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1. 发明授权

US07892755B2 Screening method 失效
标题翻译：筛选方法
公开(公告)号：US07892755B2
公开(公告)日：2011-02-22
申请号：US11661555
申请日：2005-08-29
申请人： Yasuaki Ito , Kazunori Nishi , Shoichi Ohkubo , Masataka Harada
发明人： Yasuaki Ito , Kazunori Nishi , Shoichi Ohkubo , Masataka Harada
IPC分类号： G01N33/566 , A61K38/00
CPC分类号： G01N33/6893 , C07K14/705 , G01N33/574 , G01N2500/00
摘要： The present invention provides a method of screening a compound or its salt that alters binding properties of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and a ligand capable of specifically binding to the protein or its salt, which comprises using (a) the protein, its partial peptide, or a salt thereof and (b) the ligand; a screening kit therefor, and so on. The screening method and kit of the present invention are useful for screening an agent for the prevention/treatment of, e.g., digestive tract disorders, cancer, immune disorders, type II diabetes mellitus or obesity, etc.
摘要翻译：本发明提供一种筛选化合物或其盐的方法，其改变包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列的蛋白质的结合性，或其盐，和能够特异性结合蛋白质或其盐的配体，其包括使用（a）蛋白质，其部分肽或其盐和（b）配体; 一个筛选工具，等等。本发明的筛选方法和试剂盒可用于筛选用于预防/治疗例如消化道疾病，癌症，免疫疾病，II型糖尿病或肥胖症等的药剂。

2. 发明申请

US20060073516A1 Novel screening method 审中-公开
标题翻译：新型筛选方法
公开(公告)号：US20060073516A1
公开(公告)日：2006-04-06
申请号：US10509484
申请日：2003-03-27
申请人： Yasuaki Ito , Tokuyuki Shinohara , Masaki Hosoya , Shuji Hinuma , Yuko Noguchi
发明人： Yasuaki Ito , Tokuyuki Shinohara , Masaki Hosoya , Shuji Hinuma , Yuko Noguchi
IPC分类号： G01N33/53 , A61K38/17 , C07H21/04 , C12P21/06 , A61K31/195 , C07K14/705
CPC分类号： C07K14/705
摘要： Using a novel G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same amino acid sequence as an amino acid sequence represented by SEQ ID NO: 2 or its salt together with β-alanine or L-carnosine, an agonist or an antagonist to the receptor protein or its salt can be efficiently screened.
摘要翻译：使用具有与SEQ ID NO：2表示的氨基酸序列相同或基本相同的氨基酸序列的氨基酸序列的新型G蛋白偶联受体蛋白或其盐与β-丙氨酸或L-肌肽一起使用，可以有效地筛选受体蛋白质或其盐的激动剂或拮抗剂。

3. 发明申请

US20090227037A1 NOVEL SCREENING METHOD 有权
标题翻译：新型筛选方法
公开(公告)号：US20090227037A1
公开(公告)日：2009-09-10
申请号：US12428877
申请日：2009-04-23
申请人： Yasuaki ITO , Ryo Fuji , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
发明人： Yasuaki ITO , Ryo Fuji , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
IPC分类号： G01N33/20
CPC分类号： G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
摘要： By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.
摘要翻译：通过使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和可电离金属元素或其盐可以有效地筛选上述受体蛋白质或其拮抗剂的激动剂或其盐。

4. 发明申请

US20060216286A1 Novel screening method 审中-公开
标题翻译：新型筛选方法
公开(公告)号：US20060216286A1
公开(公告)日：2006-09-28
申请号：US10552014
申请日：2004-04-23
申请人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
发明人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
摘要： By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.
摘要翻译：通过使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和可电离金属元素或其盐可以有效地筛选上述受体蛋白质或其拮抗剂的激动剂或其盐。

5. 发明授权

US4958160A Projection exposure apparatus and method of correcting projection error 失效
标题翻译：投影曝光装置和校正投影误差的方法
公开(公告)号：US4958160A
公开(公告)日：1990-09-18
申请号：US238196
申请日：1988-08-30
申请人： Yasuaki Ito , Takehiko Suzuki , Hirokazu Shimeki
发明人： Yasuaki Ito , Takehiko Suzuki , Hirokazu Shimeki
IPC分类号： G03F7/20
CPC分类号： G03F7/70691 , G03F7/70358
摘要： A projection exposure apparatus in which a wafer is illuminated with a light of slit-like shape from a mask and a carriage for supporting the mask and the wafer as a unit is moved in a predetermined direction relative to a projection optical system, including a mirror system, wherein a pattern formed on the mask is printed on the wafer, is disclosed. By adjusting the attitude of the carriage during movement, a projection error of the pattern of the mask, being projected on the wafer, is corrected. Data necessary for adjusting the carriage attitude is obtained by photoelectrically detecting alignment marks of the mask and the wafer. As a feature, a setting device is provided to allow the setting of the number of wafers, of those of a predetermined number, which are to be treated as the subject of data detection. This makes the apparatus to easily meet either of the requirements of higher precision and higher throughput, as desired. Also, the amount of actual change in the attitude of the carriage, with respect to the instruction value based on the data, is preparatorily detected before the pattern printing and is memorized. This assures higher precision correction of the projection error.
摘要翻译：投影曝光装置，其中以掩模和狭缝状的光照射晶片作为一个单元的投影光学系统相对于包括镜子的投影光学系统在预定的方向上移动系统，其中形成在掩模上的图案被印刷在晶片上。通过在移动期间调整滑架的姿态，校正投影在晶片上的掩模图案的投影误差。通过光电检测掩模和晶片的对准标记来获得调整滑架姿态所需的数据。作为特征，提供了一种设置装置，以允许设置要被视为数据检测对象的预定数量的晶片数量。这使得装置能够根据需要容易地满足更高精度和更高产量的要求。此外，在图案打印之前，预先检测出基于数据的托架姿态的实际变化量，并且被记忆。这样可以更精确地校正投影误差。

6. 发明申请

US20090012093A1 Receptor Function Regulator 有权
标题翻译：受体功能调节器
公开(公告)号：US20090012093A1
公开(公告)日：2009-01-08
申请号：US10534081
申请日：2003-11-06
申请人： Kohji Fukatsu , Shinobu Sasaki , Shuji Hinuma , Yasuaki Ito , Nobuhiro Suzuki , Masataka Harada , Tsuneo Yasuma
发明人： Kohji Fukatsu , Shinobu Sasaki , Shuji Hinuma , Yasuaki Ito , Nobuhiro Suzuki , Masataka Harada , Tsuneo Yasuma
IPC分类号： A61K31/4965 , C07C62/34 , C07D241/18 , C07D277/42 , G01N33/566 , A61K31/427 , A61K31/192
CPC分类号： C07C255/24 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/343 , A61K31/381 , A61K31/401 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/437 , C07C59/64 , C07C59/68 , C07C59/72 , C07C59/74 , C07C59/76 , C07C59/90 , C07C65/24 , C07C69/734 , C07C69/736 , C07C217/48 , C07C217/58 , C07C217/76 , C07C235/42 , C07C255/54 , C07C317/28 , C07C323/19 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D209/12 , C07D277/36 , C07D277/42 , C07D277/64 , C07D295/13 , C07D307/91 , C07D333/32 , C07D333/54 , C07D333/62 , C07D333/78 , C07D471/04
摘要： The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.
摘要翻译：本发明的GPR40受体功能调节剂包含具有芳香环的化合物和能释放阳离子的基团，可用作胰岛素促分泌素或预防或治疗糖尿病等的药剂。

7. 发明授权

US07960369B2 Receptor function regulator 有权
标题翻译：受体功能调节剂
公开(公告)号：US07960369B2
公开(公告)日：2011-06-14
申请号：US10534081
申请日：2003-11-06
申请人： Kohji Fukatsu , Shinobu Sasaki , Shuji Hinuma , Yasuaki Ito , Nobuhiro Suzuki , Masataka Harada , Tsuneo Yasuma
发明人： Kohji Fukatsu , Shinobu Sasaki , Shuji Hinuma , Yasuaki Ito , Nobuhiro Suzuki , Masataka Harada , Tsuneo Yasuma
IPC分类号： A61K31/535
CPC分类号： C07C255/24 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/343 , A61K31/381 , A61K31/401 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/437 , C07C59/64 , C07C59/68 , C07C59/72 , C07C59/74 , C07C59/76 , C07C59/90 , C07C65/24 , C07C69/734 , C07C69/736 , C07C217/48 , C07C217/58 , C07C217/76 , C07C235/42 , C07C255/54 , C07C317/28 , C07C323/19 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D209/12 , C07D277/36 , C07D277/42 , C07D277/64 , C07D295/13 , C07D307/91 , C07D333/32 , C07D333/54 , C07D333/62 , C07D333/78 , C07D471/04
摘要： The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.
摘要翻译：本发明的GPR40受体功能调节剂包含具有芳香环的化合物和能释放阳离子的基团，可用作胰岛素促分泌素或预防或治疗糖尿病等的药剂。

8. 发明申请

US20080160033A1 Novel Screening Method 审中-公开
标题翻译：新型筛选方法
公开(公告)号：US20080160033A1
公开(公告)日：2008-07-03
申请号：US10542408
申请日：2004-01-15
申请人： Yasuaki Ito , Ryo Fujii , Shuji Hinuma , Shoji Fukusumi , Minoru Maruyama
发明人： Yasuaki Ito , Ryo Fujii , Shuji Hinuma , Shoji Fukusumi , Minoru Maruyama
IPC分类号： A61K39/395 , G01N33/68 , C07H21/04 , C07K14/705 , C12N5/06 , A61P5/00 , A61P35/00 , A61P31/12 , A61P3/00 , C12P21/02 , C12N15/63 , A61K31/711 , G01N33/566
CPC分类号： C07K14/723 , A61K31/711 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： By using a G protein-coupled receptor protein comprising the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 8, or a salt thereof, and a fatty acid, a compound or its salt that changes the binding property of the receptor protein or a salt thereof to the fatty acid can be efficiently screened.
摘要翻译：通过使用包含与SEQ ID NO：1，SEQ ID NO：3或SEQ ID NO：8表示的氨基酸序列相同或基本相同的G蛋白偶联受体蛋白或其盐，和脂肪酸可以有效地筛选改变受体蛋白质或其盐与脂肪酸的结合性的化合物或其盐。

9. 发明申请

US20080103215A1 Screening Method 失效
标题翻译：筛选方法
公开(公告)号：US20080103215A1
公开(公告)日：2008-05-01
申请号：US11661555
申请日：2005-08-29
申请人： Yasuaki Ito , Kazunori Nishi , Shoichi Ohkubo , Masataka Harada
发明人： Yasuaki Ito , Kazunori Nishi , Shoichi Ohkubo , Masataka Harada
IPC分类号： A61K45/00 , G01N33/53 , G01N33/15 , A61P1/00 , A61P3/10 , A61P35/00 , A61P37/00 , A61P3/04
CPC分类号： G01N33/6893 , C07K14/705 , G01N33/574 , G01N2500/00
摘要： The present invention provides a method of screening a compound or its salt that alters binding properties of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and a ligand capable of specifically binding to the protein or its salt, which comprises using (a) the protein, its partial peptide, or a salt thereof and (b) the ligand; a screening kit therefor, and so on. The screening method and kit of the present invention are useful for screening an agent for the prevention/treatment of, e.g., digestive tract disorders, cancer, immune disorders, type II diabetes mellitus or obesity, etc.
摘要翻译：本发明提供一种筛选化合物或其盐的方法，其改变包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列的蛋白质的结合性，或其盐，和能够特异性结合蛋白质或其盐的配体，其包括使用（a）蛋白质，其部分肽或其盐和（b）配体; 一个筛选工具，等等。本发明的筛选方法和试剂盒可用于筛选用于预防/治疗例如消化道疾病，癌症，免疫疾病，II型糖尿病或肥胖症等的药剂。

10. 发明授权

US07214495B2 Screening method 失效
标题翻译：筛选方法
公开(公告)号：US07214495B2
公开(公告)日：2007-05-08
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
IPC分类号： G01N33/566
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

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