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1. 发明申请

US20070020689A1 Label-free high throughput biomolecular screening system and method 审中-公开
标题翻译：无标记的高通量生物分子筛选系统和方法
公开(公告)号：US20070020689A1
公开(公告)日：2007-01-25
申请号：US11489173
申请日：2006-07-19
申请人： Stephen Caracci , Volker Eckelt , Anthony Frutos , Mark Krol , Thomas Moore , David Pastel , Gordon Shedd
发明人： Stephen Caracci , Volker Eckelt , Anthony Frutos , Mark Krol , Thomas Moore , David Pastel , Gordon Shedd
IPC分类号： C40B30/06 , G01N33/53 , G06F19/00 , C12M1/34
CPC分类号： G01N35/028 , G01N2035/00158 , G01N2035/00356 , G01N2035/0097
摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occurr in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
摘要翻译：本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。

2. 发明申请

US20160177251A1 Microbial Electro-Photosynthesis 审中-公开
标题翻译：微生物电光合作用
公开(公告)号：US20160177251A1
公开(公告)日：2016-06-23
申请号：US14972977
申请日：2015-12-17
申请人： Justin Flory , Petra Fromme , Willem Vermaas , Bruce Rittman , Cesar Torres , Thomas Moore , Ana Moore
发明人： Justin Flory , Petra Fromme , Willem Vermaas , Bruce Rittman , Cesar Torres , Thomas Moore , Ana Moore
IPC分类号： C12M1/42 , C12N13/00 , C12M1/00 , C12N1/12
CPC分类号： C12M35/02 , C12M1/42 , C12M21/02 , C12M43/00 , C12N1/12 , C12N13/00
摘要： Methods and apparatus for growing photosynthetic organisms lacking Photosystem II (PSII) function using externally supplied electrons shuttled into the organism using redox mediators to improve photosynthetic output and to produce and recover chemicals of interest. By removing PRI, all PAR photons are funneled toward Photosystem I, thereby significantly increasing the theoretical photon utilization efficiency for CO2 fixation, energy storage and the capacity to synthesize valuable chemicals. Additional genetic modification can be performed to insert or enhance specific metabolic pathways to generate products of commercial interest.
摘要翻译：用于生长光合生物的方法和装置，其使用外部供应的电子，使用氧化还原介质穿梭于生物体中以提高光合作用产量并产生和回收感兴趣的化学物质，从而缺乏光系统II（PSII）功能。通过去除PRI，所有PAR光子向光系统I漏斗，从而显着增加了CO2固定，储能和合成有价值化学品的能力的理论光子利用效率。可以进行额外的遗传修饰以插入或增强特异性代谢途径以产生商业利益的产物。

3. 发明授权

US07824622B2 Molded part for the analysis and preparation of substances in microliter and submicroliter volumes and process for the preparation thereof 失效
标题翻译：用于分析和制备微升和亚微米体积的物质的成型部件及其制备方法
公开(公告)号：US07824622B2
公开(公告)日：2010-11-02
申请号：US10564190
申请日：2004-07-08
申请人： Anton Horn , Barbara Horn, legal representative , Thomas Moore , Renate Bublitz , Helga Endmann , Ronny Henke
发明人： Anton Horn , Thomas Moore , Renate Bublitz , Helga Endmann , Ronny Henke
IPC分类号： B01L99/00 , B01L3/02 , B32B5/18 , B01D15/08 , G01N21/00
CPC分类号： B01L3/5085 , B01L3/0275 , B01L2200/0631 , B01L2200/16 , B01L2300/069 , B01L2300/0832 , Y10T428/12479 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： An integral molded part of a plastic material for the analysis and preparation of substances, having at least one surface region and an interior region, wherein said at least one surface region is an open-pore three-dimensional network.
摘要翻译：用于分析和制备具有至少一个表面区域和内部区域的物质的塑料材料的整体模塑部分，其中所述至少一个表面区域是开孔三维网络。

4. 发明授权

US07553452B2 Procedure for channel adjustment of a multi-channel metering apparatus 有权
标题翻译：多通道计量装置的通道调整步骤
公开(公告)号：US07553452B2
公开(公告)日：2009-06-30
申请号：US10722113
申请日：2003-11-25
申请人： Peter Zimmermann , Torsten Rausch , Gerd Heiβe , Hartmut Köberich , Simon Renard , Thomas Moore , Wolfgang Krämer
发明人： Peter Zimmermann , Torsten Rausch , Gerd Heiβe , Hartmut Köberich , Simon Renard , Thomas Moore , Wolfgang Krämer
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01L2200/148 , B01L2300/0861 , B01L2400/0487 , B01L2400/06 , G01F11/28 , G01F13/006 , G01F25/0092 , G01N35/00594 , G01N35/00693 , G01N35/1016 , G01N35/1065 , G01N35/1072 , G01N2035/1039 , Y10T436/2575
摘要： Procedure for equilibration of the delivery volumes of a multi-channel metering apparatus with an arrangement of independently controlled dispensing channels 1.1-1.n, delivering individual volumes of dispensing fluid to cavities 3.1.1-3.n.n, where measured values relevant to the individual delivery volumes are measured for the same control value and from which an adjustment value is specified with a tolerance band and the control value is adjusted for dispensing channels 1.1-1.n, the measured values of which lie outside the tolerance band. The invention also applies to an apparatus for implementing the procedure.
摘要翻译：使用独立控制的分配通道1.1-1.n布置多通道计量装置的输送体积的步骤，将单独体积的分配流体输送到空腔3.1.1-3.nn，其中与对于相同的控制值测量单个输送量，并且通过公差带指定调整值，并且调整控制值以分配通道1.1-1.n，其测量值位于公差带之外。本发明也适用于实现该过程的装置。

5. 发明授权

US07541001B2 Automatic pipetting and analyzing device 失效
标题翻译：自动移液分析装置
公开(公告)号：US07541001B2
公开(公告)日：2009-06-02
申请号：US11285965
申请日：2005-11-23
申请人： Wolfgang Kraemer , Frank Tempel , Thomas Moore
发明人： Wolfgang Kraemer , Frank Tempel , Thomas Moore
IPC分类号： B01L3/02
CPC分类号： G01N35/109 , G01N2035/1051
摘要： An automatic pipetting and analyzing device for the preparation and analysis of samples in the wells of a microtitration plate has a work platform on which positioning areas for auxiliary devices and a movement area for the sample plate are provided, a passive mechanical table without its own drive unit, the sample plate lying within the inner passive slide of the passive mechanical table, and an active mechanical table which is arranged above the passive mechanical table and by which a pipetting head can be moved in X-Y direction over the work platform in order to extract, transport and dispense liquids by at least one pipetting channel and in order to displace the sample plate by a coupling connection with the inner passive slide, for example, to place the sample plate in an incubator or to position it with the individual wells in an analysis device.
摘要翻译：用于制备和分析微量滴定板孔中的样品的自动移液和分析装置具有工作平台，其上设有用于辅助装置的定位区域和样品板的移动区域，无自动驱动的被动机械台单元，位于被动机械台的内部无源滑动件内的样品板和布置在被动机械台上方的活动机械台，并且移动头可以在XY方向上移动到工作平台上以便提取，通过至少一个移液通道运输和分配液体，并且为了通过与内部被动载玻片的联接连接来移动样品板，例如将样品板放置在培养箱中或将其与各个孔定位在一个分析装置

6. 发明申请

US20070250377A1 Performance analysis support system 审中-公开
标题翻译：绩效分析支持系统
公开(公告)号：US20070250377A1
公开(公告)日：2007-10-25
申请号：US11398846
申请日：2006-04-05
申请人： James Hill , James Fuller , Thomas Moore
发明人： James Hill , James Fuller , Thomas Moore
IPC分类号： G06F11/34
CPC分类号： G06Q10/00 , G06Q10/06311 , G06Q10/0635 , G06Q10/0637 , G06Q10/06375 , G06Q10/0639
摘要： A performance analysis support system is disclosed that provides one or more recommended solutions of a performance improvement project to management and the expected improvement benefit of each solution. The performance analysis support system guides a user through a detailed, consistent analysis process, helping organizational leaders accurately diagnose critical performance or productivity issues. Then, the performance analysis support system estimates the personnel and equipment requirements, time, costs, and return on investment associated with each solution generated based on the analysis results. In addition, the performance analysis support system provides management immediate access to ongoing and past analyses.
摘要翻译：公开了一种性能分析支持系统，该系统为管理提供了一个或多个推荐的性能改进项目解决方案，以及每个解决方案的预期改进优势。绩效分析支持系统通过详细，一致的分析过程来指导用户，帮助组织领导者准确地诊断关键绩效或生产力问题。然后，绩效分析支持系统根据分析结果估算与每个生成的解决方案相关的人员和设备要求，时间，成本和投资回报。此外，绩效分析支持系统使管理人员能够立即访问正在进行的和过去的分析。

7. 发明授权

US07208724B2 Apparatus and method of detecting probe tip contact with a surface 有权
标题翻译：检测探针尖端与表面接触的装置和方法
公开(公告)号：US07208724B2
公开(公告)日：2007-04-24
申请号：US11266678
申请日：2005-11-03
申请人： Thomas Moore , Lyudmila Zaykova-Feldman
发明人： Thomas Moore , Lyudmila Zaykova-Feldman
IPC分类号： H01J3/14 , G01J5/08 , G01B5/28 , G01R31/02
CPC分类号： H01J37/22 , B82Y35/00 , H01J37/20 , H01J37/3056 , H01J2237/20 , H01J2237/202 , H01J2237/204 , H01J2237/206 , H01J2237/208 , H01J2237/2482 , H01J2237/28 , H01J2237/31745
摘要： We disclose an apparatus and method for detecting probe-tip contact with a surface, generally inside a focused ion-beam instrument, where the probe tip is attached to a capsule, and the capsule is movably secured in a probe shaft. There is a fiber-optic cable having a first end and a second end; a beam splitter having first and second output ports; and a light source connected to the beam splitter. The first output port of the beam splitter is connected to the first end of the fiber-optic cable, and the second output port of the beam splitter is connected to a photodiode. The second end of the fiber-optic cable has a mirror for reflecting incident light at approximately a ninety-degree angle to the axis of the optical path in the fiber-optic cable and onto the capsule, so that the intensity of the light reflected back from the capsule through the fiber-optic cable is proportional to the deflection of the capsule as the probe tip makes contact with the surface.
摘要翻译：我们公开了一种用于检测与通常在聚焦离子束仪器内的表面的探针 - 尖端接触的装置和方法，其中探针尖端附接到胶囊，并且胶囊可移动地固定在探针轴中。存在具有第一端和第二端的光纤电缆; 具有第一和第二输出端口的分束器; 以及连接到分束器的光源。分束器的第一输出端口连接到光纤电缆的第一端，并且分束器的第二输出端口连接到光电二极管。光纤电缆的第二端具有反射镜，用于将入射光与光纤电缆中的光路的轴线大约九十度角反射到胶囊上，使得光的强度反射回当胶囊通过光纤电缆与探针尖端与表面接触时胶囊的偏转成正比。

8. 发明申请

US20060091302A1 Apparatus and method of detecting probe tip contact with a surface 有权
标题翻译：检测探针尖端与表面接触的装置和方法
公开(公告)号：US20060091302A1
公开(公告)日：2006-05-04
申请号：US11266678
申请日：2005-11-03
申请人： Thomas Moore , Lyudmila Zaykova-Feldman
发明人： Thomas Moore , Lyudmila Zaykova-Feldman
IPC分类号： G01J1/04 , H01J3/14 , G01J5/08
CPC分类号： H01J37/22 , B82Y35/00 , H01J37/20 , H01J37/3056 , H01J2237/20 , H01J2237/202 , H01J2237/204 , H01J2237/206 , H01J2237/208 , H01J2237/2482 , H01J2237/28 , H01J2237/31745
摘要： We disclose an apparatus and method for detecting probe-tip contact with a surface, generally inside a focused ion-beam instrument, where the probe tip is attached to a capsule, and the capsule is movably secured in a probe shaft. There is a fiber-optic cable having a first end and a second end; a beam splitter having first and second output ports; and a light source connected to the beam splitter. The first output port of the beam splitter is connected to the first end of the fiber-optic cable, and the second output port of the beam splitter is connected to a photodiode. The second end of the fiber-optic cable has a mirror for reflecting incident light at approximately a ninety-degree angle to the axis of the optical path in the fiber-optic cable and onto the capsule, so that the intensity of the light reflected back from the capsule through the fiber-optic cable is proportional to the deflection of the capsule as the probe tip makes contact with the surface.
摘要翻译：我们公开了一种用于检测与通常在聚焦离子束仪器内的表面的探针 - 尖端接触的装置和方法，其中探针尖端附接到胶囊，并且胶囊可移动地固定在探针轴中。存在具有第一端和第二端的光纤电缆; 具有第一和第二输出端口的分束器; 以及连接到分束器的光源。分束器的第一输出端口连接到光纤电缆的第一端，并且分束器的第二输出端口连接到光电二极管。光纤电缆的第二端具有反射镜，用于将入射光与光纤电缆中的光路的轴线大约九十度角反射到胶囊上，使得光的强度反射回当胶囊通过光纤电缆与探针尖端与表面接触时胶囊的偏转成正比。

9. 发明申请

US20060048459A1 Modular insulated panel collapsible sport/utility shanty 审中-公开
标题翻译：模块化绝缘面板可折叠运动/效用棚户区
公开(公告)号：US20060048459A1
公开(公告)日：2006-03-09
申请号：US10935435
申请日：2004-09-07
申请人： Thomas Moore
发明人： Thomas Moore
IPC分类号： E04H6/00
CPC分类号： E04B1/34321 , E04B1/6129 , E04H1/1205 , E04H2001/1288
摘要： An enclosure constructed of vinyl foam filled blow-molded panels. These panels are structured with tongue and groove connections built in to provide quick interlock one to another without the need for tools in assembly or disassembly. The construction characteristics provide panels that are rigid, strong, insulated, sound deadened with high flotation qualities. The enclosure is transportable by towing the assembled structure on a built-in sled bottom or dissembling the panels, stacking them and transporting them in a vehicle.
摘要翻译：由乙烯泡沫填充的吹塑板构成的外壳。这些面板的结构采用舌形和沟槽式连接，内置可提供快速联锁，而无需组装或拆卸工具。施工特点提供坚固，坚固，绝缘，声音衰减的浮选质量高的面板。外壳可以通过将组装结构牵引在内置的滑轨底部或拆卸面板，堆叠并将其运输到车辆中来运输。

10. 发明申请

US20060022135A1 Method and apparatus for in-situ probe tip replacement inside a charged particle beam microscope 有权
标题翻译：用于在带电粒子束显微镜内进行原位探针尖端置换的方法和装置
公开(公告)号：US20060022135A1
公开(公告)日：2006-02-02
申请号：US11186073
申请日：2005-07-21
申请人： Thomas Moore , Lyudmilla Zaykova-Feldman
发明人： Thomas Moore , Lyudmilla Zaykova-Feldman
IPC分类号： G21K7/00
CPC分类号： H01J37/20 , H01J37/26 , H01J2237/2005 , H01J2237/2006 , H01J2237/2007 , H01J2237/201 , H01J2237/204 , H01J2237/208 , H01J2237/26 , H01J2237/262 , H01J2237/31745 , H01J2237/31749
摘要： We disclose a gripper and associated apparatus and methods for delivering nano-manipulator probe tips inside a vacuum chamber. The gripper includes a tube; a compression cylinder inside of and coaxial with the tube; and at least one elastic ring adjacent to the compression cylinder. There is a vacuum seal coaxial with the compression cylinder for receiving and sealing against a probe tip. An actuator is connected to the compression cylinder for compressing the elastic ring and causing it to grip the probe tip. Thus the probe tip can be gripped, transferred to a different location in the vacuum chamber, and released there. Samples attached to the probe tips will be transferred to a TEM sample holder, shown in several embodiments, that includes a bar having opposed ends; an arm attached to each opposed end of the bar; one or more slots for receiving a probe tip; and, each slot having an inner part and an outer part, where the inner part is smaller than the outer part. The TEM sample holders just described are inserted into a carrier cassette. A cassette for transferring one or more TEM sample holders comprises a platform; at least one bar extending upwardly from the platform; the bar having a groove for receiving and holding a TEM sample holder. A rotatable magazine holds one or more probe tips and selectively releases the tips. The magazine includes a cartridge having a plurality of longitudinal openings for receiving probe tips and dispensing probe tips.
摘要翻译：我们公开了一种夹具和相关的装置和方法，用于在真空室内输送纳米机械手探针尖端。夹具包括管; 压缩缸内部并与管同轴; 以及与压缩圆筒相邻的至少一个弹性环。存在与压缩筒同轴的真空密封件，用于接收和密封探针尖端。致动器连接到压缩气缸，用于压缩弹性环并使其夹持探针尖端。因此，探针尖端可以被夹持，转移到真空室中的不同位置，并在那里释放。附接到探针尖端的样品将转移到TEM样品保持器，如几个实施方案中所示，其包括具有相对端的棒; 连接到杆的每个相对端的臂; 用于接收探针尖端的一个或多个狭槽; 并且每个狭槽具有内部部分和外部部分，其中内部部分小于外部部分。刚刚描述的TEM样品架被插入到载体盒中。用于转移一个或多个TEM样品保持器的盒子包括平台; 从平台向上延伸的至少一个杆; 该棒具有用于容纳和保持TEM样品保持器的凹槽。一个可旋转刀库可容纳一个或多个探针尖端并选择性地释放尖端。该盒包括具有多个用于接收探针尖端并分配探针尖端的多个纵向开口的盒。

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