会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明授权
    • Crystalline forms of genistein
    • 结晶形式的染料木素
    • US09012495B2
    • 2015-04-21
    • US13133085
    • 2009-12-11
    • Anders BerkenstamStefan RehnmarkMichael-Robin WittKeith LorimerStephen Watt
    • Anders BerkenstamStefan RehnmarkMichael-Robin WittKeith LorimerStephen Watt
    • A61K31/352C07D311/74C07D311/22
    • A61K31/353A61K31/352C07B2200/13C07D311/22
    • The disclosure relates to new crystalline forms of genistein. The disclosed crystalline forms include crystalline genistein sodium salt dihydrate; crystalline genistein potassium salt dihydrate; crystalline genistein calcium salt; crystalline genistein magnesium salt; crystalline genistein L-lysine salt; crystalline genistein N-methylglucamine salt; crystalline genistein N-ethylglucamine salt; crystalline genistein diethylamine salt; and crystalline genistein monohydrate. The disclosure also relates to the novel genistein salts represented by these crystalline forms. Therapeutic compositions containing at least one of these crystalline forms of genistein and/or a genistein salt and a pharmaceutically acceptable carrier are described. The disclosure also relates to methods of treating cancer comprising the step of administering to a patient in need thereof a therapeutically effective amount of a therapeutic composition containing the compounds of the disclosure, of a crystalline form of genistein, or of a genistein salt.
    • 本公开涉及染料木素的新结晶形式。 所公开的结晶形式包括结晶染料木黄酮钠盐二水合物; 结晶染料木黄酮钾盐二水合物; 结晶染料木素钙盐; 结晶染料木素镁盐; 结晶染料木素L-赖氨酸盐; 结晶染料木素N-甲基葡糖胺盐; 结晶染料木素N-乙基葡糖胺盐; 结晶染料木素二乙胺盐; 和结晶染料木素一水合物。 本公开还涉及由这些结晶形式表示的新型染料木素盐。 描述了含有染料木素和/或染料木黄酮盐和药学上可接受的载体的这些结晶形式中的至少一种的治疗组合物。 本公开还涉及治疗癌症的方法,其包括向有需要的患者施用治疗有效量的含有本发明化合物的染料木素结晶形式或染料木黄酮盐的治疗组合物的步骤。
    • 4. 发明申请
    • Cadence management of translated multi-speaker conversations using pause marker relationship models
    • 使用暂停标记关系模型对翻译的多扬声器对话进行Cadence管理
    • US20070225967A1
    • 2007-09-27
    • US11388015
    • 2006-03-23
    • Rhonda ChildressStewart HymanDavid KumhyrStephen Watt
    • Rhonda ChildressStewart HymanDavid KumhyrStephen Watt
    • G06F17/27
    • G10L13/00
    • A system, method, and medium for cadence management of translated multi-speaker conversations including a demultiplexer for separating a multi-speaker audio source into time-related single-speaker audio tracks, each track containing first language audio snippets; and a pause relationship model generator and manager that determines the time relationships between the single-speaker snippets using pause markers to denote beginnings and endings of mutual silence pauses, collects a translated language audio track for each of single-speaker track, transforms the original pause relationship model of the snippets, and controls a multiplexer to producing a multi-speaker audio output including the translated snippets in a manner such that they are related in time according to the transformed pause relationship model.
    • 一种用于演绎多扬声器对话的节奏管理的系统,方法和媒体,包括用于将多扬声器音频源分离成时间相关的单个扬声器音频轨道的解复用器,每个轨道包含第一语言音频片段; 以及暂停关系模型生成器和管理器,其使用暂停标记来确定单个扬声器片段之间的时间关系,以表示相互静音暂停的开始和结束,为每个单个扬声器轨道收集翻译的语音音轨,转换原始暂停 并且控制多路复用器以使得它们根据转换的暂停关系模型在时间上相关联的方式产生包括转换的片段的多扬声器音频输出。
    • 7. 发明申请
    • Service oriented integration server architecture
    • 面向服务的集成服务器架构
    • US20050138208A1
    • 2005-06-23
    • US10738713
    • 2003-12-17
    • Stephen Watt
    • Stephen Watt
    • G06F15/16H04L29/06
    • H04L29/06H04L69/08
    • An integration server architecture (ISA) that facilitates communication between processes that do not share a common message format or use a common communication protocol. The ISA comprises a combination of adapters and a Queuing and Translation Engine (QTE). Every process that uses the ISA must have an adapter designed to understand that process's native message format. The adapter forwards the message to the QTE. The QTE places the forwarded message in an incoming message queue (IMQ). The QTE then retrieves messages from the IMQ in the order they arrive, identifies the sender, and locates an entry for the sender in a Configuration Database (CDB). The CDB entry designates a translation map that enables the QTE to properly translate messages into the receiving process's native format. The QTE uses the map to translate the messages into the receiving process's native format, and then forwards the translated message to the appropriate adapter.
    • 集成服务器体系结构(ISA),促进不共享公共消息格式或使用通用通信协议的进程之间的通信。 ISA包括适配器和排队和翻译引擎(QTE)的组合。 使用ISA的每个进程都必须有一个适配器,用于理解该进程的本机消息格式。 适配器将消息转发到QTE。 QTE将转发的消息放置在传入消息队列(IMQ)中。 然后,QTE按照它们到达的顺序从IMQ检索消息,识别发送方,并在配置数据库(CDB)中找到发件人的条目。 CDB条目指定一个翻译地图,使得QTE可以将消息正确地转换为接收进程的本机格式。 QTE使用映射将消息转换为接收进程的本机格式,然后将转换的消息转发到适当的适配器。
    • 8. 发明申请
    • CRYSTALLINE FORMS OF GENISTEIN
    • 基因组的结晶形式
    • US20120035253A1
    • 2012-02-09
    • US13133085
    • 2009-12-11
    • Anders BerkenstamStefan RehnmarkMichael-Robin WittKeith LorimerStephen Watt
    • Anders BerkenstamStefan RehnmarkMichael-Robin WittKeith LorimerStephen Watt
    • A61K31/352A61P35/00A61P31/00A61P43/00A61P11/00C07D311/36A61P29/00
    • A61K31/353A61K31/352C07B2200/13C07D311/22
    • The disclosure relates to new crystalline forms of genistein. The disclosed crystalline forms include crystalline genistein sodium salt dihydrate; crystalline genistein potassium salt dihydrate; crystalline genistein calcium salt; crystalline genistein magnesium salt; crystalline genistein L-lysine salt; crystalline genistein N-methylglucamine salt; crystalline genistein N-ethylglucamine salt; crystalline genistein diethylamine salt; and crystalline genistein monohydrate. The disclosure also relates to the novel genistein salts represented by these crystalline forms. Therapeutic compositions containing at least one of these crystalline forms of genistein and/or a genistein salt and a pharmaceutically acceptable carrier are described. The disclosure also relates to methods of treating cancer comprising the step of administering to a patient in need thereof a therapeutically effective amount of a therapeutic composition containing the compounds of the disclosure, of a crystalline form of genistein, or of a genistein salt.
    • 本公开涉及染料木素的新结晶形式。 所公开的结晶形式包括结晶染料木黄酮钠盐二水合物; 结晶染料木黄酮钾盐二水合物; 结晶染料木素钙盐; 结晶染料木素镁盐; 结晶染料木素L-赖氨酸盐; 结晶染料木素N-甲基葡糖胺盐; 结晶染料木素N-乙基葡糖胺盐; 结晶染料木素二乙胺盐; 和结晶染料木素一水合物。 本公开还涉及由这些结晶形式表示的新型染料木素盐。 描述了含有染料木素和/或染料木黄酮盐和药学上可接受的载体的这些结晶形式中的至少一种的治疗组合物。 本公开还涉及治疗癌症的方法,其包括向有需要的患者施用治疗有效量的含有本发明化合物的染料木素结晶形式或染料木黄酮盐的治疗组合物的步骤。