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1. 发明申请

WO2016134436A1 SYSTEM AND METHOD FOR DELTA RELAXATION ENHANCED MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译： DELTA松弛增强磁共振成像系统与方法
公开(公告)号：WO2016134436A1
公开(公告)日：2016-09-01
申请号：PCT/CA2015/000106
申请日：2015-02-23
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PANTHER, Alexander Gyles , PIRON, Cameron Anthony , STAINSBY, Jeff Alan , HARRIS, Chad Tyler
发明人： PANTHER, Alexander Gyles , PIRON, Cameron Anthony , STAINSBY, Jeff Alan , HARRIS, Chad Tyler
IPC分类号： G01R33/54 , G01R33/46 , G01R33/56
CPC分类号： G01R33/445 , A61B5/00 , A61B5/05 , G01R33/5602 , G01R33/56518
摘要： A delta-relaxation magnetic resonance imaging (DREMR) system is provided. The system includes a main field magnet and field shifting coils. A main magnetic field with a strength B0 can be generated using the main filed magnet and the strength B0 of the main magnetic field can be varied through the use of the field-shifting coils. The DREMR system can be used to perform signal acquisition based on a pulse sequence for acquiring at least one of T2*-weighted signals imaging; MR spectroscopy signals; saturation imaging signals and MR signals for fingerprinting. The MR signal acquisition can be augmented by varying the strength B0 of the main magnetic field for at least a portion of the pulse sequence used to acquire the MR signal.
摘要翻译：提供了一种Δ-松弛磁共振成像（DREMR）系统。该系统包括一个主磁场和磁场移动线圈。可以使用主磁体产生具有强度B0的主磁场，并且可以通过使用励磁线圈来改变主磁场的强度B0。 DREMR系统可以用于基于用于获取T2 *加权信号成像中的至少一个的脉冲序列执行信号采集; MR光谱信号; 饱和成像信号和MR信号进行指纹识别。可以通过改变用于获取MR信号的脉冲序列的至少一部分来改变主磁场的强度B0来增强MR信号采集。

2. 发明申请

WO2017060753A1 METHOD, SYSTEM AND APPARATUS FOR IMAGE-GUIDED INSERTION OF IMPLANT DEVICES 审中-公开
标题翻译：用于图像引导的植入装置的方法，系统和装置
公开(公告)号：WO2017060753A1
公开(公告)日：2017-04-13
申请号：PCT/IB2015/057643
申请日：2015-10-06
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , STAINSBY, Jeff Alan , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , PIRON, Cameron Anthony
发明人： STAINSBY, Jeff Alan , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , PIRON, Cameron Anthony
IPC分类号： A61B5/055 , G01R33/56 , G01R33/563 , A61N1/36
CPC分类号： A61B5/055 , G01R33/50 , G01R33/5608 , G01R33/56341
摘要： A method of imaging an implant device in a computing device is provided. The computing device includes a processor interconnected with a memory and a display. The method includes, at the processor: obtaining a first magnetic resonance (MR) image of a patient tissue, the first MR image containing a first magnetic field strength indicator; responsive to the implant device being inserted in the patient tissue, obtaining a second MR image of the patient tissue, the second MR image containing a second magnetic field strength indicator smaller than the first magnetic field strength indicator; registering the second MR image with the first MR image; generating a composite image from the first MR image and the second MR image; and presenting the composite image on the display.
摘要翻译：提供了一种在计算设备中成像植入装置的方法。计算设备包括与存储器和显示器互连的处理器。该方法包括：在处理器处：获得患者组织的第一磁共振（MR）图像，所述第一MR图像包含第一磁场强度指示符; 响应于所述植入装置被插入患者组织中，获得患者组织的第二MR图像，所述第二MR图像包含小于所述第一磁场强度指示器的第二磁场强度指示器; 用第一MR图像注册第二MR图像; 从所述第一MR图像和所述第二MR图像生成合成图像; 并在显示器上呈现合成图像。

3. 发明申请

WO2016142744A1 SYSTEM AND METHOD FOR IMAGING MACROPHAGE ACTIVITY USING DELTA RELAXATION ENHANCED MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：使用DELTA放松增强磁共振成像来成像宏块活动的系统和方法
公开(公告)号：WO2016142744A1
公开(公告)日：2016-09-15
申请号：PCT/IB2015/051762
申请日：2015-03-11
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PIRON, Cameron Anthony , HARRIS, Chad Tyler , STAINSBY, Jeff Alan , PANTHER, Alexander Gyles
发明人： PIRON, Cameron Anthony , HARRIS, Chad Tyler , STAINSBY, Jeff Alan , PANTHER, Alexander Gyles
IPC分类号： G01R33/483 , A61B5/055 , G01R33/56
CPC分类号： A61B5/414 , A61B5/055 , A61K49/101 , G01R33/445 , G01R33/4806 , G01R33/50 , G01R33/5601
摘要： A magnetic resonance imaging (MRI) system is provided for imaging immune response of soft tissue to therapy by, prior to therapy, administering a contrast agent to the soft tissue; imaging a region of interest using delta relaxation enhanced magnetic resonance (DREMR) to define a functional section; selectively sampling local cells in the functional section; conducting immuno-assay analysis on the sampled local cells; and following therapy, further imaging said region of interest using DREMR to assess immune response of said cells to therapy.
摘要翻译：提供磁共振成像（MRI）系统，用于通过在治疗之前对软组织施用造影剂来对软组织的免疫应答进行成像; 使用Δ弛豫增强磁共振（DREMR）成像感兴趣区域以限定功能区段; 选择性地对功能部分中的局部细胞进行取样; 对取样的局部细胞进行免疫分析; 并且随后的治疗，使用DREMR进一步成像所述感兴趣区域以评估所述细胞对治疗的免疫应答。

4. 发明申请

WO2016041047A1 SYSTEM AND METHOD FOR MAGNETIC RESONANCE IMAGE ACQUISITION 审中-公开
标题翻译：用于磁共振图像获取的系统和方法
公开(公告)号：WO2016041047A1
公开(公告)日：2016-03-24
申请号：PCT/CA2014/000692
申请日：2014-09-15
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PIRON, Cameron , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , MCFADYEN, Steve
发明人： PIRON, Cameron , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , MCFADYEN, Steve
IPC分类号： G01R33/54 , G01R33/561 , H03M1/12
CPC分类号： G01R33/4625 , A61B5/055 , G01R33/3621 , G01R33/4608 , G01R33/4616 , G01R33/54 , G01R33/565 , H03M1/183
摘要： A method of data acquisition at a magnetic resonance imaging (MRI) system is provided. The system receives at least a portion of raw data for an image, and detects anomalies in the portion of raw data received. When anomalies are detected, the system can correct those anomalies dynamically, without waiting for a new scan to be ordered. The system can attempt to scan the offending portion of the raw data, either upon detection of the anomaly or at some point during the scan. The system can also correct anomalies using digital correction methods based on expected values. The anomalies can be detected based on variations from thresholds, masks and expected values all of which can be obtained using one of the ongoing scan, previously performed scans and apriori information relating to the type of scan being performed.
摘要翻译：提供了一种在磁共振成像（MRI）系统中进行数据采集的方法。系统接收图像的原始数据的至少一部分，并且检测接收的原始数据的部分中的异常。当检测到异常时，系统可以动态地纠正这些异常，而不需要等待新的扫描。系统可以在检测到异常时或扫描期间的某个时刻尝试扫描原始数据的违规部分。该系统还可以使用基于预期值的数字校正方法来校正异常。可以基于来自阈值，掩模和期望值的变化来检测异常，所有这些都可以使用正在进行的扫描，先前执行的扫描之一和与所执行的扫描类型有关的先验信息来获得。

5. 发明申请

WO2016174498A1 ADAPTIVE ELECTROMAGNET FOR HIGH PERFORMANCE MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于高性能磁共振成像的自适应电磁铁
公开(公告)号：WO2016174498A1
公开(公告)日：2016-11-03
申请号：PCT/IB2015/053062
申请日：2015-04-27
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , HARRIS, Chad Tyler , PANTHER, Alexander Gyles , MCFADYEN, Stephen B.e.
发明人： HARRIS, Chad Tyler , PANTHER, Alexander Gyles , MCFADYEN, Stephen B.e.
IPC分类号： G01R33/385 , G01R33/387
CPC分类号： G01R33/381 , G01R33/3664 , G01R33/385 , G01R33/3875 , G01R33/4833 , G01R33/543 , H01F7/064
摘要： A method of configuring a conducting grid of elements interconnected at intersecting nodes by switches is described. The method includes: constructing a background grid by connection of centroids of the cell shape of the conducting grid; identifying a subset of elements in the background grid that intersect the smooth pattern of loops; identifying a subset of elements in the conducting grid that intersect the subset of elements in the background grid; the subset of elements in the conducting grid forming a discretized pattern of loops representing the smooth pattern of loops; for each of the discretized pattern of loops identifying current-in and current-out nodes; altering the on-off state of individual switches in accordance with the discretized pattern of loops; opening the switch between each respective pair of current-in and current out nodes; and applying power to the conducting grid via at least one pair of the input and output current nodes such that the current flow through the elements generates the magnetic field profile.
摘要翻译：描述了通过交换机在交叉节点处互连的元件的导电栅格的配置方法。该方法包括：通过连接导电栅格的单元格形状的质心来构建背景网格; 识别背景网格中与循环平滑模式相交的元素的子集; 识别导电网格中与背景网格中的元素子集相交的元素的子集; 导电栅格中的元素的子集形成表示环的平滑图案的环的离散模式; 对于每个离散的模式的环路识别电流输入和电流输出节点; 根据循环的离散模式改变各个开关的开关状态; 在每个相应的一对电流输入和当前输出节点之间打开开关; 以及经由至少一对所述输入和输出电流节点向所述导电栅格施加电力，使得通过所述元件的电流产生所述磁场分布。

6. 发明申请

WO2016174497A1 SYSTEM AND METHOD FOR IMAGE WARP CORRECTION FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的图像温度校正的系统和方法
公开(公告)号：WO2016174497A1
公开(公告)日：2016-11-03
申请号：PCT/IB2015/053059
申请日：2015-04-27
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , BEATTY, Phillip J.
发明人： PANTHER, Alexander Gyles , HARRIS, Chad Tyler , BEATTY, Phillip J.
IPC分类号： G01R33/565
CPC分类号： G01R33/56572 , G01R33/385 , G01R33/4818 , G01R33/4822
摘要： A method of correcting warping of an acquired image in an MRI system, caused by non- linearities in gradient field profiles of gradient coils is set forth, comprising a) constructing a computer model representing conducting pathways for each gradient coil in said MRI system; b) calculating a predicted magnetic field at each point in space for each said gradient coil in said model; c) measuring actual magnetic field at each point in space for each said gradient coil in said MRI system; d) verifying accuracy of said model by comparing said predicted magnetic field to said actual magnetic field at each said point in space and in the event said model is not accurate then repeating a) – d), and in the event said model is accurate then; constructing a distortion map for mapping coordinates in real space to coordinates in warped space of said acquired image based on deviations of said predicted magnetic field from linearity; and unwarping said warping of the acquired image using said distortion map.
摘要翻译：提出了一种校正由梯度线圈的梯度场分布中的非线性引起的MRI系统中获得的图像的翘曲的方法，包括：a）构建表示所述MRI系统中每个梯度线圈的导电路径的计算机模型; b）在所述模型中计算每个所述梯度线圈的每个空间点处的预测磁场; c）测量所述MRI系统中每个所述梯度线圈的每个空间点处的实际磁场; d）通过将所述预测磁场与空间中的每个所述点处的所述实际磁场进行比较并且在所述模型不准确然后重复a）至d）的情况下验证所述模型的精确度，并且在所述模型是准确的情况下 ; 根据所述预测磁场的偏离线性，构造用于将实空间中的坐标映射到所述获取图像的翘曲空间中的坐标的失真图; 并且使用所述失真图来不理想所获取的图像的所述翘曲。

7. 发明申请

WO2017035626A1 CEREBROSPINAL DIFFUSION PHANTOM 审中-公开
标题翻译：骨髓扩张剂
公开(公告)号：WO2017035626A1
公开(公告)日：2017-03-09
申请号：PCT/CA2015/050849
申请日：2015-09-04
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , KERINS, Fergal , WHITTON, Gregory Allan , GMEINER, Timotheus Anton , STAINSBY, Jeff Alan , HARRIS, Chad Tyler , THINGVOLD, Sheryl Rae
发明人： KERINS, Fergal , WHITTON, Gregory Allan , GMEINER, Timotheus Anton , STAINSBY, Jeff Alan , HARRIS, Chad Tyler , THINGVOLD, Sheryl Rae
IPC分类号： G09B23/30 , A61B5/055
CPC分类号： G01R33/58 , A61B5/055 , G01R33/4806 , G01R33/56341 , G09B23/30
摘要： Disclosed herein are cerebrospinal diffusion phantoms which include a housing having a shape and size configured for insertion into a magnetic resonance coil in one or more preselected poses. A scaffold support structure is mounted on an interior of said housing and a plurality of elongated diffusion mimicking members supported on the support array. The elongated diffusion mimicking members are affixed to the scaffold support structure such that elongated diffusion mimicking members extend in directions needed to substantially emulate a 3 dimensional arrangement of cerebrospinal diffusion fiber tracts in a living organism; as well as modules for elimination of resolution based-bias, angular accuracy evaluation, diffusion rate calibration, and quality assurance image referencing. Each elongated diffusion mimicking member includes an aqueous component which can undergo diffusion along the elongated diffusion mimicking member. The phantom includes a cerebrospinal tissue mimic matrix material contained in the housing enveloping the array of elongated diffusion mimicking members. The housing is made of a material whose magnetic susceptibility substantially matches that of the cerebrospinal mimic matrix material.
摘要翻译：这里公开的是脑脊液扩散体，其包括壳体，该壳体的形状和尺寸被配置为在一个或多个预选姿势中插入到磁共振线圈中。脚手架支撑结构安装在所述壳体的内部和支撑在支撑阵列上的多个细长扩散模拟构件。细长的扩散模拟构件被固定到支架支撑结构上，使得细长的扩散模拟构件在基本上模拟生物体中脑脊髓扩散纤维束的3维排列所需的方向上延伸; 以及用于消除基于分辨率偏差，角度精度评估，扩散速率校准和质量保证图像引用的模块。每个细长扩散模拟构件包括可以沿着细长扩散模拟构件扩散的水性组分。幻影包括包含在壳体中的脑脊液组织模拟基质材料，其包围细长的扩散模拟构件阵列。壳体由其磁化率基本上与脑脊液模拟基质材料的磁化率相匹配的材料制成。

8. 发明申请

WO2014138914A1 SYSTEM AND METHOD FOR MAGNETIC RESONANCE IMAGE ACQUISITION 审中-公开
标题翻译：用于磁共振图像获取的系统和方法
公开(公告)号：WO2014138914A1
公开(公告)日：2014-09-18
申请号：PCT/CA2014/000245
申请日：2014-03-14
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PIRON, Cameron , PANTHER, Alex , LUCIANI, Vincent , HARRIS, Chad Tyler
发明人： PIRON, Cameron , PANTHER, Alex , LUCIANI, Vincent , HARRIS, Chad Tyler
IPC分类号： G01R33/565
CPC分类号： G01R33/34046 , G01R33/34007 , G01R33/34084 , G01R33/341 , G01R33/3415 , G01R33/365 , G01R33/385 , G01R33/4818 , G01R33/482 , G01R33/546 , G01R33/5608 , G01R33/565
摘要： A method of data acquisition at a magnetic resonance imaging (MRI) system is provided. The system receives at least a portion of raw data for an image, and detects anomalies in the portion of raw data received. When anomalies are detected, the system can correct those anomalies dynamically, without waiting for a new scan to be ordered. The system can attempt to scan the offending portion of the raw data, either upon detection of the anomaly or at some point during the scan. The system can also correct anomalies using digital correction methods based on expected values. The anomalies can be detected based on variations from thresholds, masks and expected values all of which can be obtained using one of the ongoing scan, previously performed scans and apriori information relating to the type of scan being performed.
摘要翻译：提供了一种在磁共振成像（MRI）系统中进行数据采集的方法。系统接收图像的原始数据的至少一部分，并且检测接收的原始数据的部分中的异常。当检测到异常时，系统可以动态地纠正这些异常，而不需要等待新的扫描。系统可以在检测到异常时或扫描期间的某个时刻尝试扫描原始数据的违规部分。该系统还可以使用基于预期值的数字校正方法来校正异常。可以基于来自阈值，掩模和期望值的变化来检测异常，所有这些都可以使用正在进行的扫描，先前执行的扫描之一和与所执行的扫描类型有关的先验信息来获得。

9. 发明申请

WO2016090453A1 SYSTEM AND METHOD FOR ELECTROMAGNET COIL CONSTRUCTION 审中-公开
标题翻译：电磁线圈结构的系统与方法
公开(公告)号：WO2016090453A1
公开(公告)日：2016-06-16
申请号：PCT/CA2014/000873
申请日：2014-12-09
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , BINDSEIL, Geron , HARRIS, Chad Tyler
发明人： BINDSEIL, Geron , HARRIS, Chad Tyler
IPC分类号： G01R33/381 , G01R33/3875 , H01F41/04
CPC分类号： G01R33/381 , G01R33/0052 , G01R33/385 , G01R33/3854 , G01R33/3875 , H01F41/04
摘要： A method of manufacturing electromagnet coils for use in a magnetic resonance imaging (MRI) system is provided. The electromagnet coils are located in a non-homogeneous external magnetic field. The method comprises forming a coil representation of a coil surface for the electromagnet coils; setting limits for performance metrics for the electromagnet coils including a magnetic field-shape metric and at least one of an external torque metric and an external force metric, the external torque metric and the external force metric based, respectively, at least in part on a torque and a force exerted on the electromagnet coil by the non-homogeneous external magnetic field; forming a performance functional, based on the coil representation and the performance metrics, for generating a current density pattern over the coil surface; optimizing the performance functional and generating a current density pattern based on the optimized performance functional; and obtaining coil windings.
摘要翻译：提供一种制造用于磁共振成像（MRI）系统的电磁线圈的方法。电磁线圈位于非均匀的外部磁场中。该方法包括形成用于电磁线圈的线圈表面的线圈表示; 设置包括磁场形状度量的电磁线圈的性能指标的限制，以及外部扭矩度量和外力度量中的至少一种，外部扭矩度量和外力度量分别至少部分地基于扭矩和由非均匀外部磁场施加在电磁线圈上的力; 基于线圈表示和性能度量形成用于在线圈表面上产生电流密度模式的性能功能; 基于优化的性能功能优化性能功能并产生电流密度模式; 并获得线圈绕组。

10. 发明申请

WO2016134437A1 SYSTEM AND METHOD FOR MAGNETIC RESONANCE COIL ARRANGEMENT 审中-公开
标题翻译：磁共振线圈布置系统与方法
公开(公告)号：WO2016134437A1
公开(公告)日：2016-09-01
申请号：PCT/CA2015/000107
申请日：2015-02-23
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , BINDSEIL, Geron André , HARRIS, Chad Tyler , HANDLER, William Bradfield , CHRONIK, Blaine Alexander
发明人： BINDSEIL, Geron André , HARRIS, Chad Tyler , HANDLER, William Bradfield , CHRONIK, Blaine Alexander
IPC分类号： G01R33/385
CPC分类号： G01R33/3856 , G01R33/3802 , G01R33/381 , G01R33/385 , G01R33/421 , G01R33/445
摘要： A magnetic resonance imaging (MRI) system is provided. The system includes a main field magnet generating a main magnetic field B0. Moreover, the system further includes an integrated magnet device. The integrated magnet device has field-shift coils including primary field-shift coils and field-shift shield coils, the primary field shift coils being placed closer to an object to be imaged within the imaging volume than the field-shift shield coils. The gradient coils are placed between the primary field-shift coils and field-shift shield coils. At least one substrate layer is included to provide mechanical support for the field-shift coils and the gradient coils.
摘要翻译：提供磁共振成像（MRI）系统。该系统包括产生主磁场B0的主磁场磁体。此外，该系统还包括集成磁体装置。集成磁体装置具有包括主场移动线圈和场移屏蔽线圈的场移动线圈，主场移动线圈被放置成比场移屏蔽线圈更靠近成像体内成像对象。梯度线圈被放置在主场移动线圈和场移屏蔽线圈之间。包括至少一个基底层以为场移线圈和梯度线圈提供机械支撑。

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