专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06660834B2 Reagents useful for detecting diseases of the gastrointestinal tract 失效
标题翻译：用于检测胃肠道疾病的试剂
公开(公告)号：US06660834B2
公开(公告)日：2003-12-09
申请号：US10278547
申请日：2002-10-23
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
IPC分类号： C07K1447
CPC分类号： G01N33/6893 , C07K14/47 , C07K16/3046 , C12Q1/6886 , C12Q2600/136 , G01N2800/06 , Y10S435/81 , Y10S530/828
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
摘要翻译：描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS198并从胃肠道组织转录。这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。还提供了特异性结合CS198编码的多肽或蛋白质的抗体，以及预防组织特异性CS198多肽的作用的激动剂或抑制剂，该分子可用于胃肠道疾病，肿瘤或转移瘤的治疗性治疗。

2. 发明授权

US06552169B1 Density enhanced protein tyrosine phosphatases 失效
标题翻译：密度增强蛋白酪氨酸磷酸酶
公开(公告)号：US06552169B1
公开(公告)日：2003-04-22
申请号：US09447533
申请日：1999-11-23
申请人： Nicholas K. Tonks , Arne Ostman
发明人： Nicholas K. Tonks , Arne Ostman
IPC分类号： C07K1447
CPC分类号： C07K16/40 , A61K38/00 , C12N9/16 , C12Q1/42 , G01N33/573
摘要： Novel Type III density enhanced protein tyrosine phosphatases are disclosed and exemplified by human DEP-1 enzyme. Polynucleotides encoding huDEP-1 are disclosed, along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for DEP-1 are also disclosed as useful for modulating the biological activities of DEP-1.
摘要翻译：新型III型密度增强蛋白酪氨酸磷酸酶由人DEP-1酶公开和示例。公开了编码huDEP-1的多核苷酸，以及通过重组程序生产其的方法和材料。还公开了对DEP-1特异性的结合分子可用于调节DEP-1的生物活性。

3. 发明授权

US06462176B1 Apo-3 polypeptide 失效
标题翻译： Apo-3多肽
公开(公告)号：US06462176B1
公开(公告)日：2002-10-08
申请号：US08928069
申请日：1997-09-11
申请人： Avi J. Ashkenazi
发明人： Avi J. Ashkenazi
IPC分类号： C07K1447
CPC分类号： C07K14/70578 , A61K38/00 , A61K2039/505 , C07K14/4747 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C07K2319/30
摘要： Novel polypeptides, designated Apo-3, which are capable of stimulating or inducing apoptosis are provided. Compositions including Apo-3 chimeras, nucleic acid encoding Apo-3, and antibodies to Apo-3 are also provided.
摘要翻译：提供了能够刺激或诱导细胞凋亡的新型多肽，称为Apo-3。还提供了包含Apo-3嵌合体，编码Apo-3的核酸和Apo-3抗体的组合物。

4. 发明授权

US06268478B1 Intracellular vitamin D binding protein 失效
标题翻译：细胞内维生素D结合蛋白
公开(公告)号：US06268478B1
公开(公告)日：2001-07-31
申请号：US08797358
申请日：1997-02-11
申请人： John S. Adams
发明人： John S. Adams
IPC分类号： C07K1447
CPC分类号： C07K14/57 , A61K38/00
摘要： The invention relates to the discovery and purification of novel intracellular vitamin D binding proteins (IDBPs) and the isolation of polynucleotide sequences encoding the proteins. IDBPs are of interest because they mediate the vitamin D resistance, i.e., insensitivity, observed in new world primates. IDBPs are distinct from the vitamin D receptor and other intracellular receptors, e.g. estrogen receptor. One aspect of the invention is to provide purified IDBPs as pharmaceutical compositions to affect steroid hormone activity. Another aspect of the invention provides polynucleotides encoding the IDBPs of the invention for use in altering the expression of IDBPs. Yet another aspect of the invention is to provide assays for the detection or screening of therapeutic compounds that interfere with the interaction between IDBP and vitamin D (or other ligands that bind to IDBP), and the use of such compounds as pharmaceutical compositions.
摘要翻译：本发明涉及新型细胞内维生素D结合蛋白（IDBPs）的发现和纯化以及编码蛋白质的多核苷酸序列的分离。 IDBPs是有意义的，因为它们介导在新世界灵长类动物中观察到的维生素D抗性，即不敏感性。 IDBPs不同于维生素D受体和其他细胞内受体，例如。雌激素受体。本发明的一个方面是提供纯化的IDBPs作为影响类固醇激素活性的药物组合物。本发明的另一方面提供编码本发明的IDBPs的多核苷酸，用于改变IDBP的表达。本发明的另一方面是提供用于检测或筛选干扰IDBP和维生素D（或与IDBP结合的其它配体）之间的相互作用的治疗化合物的测定，以及使用这些化合物作为药物组合物。

5. 发明授权

US06228984B1 Polypeptides their production and use 失效
标题翻译：多肽的生产和使用
公开(公告)号：US06228984B1
公开(公告)日：2001-05-08
申请号：US08776971
申请日：1997-02-07
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K1447
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译：本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选的药物候选化合物。特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

6. 发明授权

US06207801B1 FADD-like anti-apoptotic molecules, methods of using the same, and compositions for and methods of making the same 有权
标题翻译： FADD样抗凋亡分子，其使用方法，组合物及其制备方法
公开(公告)号：US06207801B1
公开(公告)日：2001-03-27
申请号：US09276993
申请日：1999-03-26
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C07K1447
CPC分类号： B82Y30/00 , A61K38/00 , C07K14/47 , C07K14/4747
摘要： Two FADD-like anti-apoptotic proteins that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic acid molecules and making the proteins. Pharmaceutical compositions and methods of using the same are disclosed. Reagents, kits and methods of identifying compounds that inhibit anti-apoptotic activity of the proteins and methods of identifying compounds that inhibit binding activity of the proteins are disclosed.
摘要翻译：公开了调节Fas / TNFR1或UV诱导的凋亡的两种FADD样抗凋亡蛋白。公开了编码蛋白质的核苷酸序列，作为使用核酸分子和制备蛋白质的方法。公开了药物组合物及其使用方法。公开了鉴定抑制蛋白质的抗凋亡活性的化合物的试剂，试剂盒和方法以及鉴定抑制蛋白质结合活性的化合物的方法。

7. 发明授权

US06831151B1 Mast cell-specific signal transducing molecules and cDNAs thereof 失效
标题翻译：肥大细胞特异性信号转导分子及其cDNA
公开(公告)号：US06831151B1
公开(公告)日：2004-12-14
申请号：US09856061
申请日：2001-07-10
申请人： Ryo Goitsuka
发明人： Ryo Goitsuka
IPC分类号： C07K1447
CPC分类号： C07K14/47
摘要： The present invention provides a signal transducer specifically expressed in mouse mast cells that has the amino acid sequence of SEQ ID No. 2, a signal transducer specifically expressed in human mast cells that has the amino acid sequence of SEQ ID No. 4, polynucleotides encoding these proteins, an expression vector involving these polynucleotides, transformed cells induced by these expression vectors, and antibodies against the foregoing proteins. The signal transducer provided in the present invention is useful for screening of novel medicines against allergic diseases.
摘要翻译：本发明提供了特异性表达于具有SEQ ID No.2的氨基酸序列的小鼠肥大细胞中的信号转导体，特异性表达于具有SEQ ID No.4的氨基酸序列的人肥大细胞中的信号转导体，编码这些蛋白质，涉及这些多核苷酸的表达载体，由这些表达载体诱导的转化细胞，以及针对上述蛋白质的抗体。本发明提供的信号转导体可用于筛选抗过敏性疾病的新型药物。

8. 发明授权

US06777538B2 Binding protein 失效
标题翻译：结合蛋白
公开(公告)号：US06777538B2
公开(公告)日：2004-08-17
申请号：US09755251
申请日：2001-01-05
申请人： Sergio Abrignani
发明人： Sergio Abrignani
IPC分类号： C07K1447
CPC分类号： G01N33/56983 , C07K14/705 , G01N33/5767 , G01N2333/18 , G01N2333/705 , G01N2469/20
摘要： A 24 kd protein capable of binding the E2 envelope protein of hepatitis C virus (HCV), and functionally equivalent variants or fragments of the 24 kd protein, are disclosed. Processes for production and purification of the 24 kd protein, and functionally equivalent variants or fragments thereof, are also disclosed.
摘要翻译：公开了能够结合丙型肝炎病毒（HCV）的E2包膜蛋白和24kd蛋白的功能等同变体或片段的24kd蛋白质。还公开了24kd蛋白质的生产和纯化方法及其功能上等同的变体或片段。

9. 发明授权

US06586569B1 Endometriosis-associated gene 失效
标题翻译：子宫内膜异位症相关基因
公开(公告)号：US06586569B1
公开(公告)日：2003-07-01
申请号：US09725311
申请日：2000-11-29
申请人： Anna Starzinski-Powitz , Kotzian Silvia , Heike Handrow-Metzmacher
发明人： Anna Starzinski-Powitz , Kotzian Silvia , Heike Handrow-Metzmacher
IPC分类号： C07K1447
CPC分类号： C07K14/4748 , A61K38/00 , A61K48/00 , C07K16/18
摘要： The invention relates to a gene associated with invasive processes, e.g. endometriosis, to a polypeptide coded by said gene, to an antibody directed against the polypeptide, and to the pharmaceutical application of the nucleic acid, the polypeptide and the antibody.
摘要翻译：本发明涉及与侵入性过程相关的基因，例如子宫内膜异位症，由所述基因编码的多肽，针对针对多肽的抗体，以及核酸，多肽和抗体的药物应用。

10. 发明授权

US06525174B1 Precerebellin-like protein 失效
标题翻译：类似前脑苷脂的蛋白质
公开(公告)号：US06525174B1
公开(公告)日：2003-02-25
申请号：US09205258
申请日：1998-12-04
申请人： Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
发明人： Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
IPC分类号： C07K1447
CPC分类号： G01N33/68 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式