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1. 发明授权

US5266202A Reverse osmosis treatment process 失效
标题翻译：反渗透处理工艺
公开(公告)号：US5266202A
公开(公告)日：1993-11-30
申请号：US655199
申请日：1991-02-14
申请人： Shigeo Okonogi , Mamoru Tomita , Yasuo Fukuwatari , Koichi Matsumoto , Yoshitaka Tamura , Teruhiko Mizota , Atsushi Nakajima , Haruo Endo , Norio Sato , Koji Inagaki
发明人： Shigeo Okonogi , Mamoru Tomita , Yasuo Fukuwatari , Koichi Matsumoto , Yoshitaka Tamura , Teruhiko Mizota , Atsushi Nakajima , Haruo Endo , Norio Sato , Koji Inagaki
IPC分类号： A23C9/142 , B01D61/02 , B01D61/12 , B21D61/12
CPC分类号： B01D61/12 , A23C9/1427 , B01D61/022
摘要： This invention relates to a reverse osmosis treatment process, particularly a stable reverse osmosis treatment process which prevents a lowering in throughput capacity by carrying out treatment while keeping the permeate flux of a reverse osmosis membrane constant through the time of use of a module. The process of this invention can keep the throughput capacity constant, can prevent adhesion and pollution onto membrane surfaces and fouling thereon, and moreover can maintain stable operation in a continuous run.
摘要翻译：本发明涉及一种反渗透处理方法，特别是一种稳定的反渗透处理方法，其通过在使用模块时保持反渗透膜的渗透通量不变的同时进行处理，防止通过量下降。本发明的方法可以保持生产能力恒定，可以防止膜表面的粘附和污染，并在其上污染，而且可以在连续运行中保持稳定的操作。

2. 发明授权

US4971814A Water-soluble dietary fibers and method for preparation of same 失效
标题翻译：水溶性膳食纤维及其制备方法
公开(公告)号：US4971814A
公开(公告)日：1990-11-20
申请号：US459327
申请日：1989-12-29
申请人： Mamoru Tomita , Joji Ono , Yasuo Fukuwatari , Teruhiko Mizota , Kazuyoshi Nanba
发明人： Mamoru Tomita , Joji Ono , Yasuo Fukuwatari , Teruhiko Mizota , Kazuyoshi Nanba
IPC分类号： C12P19/14 , A21D2/18 , A23L1/05 , A23L1/214 , A23L1/308 , C08B37/00 , C12R1/66
CPC分类号： C12Y302/01021 , A21D2/18 , A23L19/115 , A23L33/21
摘要： Dietary fibers having average molecular weight of 2,000-15,000, which are prepared by partially hydrolyzing polysaccharides of Konnyaku powder with a cellulase derived from microorganisms belonging to the genus Aspergillus, which are readily soluble in water, which do not prevent adsorption of useful minerals such as calcium in the digestive tract, and which do not give rise to diarrhea when an excessive amount thereof is ingested.

3. 发明授权

US5296464A Bioactive agents and compositions for materials comprising the bioactive agent and a method for treating materials therewith 失效
标题翻译：用于包含生物活性剂的材料的生物活性剂和组合物以及用于处理材料的方法
公开(公告)号：US5296464A
公开(公告)日：1994-03-22
申请号：US780535
申请日：1991-10-21
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
IPC分类号： A01N63/02 , A23C9/152 , A23J1/20 , A23K1/16 , A23K1/175 , A23L3/3463 , A23L3/3526 , A61K38/00 , C07K14/79 , A61K37/14 , C07K15/22 , C12N1/38
CPC分类号： C07K14/79 , A01N63/02 , A23C9/1522 , A23J1/20 , A23K20/147 , A23K20/30 , A23L3/3463 , A23L3/3526 , A61K38/00
摘要： Bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin and having selective biological activities, i.e. growth-inhibitory activity against certain harmful microorganisms on one hand and growth-promoting activity upon certain useful microorganisms on the other hand; as well as compositions, products or materials therefor comprising the bioactive agents consisting of one or more lactoferrin-compounds selected from the group; and a method for treating materials, which are edible for human beings or animals or which are applicable to a portion of body of human beings or animals, with the bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin or the compositions comprising the bioactive agent consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin as an effective component.
摘要翻译：由选自Zn-，Cu-和Mn-乳铁蛋白的一种或多种乳铁蛋白化合物组成并具有选择性生物活性的生物活性剂，即一方面对某些有害微生物的生长抑制活性，以及一定程度上的生长促进活性另一方面有用的微生物; 以及其组合物，产品或材料，其包含由选自该组的一种或多种乳铁蛋白化合物组成的生物活性剂; 以及用于处理可用于人类或动物或适用于人或动物的一部分身体的材料的方法，所述生物活性剂由一种或多种选自以下的乳铁蛋白化合物组成：Zn- ，Cu-和Mn-乳铁蛋白或包含由一种或多种选自Zn-，Cu-和Mn-乳铁蛋白作为有效成分的乳铁蛋白化合物组成的生物活性剂的组合物。

4. 发明授权

US5656591A Antimicrobial agents and method for treating products therewith 失效
标题翻译：抗微生物剂及其制品的处理方法
公开(公告)号：US5656591A
公开(公告)日：1997-08-12
申请号：US256771
申请日：1994-11-29
申请人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokita
发明人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokita
IPC分类号： A01N63/02 , A61K38/00 , A61K38/01 , A61K38/12 , A61K38/40 , A61K38/47 , C07K14/79 , A61K37/16 , A23L3/34
CPC分类号： C07K14/79 , A01N63/02 , A61K31/43 , A61K38/12 , A61K45/06 , A61K38/00 , Y10S530/833
摘要： There is disclosed an antimicrobial agent comprising one or more of antimicrobial peptides derived from lactoferrins, and one or more of specific compounds and/or at least an antibiotic, and a method for treating matters with said antimicrobial agent. The antimicrobial agent has a potent antimicrobial activity against wide variety of microorganisms, thus it is useful not only as a medication, but also useful for making antimicrobial treatment of matters such as foods, non-medical products, and the like with safety and great efficiency.
摘要翻译： PCT No.PCT / JP92 / 01563。 371日期：1994年11月29日 102（e）日期1994年11月29日PCT 1991年11月30日PCT PCT。公开号WO93 / 14640 PCT 日本公开1993年8月5日公开了一种抗微生物剂，其包含一种或多种衍生自乳铁蛋白的抗微生物肽，以及一种或多种特定化合物和/或至少抗生素，以及用所述抗微生物剂处理物质的方法。抗微生物剂对各种微生物具有有效的抗微生物活性，因此不仅可用作药物，而且可用于以安全性和高效率对食品，非医药产品等物质进行抗菌处理。

5. 发明授权

US5314873A Milk-protein hydrolyzates and compositions for use as hair and skin treating agent 失效
标题翻译：乳蛋白水解物和用作头发和皮肤处理剂的组合物
公开(公告)号：US5314873A
公开(公告)日：1994-05-24
申请号：US701866
申请日：1991-05-17
申请人： Mamoru Tomita , Takesi Kitazawa , Seiji Kawaura , Yasuo Fukuwatari , Masanobu Nojiri
发明人： Mamoru Tomita , Takesi Kitazawa , Seiji Kawaura , Yasuo Fukuwatari , Masanobu Nojiri
IPC分类号： A61K8/64 , A61K8/98 , A61K38/00 , A61K38/01 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q19/00 , C07K4/12 , C07K14/47 , A61K37/02 , C07K1/12 , C07K3/10
CPC分类号： C07K14/4732 , A61K38/018 , A61K8/64 , A61K8/986 , A61Q19/00 , A61Q5/00 , C07K4/12 , A61Q5/02 , A61Q5/12 , Y10S530/832 , Y10S530/833
摘要： A milk-protein hydrolyzate consisting of a mixture of peptides and free amino acids having proliferation activating property on human cutaneous cells but not having antigenicity of the milk-protein may be obtained by enzymatic hydrolysis of milk protein. The peptides of the hydrolyzate have molecular weights less than 1000 daltons, and the hydrolyzate has a free aromatic amino acid/total aromatic amino acid ratio of at least 90%. Fractionation of the milk protein hydrolyzate yields a fraction consisting of a mixture of peptides. The fraction has a proliferation activating property on human cutaneous cells but does not have the antigenicity of the milk protein. The fraction contains aromatic amino acids in an amount of less than 5% by weight of total amino acids. Both the hydrolyzate and the fraction can be formulated into cosmetic compositions for application to the hair and skin.
摘要翻译：可以通过乳蛋白的酶水解获得由肽和游离氨基酸混合物组成的乳蛋白水解产物，其在人皮肤细胞上具有增殖活化性质但不具有乳蛋白的抗原性。水解产物的肽具有小于1000道尔顿的分子量，并且水解产物具有至少90％的游离芳族氨基酸/总芳族氨基酸比例。乳蛋白水解产物的分级产生由肽混合物组成的级分。该级分在人皮肤细胞上具有增殖活化性质，但不具有乳蛋白的抗原性。该级分含有少于总氨基酸重量的5％的芳香族氨基酸。水解产物和级分均可配制成用于头发和皮肤的化妆品组合物。

6. 发明授权

US5317084A Process for large-scale production of antimicrobal peptide in high purity 失效
标题翻译：大规模生产高纯度抗微生物肽的方法
公开(公告)号：US5317084A
公开(公告)日：1994-05-31
申请号：US891174
申请日：1992-05-29
申请人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Bellamy , Tomoyuki Hagiwara , Hiroyuki Matukuma
发明人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Bellamy , Tomoyuki Hagiwara , Hiroyuki Matukuma
IPC分类号： A61K38/00 , A61P31/04 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/24 , C07K14/00 , C07K14/47 , C07K14/79 , C12P21/06 , C12N9/08 , C07K3/22 , C07K13/00
CPC分类号： C07K14/79 , A61K38/00
摘要： Lactoferricin (Trade Mark), also called LFCIN (Trade Mark), a potent antimicrobial peptide, is produced by contacting an enzymatic hydrolysate of bovine lactoferrin or any mixture of peptides containing lactoferricin preferably with a butyl moiety-containing hydrophobic interaction chromatography medium, or alternatively with a carboxymethyl moiety-containing cation-exchange chromatography medium, rinsing the medium to remove unbound peptides, desorbing the lactoferricin solution at constant pH, and desalting the desorbed solution. The utility of the process is illustrated, for example, as follows. An enzymatic hydrolysate of bovine lactoferrin (600 g) was contacted with 3000 ml of BUTYL-TOYOPEARL 650M, the medium was rinsed with water, and then with McIlvaine (citric acid-sodium phosphate) buffer at pH 7.0., and lactoferricin was desorbed with McIlvaine buffer at pH 5.0. The desorbed material was desalted by contacting it with BUTYL-TOYOPEARL 650M, rinsing the medium with water to remove the buffer salts, and desorbing the lactoferricin with 10 mM HCl. A yield of 10.5 g of 99% purity was obtained. The product has applications as a safe and effective antimicrobial agent for use in oral hygiene products, cosmetics, clinical foods, etc.
摘要翻译：通过使牛乳铁蛋白的酶水解物或含有乳铁蛋白的任何混合物优选与含有丁基部分的疏水相互作用色谱介质接触来产生乳铁蛋白（商标），也称为LFCIN（商标），其是有效的抗微生物肽。用含有羧甲基部分的阳离子交换层析介质，漂洗培养基以除去未结合的肽，在恒定pH下解吸乳铁蛋白溶液，并脱盐解吸溶液。该过程的实用性例如如下所示。将牛乳铁蛋白（600g）的酶水解物与3000ml BUTYL-TOYOPEARL 650M接触，用水冲洗培养基，然后用pH 7.0的McIlaine（柠檬酸 - 磷酸钠）缓冲液洗涤，并用乳糖铁蛋白溶解 McIlvaine缓冲液pH 5.0。通过与BUTYL-TOYOPEARL 650M接触将脱附的物质脱盐，用水冲洗培养基以除去缓冲盐，并用10mM HCl解吸乳铁蛋白。得到10.5g 99％纯度的产率。该产品作为安全有效的抗微生物剂应用于口腔卫生用品，化妆品，临床食品等。

7. 发明授权

US5804555A Antioxidant 失效
标题翻译：抗氧化剂
公开(公告)号：US5804555A
公开(公告)日：1998-09-08
申请号：US381984
申请日：1995-04-11
申请人： Mamoru Tomita , Seiichi Shimamura , Kouzo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokida
发明人： Mamoru Tomita , Seiichi Shimamura , Kouzo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokida
IPC分类号： A61K8/96 , A23L3/3526 , A23L3/3571 , A61K8/00 , A61K8/64 , A61K8/66 , A61K8/98 , A61K38/00 , A61K38/16 , A61P39/06 , A61P43/00 , A61Q11/00 , A61Q19/00 , C09K15/18 , C09K15/22 , C11B5/00 , A61K38/01 , C07K14/79
CPC分类号： C09K15/18 , A23L3/3526 , A23L3/3571 , C09K15/22 , C11B5/0007
摘要： The present invention provides a safe antioxidant applicable for food, drug medicine, non-medical drug and other products. The antioxidant of the present invention contains, as an effective ingredient, an antioxidant substance selected from the group consisting of a hydrolysate of lactoferrin, one or more peptides isolated from a hydrolysate of lactoferrins, one or more synthetic peptides having the same sequence as that of the peptide isolated from the hydrolysate of lactoferrins, and any mixture thereof, or said antioxidant substance and oxidant preventive agent. This antioxidant has an excellent antioxidant action for various lipids, and is very safe even when used in foods and drug medicine. Scince it exhibits antioxidant effect with only small quantity, there is almost no adverse effect on flavor even when applied in foods and the like.
摘要翻译： PCT No.PCT / JP93 / 01090 Sec。 371日期1995年04月11日 102（e）日期1995年4月11日PCT提交1993年8月4日PCT公布。第WO94 / 03555号公报日期1994年2月17日本发明提供了适用于食品，药物，非医药等产品的安全抗氧化剂。本发明的抗氧化剂含有选自乳铁蛋白的水解产物，从乳铁蛋白水解产物分离的一种或多种肽的一种或多种肽，作为有效成分的一种或多种合成肽，具有与分离自乳铁蛋白的水解产物的肽，及其任何混合物，或所述抗氧化物质和氧化剂预防剂。这种抗氧化剂对各种脂质具有优异的抗氧化作用，即使用于食品和药物也非常安全。 Scince它仅具有少量的抗氧化作用，即使应用于食品等也几乎没有不利影响。

8. 发明授权

US5543392A Digestive tract cell activating agent of EGF and lactoferrin 失效
标题翻译： EGF和乳铁蛋白的消化道细胞活化剂
公开(公告)号：US5543392A
公开(公告)日：1996-08-06
申请号：US374785
申请日：1995-04-03
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Ichizo Shinoda
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Ichizo Shinoda
IPC分类号： A61K38/00 , A61K38/01 , A61K38/16 , A61K38/40 , A61P1/00 , A61P43/00 , A61K38/14 , A61K38/18
CPC分类号： A61K38/1808 , A61K38/40
摘要： The present invention provides an activating agent of digestive tract cells, which contains an epidermal growth factor, lactoferrins, a hydrolysate of the lactoferrins, or a mixture thereof.The activating agent of digestive tract cells of the present invention has such effects as prevention and improvement of a damage to the digestive tract, improvement of digestive tract functions deteriorating with age, and acceleration of growth and proliferation of digestive tract cells of a newborn. It is also possible to add it to, or mixed with, various food products to obtain digestive tract cels activating foods.
摘要翻译： PCT No.PCT / JP93 / 00235 Sec。 371日期：1995年4月3日 102（e）日期1995年4月3日PCT提交1993年2月25日PCT公布。公开号WO94 / 03203 日期：1994年2月17日本发明提供消化道细胞活化剂，其含有表皮生长因子，乳铁蛋白，乳铁蛋白的水解物或其混合物。本发明的消化道细胞的活化剂具有预防和改善消化道损伤，改善消化道功能随年龄恶化，加速新生儿消化道细胞生长和增殖的作用。也可以将其添加到各种食品中或与其混合以获得消化道丝激活食物。

9. 发明授权

US5322836A Bioactive agents, compositions and materials comprising said bioactive agents 失效
标题翻译：包含所述生物活性剂的生物活性剂，组合物和材料
公开(公告)号：US5322836A
公开(公告)日：1994-06-21
申请号：US917693
申请日：1991-03-06
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
IPC分类号： A61K38/16 , A23C9/123 , A23K1/16 , A23L1/30 , A61K38/00 , A61P1/12 , C07K14/79 , C12N1/20 , C12N1/38 , C12R1/01 , A61K37/14 , A23C9/12 , A23C17/00
CPC分类号： C12N1/38 , A23C9/1234 , A23K20/147 , C07K14/79 , A61K38/00 , Y10S530/832
摘要： Bioactive agents, having growth-promoting activity upon Bifidobacteria, consisting of one or more lactoferrin-compounds selected from the group consisting of bovine lactoferrin, bovine apolactoferrin and bovine Fe-lactoferrin, which can be used as it is as agents to promote proliferation of Bifidobacteria both in vivo and in vitro, and as additives to prepare compositions, materials and products to afford growth-promoting activity thereto, and to improve survivability of Bifidobacteria, if contained therein.
摘要翻译：由双歧杆菌生长促进活性的生物活性剂，由一种或多种选自牛乳铁蛋白，牛非球蛋白铁和牛铁铁乳蛋白的乳铁蛋白化合物组成，可作为促进双歧杆菌增殖的药剂以及用作制备组合物，材料和产品以提供生长促进活性的添加剂，以及如果其中包含双歧杆菌的生存能力的添加剂。

10. 发明授权

US07176014B2 Solid culture medium and method for preparing the same 失效
标题翻译：固体培养基及其制备方法
公开(公告)号：US07176014B2
公开(公告)日：2007-02-13
申请号：US10432089
申请日：2001-08-09
申请人： Kazuyoshi Sotoyama , Yasuo Fukuwatari , Yoichiro Yano , Kenji Kiyotaki , Minoru Nakagawa , Kenichiro Karino , Kazue Sasaki
发明人： Kazuyoshi Sotoyama , Yasuo Fukuwatari , Yoichiro Yano , Kenji Kiyotaki , Minoru Nakagawa , Kenichiro Karino , Kazue Sasaki
IPC分类号： C12N1/12
CPC分类号： C12N1/20 , C12N1/00 , G01N33/56911 , G01N33/56938 , G01N2333/31 , G01N2333/32
摘要： A solid medium having a 10 minute-average water absorption rate of at least 0.05 ml/minute, which is obtainable by a method for producing a solid medium comprising the steps of dissolving components of the solid medium other than solvent water into the solvent water, solidifying the obtained solution, and drying the solidified medium to remove water, wherein water is removed in such an amount that the solid medium after the removal of water should have the 10 minute-average water absorption rate of at least 0.05 ml/minute, and the amount of the solvent water is larger than a prescribed amount by an amount almost equal to the amount of the water to be removed. The solid medium does not cause growth inhibition of microorganisms due to drying, shows a superior water absorption rate to enable application of a larger amount of a sample in a short period of time, and is suitable for quick and accurate measurement tests of microbial numbers.
摘要翻译： 10.一种固体介质，其具有至少0.05ml /分钟的10分钟平均吸水率，其可通过固体介质的制备方法获得，所述方法包括将溶剂水以外的固体介质的组分溶解在溶剂水中，固化所得溶液，并干燥固化的介质以除去水，其中除去水的量使得除去水后的固体介质的10分钟平均吸水率至少为0.05ml /分钟，并且溶剂水的量大于规定量，其量几乎等于要除去的水量。固体培养基不会由于干燥而导致微生物的生长抑制，显示出优异的吸水率，能够在短时间内施加较大量的样品，并且适合于微生物数量的快速和准确的测量测试。

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