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1. 发明授权

US08697374B2 Antibodies to Clostridium difficile spores and uses thereof 失效
标题翻译：艰难梭菌孢子的抗体及其用途
公开(公告)号：US08697374B2
公开(公告)日：2014-04-15
申请号：US12919254
申请日：2009-02-25
申请人： Raj Rajagopal , Ai-Ping Wei
发明人： Raj Rajagopal , Ai-Ping Wei
IPC分类号： G01N33/554 , G01N33/569
CPC分类号： G01N33/56911 , C07K16/1282 , C07K16/40 , G01N2333/33 , G01N2469/10 , G01N2800/067
摘要： The present invention provides antibodies that bind to the endospore of the bacterium Clostridium difficile, methods of making such antibodies, and methods of using such antibodies, including methods of detecting C. difficile endospores.
摘要翻译：本发明提供了结合细菌艰难梭菌的内生孢子的抗体，制备这种抗体的方法，以及使用这些抗体的方法，包括检测艰难梭菌内切孢子的方法。

2. 发明授权

US08257976B2 Monitoring of frying oil quality using combined optical interrogation methods and devices 有权
标题翻译：使用组合光学询问方法和装置监测油炸油质量
公开(公告)号：US08257976B2
公开(公告)日：2012-09-04
申请号：US12920514
申请日：2009-03-02
申请人： Ai-Ping Wei , Milind Balwant Sabade , Abolghassem B. Mahmoodi
发明人： Ai-Ping Wei , Milind Balwant Sabade , Abolghassem B. Mahmoodi
IPC分类号： G01N33/26 , G01N33/03 , G01N30/00
CPC分类号： G01N33/03 , G01N21/643 , G01N21/78 , G01N31/22
摘要： Herein are disclosed methods and devices for optically monitoring multiple parameters of an oil sample. In one embodiment, the methods and devices can be used for determining the quality of cooking or flying oil in terms of the free fatty acid content and total polar compound content of the oil. The methods use an optical absorbtive/reflective property in evaluating the free fatty acid content, and use optical fluorescence in evaluating the total polar compound content, with both measurements using a single sampling substrate and a single measuring device.
摘要翻译：本文公开了用于光学监测油样品的多个参数的方法和装置。在一个实施方案中，方法和装置可以用于根据游离脂肪酸含量和油的总极性化合物含量来确定烹饪或飞行油的质量。该方法在评估游离脂肪酸含量时使用光学吸收/反射性质，并且使用光学荧光来评估总极性化合物含量，两次测量使用单个取样基板和单个测量装置。

3. 发明申请

US20110051141A1 METHODS AND DEVICES FOR MONITORING OF FRYING OIL QUALITY 有权
标题翻译：用于监测油脂质量的方法和装置
公开(公告)号：US20110051141A1
公开(公告)日：2011-03-03
申请号：US12920520
申请日：2009-03-02
申请人： Abolghassem B. Mahmoodi , Milind Balwant Sabade , Ai-Ping Wei
发明人： Abolghassem B. Mahmoodi , Milind Balwant Sabade , Ai-Ping Wei
IPC分类号： G01N21/55
CPC分类号： G01N33/03 , G01N21/78 , G01N31/22
摘要： Herein are disclosed methods and devices for evaluating the quality of oils (e.g., cooking oil or flying oil). The methods can provide an indication of the free fatty acid content of the oil. The methods use an optical interrogation device to provide an indication of free fatty acid based on quantitative measurements of optical reflectance from test zones on a sampling substrate.
摘要翻译：这里公开了用于评估油（例如烹饪油或飞油）的质量的方法和装置。该方法可以提供油的游离脂肪酸含量的指示。该方法使用光学询问装置来提供游离脂肪酸的指示，其基于在取样基底上的测试区域的光学反射率的定量测量。

4. 发明申请

US20100260903A1 DEVICE FOR THE QUALIFICATION OF COOKING OILS, AND METHODS 审中-公开
标题翻译：烹饪油质量鉴定装置及方法
公开(公告)号：US20100260903A1
公开(公告)日：2010-10-14
申请号：US12521803
申请日：2008-01-04
申请人： Ai-Ping . Wei , Raj Rajagopal , Catherine Bineau
发明人： Ai-Ping . Wei , Raj Rajagopal , Catherine Bineau
IPC分类号： G01N33/03 , G01N33/26 , G01N21/64 , G01J1/42
CPC分类号： G01N33/03 , G01N21/6428 , G01N21/645 , G01N2201/0221 , G01N2201/0245
摘要： A method of determining the quality of oil by irradiating the oil at a first wavelength, e.g., of about 470 nm, measuring a level of fluorescence of the oil at a second wavelength, e.g., of about 520 nm, comparing the measured fluorescence level to a predetermined threshold level to determine whether or not the oil quality is acceptable. The oil is preferably discarded if the measured fluorescence level exceeds the predetermined threshold level, which can be generally dependent on the oil composition. The fluorescence is correlated to the level of polar components in the oil. Also described are devices for determining the quality of oil via fluorescence.
摘要翻译：通过以例如约470nm的第一波长（例如约470nm）照射油来测定油的质量的方法，测量在第二波长例如约520nm的油的荧光水平，将测量的荧光水平与预定的阈值水平以确定油品质量是否可接受。如果测量的荧光水平超过预定阈值水平，则油优选地被丢弃，其通常可以取决于油组成。荧光与油中极性组分的水平相关。还描述了用于通过荧光确定油质量的装置。

5. 发明授权

US06916925B1 Dye labeled imidazoquinoline compounds 失效
标题翻译：染料标记咪唑并喹啉化合物
公开(公告)号：US06916925B1
公开(公告)日：2005-07-12
申请号：US10624419
申请日：2003-07-22
申请人： Michael J. Rice , Mark A. Tomai , Ai-Ping Wei
发明人： Michael J. Rice , Mark A. Tomai , Ai-Ping Wei
IPC分类号： C07D471/04 , C09B11/08 , C09B57/10 , C09B69/00 , G01N33/68 , C07F5/02
CPC分类号： C07D471/04 , C09B11/08 , C09B57/10 , C09B69/00 , G01N33/6863
摘要： Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds arc useful, inter alia, for determining the binding and/or receptor sites of the molecules.
摘要翻译：公开了具有免疫应答调节活性的染料标记的咪唑并吡啶，咪唑并吡啶和咪唑并喹啉化合物。该化合物尤其用于测定分子的结合和/或受体位点。

6. 发明授权

US06696286B1 Method and devices for detecting and enumerating microorganisms 失效
标题翻译：用于检测和列举微生物的方法和装置
公开(公告)号：US06696286B1
公开(公告)日：2004-02-24
申请号：US09495092
申请日：2000-02-01
申请人： Kurt J. Halverson , Ai-Ping Wei , Jean Qiu , Clyde D. Calhoun , James G. Berg , James G. Bentsen , Raymond P. Johnston
发明人： Kurt J. Halverson , Ai-Ping Wei , Jean Qiu , Clyde D. Calhoun , James G. Berg , James G. Bentsen , Raymond P. Johnston
IPC分类号： C12M134
CPC分类号： C12Q1/02
摘要： A method for detecting a microorganism in a test sample is described. The method involves distributing microvolumes of a sample to a plurality of microcompartments of a culture device, incubating for a time sufficient to permit at least one cell division cycle of the microorganism, then detecting the presence or absence of the microorganism in the microcompartments. Also disclosed are devices for carrying out these methods.
摘要翻译：描述了测试样品中微生物检测方法。该方法包括将样品的微量体积分配到培养装置的多个微室中，孵育足以允许微生物的至少一个细胞分裂周期的时间，然后检测微室中的微生物的存在或不存在。还公开了用于执行这些方法的装置。

7. 发明授权

US06630588B2 Dye labeled imidazoquinoline compounds 失效
公开(公告)号：US06630588B2
公开(公告)日：2003-10-07
申请号：US10078645
申请日：2002-02-19
申请人： Michael J. Rice , Mark A. Tomai , Ai-Ping Wei
发明人： Michael J. Rice , Mark A. Tomai , Ai-Ping Wei
IPC分类号： C07D47104
CPC分类号： C07D471/04 , C09B11/08 , C09B57/10 , C09B69/00 , G01N33/6863
摘要： Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.

8. 发明申请

US20110195442A1 STERILITY INDICATING BIOLOGICAL COMPOSITIONS, ARTICLES AND METHODS 审中-公开
标题翻译：表明生物组成的无效性，文章和方法
公开(公告)号：US20110195442A1
公开(公告)日：2011-08-11
申请号：US13123824
申请日：2009-10-15
申请人： Sailaja Chandrapati , Heather M. Webb , Ai-Ping Wei
发明人： Sailaja Chandrapati , Heather M. Webb , Ai-Ping Wei
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , A61L2/28 , C12Q1/22
摘要： A sterility indicating composition comprising a plurality of sterilization process resistant spores which contain an active protease during germination and initial outgrowth of the spores; and a germination medium comprising at least one labeled protease substrate and at least one nutrient for germination of the spores; wherein the medium is essentially free of a) any active protease other than the active protease contained by the plurality of spores and b) any protease substrate other than the at least one labeled protease substrate, other than any protease substrate originating from the plurality of spores, and other than any protease substrate which does not compete with the labeled protease substrate for the active protease; and wherein the at least one labeled protease substrate comprises a peptide which can be cleaved by the active protease and which is labeled with one or more dye groups, at least one of which undergoes a detectable change when the peptide is cleaved by the active protease, and wherein the labeled protease substrate is stable at least at a temperature for incubating the spores, a sterilization process indicator comprising the composition, and a method of determining the effectiveness of a sterilization process using the composition and indicator are disclosed.
摘要翻译：一种不育指示组合物，其包含多个灭菌过程抗性孢子，其在萌发期间含有活性蛋白酶和孢子的初始产生; 以及包含至少一种标记的蛋白酶底物和至少一种用于孢子发芽的营养物的发芽培养基; 其中所述培养基基本上不含a）除所述多个孢子所含的活性蛋白酶以外的任何活性蛋白酶，和b）除所述至少一个标记的蛋白酶底物之外的任何蛋白酶底物，而不是源于所述多个孢子的任何蛋白酶底物，而不是与活性蛋白酶的标记的蛋白酶底物竞争的任何蛋白酶底物以外的其它蛋白酶底物; 并且其中所述至少一个标记的蛋白酶底物包含可被活性蛋白酶切割并且被一个或多个染料基团标记的肽，当肽被活性蛋白酶切割时，其至少一种经历可检测的变化，并且其中标记的蛋白酶底物至少在用于培养孢子的温度下是稳定的，包括该组合物的灭菌过程指示剂以及使用该组合物和指示剂确定灭菌过程的有效性的方法。

9. 发明申请

US20080306252A1 SULFONAMIDO ETHER SUBSTITUTED IMIDAZOQUINOLINES 审中-公开
标题翻译：磺酰胺取代的咪唑啉醇
公开(公告)号：US20080306252A1
公开(公告)日：2008-12-11
申请号：US12131023
申请日：2008-05-30
申请人： Stephen L. Crooks , George W. Griesgraber , Philip D. Heppner , Bryon A. Merrill , Ralph R. Roberts , Ai-Ping Wei
发明人： Stephen L. Crooks , George W. Griesgraber , Philip D. Heppner , Bryon A. Merrill , Ralph R. Roberts , Ai-Ping Wei
IPC分类号： C09B29/36 , C07D471/04
CPC分类号： C07D471/04
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译：在1位含有醚和磺酰胺或磺酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

10. 发明授权

US07256012B2 Fluorogenic protease substrates based on dye-dimerization 失效
标题翻译：基于染料二聚化的荧光蛋白酶底物
公开(公告)号：US07256012B2
公开(公告)日：2007-08-14
申请号：US10930522
申请日：2004-08-31
申请人： Ai-Ping Wei , Michael George Williams
发明人： Ai-Ping Wei , Michael George Williams
IPC分类号： C12Q1/37 , C12Q1/04 , C07K7/06 , G01N2/64
CPC分类号： C07K7/06 , C12Q1/37 , C12Q2337/40 , Y02A50/451
摘要： A method of biological assay comprises the steps of providing an enzyme substrate comprising two fluorescence dye groups bound to a flexible peptide, the dye groups being of proximity sufficiently close so as to allow free energy attractions to draw the dyes together to essentially self-quench fluorescence of the dye groups, wherein self quenching of fluorescence of the dye groups is effected by dye dimerization or stacking, and enzymatically cleaving the peptide to release the fluorescence dye groups from dye dimerization or stacking, thereby producing an increase in fluorescence intensity. A protease substrate for use in the method of the invention is also disclosed. This invention finds use in detection and identification of microorganisms, sterilization assurance, pharmaceutical discovery, enzyme assays, immunoassays, and other biological assays.
摘要翻译：一种生物测定方法包括以下步骤：提供包含与柔性肽结合的两个荧光染料基团的酶底物，所述染料组的接近度足够接近，以便使自由能吸引力将染料一起吸收到基本上自熄灭荧光的染料基团，其中染料基团的荧光自发淬灭通过染料二聚化或堆叠进行，并且酶切割肽以使荧光染料基团从染料二聚化或堆叠释放，从而产生荧光强度的增加。还公开了用于本发明方法的蛋白酶底物。本发明用于微生物的检测和鉴定，灭菌保证，药物发现，酶测定，免疫测定和其他生物测定。

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