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1. 发明授权

US06399316B1 PACAP receptor protein, method for preparing said protein, and use thereof 失效
标题翻译： PACAP受体蛋白质，所述蛋白质的制备方法及其用途
公开(公告)号：US06399316B1
公开(公告)日：2002-06-04
申请号：US09201474
申请日：1998-11-30
申请人： Haruo Onda , Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata , Norio Shimamoto
发明人： Haruo Onda , Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata , Norio Shimamoto
IPC分类号： G01N3353
CPC分类号： C07K14/72 , A61K38/00 , A61K48/00
摘要： This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein, and use of the protein, DNA, and antibodies. A PACAP receptor protein was purified from the bovine cerebrum. DNAs coding for PACAP receptor proteins were isolated from bovine, rat and human cDNA libraries, and their nucleotide sequences were determined. Further, amino acid sequences deduced from the nucleotide sequences were determined. The PACAP receptor proteins and the DNAs coding for the proteins of the present invention can be used for (1) acquisition of antibodies and antisera, (2) construction of expression systems of recombinant receptor proteins, (3) development of receptor binding assay systems using said expression systems and screening of potential compounds for drugs, (4) execution of drug design based on the comparison of ligands and receptors which are structurally similar to each other, (5) preparation of probes and PCR primers in gene diagnosis, and the like.
摘要翻译：本发明公开了一种PACAP受体蛋白或其盐，包含编码该蛋白质的DNA片段的DNA，该蛋白质的制备方法，针对该蛋白质的抗体以及该蛋白质，DNA及抗体的用途。从牛大脑中纯化PACAP受体蛋白。从牛，大鼠和人类cDNA文库中分离编码PACAP受体蛋白的DNA，测定其核苷酸序列。此外，确定从核苷酸序列推导的氨基酸序列。 PACAP受体蛋白和编码本发明蛋白的DNA可用于（1）获得抗体和抗血清，（2）构建重组受体蛋白质的表达系统，（3）开发受体结合测定系统，使用表达系统和药物潜在化合物的筛选，（4）基于结构相似的配体和受体的比较来执行药物设计，（5）基因诊断中探针和PCR引物的制备等。

2. 发明授权

US5973117A PACAP receptor protein, method for preparing said protein, and use thereof 失效
标题翻译： PACAP受体蛋白质，所述蛋白质的制备方法及其用途
公开(公告)号：US5973117A
公开(公告)日：1999-10-26
申请号：US856154
申请日：1997-05-14
申请人： Haruo Onda , Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata , Norio Shimamoto
发明人： Haruo Onda , Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata , Norio Shimamoto
IPC分类号： A61K38/00 , C07K14/575 , C07K14/72 , C12N1/21 , C12N15/12 , C12P21/08 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/705
CPC分类号： C07K14/57563 , C07K14/72 , A61K38/00
摘要： This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein and use of the protein, DNA and antibodies.
摘要翻译：本发明公开了一种PACAP受体蛋白或其盐，包含编码该蛋白质的DNA片段的DNA，该蛋白质的制备方法，针对该蛋白质的抗体及该蛋白质，DNA及抗体的用途。

3. 发明授权

US07064181B1 Physiologically active peptide and its use 失效
标题翻译：生理活性肽及其用途
公开(公告)号：US07064181B1
公开(公告)日：2006-06-20
申请号：US09646078
申请日：1999-03-24
申请人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
发明人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
IPC分类号： C07K14/00
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/72
摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, a appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.
摘要翻译：本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

4. 发明授权

US07374910B2 DNA encoding galanin receptor activating peptide 失效
标题翻译：编码甘丙肽受体激活肽的DNA
公开(公告)号：US07374910B2
公开(公告)日：2008-05-20
申请号：US11376694
申请日：2006-03-15
申请人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
发明人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
IPC分类号： C01N15/11 , C01N15/63 , C01N5/10
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/72
摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.
摘要翻译：本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

5. 发明申请

US20060155109A1 Novel physiologically active peptide and its use 失效
标题翻译：新型生理活性肽及其用途
公开(公告)号：US20060155109A1
公开(公告)日：2006-07-13
申请号：US11376694
申请日：2006-03-15
申请人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
发明人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/72
摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof. An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.
摘要翻译：本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

6. 发明授权

US5892004A Method for preparing PACAP receptor protein 失效
标题翻译：制备PACAP受体蛋白的方法
公开(公告)号：US5892004A
公开(公告)日：1999-04-06
申请号：US855213
申请日：1997-05-13
申请人： Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi
发明人： Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi
IPC分类号： A61K38/00 , C07K14/575 , C07K14/72 , C12N1/21 , C12N15/12 , C12P21/08 , C07K1/14 , C07K1/16
CPC分类号： C07K14/57563 , C07K14/72 , A61K38/00
摘要： The present invention relates to a pituitary adenylate cyclase activating polypeptide (PACAP) receptor protein or a salt thereof which is capable of binding PACAP and a method for preparing said receptor protein or salt thereof.
摘要翻译：本发明涉及能够结合PACAP的垂体腺苷酸环化酶活化多肽（PACAP）受体蛋白或其盐，以及制备所述受体蛋白或其盐的方法。

7. 发明授权

US07217808B2 RFRP-3 and DNA thereof 失效
标题翻译： RFRP-3及其DNA
公开(公告)号：US07217808B2
公开(公告)日：2007-05-15
申请号：US11223294
申请日：2005-09-09
申请人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
发明人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
IPC分类号： C07H21/04 , C07K14/00 , C12P21/06
CPC分类号： C07K14/47 , A61K38/00
摘要： The RFRP-3 peptide of the present invention which is an agent for promoting prolactin secretion is useful as a prophylactic and/or therapeutic agent for various diseases associated with prolactin secretion, such as hypoovarianism, seminal vesicle hypoplasia, menopausal syndrome and hypothyroidism.
摘要翻译：作为促进催乳素分泌的药剂的本发明的RFRP-3肽可用作与催乳素分泌相关的各种疾病的预防和/或治疗剂，例如低血浆病，精囊发育不全，绝经期综合征和甲状腺机能减退。

8. 发明申请

US20050170461A1 Polypeptides, their production and use 审中-公开
公开(公告)号：US20050170461A1
公开(公告)日：2005-08-04
申请号：US11054211
申请日：2005-02-08
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： A61K38/00 , C07H21/04 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28 , C12N1/21 , C12N15/12
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

9. 发明授权

US06881545B1 Polypeptides, their production and use 失效
标题翻译：多肽，其生产和使用
公开(公告)号：US06881545B1
公开(公告)日：2005-04-19
申请号：US09716147
申请日：2000-11-17
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K14/575 , C07K14/705 , G01N33/53 , C07K7/08 , C07K14/72
CPC分类号： C07K14/705 , C07K14/575
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins.The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds.In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译：本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。编码配体多肽的配体多肽或DNA可用于（1）开发药物，例如垂体功能调节剂，中枢神经系统功能调节剂和胰功能调节剂，以及（2）开发受体结合测定系统，其使用重组受体蛋白的表达和药物候选化合物的筛选。特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

10. 发明授权

US07799533B2 Polypeptides, their production and use 失效
标题翻译：多肽，其生产和使用
公开(公告)号：US07799533B2
公开(公告)日：2010-09-21
申请号：US12166444
申请日：2008-07-02
申请人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
发明人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
摘要翻译：本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物，例如艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。

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