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1. 发明授权

US07214495B2 Screening method 失效
标题翻译：筛选方法
公开(公告)号：US07214495B2
公开(公告)日：2007-05-08
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
IPC分类号： G01N33/566
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

2. 发明申请

US20050089866A1 Novel screening method 失效
标题翻译：新型筛选方法
公开(公告)号：US20050089866A1
公开(公告)日：2005-04-28
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

3. 发明申请

US20050118639A1 Method of determining ligand 审中-公开
标题翻译：测定配体的方法
公开(公告)号：US20050118639A1
公开(公告)日：2005-06-02
申请号：US10505486
申请日：2003-02-21
申请人： Shuji Hinuma , Ryo Fujii , Kazuhiro Ogi , Hidetoshi Komatsu , Yuji Kawamata , Masaki Hosoya
发明人： Shuji Hinuma , Ryo Fujii , Kazuhiro Ogi , Hidetoshi Komatsu , Yuji Kawamata , Masaki Hosoya
IPC分类号： C07K14/705 , C07K14/72 , G01N33/566 , G01N33/58 , G01N33/74 , G01N33/92 , G01N33/53
CPC分类号： G01N33/582 , G01N33/566 , G01N2333/726
摘要： The present invention aims at providing a method of determining a ligand to an orphan receptor. Specifically, the present invention provides a method of determining a ligand to a receptor protein, to which no ligand has been determined, which comprises using a fusion protein of the receptor protein and a fluorescent protein.
摘要翻译：本发明旨在提供一种测定孤儿受体配体的方法。具体地，本发明提供了确定受体蛋白质的配体的方法，其中没有确定配体，其包括使用受体蛋白质的融合蛋白和荧光蛋白质。

4. 发明申请

US20050153289A1 Method of analyzing gene expression 审中-公开
标题翻译：分析基因表达的方法
公开(公告)号：US20050153289A1
公开(公告)日：2005-07-14
申请号：US10498848
申请日：2002-12-13
申请人： Shuji Hinuma , Makoto Kobayashi , Toshimitsu Arai , Shoji Fukusumi , Ryo Fujii , Hidetoshi Komatsu , Fumika Matsumura , Yuji Kawamata , Kazuhiro Ogi
发明人： Shuji Hinuma , Makoto Kobayashi , Toshimitsu Arai , Shoji Fukusumi , Ryo Fujii , Hidetoshi Komatsu , Fumika Matsumura , Yuji Kawamata , Kazuhiro Ogi
IPC分类号： A61K38/17 , A61P35/00 , C07K14/47 , C07K14/705 , C12Q1/68 , G01N33/566 , G01N33/68 , C07H21/04 , C07K14/42 , C07K16/30 , G01N33/574
CPC分类号： A61K38/1709 , C07K14/4726 , C07K14/705 , C12Q1/6886 , C12Q2600/136 , G01N33/566 , G01N33/689 , G01N2333/705 , G01N2333/726
摘要： The present invention intends to provide a method for analyzing gene expression, a novel use for a receptor protein and the like. Specifically, the present invention provides a method for analyzing gene expression, which is characterized by identifying genes, which are characteristically promoted or suppressed in certain cells or tissues by quantitatively analyzing the individual expressed amounts of a plural number of genes collectively, an assay kit employed in the method and the like. The present invention also provides a method of screening compounds or salts thereof which alter the binding properties of a novel G protein coupled receptor protein comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID NO: 9 or a salt thereof with a ligand, characterized by the use of the protein or salt thereof and a protein (such as a lectin) showing an affinity for a sugar chain which is one of the ligands.
摘要翻译：本发明意在提供分析基因表达的方法，受体蛋白质的新用途等。具体地说，本发明提供一种分析基因表达的方法，其特征在于通过定量分析多个基因的个体表达量来统一地鉴定某些细胞或组织中特征性促进或抑制的基因，所用的测定试剂盒在该方法等中。本发明还提供一种筛选化合物或其盐的方法，其改变新型G蛋白偶联受体蛋白的结合性质，其包含与SEQ ID NO：9所示的氨基酸序列相同或基本上相同的氨基酸序列或盐其特征在于使用蛋白质或其盐和显示对作为配体之一的糖链的亲和性的蛋白质（例如凝集素）。

5. 发明授权

US07410641B2 Antibodies to insulin/IGF/relaxin family polypeptides 失效
标题翻译：胰岛素/ IGF /松弛素家族多肽的抗体
公开(公告)号：US07410641B2
公开(公告)日：2008-08-12
申请号：US11284367
申请日：2005-11-21
申请人： Yasuaki Itoh , Nobuhiro Suzuki , Kazunori Nishi , Hideki Kizawa , Masataka Harada , Kazuhiro Ogi
发明人： Yasuaki Itoh , Nobuhiro Suzuki , Kazunori Nishi , Hideki Kizawa , Masataka Harada , Kazuhiro Ogi
IPC分类号： A61K39/395 , C07K16/22 , C12N5/06
CPC分类号： G01N33/74 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/575 , C07K14/64 , C07K14/65 , C07K16/26 , G01N2333/62 , G01N2333/64
摘要： The present invention relates to antibodies that bind to the A chain N-terminal peptide. The present invention also relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:8 (B chain), (3) a polypeptide wherein the A and B chains are bonded to each other via disulfide bonds (2 chains) or its salt., (4) DNAs encoding the same, etc. These polypeptides and DNAs encoding the same can be used for the diagnosis, treatment, prevention, etc. for diseases, including abnormalities (e.g., diabetes mellitus, etc.) in metabolic regulation (sugar metabolism, lipid metabolism, etc.) of energy sources such as carbohydrates.
摘要翻译：本发明涉及结合A链N末端肽的抗体。本发明还涉及（1）含有与SEQ ID NO：7（A链）所示的氨基酸序列相同或基本相同的氨基酸序列的多肽，（2）含有相同或基本相同的多肽氨基酸序列作为由SEQ ID NO：8（B链）表示的氨基酸序列，（3）其中A和B链通过二硫键（2链）或其盐彼此键合的多肽，（4））编码相同的DNA等。这些多肽和编码它们的DNA可以用于疾病的诊断，治疗，预防等，包括代谢调节中的异常（例如糖尿病等）（糖代谢，脂质代谢等）能源如碳水化合物。

6. 发明授权

US07049403B2 Insulin/IGF/relaxin family polypeptides and DNAS thereof 失效
标题翻译：胰岛素/ IGF /松弛素家族多肽及其DNAS
公开(公告)号：US07049403B2
公开(公告)日：2006-05-23
申请号：US10257848
申请日：2001-04-20
申请人： Yasuaki Itoh , Nobuhiro Suzuki , Kazunori Nishi , Hideki Kizawa , Masataka Harada , Kazuhiro Ogi
发明人： Yasuaki Itoh , Nobuhiro Suzuki , Kazunori Nishi , Hideki Kizawa , Masataka Harada , Kazuhiro Ogi
IPC分类号： C07K14/00 , A01N37/18 , A61K39/00
CPC分类号： G01N33/74 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/575 , C07K14/64 , C07K14/65 , C07K16/26 , G01N2333/62 , G01N2333/64
摘要： The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:8 (B chain), (3) a polypeptide wherein the A and B chains are bonded to each other via disulfide bonds (2 chains) or its salt, (4) DNAs encoding the same, etc.These polypeptides and DNAs encoding the same can be used for the diagnosis, treatment, prevention, etc. for diseases, including abnormalities (e.g., diabetes mellitus, etc.) in metabolic regulation (sugar metabolism, lipid metabolism, etc.) of energy sources such as carbohydrates.
摘要翻译：本发明涉及（1）含有与SEQ ID NO：7（A链）所示氨基酸序列相同或基本相同的氨基酸序列的多肽，（2）含有相同或基本相同氨基的多肽酸序列作为由SEQ ID NO：8（B链）表示的氨基酸序列，（3）其中A和B链通过二硫键（2链）或其盐彼此键合的多肽，（4）DNA 编码相同的这些多肽和DNA可用于诊断，治疗，预防等疾病，包括代谢调节异常（如糖尿病等）（糖代谢，脂质代谢，等等）的能源，如碳水化合物。

7. 发明申请

US20060073567A1 Novel insulin/IGF/relaxin family polypeptides and DNAs thereof 失效
标题翻译：新型胰岛素/ IGF /松弛素家族多肽及其DNA
公开(公告)号：US20060073567A1
公开(公告)日：2006-04-06
申请号：US11284367
申请日：2005-11-21
申请人： Yasuaki Itoh , Nobuhiro Suzuki , Kazunori Nishi , Hideki Kizawa , Masataka Harada , Kazuhiro Ogi
发明人： Yasuaki Itoh , Nobuhiro Suzuki , Kazunori Nishi , Hideki Kizawa , Masataka Harada , Kazuhiro Ogi
IPC分类号： C07H21/04 , C12P21/06 , A61K39/395 , A61K38/28 , A61K38/27 , C07K14/65 , C07K14/62
CPC分类号： G01N33/74 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/575 , C07K14/64 , C07K14/65 , C07K16/26 , G01N2333/62 , G01N2333/64
摘要： The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:8 (B chain), (3) a polypeptide wherein the A and B chains are bonded to each other via disulfide bonds (2 chains) or its salt, (4) DNAs encoding the same, etc. These polypeptides and DNAs encoding the same can be used for the diagnosis, treatment, prevention, etc. for diseases, including abnormalities (e.g., diabetes mellitus, etc.) in metabolic regulation (sugar metabolism, lipid metabolism, etc.) of energy sources such as carbohydrates.
摘要翻译：本发明涉及（1）含有与SEQ ID NO：7（A链）所示氨基酸序列相同或基本相同的氨基酸序列的多肽，（2）含有相同或基本相同氨基的多肽酸序列作为由SEQ ID NO：8（B链）表示的氨基酸序列，（3）其中A和B链通过二硫键（2链）或其盐彼此键合的多肽，（4）DNA 编码相同的这些多肽和DNA可用于诊断，治疗，预防等疾病，包括代谢调节异常（如糖尿病等）（糖代谢，脂质代谢，等等）的能源，如碳水化合物。

8. 发明授权

US06797483B1 Polypeptide and DNA thereof 失效
标题翻译：多肽及其DNA
公开(公告)号：US06797483B1
公开(公告)日：2004-09-28
申请号：US10019455
申请日：2001-12-28
申请人： Yasuaki Itoh , Kazunori Nishi , Kazuhiro Ogi , Shoichi Ohkubo , Shinichi Mogi , Yuko Noguchi , Koji Yoshimura , Hideyuki Tanaka
发明人： Yasuaki Itoh , Kazunori Nishi , Kazuhiro Ogi , Shoichi Ohkubo , Shinichi Mogi , Yuko Noguchi , Koji Yoshimura , Hideyuki Tanaka
IPC分类号： G01N3353
CPC分类号： C07K14/4703 , A61K38/00
摘要： The present invention relates to novel secretory polypeptides and precursor proteins thereof, which show a high homology to MIA (melanoma inhibitor activity)/CD-RAP (bovine cartilage-derived retinoic acid-sensitive protein); are specifically expressed in the cartilage tissue; and have an effect on the cartilage differentiation. The polypeptides and the DNAs encoding the same can be used for the diagnosis, treatment, or prevention of bone and joint diseases or pathological angiogenesis. As well, the polypeptides are useful as a reagent for screening a compound that promotes or inhibits the activity of the polypeptides. The antibody to the polypeptides can be used for the detection, quantification, or neutralization of the polypeptide in a test sample fluid. Further by using the promoter of the present invention, a therapeutic protein can be expressed predominantly in the cartilage tissue for a gene therapy.
摘要翻译：本发明涉及与MIA（黑素瘤抑制剂活性）/ CD-RAP（牛软骨衍生的视黄酸敏感蛋白）高同源性的新型分泌多肽及其前体蛋白; 在软骨组织中特异性表达; 并对软骨分化有影响。编码该多肽和DNA的DNA可用于诊断，治疗或预防骨和关节疾病或病理性血管生成。同样，多肽可用作筛选促进或抑制多肽活性的化合物的试剂。多肽的抗体可用于在测试样品流体中检测，定量或中和多肽。此外，通过使用本发明的启动子，治疗性蛋白质主要在软骨组织中表达用于基因治疗。

9. 发明授权

US5858787A DNA encoding PACAP receptor protein and method for preparing said protein 失效
标题翻译：编码PACAP受体蛋白的DNA及其制备方法
公开(公告)号：US5858787A
公开(公告)日：1999-01-12
申请号：US811897
申请日：1997-03-05
申请人： Haruo Onda , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata
发明人： Haruo Onda , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata
IPC分类号： A61K38/00 , C07K14/575 , C07K14/72 , C12N1/21 , C12N15/12 , C12P21/08 , C12N5/10 , C12N15/63
CPC分类号： C07K14/57563 , C07K14/72 , A61K38/00
摘要： This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein and use of the protein, DNA and antibodies. A PACAP receptor protein was purified from the bovine cerebrum. DNAs coding for PACAP receptor proteins were isolated from bovine, rat and human cDNA libraries, and their nucleotide sequences were determined. The PACAP receptor proteins and the DNAs coding for the proteins of the present invention can be used for (1) acquisition of antibodies and antisera, (2) construction of expression systems of recombinant receptor proteins, (3) development of receptor binding assay systems using said expression systems and screening of potential compounds for drugs, (4) execution of drug design based on the comparison of ligands and receptors which are structurally similar to each other, (5) preparation of probes and PCR primers in gene diagnosis, and the like.
摘要翻译：本发明公开了一种PACAP受体蛋白质或其盐，包含编码该蛋白质的DNA片段的DNA，该蛋白质的制备方法，针对该蛋白质的抗体及该蛋白质，DNA及抗体的用途。从牛大脑中纯化PACAP受体蛋白。从牛，大鼠和人类cDNA文库中分离编码PACAP受体蛋白的DNA，测定其核苷酸序列。 PACAP受体蛋白和编码本发明蛋白的DNA可用于（1）获得抗体和抗血清，（2）构建重组受体蛋白质的表达系统，（3）开发受体结合测定系统，使用表达系统和药物潜在化合物的筛选，（4）基于结构相似的配体和受体的比较进行药物设计，（5）基因诊断中探针和PCR引物的制备等。

10. 发明授权

US5973117A PACAP receptor protein, method for preparing said protein, and use thereof 失效
标题翻译： PACAP受体蛋白质，所述蛋白质的制备方法及其用途
公开(公告)号：US5973117A
公开(公告)日：1999-10-26
申请号：US856154
申请日：1997-05-14
申请人： Haruo Onda , Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata , Norio Shimamoto
发明人： Haruo Onda , Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata , Norio Shimamoto
IPC分类号： A61K38/00 , C07K14/575 , C07K14/72 , C12N1/21 , C12N15/12 , C12P21/08 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/705
CPC分类号： C07K14/57563 , C07K14/72 , A61K38/00
摘要： This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein and use of the protein, DNA and antibodies.
摘要翻译：本发明公开了一种PACAP受体蛋白或其盐，包含编码该蛋白质的DNA片段的DNA，该蛋白质的制备方法，针对该蛋白质的抗体及该蛋白质，DNA及抗体的用途。

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