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1. 发明授权

US4971814A Water-soluble dietary fibers and method for preparation of same 失效
标题翻译：水溶性膳食纤维及其制备方法
公开(公告)号：US4971814A
公开(公告)日：1990-11-20
申请号：US459327
申请日：1989-12-29
申请人： Mamoru Tomita , Joji Ono , Yasuo Fukuwatari , Teruhiko Mizota , Kazuyoshi Nanba
发明人： Mamoru Tomita , Joji Ono , Yasuo Fukuwatari , Teruhiko Mizota , Kazuyoshi Nanba
IPC分类号： C12P19/14 , A21D2/18 , A23L1/05 , A23L1/214 , A23L1/308 , C08B37/00 , C12R1/66
CPC分类号： C12Y302/01021 , A21D2/18 , A23L19/115 , A23L33/21
摘要： Dietary fibers having average molecular weight of 2,000-15,000, which are prepared by partially hydrolyzing polysaccharides of Konnyaku powder with a cellulase derived from microorganisms belonging to the genus Aspergillus, which are readily soluble in water, which do not prevent adsorption of useful minerals such as calcium in the digestive tract, and which do not give rise to diarrhea when an excessive amount thereof is ingested.

2. 发明授权

US5266202A Reverse osmosis treatment process 失效
标题翻译：反渗透处理工艺
公开(公告)号：US5266202A
公开(公告)日：1993-11-30
申请号：US655199
申请日：1991-02-14
申请人： Shigeo Okonogi , Mamoru Tomita , Yasuo Fukuwatari , Koichi Matsumoto , Yoshitaka Tamura , Teruhiko Mizota , Atsushi Nakajima , Haruo Endo , Norio Sato , Koji Inagaki
发明人： Shigeo Okonogi , Mamoru Tomita , Yasuo Fukuwatari , Koichi Matsumoto , Yoshitaka Tamura , Teruhiko Mizota , Atsushi Nakajima , Haruo Endo , Norio Sato , Koji Inagaki
IPC分类号： A23C9/142 , B01D61/02 , B01D61/12 , B21D61/12
CPC分类号： B01D61/12 , A23C9/1427 , B01D61/022
摘要： This invention relates to a reverse osmosis treatment process, particularly a stable reverse osmosis treatment process which prevents a lowering in throughput capacity by carrying out treatment while keeping the permeate flux of a reverse osmosis membrane constant through the time of use of a module. The process of this invention can keep the throughput capacity constant, can prevent adhesion and pollution onto membrane surfaces and fouling thereon, and moreover can maintain stable operation in a continuous run.
摘要翻译：本发明涉及一种反渗透处理方法，特别是一种稳定的反渗透处理方法，其通过在使用模块时保持反渗透膜的渗透通量不变的同时进行处理，防止通过量下降。本发明的方法可以保持生产能力恒定，可以防止膜表面的粘附和污染，并在其上污染，而且可以在连续运行中保持稳定的操作。

3. 发明申请

US20050166911A1 Process for producing lacturose-containing powder composition, lacturose-containing powder composition obtained by the process and feed additive 失效
标题翻译：用于制备含有内含头骨的粉末组合物的方法，通过该工艺和饲料添加剂获得的含有内含头孢的粉末组合物
公开(公告)号：US20050166911A1
公开(公告)日：2005-08-04
申请号：US10516362
申请日：2003-05-28
申请人： Mamoru Tomita , Sadayuki Kokubo , Teruhiko Mizota , Nobuo Ichihashi , Nobuo Seki , Kenji Nishi
发明人： Mamoru Tomita , Sadayuki Kokubo , Teruhiko Mizota , Nobuo Ichihashi , Nobuo Seki , Kenji Nishi
IPC分类号： C13B50/00 , A23K1/16 , A23L1/30 , A23P1/06 , A61K31/7016 , A61P1/00 , C13B20/16 , C13K13/00 , C13K5/00
CPC分类号： A61K31/7016 , A23K20/163 , A23V2002/00 , A23V2250/614 , A23V2250/54246 , A23V2250/1582 , A23V2250/54252 , A23V2250/5488
摘要： A lactulose-containing powder composition is produced by preparing a raw material liquid so that a lactulose content within a powder produced following spray drying is 10 to 50% by weight, a protein content is 0.2 to 9.0 parts by weight per 1 part by weight of lactulose, and a chlorine content is no more than 0.08 parts by weight per 1 part by weight of protein, and subsequently subjecting this raw material liquid to spray drying.
摘要翻译：通过制备原料液制备含乳果糖的粉末组合物，使得喷雾干燥后产生的粉末中的乳果糖含量为10〜50重量％，蛋白质含量为每1重量份的蛋白质含量为0.2〜9.0重量份乳果糖和氯含量相对于每1重量份蛋白质不超过0.08重量份，随后使该原料液体喷雾干燥。

4. 发明授权

US4791193A Process for producing bovine lactoferrin in high purity 失效
标题翻译：制备高纯度牛乳铁蛋白的方法
公开(公告)号：US4791193A
公开(公告)日：1988-12-13
申请号：US74034
申请日：1987-07-16
申请人： Shigeo Okonogi , Mamoru Tomita , Toshio Tomimura , Yoshitaka Tamura , Teruhiko Mizota
发明人： Shigeo Okonogi , Mamoru Tomita , Toshio Tomimura , Yoshitaka Tamura , Teruhiko Mizota
IPC分类号： C07K14/00 , A23J1/20
CPC分类号： A23J1/20 , Y10S530/832 , Y10S530/833
摘要： A process for producing bovine lactoferrin in high purity form raw milk-materials containing skim milk or whey originated form cow's milk which comprises: adsoption step wherein said raw materials are contacted, at a temperature between 0.degree.-60.degree. C., with weakly acidic cation-exchanger which includes carboxymethyl groups as ion exchanging groups and has haemoglobin adsorption property more than 3.5 g/100 ml; rinsing step wherein said exchanger is washed with water to remove substances other than those adsorbed to said exchanger; and desorption step wherein the substances adsorbed to said exchanger are desorbed therefrom with a solution of one or more of salts to thereby yield highly purified bovine lactoferrin without deterirating raw milk materials. Said desorption step can be carried out in a single stage to produce lactoferrin more than 80% purity to total proteins recovered, and in two stage to attain more than 98% purity.

5. 发明授权

US4142916A Method for preparing a non-hygroscopic lactulose-containing powder 失效
标题翻译：制备非吸湿含乳果糖的粉末的方法
公开(公告)号：US4142916A
公开(公告)日：1979-03-06
申请号：US902752
申请日：1978-05-03
申请人： Katsuhiro Ogasa , Mamoru Tomita , Teruhiko Mizota
发明人： Katsuhiro Ogasa , Mamoru Tomita , Teruhiko Mizota
IPC分类号： C07H3/04 , C13K13/00 , C13F1/14
CPC分类号： C13K13/005
摘要： Method for manufacturing a lactulose powder with a low hygroscopicity by mixing ethyl alcohol to a highly hygroscopic lactulose-containing powder followed by allowing the resulting mixture to stand or stirring it for at least 1 hour, separating the lactulose-containing material insoluble in ethyl alcohol from the mixture and removing ethyl alcohol from the material separated.
摘要翻译：通过将乙醇与高吸湿性含乳果糖的粉末混合，然后使所得混合物静置或搅拌至少1小时，将不溶于乙醇的含有乳果糖的材料分离出来，制造具有低吸湿性的乳果糖粉末的方法混合物并从分离的物质中除去乙醇。

6. 发明授权

US07037377B2 Process for producing lacturose-containing powder composition, lacturose-containing powder composition obtained by the process and feed additive 失效
标题翻译：用于制备含有内含头骨的粉末组合物的方法，通过该工艺和饲料添加剂获得的含有内含头孢的粉末组合物
公开(公告)号：US07037377B2
公开(公告)日：2006-05-02
申请号：US10516362
申请日：2003-05-28
申请人： Mamoru Tomita , Sadayuki Kokubo , Teruhiko Mizota , Nobuo Ichihashi , Nobuo Seki , Kenji Nishi
发明人： Mamoru Tomita , Sadayuki Kokubo , Teruhiko Mizota , Nobuo Ichihashi , Nobuo Seki , Kenji Nishi
IPC分类号： C13F3/00 , C13D3/16
CPC分类号： A61K31/7016 , A23K20/163 , A23V2002/00 , A23V2250/614 , A23V2250/54246 , A23V2250/1582 , A23V2250/54252 , A23V2250/5488
摘要： A lactulose-containing powder composition is produced by preparing a raw material liquid so that a lactulose content within a powder produced following spray drying is 10 to 50% by weight, a protein content is 0.2 to 9.0 parts by weight per 1 part by weight of lactulose, and a chlorine content is no more than 0.08 parts by weight per 1 part by weight of protein, and subsequently subjecting this raw material liquid to spray drying.
摘要翻译：通过制备原料液制备含乳果糖的粉末组合物，使得喷雾干燥后产生的粉末中的乳果糖含量为10〜50重量％，蛋白质含量为每1重量份的蛋白质含量为0.2〜9.0重量份乳果糖和氯含量相对于每1重量份蛋白质不超过0.08重量份，随后使该原料液体喷雾干燥。

7. 发明授权

US5304251A Crystalline lactulose trihydrate and a method for its manufacture 失效
标题翻译：结晶乳果糖三水合物及其制造方法
公开(公告)号：US5304251A
公开(公告)日：1994-04-19
申请号：US926308
申请日：1992-08-10
申请人： Mamoru Tomita , Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Satoshi Nakano , Itsuko Suzawa
发明人： Mamoru Tomita , Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Satoshi Nakano , Itsuko Suzawa
IPC分类号： A23L27/30 , C07H1/00 , C07H3/04 , C13B30/02 , C13K13/00 , C13F3/00 , C07H3/00 , C08B37/00
CPC分类号： C07H3/04 , A23L27/33 , C07H1/00 , C13K13/002
摘要： A crystalline lactulose trihydrate having molecular formula of C.sub.12 H.sub.22 O.sub.11.3H.sub.2 O and a method for its manufacture, which comprises crystallization from a lactulose syrup at a temperature of 2.degree.-20.degree. C., the starting lactulose syrup having a lactulose content of 70-90% of a total solid matters by weight, and having been concentrated to the total solid matters of 65-75% by weight and a ratio of lactose to water of less than 10% by weight.
摘要翻译：分子式为C12H22O11.3H2O的结晶乳果糖三水合物及其制造方法，其包括在2℃-20℃的温度下从乳果糖糖浆中结晶，所述起始乳果糖糖浆的乳果糖含量为70-90％的总固体重量，并且已经浓缩至总固体物质的65-75重量％，乳糖与水的比例小于10重量％。

8. 发明授权

US4015020A Tartar removal by electrodialysis and potassium level control in wine 失效
标题翻译：通过电渗析去除鞑靼葡萄酒中的钾水平控制
公开(公告)号：US4015020A
公开(公告)日：1977-03-29
申请号：US572726
申请日：1975-04-29
申请人： Taro Nagasawa , Mamoru Tomita , Yoshitaka Tamura , Teruhiko Mizota
发明人： Taro Nagasawa , Mamoru Tomita , Yoshitaka Tamura , Teruhiko Mizota
IPC分类号： C12G3/08
CPC分类号： C12G3/085
摘要： A method of treating wine, comprising introducing crude wine to both the dilution and concentration chambers of an electrodialysis apparatus; operating said apparatus so that the potassium concentration of the wine in the dilution chamber falls to below 500 mg/liter and the potassium content of the wine in the concentration chamber is increased into the range 1000 to 2000 mg/liters; cooling the wine from the concentration chamber to below 10.degree. C and adding tartaric acid crystals to said wine in order to adjust the pH into the range of 2.8 to 3.2 thereby precipitating tartar; separating the tartar from the wine and admixing said wine with wine emerging from the dilution chamber of the electrodialysis apparatus in a ratio such that the potassium content of the resulting mixture is below 500 mg/liter.
摘要翻译：一种处理葡萄酒的方法，包括将粗酒引入电渗析装置的稀释和浓缩室; 操作所述装置，使得稀释室中的葡萄酒的钾浓度降至500mg /升以下，浓缩室中酒的钾含量增加到1000-2000mg /升; 将葡萄酒从浓缩室冷却至10℃以下，并将酒石酸晶体加入到所述葡萄酒中，以将pH调节至2.8至3.2的范围，从而沉淀出牙垢; 将酒石与葡萄酒分离，并将所述葡萄酒与电渗析装置的稀释室中出现的葡萄酒混合，使得所得混合物的钾含量低于500mg /升。

9. 发明授权

US5317084A Process for large-scale production of antimicrobal peptide in high purity 失效
标题翻译：大规模生产高纯度抗微生物肽的方法
公开(公告)号：US5317084A
公开(公告)日：1994-05-31
申请号：US891174
申请日：1992-05-29
申请人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Bellamy , Tomoyuki Hagiwara , Hiroyuki Matukuma
发明人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Bellamy , Tomoyuki Hagiwara , Hiroyuki Matukuma
IPC分类号： A61K38/00 , A61P31/04 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/24 , C07K14/00 , C07K14/47 , C07K14/79 , C12P21/06 , C12N9/08 , C07K3/22 , C07K13/00
CPC分类号： C07K14/79 , A61K38/00
摘要： Lactoferricin (Trade Mark), also called LFCIN (Trade Mark), a potent antimicrobial peptide, is produced by contacting an enzymatic hydrolysate of bovine lactoferrin or any mixture of peptides containing lactoferricin preferably with a butyl moiety-containing hydrophobic interaction chromatography medium, or alternatively with a carboxymethyl moiety-containing cation-exchange chromatography medium, rinsing the medium to remove unbound peptides, desorbing the lactoferricin solution at constant pH, and desalting the desorbed solution. The utility of the process is illustrated, for example, as follows. An enzymatic hydrolysate of bovine lactoferrin (600 g) was contacted with 3000 ml of BUTYL-TOYOPEARL 650M, the medium was rinsed with water, and then with McIlvaine (citric acid-sodium phosphate) buffer at pH 7.0., and lactoferricin was desorbed with McIlvaine buffer at pH 5.0. The desorbed material was desalted by contacting it with BUTYL-TOYOPEARL 650M, rinsing the medium with water to remove the buffer salts, and desorbing the lactoferricin with 10 mM HCl. A yield of 10.5 g of 99% purity was obtained. The product has applications as a safe and effective antimicrobial agent for use in oral hygiene products, cosmetics, clinical foods, etc.
摘要翻译：通过使牛乳铁蛋白的酶水解物或含有乳铁蛋白的任何混合物优选与含有丁基部分的疏水相互作用色谱介质接触来产生乳铁蛋白（商标），也称为LFCIN（商标），其是有效的抗微生物肽。用含有羧甲基部分的阳离子交换层析介质，漂洗培养基以除去未结合的肽，在恒定pH下解吸乳铁蛋白溶液，并脱盐解吸溶液。该过程的实用性例如如下所示。将牛乳铁蛋白（600g）的酶水解物与3000ml BUTYL-TOYOPEARL 650M接触，用水冲洗培养基，然后用pH 7.0的McIlaine（柠檬酸 - 磷酸钠）缓冲液洗涤，并用乳糖铁蛋白溶解 McIlvaine缓冲液pH 5.0。通过与BUTYL-TOYOPEARL 650M接触将脱附的物质脱盐，用水冲洗培养基以除去缓冲盐，并用10mM HCl解吸乳铁蛋白。得到10.5g 99％纯度的产率。该产品作为安全有效的抗微生物剂应用于口腔卫生用品，化妆品，临床食品等。

10. 发明授权

US5296464A Bioactive agents and compositions for materials comprising the bioactive agent and a method for treating materials therewith 失效
标题翻译：用于包含生物活性剂的材料的生物活性剂和组合物以及用于处理材料的方法
公开(公告)号：US5296464A
公开(公告)日：1994-03-22
申请号：US780535
申请日：1991-10-21
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
IPC分类号： A01N63/02 , A23C9/152 , A23J1/20 , A23K1/16 , A23K1/175 , A23L3/3463 , A23L3/3526 , A61K38/00 , C07K14/79 , A61K37/14 , C07K15/22 , C12N1/38
CPC分类号： C07K14/79 , A01N63/02 , A23C9/1522 , A23J1/20 , A23K20/147 , A23K20/30 , A23L3/3463 , A23L3/3526 , A61K38/00
摘要： Bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin and having selective biological activities, i.e. growth-inhibitory activity against certain harmful microorganisms on one hand and growth-promoting activity upon certain useful microorganisms on the other hand; as well as compositions, products or materials therefor comprising the bioactive agents consisting of one or more lactoferrin-compounds selected from the group; and a method for treating materials, which are edible for human beings or animals or which are applicable to a portion of body of human beings or animals, with the bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin or the compositions comprising the bioactive agent consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin as an effective component.
摘要翻译：由选自Zn-，Cu-和Mn-乳铁蛋白的一种或多种乳铁蛋白化合物组成并具有选择性生物活性的生物活性剂，即一方面对某些有害微生物的生长抑制活性，以及一定程度上的生长促进活性另一方面有用的微生物; 以及其组合物，产品或材料，其包含由选自该组的一种或多种乳铁蛋白化合物组成的生物活性剂; 以及用于处理可用于人类或动物或适用于人或动物的一部分身体的材料的方法，所述生物活性剂由一种或多种选自以下的乳铁蛋白化合物组成：Zn- ，Cu-和Mn-乳铁蛋白或包含由一种或多种选自Zn-，Cu-和Mn-乳铁蛋白作为有效成分的乳铁蛋白化合物组成的生物活性剂的组合物。

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