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1. 发明授权

US5804555A Antioxidant 失效
标题翻译：抗氧化剂
公开(公告)号：US5804555A
公开(公告)日：1998-09-08
申请号：US381984
申请日：1995-04-11
申请人： Mamoru Tomita , Seiichi Shimamura , Kouzo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokida
发明人： Mamoru Tomita , Seiichi Shimamura , Kouzo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokida
IPC分类号： A61K8/96 , A23L3/3526 , A23L3/3571 , A61K8/00 , A61K8/64 , A61K8/66 , A61K8/98 , A61K38/00 , A61K38/16 , A61P39/06 , A61P43/00 , A61Q11/00 , A61Q19/00 , C09K15/18 , C09K15/22 , C11B5/00 , A61K38/01 , C07K14/79
CPC分类号： C09K15/18 , A23L3/3526 , A23L3/3571 , C09K15/22 , C11B5/0007
摘要： The present invention provides a safe antioxidant applicable for food, drug medicine, non-medical drug and other products. The antioxidant of the present invention contains, as an effective ingredient, an antioxidant substance selected from the group consisting of a hydrolysate of lactoferrin, one or more peptides isolated from a hydrolysate of lactoferrins, one or more synthetic peptides having the same sequence as that of the peptide isolated from the hydrolysate of lactoferrins, and any mixture thereof, or said antioxidant substance and oxidant preventive agent. This antioxidant has an excellent antioxidant action for various lipids, and is very safe even when used in foods and drug medicine. Scince it exhibits antioxidant effect with only small quantity, there is almost no adverse effect on flavor even when applied in foods and the like.
摘要翻译： PCT No.PCT / JP93 / 01090 Sec。 371日期1995年04月11日 102（e）日期1995年4月11日PCT提交1993年8月4日PCT公布。第WO94 / 03555号公报日期1994年2月17日本发明提供了适用于食品，药物，非医药等产品的安全抗氧化剂。本发明的抗氧化剂含有选自乳铁蛋白的水解产物，从乳铁蛋白水解产物分离的一种或多种肽的一种或多种肽，作为有效成分的一种或多种合成肽，具有与分离自乳铁蛋白的水解产物的肽，及其任何混合物，或所述抗氧化物质和氧化剂预防剂。这种抗氧化剂对各种脂质具有优异的抗氧化作用，即使用于食品和药物也非常安全。 Scince它仅具有少量的抗氧化作用，即使应用于食品等也几乎没有不利影响。

2. 发明授权

US5656591A Antimicrobial agents and method for treating products therewith 失效
标题翻译：抗微生物剂及其制品的处理方法
公开(公告)号：US5656591A
公开(公告)日：1997-08-12
申请号：US256771
申请日：1994-11-29
申请人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokita
发明人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokita
IPC分类号： A01N63/02 , A61K38/00 , A61K38/01 , A61K38/12 , A61K38/40 , A61K38/47 , C07K14/79 , A61K37/16 , A23L3/34
CPC分类号： C07K14/79 , A01N63/02 , A61K31/43 , A61K38/12 , A61K45/06 , A61K38/00 , Y10S530/833
摘要： There is disclosed an antimicrobial agent comprising one or more of antimicrobial peptides derived from lactoferrins, and one or more of specific compounds and/or at least an antibiotic, and a method for treating matters with said antimicrobial agent. The antimicrobial agent has a potent antimicrobial activity against wide variety of microorganisms, thus it is useful not only as a medication, but also useful for making antimicrobial treatment of matters such as foods, non-medical products, and the like with safety and great efficiency.
摘要翻译： PCT No.PCT / JP92 / 01563。 371日期：1994年11月29日 102（e）日期1994年11月29日PCT 1991年11月30日PCT PCT。公开号WO93 / 14640 PCT 日本公开1993年8月5日公开了一种抗微生物剂，其包含一种或多种衍生自乳铁蛋白的抗微生物肽，以及一种或多种特定化合物和/或至少抗生素，以及用所述抗微生物剂处理物质的方法。抗微生物剂对各种微生物具有有效的抗微生物活性，因此不仅可用作药物，而且可用于以安全性和高效率对食品，非医药产品等物质进行抗菌处理。

3. 发明授权

US5317084A Process for large-scale production of antimicrobal peptide in high purity 失效
标题翻译：大规模生产高纯度抗微生物肽的方法
公开(公告)号：US5317084A
公开(公告)日：1994-05-31
申请号：US891174
申请日：1992-05-29
申请人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Bellamy , Tomoyuki Hagiwara , Hiroyuki Matukuma
发明人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Bellamy , Tomoyuki Hagiwara , Hiroyuki Matukuma
IPC分类号： A61K38/00 , A61P31/04 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/24 , C07K14/00 , C07K14/47 , C07K14/79 , C12P21/06 , C12N9/08 , C07K3/22 , C07K13/00
CPC分类号： C07K14/79 , A61K38/00
摘要： Lactoferricin (Trade Mark), also called LFCIN (Trade Mark), a potent antimicrobial peptide, is produced by contacting an enzymatic hydrolysate of bovine lactoferrin or any mixture of peptides containing lactoferricin preferably with a butyl moiety-containing hydrophobic interaction chromatography medium, or alternatively with a carboxymethyl moiety-containing cation-exchange chromatography medium, rinsing the medium to remove unbound peptides, desorbing the lactoferricin solution at constant pH, and desalting the desorbed solution. The utility of the process is illustrated, for example, as follows. An enzymatic hydrolysate of bovine lactoferrin (600 g) was contacted with 3000 ml of BUTYL-TOYOPEARL 650M, the medium was rinsed with water, and then with McIlvaine (citric acid-sodium phosphate) buffer at pH 7.0., and lactoferricin was desorbed with McIlvaine buffer at pH 5.0. The desorbed material was desalted by contacting it with BUTYL-TOYOPEARL 650M, rinsing the medium with water to remove the buffer salts, and desorbing the lactoferricin with 10 mM HCl. A yield of 10.5 g of 99% purity was obtained. The product has applications as a safe and effective antimicrobial agent for use in oral hygiene products, cosmetics, clinical foods, etc.
摘要翻译：通过使牛乳铁蛋白的酶水解物或含有乳铁蛋白的任何混合物优选与含有丁基部分的疏水相互作用色谱介质接触来产生乳铁蛋白（商标），也称为LFCIN（商标），其是有效的抗微生物肽。用含有羧甲基部分的阳离子交换层析介质，漂洗培养基以除去未结合的肽，在恒定pH下解吸乳铁蛋白溶液，并脱盐解吸溶液。该过程的实用性例如如下所示。将牛乳铁蛋白（600g）的酶水解物与3000ml BUTYL-TOYOPEARL 650M接触，用水冲洗培养基，然后用pH 7.0的McIlaine（柠檬酸 - 磷酸钠）缓冲液洗涤，并用乳糖铁蛋白溶解 McIlvaine缓冲液pH 5.0。通过与BUTYL-TOYOPEARL 650M接触将脱附的物质脱盐，用水冲洗培养基以除去缓冲盐，并用10mM HCl解吸乳铁蛋白。得到10.5g 99％纯度的产率。该产品作为安全有效的抗微生物剂应用于口腔卫生用品，化妆品，临床食品等。

4. 发明授权

US5389611A Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效
标题翻译：乳铁蛋白水解物用作抗菌剂和酪氨酸酶抑制剂
公开(公告)号：US5389611A
公开(公告)日：1995-02-14
申请号：US803955
申请日：1991-12-09
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02 , C07K3/10 , C07K1/12
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent, and which have remarkably more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.
摘要翻译：乳铁蛋白水解物，通过甲酸滴定测定的分解率为6％-20％，用作抗菌剂，并且具有比未水解的乳铁蛋白显着更强的活性; 和通过甲酸滴定测定的分解率为4-50％的乳铁蛋白水解物，用作酪氨酸酶抑制剂，可通过用酸或酶水解的常规方法获得，并且对加热稳定。

5. 发明授权

US5214028A Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效
标题翻译：用作抗菌剂和作为酪氨酸酶抑制剂的LACTOFERRIN水解产物
公开(公告)号：US5214028A
公开(公告)日：1993-05-25
申请号：US634763
申请日：1990-12-27
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent and which have remarkly more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.

6. 发明授权

US5296464A Bioactive agents and compositions for materials comprising the bioactive agent and a method for treating materials therewith 失效
标题翻译：用于包含生物活性剂的材料的生物活性剂和组合物以及用于处理材料的方法
公开(公告)号：US5296464A
公开(公告)日：1994-03-22
申请号：US780535
申请日：1991-10-21
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
IPC分类号： A01N63/02 , A23C9/152 , A23J1/20 , A23K1/16 , A23K1/175 , A23L3/3463 , A23L3/3526 , A61K38/00 , C07K14/79 , A61K37/14 , C07K15/22 , C12N1/38
CPC分类号： C07K14/79 , A01N63/02 , A23C9/1522 , A23J1/20 , A23K20/147 , A23K20/30 , A23L3/3463 , A23L3/3526 , A61K38/00
摘要： Bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin and having selective biological activities, i.e. growth-inhibitory activity against certain harmful microorganisms on one hand and growth-promoting activity upon certain useful microorganisms on the other hand; as well as compositions, products or materials therefor comprising the bioactive agents consisting of one or more lactoferrin-compounds selected from the group; and a method for treating materials, which are edible for human beings or animals or which are applicable to a portion of body of human beings or animals, with the bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin or the compositions comprising the bioactive agent consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin as an effective component.
摘要翻译：由选自Zn-，Cu-和Mn-乳铁蛋白的一种或多种乳铁蛋白化合物组成并具有选择性生物活性的生物活性剂，即一方面对某些有害微生物的生长抑制活性，以及一定程度上的生长促进活性另一方面有用的微生物; 以及其组合物，产品或材料，其包含由选自该组的一种或多种乳铁蛋白化合物组成的生物活性剂; 以及用于处理可用于人类或动物或适用于人或动物的一部分身体的材料的方法，所述生物活性剂由一种或多种选自以下的乳铁蛋白化合物组成：Zn- ，Cu-和Mn-乳铁蛋白或包含由一种或多种选自Zn-，Cu-和Mn-乳铁蛋白作为有效成分的乳铁蛋白化合物组成的生物活性剂的组合物。

7. 发明授权

US5543392A Digestive tract cell activating agent of EGF and lactoferrin 失效
标题翻译： EGF和乳铁蛋白的消化道细胞活化剂
公开(公告)号：US5543392A
公开(公告)日：1996-08-06
申请号：US374785
申请日：1995-04-03
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Ichizo Shinoda
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Ichizo Shinoda
IPC分类号： A61K38/00 , A61K38/01 , A61K38/16 , A61K38/40 , A61P1/00 , A61P43/00 , A61K38/14 , A61K38/18
CPC分类号： A61K38/1808 , A61K38/40
摘要： The present invention provides an activating agent of digestive tract cells, which contains an epidermal growth factor, lactoferrins, a hydrolysate of the lactoferrins, or a mixture thereof.The activating agent of digestive tract cells of the present invention has such effects as prevention and improvement of a damage to the digestive tract, improvement of digestive tract functions deteriorating with age, and acceleration of growth and proliferation of digestive tract cells of a newborn. It is also possible to add it to, or mixed with, various food products to obtain digestive tract cels activating foods.
摘要翻译： PCT No.PCT / JP93 / 00235 Sec。 371日期：1995年4月3日 102（e）日期1995年4月3日PCT提交1993年2月25日PCT公布。公开号WO94 / 03203 日期：1994年2月17日本发明提供消化道细胞活化剂，其含有表皮生长因子，乳铁蛋白，乳铁蛋白的水解物或其混合物。本发明的消化道细胞的活化剂具有预防和改善消化道损伤，改善消化道功能随年龄恶化，加速新生儿消化道细胞生长和增殖的作用。也可以将其添加到各种食品中或与其混合以获得消化道丝激活食物。

8. 发明授权

US5322836A Bioactive agents, compositions and materials comprising said bioactive agents 失效
标题翻译：包含所述生物活性剂的生物活性剂，组合物和材料
公开(公告)号：US5322836A
公开(公告)日：1994-06-21
申请号：US917693
申请日：1991-03-06
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
IPC分类号： A61K38/16 , A23C9/123 , A23K1/16 , A23L1/30 , A61K38/00 , A61P1/12 , C07K14/79 , C12N1/20 , C12N1/38 , C12R1/01 , A61K37/14 , A23C9/12 , A23C17/00
CPC分类号： C12N1/38 , A23C9/1234 , A23K20/147 , C07K14/79 , A61K38/00 , Y10S530/832
摘要： Bioactive agents, having growth-promoting activity upon Bifidobacteria, consisting of one or more lactoferrin-compounds selected from the group consisting of bovine lactoferrin, bovine apolactoferrin and bovine Fe-lactoferrin, which can be used as it is as agents to promote proliferation of Bifidobacteria both in vivo and in vitro, and as additives to prepare compositions, materials and products to afford growth-promoting activity thereto, and to improve survivability of Bifidobacteria, if contained therein.
摘要翻译：由双歧杆菌生长促进活性的生物活性剂，由一种或多种选自牛乳铁蛋白，牛非球蛋白铁和牛铁铁乳蛋白的乳铁蛋白化合物组成，可作为促进双歧杆菌增殖的药剂以及用作制备组合物，材料和产品以提供生长促进活性的添加剂，以及如果其中包含双歧杆菌的生存能力的添加剂。

9. 发明授权

US5466669A Immunostimulatory agent 失效
标题翻译：免疫刺激剂
公开(公告)号：US5466669A
公开(公告)日：1995-11-14
申请号：US971981
申请日：1993-02-19
申请人： Wolfgang Konig , Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Mitsunori Takase , Wayne R. Bellamy
发明人： Wolfgang Konig , Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Mitsunori Takase , Wayne R. Bellamy
IPC分类号： A61K38/16 , A61K8/64 , A61K38/00 , A61P37/04 , A61Q11/00 , A61Q19/00 , C07K14/475 , C07K14/79 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K14/79 , A61K8/64 , A61Q19/00 , A61K38/00 , A61Q11/00
摘要： There is disclosed an immunostimulatory agent comprising a peptide derived from lactoferrin having activity to modulate the release of inflammatory mediators from cells of the immune system. The peptide promotes the release of leukotriene B4 from polymorphonuclear neutrophils induced by activators such as the calcium ionophor A23187, It also promotes the release of histamine from mast cells induced by activators such as .alpha.-toxin-producing Staphylococcus aureus cells or the calcium ionophor A23187. The peptide is effective at low concentrations within the range of 1 to 100 ppm. By promoting the release of such inflammatory mediators the peptide can potentiate the cellular immune response and stimulate the host defense against infectious disease. This newly discovered immunostimulatory agent is useful as an active component of pharmaceuticals, hygiene products, clinical foods, etc., for prevention and treatment of bacterial, fungal, and viral infectious in humans and animals.
摘要翻译： PCT No.PCT / JP92 / 00275 Sec。 371日期：1993年2月19日 102（e）日期1993年2月19日PCT提交1992年3月7日PCT公布。公开号WO93 / 18061 日本公报1993年9月16日。公开了包含衍生自乳铁蛋白的肽的免疫刺激剂，其具有调节炎症介质从免疫系统细胞释放的活性。该肽促进白三烯B4从诸如钙离子电极A23187的激活剂诱导的多形核嗜中性粒细胞的释放。它还促进由活化剂如产生α-毒素的金黄色葡萄球菌细胞或钙离子体A23187诱导的肥大细胞释放组胺。该肽在1至100ppm范围内的低浓度下是有效的。通过促进这种炎症介质的释放，肽可以增强细胞免疫应答并刺激宿主防止感染性疾病。这种新发现的免疫刺激剂可用作药物，卫生用品，临床食品等的活性成分，用于预防和治疗感染人类和动物的细菌，真菌和病毒。

10. 发明授权

US5304251A Crystalline lactulose trihydrate and a method for its manufacture 失效
标题翻译：结晶乳果糖三水合物及其制造方法
公开(公告)号：US5304251A
公开(公告)日：1994-04-19
申请号：US926308
申请日：1992-08-10
申请人： Mamoru Tomita , Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Satoshi Nakano , Itsuko Suzawa
发明人： Mamoru Tomita , Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Satoshi Nakano , Itsuko Suzawa
IPC分类号： A23L27/30 , C07H1/00 , C07H3/04 , C13B30/02 , C13K13/00 , C13F3/00 , C07H3/00 , C08B37/00
CPC分类号： C07H3/04 , A23L27/33 , C07H1/00 , C13K13/002
摘要： A crystalline lactulose trihydrate having molecular formula of C.sub.12 H.sub.22 O.sub.11.3H.sub.2 O and a method for its manufacture, which comprises crystallization from a lactulose syrup at a temperature of 2.degree.-20.degree. C., the starting lactulose syrup having a lactulose content of 70-90% of a total solid matters by weight, and having been concentrated to the total solid matters of 65-75% by weight and a ratio of lactose to water of less than 10% by weight.
摘要翻译：分子式为C12H22O11.3H2O的结晶乳果糖三水合物及其制造方法，其包括在2℃-20℃的温度下从乳果糖糖浆中结晶，所述起始乳果糖糖浆的乳果糖含量为70-90％的总固体重量，并且已经浓缩至总固体物质的65-75重量％，乳糖与水的比例小于10重量％。

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