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1. 发明授权

US07214495B2 Screening method 失效
标题翻译：筛选方法
公开(公告)号：US07214495B2
公开(公告)日：2007-05-08
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
IPC分类号： G01N33/566
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

2. 发明申请

US20050089866A1 Novel screening method 失效
标题翻译：新型筛选方法
公开(公告)号：US20050089866A1
公开(公告)日：2005-04-28
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

3. 发明申请

US20050118639A1 Method of determining ligand 审中-公开
标题翻译：测定配体的方法
公开(公告)号：US20050118639A1
公开(公告)日：2005-06-02
申请号：US10505486
申请日：2003-02-21
申请人： Shuji Hinuma , Ryo Fujii , Kazuhiro Ogi , Hidetoshi Komatsu , Yuji Kawamata , Masaki Hosoya
发明人： Shuji Hinuma , Ryo Fujii , Kazuhiro Ogi , Hidetoshi Komatsu , Yuji Kawamata , Masaki Hosoya
IPC分类号： C07K14/705 , C07K14/72 , G01N33/566 , G01N33/58 , G01N33/74 , G01N33/92 , G01N33/53
CPC分类号： G01N33/582 , G01N33/566 , G01N2333/726
摘要： The present invention aims at providing a method of determining a ligand to an orphan receptor. Specifically, the present invention provides a method of determining a ligand to a receptor protein, to which no ligand has been determined, which comprises using a fusion protein of the receptor protein and a fluorescent protein.
摘要翻译：本发明旨在提供一种测定孤儿受体配体的方法。具体地，本发明提供了确定受体蛋白质的配体的方法，其中没有确定配体，其包括使用受体蛋白质的融合蛋白和荧光蛋白质。

4. 发明申请

US20050153289A1 Method of analyzing gene expression 审中-公开
标题翻译：分析基因表达的方法
公开(公告)号：US20050153289A1
公开(公告)日：2005-07-14
申请号：US10498848
申请日：2002-12-13
申请人： Shuji Hinuma , Makoto Kobayashi , Toshimitsu Arai , Shoji Fukusumi , Ryo Fujii , Hidetoshi Komatsu , Fumika Matsumura , Yuji Kawamata , Kazuhiro Ogi
发明人： Shuji Hinuma , Makoto Kobayashi , Toshimitsu Arai , Shoji Fukusumi , Ryo Fujii , Hidetoshi Komatsu , Fumika Matsumura , Yuji Kawamata , Kazuhiro Ogi
IPC分类号： A61K38/17 , A61P35/00 , C07K14/47 , C07K14/705 , C12Q1/68 , G01N33/566 , G01N33/68 , C07H21/04 , C07K14/42 , C07K16/30 , G01N33/574
CPC分类号： A61K38/1709 , C07K14/4726 , C07K14/705 , C12Q1/6886 , C12Q2600/136 , G01N33/566 , G01N33/689 , G01N2333/705 , G01N2333/726
摘要： The present invention intends to provide a method for analyzing gene expression, a novel use for a receptor protein and the like. Specifically, the present invention provides a method for analyzing gene expression, which is characterized by identifying genes, which are characteristically promoted or suppressed in certain cells or tissues by quantitatively analyzing the individual expressed amounts of a plural number of genes collectively, an assay kit employed in the method and the like. The present invention also provides a method of screening compounds or salts thereof which alter the binding properties of a novel G protein coupled receptor protein comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID NO: 9 or a salt thereof with a ligand, characterized by the use of the protein or salt thereof and a protein (such as a lectin) showing an affinity for a sugar chain which is one of the ligands.
摘要翻译：本发明意在提供分析基因表达的方法，受体蛋白质的新用途等。具体地说，本发明提供一种分析基因表达的方法，其特征在于通过定量分析多个基因的个体表达量来统一地鉴定某些细胞或组织中特征性促进或抑制的基因，所用的测定试剂盒在该方法等中。本发明还提供一种筛选化合物或其盐的方法，其改变新型G蛋白偶联受体蛋白的结合性质，其包含与SEQ ID NO：9所示的氨基酸序列相同或基本上相同的氨基酸序列或盐其特征在于使用蛋白质或其盐和显示对作为配体之一的糖链的亲和性的蛋白质（例如凝集素）。

5. 发明授权

US06228984B1 Polypeptides their production and use 失效
标题翻译：多肽的生产和使用
公开(公告)号：US06228984B1
公开(公告)日：2001-05-08
申请号：US08776971
申请日：1997-02-07
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K1447
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译：本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选的药物候选化合物。特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

6. 发明授权

US06794491B1 Polypeptides, their production and use 失效
标题翻译：多肽，其生产和使用
公开(公告)号：US06794491B1
公开(公告)日：2004-09-21
申请号：US09576290
申请日：2000-05-23
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K14475
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译：本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。配体多肽或编码配体多肽的DNA可用于（1）开发诸如垂体的药物功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）使用重组受体蛋白质的表达和药物候选化合物的筛选开发受体结合测定系统。特别地，通过受体结合测定系统利用表达根据本发明的重组G蛋白偶联受体蛋白质，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，并且所获得的激动剂或拮抗剂可用作治疗和预防各种疾病的代理

7. 发明申请

US20050170461A1 Polypeptides, their production and use 审中-公开
公开(公告)号：US20050170461A1
公开(公告)日：2005-08-04
申请号：US11054211
申请日：2005-02-08
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： A61K38/00 , C07H21/04 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28 , C12N1/21 , C12N15/12
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

8. 发明授权

US06881545B1 Polypeptides, their production and use 失效
标题翻译：多肽，其生产和使用
公开(公告)号：US06881545B1
公开(公告)日：2005-04-19
申请号：US09716147
申请日：2000-11-17
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K14/575 , C07K14/705 , G01N33/53 , C07K7/08 , C07K14/72
CPC分类号： C07K14/705 , C07K14/575
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins.The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds.In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译：本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。编码配体多肽的配体多肽或DNA可用于（1）开发药物，例如垂体功能调节剂，中枢神经系统功能调节剂和胰功能调节剂，以及（2）开发受体结合测定系统，其使用重组受体蛋白的表达和药物候选化合物的筛选。特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

9. 发明授权

US07172876B2 Method of screening therapeutic agents for nerve degeneration associated diseases 有权
标题翻译：筛选神经变性相关疾病的治疗剂的方法
公开(公告)号：US07172876B2
公开(公告)日：2007-02-06
申请号：US10517956
申请日：2003-06-12
申请人： Shuji Hinuma , Ryo Fujii , Masataka Harada , Masaki Hosoya
发明人： Shuji Hinuma , Ryo Fujii , Masataka Harada , Masaki Hosoya
IPC分类号： G01N33/567
CPC分类号： G01N33/74 , C07K14/4747 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： By using a G protein-coupled receptor protein containing an amino acid sequence, which is the same or the substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:10, SEQ ID NO:12 or SEQ ID NO:14, or its salt together with humanin, a compound or its salt capable of changing the binding properties of the above receptor protein or its salt to humanin can be efficiently screened.
摘要翻译：通过使用含有与SEQ ID NO：1，SEQ ID NO：10，SEQ ID NO：12或SEQ ID NO：12表示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白可以有效地筛选能够改变上述受体蛋白质或其盐对人源的结合特性的化合物或其盐与人源化合物或其盐。

10. 发明申请

US20050233326A1 Novel screening method 有权
标题翻译：新型筛选方法
公开(公告)号：US20050233326A1
公开(公告)日：2005-10-20
申请号：US10517956
申请日：2003-06-12
申请人： Shuji Hinuma , Ryo Fujii , Masataka Harada , Masaki Hosoya
发明人： Shuji Hinuma , Ryo Fujii , Masataka Harada , Masaki Hosoya
IPC分类号： A61P9/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07K14/47 , C07K14/705 , C12N15/12 , G01N33/74 , C12Q1/68 , A61K38/17 , C12Q1/48 , G01N33/53 , G01N33/567
CPC分类号： G01N33/74 , C07K14/4747 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： By using a G protein-coupled receptor protein containing an amino acid sequence, which is the same or the substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:10, SEQ ID NO:12 or SEQ ID NO:14, or its salt together with humanin, a compound or its salt capable of changing the binding properties of the above receptor protein or its salt to humanin can be efficiently screened.
摘要翻译：通过使用含有与SEQ ID NO：1，SEQ ID NO：10，SEQ ID NO：12或SEQ ID NO：12表示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白可以有效地筛选能够改变上述受体蛋白质或其盐对人源的结合特性的化合物或其盐与人源化合物或其盐。

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