to a method of preventing or treating a disease correlated with or caused by non-physiologically increased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically effective amount of a protein selected from the group of MID1 or MID2 or a nucleic acid encoding said protein. The invention further relates to a method of preventing or treating a disease correlated with or caused by non-physiologically decreased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically effective amount of a peptidic fragment of MID1 or MID2 wherein said peptidic fragment comprises amino acids 108-165 (preferably 110-165) of MID1, amino acids 108-165 (preferably 110-165) of MID2 or with an effective amount of a fragment of PP2Ac wherein said fragment comprises the binding site to a4 or of a peptide fragment of a4 comprising amino acids 236-279 or with an effective amount of a nucleic acid molecule encoding said peptide fragment or with an effective amount of a molecule interfering with the interaction of MID1 with a4 or with an effective amount of a molecule interfering with the expression or activity of MID1 and/or a 4.
摘要翻译：本发明涉及一种预防或治疗与微管相关蛋白磷酸酶2A（PP2Ac）的催化亚单位的非生理上增加的细胞内水平相关或由其引起的疾病的方法，包括对受所述疾病或危险的受试者施用开发所述疾病的药学有效量的选自MID1或MID2的蛋白质或编码所述蛋白质的核酸。本发明还涉及一种预防或治疗与微管相关蛋白磷酸酶2A（PP2Ac）的催化亚单位的非生理降低的细胞内水平相关或由其引起的疾病的方法，包括对受所述疾病或危险的受试者施用开发所述疾病是药物有效量的MID1或MID2的肽片段，其中所述肽片段包含MID1的氨基酸108-165（优选110-165），MID2的氨基酸108-165（优选110-165），或包含有效量的PP2Ac片段，其中所述片段包含与a4的结合位点或包含氨基酸236-279的a4的肽片段或与有效量的编码所述肽片段的核酸分子或与有效量的一种干扰MID1与a4或与有效量的干扰MID1的表达或活性的分子的相互作用的分子，以及 /或a 4。

5. 发明申请

US20110263691A1 METHODS CONCERNING PPAR DELTA AND ANTAGONISTS THEREOF 有权
标题翻译：关于PPAR DELTA及其拮抗剂的方法
公开(公告)号：US20110263691A1
公开(公告)日：2011-10-27
申请号：US13057113
申请日：2009-07-31
申请人： Colin Palmer , John Foerster , Nainamalai Sitheswaran
发明人： Colin Palmer , John Foerster , Nainamalai Sitheswaran
IPC分类号： A61K31/381 , A61P17/06 , C12Q1/02 , A01K67/033 , A61K49/00
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2207/20 , A01K2217/00 , A01K2217/052 , A01K2217/203 , A01K2227/105 , A01K2267/0368 , C07K14/4702 , C12N15/8509 , C12N2830/008 , C12N2840/002
摘要： Non-human animals which overexpress PPARd or which express transgenic PPARd are useful as models for inflammatory skin conditions such as psoriasis. Test substances can be screened to assess their suitability for the treatment of inflammatory skin conditions such as psoriasis. Methyl 3-({[2-(methoxy)-4-phenyl]amino}sulfonyl)-2-thiophenecarboxylate can be administered topically for the prevention or treatment of psoriasis.
摘要翻译：过表达PPARd或表达转基因PPARd的非人动物可用作炎性皮肤病症如牛皮癣的模型。可以筛选测试物质以评估其适用于治疗炎症性皮肤病症如银屑病。可以局部施用3 - （{[2-（甲氧基）-4-苯基]氨基}磺酰基）-2-噻吩甲酸甲酯，用于预防或治疗牛皮癣。

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