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1. 发明申请

US20130224849A1 BIOLOGICAL STERILIZATION INDICATOR 有权
标题翻译：生物灭菌指标
公开(公告)号：US20130224849A1
公开(公告)日：2013-08-29
申请号：US13881741
申请日：2011-10-28
申请人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
发明人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
IPC分类号： C12Q1/22
CPC分类号： C12M37/06 , C12M23/32 , C12M25/06 , C12Q1/04 , C12Q1/22 , G01N21/6486
摘要： A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
摘要翻译：生物灭菌指示剂（BI）。 BI可以包括壳体和位于壳体中的容器。容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。第二室可以包括至少一种生物活性来源。 BI还可以包括位于第一室和第二室之间的壳体中的衬底。衬底可以定位成与第一腔室和第二腔室流体连通，并且衬底可以进一步定位成使得衬底不与生物活性源直接接触。

2. 发明授权

US09322046B2 Biological sterilization indicator 有权
标题翻译：生物灭菌指标
公开(公告)号：US09322046B2
公开(公告)日：2016-04-26
申请号：US13881741
申请日：2011-10-28
申请人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
发明人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
IPC分类号： C12Q1/22 , C12Q1/04 , C12M1/00 , G01N21/64
CPC分类号： C12M37/06 , C12M23/32 , C12M25/06 , C12Q1/04 , C12Q1/22 , G01N21/6486
摘要： A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
摘要翻译：生物灭菌指示剂（BI）。 BI可以包括壳体和位于壳体中的容器。容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。第二室可以包括至少一种生物活性来源。 BI还可以包括位于第一室和第二室之间的壳体中的衬底。衬底可以定位成与第一腔室和第二腔室流体连通，并且衬底可以进一步定位成使得衬底不与生物活性源直接接触。

3. 发明申请

US20130210048A1 METHOD OF DETECTING A BIOLOGICAL ACTIVITY 审中-公开
标题翻译：检测生物活性的方法
公开(公告)号：US20130210048A1
公开(公告)日：2013-08-15
申请号：US13825143
申请日：2011-10-28
申请人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Brian J. Engel
发明人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Brian J. Engel
IPC分类号： C12Q1/22 , C12Q1/04
CPC分类号： C12Q1/22 , C12Q1/04
摘要： A method of detecting a biological activity is provided. The method includes contacting; in a liquid medium selected to facilitate a predetermined biological activity; a sample, an indicator reagent, and a substrate that receives and concentrates a biological derivative of the indicator reagent. The method further includes observing a portion of the substrate to detect the biological derivative. The method can be used to detect the presence or absence of a target cell.
摘要翻译：提供了检测生物活性的方法。该方法包括接触; 在选择用于促进预定生物活性的液体介质中; 样品，指示剂试剂和接收并浓缩指示剂试剂的生物衍生物的底物。该方法还包括观察基底的一部分以检测生物衍生物。该方法可用于检测靶细胞的存在或不存在。

4. 发明申请

US20110182770A1 BIOLOGICAL STERILIZATION INDICATOR, SYSTEM, AND METHODS OF USING SAME 有权
标题翻译：生物灭菌指示剂，系统和使用方法
公开(公告)号：US20110182770A1
公开(公告)日：2011-07-28
申请号：US13063945
申请日：2009-10-12
申请人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
发明人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
IPC分类号： A61L2/18
CPC分类号： A61L2/28 , C12Q1/22
摘要： A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
摘要翻译：一种生物灭菌指标，系统和确定灭菌过程有效性的方法。生物灭菌指示剂可以包括孢子的位点，含有液体的储存器和定位成在气氛和孢子的位置之间提供流体连通的消毒剂通道。储存器可以具有闭合状态，其中储存器不与孢子的轨迹流体连通，并且储存器与孢子的轨迹流体连通的打开状态。生物灭菌指示器系统可以包括生物灭菌指示器和适于联接到生物灭菌指示器的检测装置。在一些实施方案中，该方法可以包括测定孢子以获得特征的可检测变化，并且检测基本上所有可检测的变化。

5. 发明授权

US08969029B2 Biological sterilization indicator, system, and methods of using same 有权
标题翻译：生物灭菌指标，系统及使用方法
公开(公告)号：US08969029B2
公开(公告)日：2015-03-03
申请号：US13063945
申请日：2009-10-12
申请人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
发明人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
IPC分类号： C12Q1/22 , C12M1/00 , C12Q1/68 , A61L2/28
CPC分类号： A61L2/28 , C12Q1/22
摘要： A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
摘要翻译：一种生物灭菌指标，系统和确定灭菌过程有效性的方法。生物灭菌指示剂可以包括孢子的位点，含有液体的储存器和定位成在气氛和孢子的位置之间提供流体连通的消毒剂通道。储存器可以具有闭合状态，其中储存器不与孢子的轨迹流体连通，并且储存器与孢子的轨迹流体连通的打开状态。生物灭菌指示器系统可以包括生物灭菌指示器和适于联接到生物灭菌指示器的检测装置。在一些实施方案中，该方法可以包括测定孢子以获得特征的可检测变化，并且检测基本上所有可检测的变化。

6. 发明授权

US08802392B2 Method of determining efficacy of a sterilization process 有权
标题翻译：确定灭菌过程功效的方法
公开(公告)号：US08802392B2
公开(公告)日：2014-08-12
申请号：US13825881
申请日：2011-10-28
申请人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Kurt J. Halverson , Brian R. Engel
发明人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Kurt J. Halverson , Brian R. Engel
IPC分类号： C12Q1/22
CPC分类号： C12M37/06 , C12M23/32 , C12M25/06 , C12Q1/04 , C12Q1/22 , G01N21/6486
摘要： The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. The second indicator reagent is converted by the predetermined biological activity to a second biological derivative with a second emission spectrum. The first absorbance spectrum includes detectable absorbance in at least a portion of wavelengths present in the second emission spectrum. The first indicator reagent is received and concentrated from an aqueous liquid by a substrate, facilitating the detection of the second biological derivative.
摘要翻译：本发明提供了检测预定生物活性的方法。该方法包括使用包含具有第一吸收光谱的第一指示剂和第二指示剂试剂的含水混合物。第二指示剂通过预定的生物活性转化为具有第二发射光谱的第二生物衍生物。第一吸收光谱包括在第二发射光谱中存在的波长的至少一部分中的可检测吸光度。第一指示剂被含水液体接收并通过底物浓缩，便于检测第二生物衍生物。

7. 发明申请

US20130210067A1 METHOD OF DETECTING A BIOLOGICAL ACTIVITY 有权
标题翻译：检测生物活性的方法
公开(公告)号：US20130210067A1
公开(公告)日：2013-08-15
申请号：US13825881
申请日：2011-10-28
申请人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Kurt J. Halverson , Brian R. Engel
发明人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Kurt J. Halverson , Brian R. Engel
IPC分类号： G01N21/64
CPC分类号： C12M37/06 , C12M23/32 , C12M25/06 , C12Q1/04 , C12Q1/22 , G01N21/6486
摘要： The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. The second indicator reagent is converted by the predetermined biological activity to a second biological derivative with a second emission spectrum. The first absorbance spectrum includes detectable absorbance in at least a portion of wavelengths present in the second emission spectrum. The first indicator reagent is received and concentrated from an aqueous liquid by a substrate, facilitating the detection of the second biological derivative.
摘要翻译：本发明提供了检测预定生物活性的方法。该方法包括使用包含具有第一吸收光谱的第一指示剂和第二指示剂试剂的含水混合物。第二指示剂通过预定的生物活性转化为具有第二发射光谱的第二生物衍生物。第一吸收光谱包括在第二发射光谱中存在的波长的至少一部分中的可检测吸光度。第一指示剂被含水液体接收并通过底物浓缩，便于检测第二生物衍生物。

8. 发明申请

US20110200992A1 Biological Compositions, Articles and Methods for Monitoring Sterilization Processes 审中-公开
标题翻译：生物成分，用于监测灭菌过程的文章和方法
公开(公告)号：US20110200992A1
公开(公告)日：2011-08-18
申请号：US13123974
申请日：2009-10-16
申请人： Sailaja Chandrapati , Heather M. Webb , Kurt J. Halverson
发明人： Sailaja Chandrapati , Heather M. Webb , Kurt J. Halverson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/22
摘要： A sterility indicating composition comprising a plurality of sterilization process resistant spores; a germination medium comprising a sub-lethal amount of at least one cell-permeant nucleic acid-interacting fluorescent dye and at least one nutrient for germination of the spores; wherein the at least one cell-permeant fluorescent dye can interact with nucleic acids present in and produced by the plurality of spores during germination or during germination and outgrowth of the spores to produce an increase in fluorescence intensity, indicating that viable spores are present, and wherein the cell-permeant fluorescent dye is sufficiently stable at least at a temperature for incubating the spores to produce the increase in fluorescence intensity, a sterilization process indicator comprising the composition, and a method of determining the effectiveness of a sterilization process using the composition and indicator are disclosed.
摘要翻译：一种无菌指示组合物，其包含多个耐灭菌过程的孢子; 包含亚致死量的至少一种细胞渗透性核酸相互作用荧光染料和至少一种用于孢子发芽的营养物的发芽培养基; 其中所述至少一种细胞透过性荧光染料可以在发芽过程中或在芽孢的发芽和生长期间与存在于和由多个孢子产生的核酸相互作用以产生荧光强度的增加，从而表明存在可行的孢子，以及其中所述细胞透过性荧光染料至少在用于培养孢子以产生荧光强度增加的温度下是足够稳定的，包含该组合物的灭菌过程指示剂以及使用该组合物确定灭菌过程的有效性的方法，以及指标。

9. 发明申请

US20110195442A1 STERILITY INDICATING BIOLOGICAL COMPOSITIONS, ARTICLES AND METHODS 审中-公开
标题翻译：表明生物组成的无效性，文章和方法
公开(公告)号：US20110195442A1
公开(公告)日：2011-08-11
申请号：US13123824
申请日：2009-10-15
申请人： Sailaja Chandrapati , Heather M. Webb , Ai-Ping Wei
发明人： Sailaja Chandrapati , Heather M. Webb , Ai-Ping Wei
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , A61L2/28 , C12Q1/22
摘要： A sterility indicating composition comprising a plurality of sterilization process resistant spores which contain an active protease during germination and initial outgrowth of the spores; and a germination medium comprising at least one labeled protease substrate and at least one nutrient for germination of the spores; wherein the medium is essentially free of a) any active protease other than the active protease contained by the plurality of spores and b) any protease substrate other than the at least one labeled protease substrate, other than any protease substrate originating from the plurality of spores, and other than any protease substrate which does not compete with the labeled protease substrate for the active protease; and wherein the at least one labeled protease substrate comprises a peptide which can be cleaved by the active protease and which is labeled with one or more dye groups, at least one of which undergoes a detectable change when the peptide is cleaved by the active protease, and wherein the labeled protease substrate is stable at least at a temperature for incubating the spores, a sterilization process indicator comprising the composition, and a method of determining the effectiveness of a sterilization process using the composition and indicator are disclosed.
摘要翻译：一种不育指示组合物，其包含多个灭菌过程抗性孢子，其在萌发期间含有活性蛋白酶和孢子的初始产生; 以及包含至少一种标记的蛋白酶底物和至少一种用于孢子发芽的营养物的发芽培养基; 其中所述培养基基本上不含a）除所述多个孢子所含的活性蛋白酶以外的任何活性蛋白酶，和b）除所述至少一个标记的蛋白酶底物之外的任何蛋白酶底物，而不是源于所述多个孢子的任何蛋白酶底物，而不是与活性蛋白酶的标记的蛋白酶底物竞争的任何蛋白酶底物以外的其它蛋白酶底物; 并且其中所述至少一个标记的蛋白酶底物包含可被活性蛋白酶切割并且被一个或多个染料基团标记的肽，当肽被活性蛋白酶切割时，其至少一种经历可检测的变化，并且其中标记的蛋白酶底物至少在用于培养孢子的温度下是稳定的，包括该组合物的灭菌过程指示剂以及使用该组合物和指示剂确定灭菌过程的有效性的方法。

10. 发明申请

US20100099115A1 SYSTEMS AND METHODS FOR PREPARING AND ANALYZING SAMPLES 审中-公开
标题翻译：用于制备和分析样品的系统和方法
公开(公告)号：US20100099115A1
公开(公告)日：2010-04-22
申请号：US12515789
申请日：2007-11-20
申请人： Patrick A. Mach , Lynn P. Cloney , Chunmei Guo , Paul C. Harris , Kevin R. Katzenmaier , Barbara R. Kinnaird , Mara S. Reif-Wenner , Michelle L. Rosauer , Jeffrey D. Smith , Heather M. Webb
发明人： Patrick A. Mach , Lynn P. Cloney , Chunmei Guo , Paul C. Harris , Kevin R. Katzenmaier , Barbara R. Kinnaird , Mara S. Reif-Wenner , Michelle L. Rosauer , Jeffrey D. Smith , Heather M. Webb
IPC分类号： G01N33/53 , C12M1/34 , B01L3/00 , G01N33/569
CPC分类号： G01N33/56911 , G01N1/38 , G01N33/558 , G01N33/56938
摘要： The invention relates to systems and methods for preparing and analyzing samples (e.g., mucosal samples) for a microorganism of interest. In particular, the systems and methods are useful for detecting one or more analytes characteristic of a microorganism (i.e., microbe) of interest, such as components of cell walls that are characteristic of a microbe, particularly Staphylococcus aureus.
摘要翻译：本发明涉及用于制备和分析感兴趣的微生物的样品（例如粘膜样品）的系统和方法。特别地，所述系统和方法可用于检测感兴趣的微生物（即微生物）特征的一种或多种分析物，例如微生物特别是金黄色葡萄球菌的细胞壁组分。

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