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    • 5. 发明申请
    • METHODS AND COMPOSITIONS TO DETECT A BIOLOGICAL ACTIVITY
    • 检测生物活性的方法和组合物
    • US20130230876A1
    • 2013-09-05
    • US13883620
    • 2011-10-28
    • Stephen B. RoscoeKurt J. HalversonJesse D. MillerStephanie J. MoellerJason W. Bjork
    • Stephen B. RoscoeKurt J. HalversonJesse D. MillerStephanie J. MoellerJason W. Bjork
    • G01N21/64
    • G01N21/6486C12Q1/04
    • Compositions that comprise water, a first indicator reagent that can be converted by a first biological activity to a first biological derivative, and a plurality of particles are provided. The first indicator reagent can comprise a fluorogenic enzyme substrate having a fluorophore selected from the group consisting of umbelliferone, 7-aminocoumarin, β-naphthylamine, β-naphthol, fluorescein, resorufin, 9H-(1,3-dichloro-9,9-dimethyl acridin-2-one), rhodamine 110, a derivative of any of the foregoing fluorophores, and a combination of any of the foregoing fluorophores. The particles are capable of receiving and retaining the first biological derivative from an aqueous liquid. The first biological derivative can be indicative of a microorganism. The compositions further can comprise a gelling agent. Methods of using the compositions to detect the presence or absence of a microorganism in a sample are also provided.
    • 提供了包含水,可以通过第一生物活性转化为第一生物衍生物的第一指示剂试剂和多个颗粒的组合物。 第一指示剂可以包括具有选自伞形酮,7-氨基香豆素,β-萘胺,β-萘酚,荧光素,再次吸收的9H-(1,3-二氯-9,9-四氢 - 二甲基吖啶-2-酮),罗丹明110,任何前述荧光团的衍生物,以及任何上述荧光团的组合。 颗粒能够从水性液体中接收和保留第一生物衍生物。 第一种生物衍生物可以指示微生物。 组合物还可以包含胶凝剂。 还提供了使用组合物来检测样品中微生物的存在或不存在的方法。