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1. 发明授权

US09322046B2 Biological sterilization indicator 有权
标题翻译：生物灭菌指标
公开(公告)号：US09322046B2
公开(公告)日：2016-04-26
申请号：US13881741
申请日：2011-10-28
申请人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
发明人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
IPC分类号： C12Q1/22 , C12Q1/04 , C12M1/00 , G01N21/64
CPC分类号： C12M37/06 , C12M23/32 , C12M25/06 , C12Q1/04 , C12Q1/22 , G01N21/6486
摘要： A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
摘要翻译：生物灭菌指示剂（BI）。 BI可以包括壳体和位于壳体中的容器。容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。第二室可以包括至少一种生物活性来源。 BI还可以包括位于第一室和第二室之间的壳体中的衬底。衬底可以定位成与第一腔室和第二腔室流体连通，并且衬底可以进一步定位成使得衬底不与生物活性源直接接触。

2. 发明申请

US20130224849A1 BIOLOGICAL STERILIZATION INDICATOR 有权
标题翻译：生物灭菌指标
公开(公告)号：US20130224849A1
公开(公告)日：2013-08-29
申请号：US13881741
申请日：2011-10-28
申请人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
发明人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
IPC分类号： C12Q1/22
CPC分类号： C12M37/06 , C12M23/32 , C12M25/06 , C12Q1/04 , C12Q1/22 , G01N21/6486
摘要： A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
摘要翻译：生物灭菌指示剂（BI）。 BI可以包括壳体和位于壳体中的容器。容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。第二室可以包括至少一种生物活性来源。 BI还可以包括位于第一室和第二室之间的壳体中的衬底。衬底可以定位成与第一腔室和第二腔室流体连通，并且衬底可以进一步定位成使得衬底不与生物活性源直接接触。

3. 发明授权

US08840837B2 Biological sterilization indicator and method of using same 有权
标题翻译：生物灭菌指标及其使用方法
公开(公告)号：US08840837B2
公开(公告)日：2014-09-23
申请号：US13881154
申请日：2011-10-28
申请人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati , RuthAnn R. Duda
发明人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati , RuthAnn R. Duda
IPC分类号： C12Q1/22 , C12Q1/02
CPC分类号： C12Q1/22
摘要： A biological sterilization indicator (BI) and method of using same. The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a first fluid path positioned to fluidly couple the first chamber and the second chamber, and a second fluid path positioned to allow displaced gas to move out of the second chamber. The method can include moving displaced gas out of the second chamber via the second fluid path as a sterilant is moved into the second chamber via the first fluid path and/or as the liquid is moved into the second chamber via the first fluid path.
摘要翻译：生物灭菌指示剂（BI）及其使用方法。 BI可以包括壳体和位于壳体中的容器。容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。第二室可以包括至少一种生物活性来源。 BI还可以包括定位成流体耦合第一室和第二室的第一流体路径，以及定位成允许排出的气体移出第二室的第二流体路径。该方法可以包括当消毒剂经由第一流体路径移动到第二室中时和/或当液体经由第一流体路径移动到第二室中时，通过第二流体路径将移动的气体移出第二室。

4. 发明申请

US20130302849A1 BIOLOGICAL STERILIZATION INDICATOR AND METHOD OF USING SAME 有权
公开(公告)号：US20130302849A1
公开(公告)日：2013-11-14
申请号：US13881154
申请日：2011-10-28
申请人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati , RuthAnn R. Duda
发明人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati , RuthAnn R. Duda
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22
摘要： A biological sterilization indicator (BI) and method of using same. The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a first fluid path positioned to fluidly couple the first chamber and the second chamber, and a second fluid path positioned to allow displaced gas to move out of the second chamber. The method can include moving displaced gas out of the second chamber via the second fluid path as a sterilant is moved into the second chamber via the first fluid path and/or as the liquid is moved into the second chamber via the first fluid path.

5. 发明申请

US20110182770A1 BIOLOGICAL STERILIZATION INDICATOR, SYSTEM, AND METHODS OF USING SAME 有权
标题翻译：生物灭菌指示剂，系统和使用方法
公开(公告)号：US20110182770A1
公开(公告)日：2011-07-28
申请号：US13063945
申请日：2009-10-12
申请人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
发明人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
IPC分类号： A61L2/18
CPC分类号： A61L2/28 , C12Q1/22
摘要： A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
摘要翻译：一种生物灭菌指标，系统和确定灭菌过程有效性的方法。生物灭菌指示剂可以包括孢子的位点，含有液体的储存器和定位成在气氛和孢子的位置之间提供流体连通的消毒剂通道。储存器可以具有闭合状态，其中储存器不与孢子的轨迹流体连通，并且储存器与孢子的轨迹流体连通的打开状态。生物灭菌指示器系统可以包括生物灭菌指示器和适于联接到生物灭菌指示器的检测装置。在一些实施方案中，该方法可以包括测定孢子以获得特征的可检测变化，并且检测基本上所有可检测的变化。

6. 发明授权

US08969029B2 Biological sterilization indicator, system, and methods of using same 有权
标题翻译：生物灭菌指标，系统及使用方法
公开(公告)号：US08969029B2
公开(公告)日：2015-03-03
申请号：US13063945
申请日：2009-10-12
申请人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
发明人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
IPC分类号： C12Q1/22 , C12M1/00 , C12Q1/68 , A61L2/28
CPC分类号： A61L2/28 , C12Q1/22
摘要： A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
摘要翻译：一种生物灭菌指标，系统和确定灭菌过程有效性的方法。生物灭菌指示剂可以包括孢子的位点，含有液体的储存器和定位成在气氛和孢子的位置之间提供流体连通的消毒剂通道。储存器可以具有闭合状态，其中储存器不与孢子的轨迹流体连通，并且储存器与孢子的轨迹流体连通的打开状态。生物灭菌指示器系统可以包括生物灭菌指示器和适于联接到生物灭菌指示器的检测装置。在一些实施方案中，该方法可以包括测定孢子以获得特征的可检测变化，并且检测基本上所有可检测的变化。

7. 发明授权

US08980622B2 Biological sterilization indicator and method of using same 有权
标题翻译：生物灭菌指标及其使用方法
公开(公告)号：US08980622B2
公开(公告)日：2015-03-17
申请号：US13384886
申请日：2010-07-06
申请人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
发明人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
IPC分类号： C12M1/34 , A61L2/28 , C12Q1/22
CPC分类号： C12Q1/22 , A61L2/28
摘要： A biological sterilization indicator (BI) and a method of using same for assaying the lethality of a sterilization process. The BI can include a housing, which can include a first portion, and a second portion, which can be movable with respect to the first portion between a first and second position. The BI can further include a frangible container comprising a liquid. The BI can further include a spore reservoir and a projection positioned in the housing. The projection can be configured to fracture the container when the second portion of the housing is moved from the first position to the second position. The method can include maintaining a minimal cross-sectional area of space around the container when the second portion of the housing is in the first position, and fracturing the container in response to moving the second portion between the first and second positions.
摘要翻译：生物灭菌指示剂（BI）及其用于测定灭菌过程的致死性的方法。 BI可以包括可以包括第一部分的壳体和可以在第一和第二位置之间相对于第一部分移动的第二部分。 BI可进一步包括包含液体的易碎容器。 BI还可以包括孢子贮存器和位于壳体中的突起。当壳体的第二部分从第一位置移动到第二位置时，突起可被构造成使容器破裂。该方法可以包括当壳体的第二部分处于第一位置时保持围绕容器的最小的空间横截面面积，并响应于在第一和第二位置之间移动第二部分而破裂容器。

8. 发明申请

US20120149094A1 Biological Sterilization Indicator and Method of Using Same 有权
标题翻译：生物灭菌指标及其使用方法
公开(公告)号：US20120149094A1
公开(公告)日：2012-06-14
申请号：US13384886
申请日：2010-07-06
申请人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
发明人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
IPC分类号： C12M1/34 , C12M1/40
CPC分类号： C12Q1/22 , A61L2/28
摘要： A biological sterilization indicator (BI) and a method of using same for assaying the lethality of a sterilization process. The BI can include a housing, which can include a first portion, and a second portion, which can be movable with respect to the first portion between a first and second position. The BI can further include a frangible container comprising a liquid. The BI can further include a spore reservoir and a projection positioned in the housing. The projection can be configured to fracture the container when the second portion of the housing is moved from the first position to the second position. The method can include maintaining a minimal cross-sectional area of space around the container when the second portion of the housing is in the first position, and fracturing the container in response to moving the second portion between the first and second positions.
摘要翻译：生物灭菌指示剂（BI）及其用于测定灭菌过程的致死性的方法。 BI可以包括可以包括第一部分的壳体和可以在第一和第二位置之间相对于第一部分移动的第二部分。 BI可进一步包括包含液体的易碎容器。 BI还可以包括孢子贮存器和位于壳体中的突起。当壳体的第二部分从第一位置移动到第二位置时，突出部可以构造成使容器破裂。该方法可以包括当壳体的第二部分处于第一位置时保持围绕容器的最小的空间横截面面积，并且响应于在第一和第二位置之间移动第二部分来压裂容器。

9. 外观设计

USD665509S1 Sterility indicator vial 有权
标题翻译：无菌指示剂小瓶
公开(公告)号：USD665509S1
公开(公告)日：2012-08-14
申请号：US29378224
申请日：2010-11-01
申请人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
设计人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati

10. 发明申请

US20100099115A1 SYSTEMS AND METHODS FOR PREPARING AND ANALYZING SAMPLES 审中-公开
标题翻译：用于制备和分析样品的系统和方法
公开(公告)号：US20100099115A1
公开(公告)日：2010-04-22
申请号：US12515789
申请日：2007-11-20
申请人： Patrick A. Mach , Lynn P. Cloney , Chunmei Guo , Paul C. Harris , Kevin R. Katzenmaier , Barbara R. Kinnaird , Mara S. Reif-Wenner , Michelle L. Rosauer , Jeffrey D. Smith , Heather M. Webb
发明人： Patrick A. Mach , Lynn P. Cloney , Chunmei Guo , Paul C. Harris , Kevin R. Katzenmaier , Barbara R. Kinnaird , Mara S. Reif-Wenner , Michelle L. Rosauer , Jeffrey D. Smith , Heather M. Webb
IPC分类号： G01N33/53 , C12M1/34 , B01L3/00 , G01N33/569
CPC分类号： G01N33/56911 , G01N1/38 , G01N33/558 , G01N33/56938
摘要： The invention relates to systems and methods for preparing and analyzing samples (e.g., mucosal samples) for a microorganism of interest. In particular, the systems and methods are useful for detecting one or more analytes characteristic of a microorganism (i.e., microbe) of interest, such as components of cell walls that are characteristic of a microbe, particularly Staphylococcus aureus.
摘要翻译：本发明涉及用于制备和分析感兴趣的微生物的样品（例如粘膜样品）的系统和方法。特别地，所述系统和方法可用于检测感兴趣的微生物（即微生物）特征的一种或多种分析物，例如微生物特别是金黄色葡萄球菌的细胞壁组分。

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