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1. 发明申请

WO2017035626A1 CEREBROSPINAL DIFFUSION PHANTOM 审中-公开
标题翻译：骨髓扩张剂
公开(公告)号：WO2017035626A1
公开(公告)日：2017-03-09
申请号：PCT/CA2015/050849
申请日：2015-09-04
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , KERINS, Fergal , WHITTON, Gregory Allan , GMEINER, Timotheus Anton , STAINSBY, Jeff Alan , HARRIS, Chad Tyler , THINGVOLD, Sheryl Rae
发明人： KERINS, Fergal , WHITTON, Gregory Allan , GMEINER, Timotheus Anton , STAINSBY, Jeff Alan , HARRIS, Chad Tyler , THINGVOLD, Sheryl Rae
IPC分类号： G09B23/30 , A61B5/055
CPC分类号： G01R33/58 , A61B5/055 , G01R33/4806 , G01R33/56341 , G09B23/30
摘要： Disclosed herein are cerebrospinal diffusion phantoms which include a housing having a shape and size configured for insertion into a magnetic resonance coil in one or more preselected poses. A scaffold support structure is mounted on an interior of said housing and a plurality of elongated diffusion mimicking members supported on the support array. The elongated diffusion mimicking members are affixed to the scaffold support structure such that elongated diffusion mimicking members extend in directions needed to substantially emulate a 3 dimensional arrangement of cerebrospinal diffusion fiber tracts in a living organism; as well as modules for elimination of resolution based-bias, angular accuracy evaluation, diffusion rate calibration, and quality assurance image referencing. Each elongated diffusion mimicking member includes an aqueous component which can undergo diffusion along the elongated diffusion mimicking member. The phantom includes a cerebrospinal tissue mimic matrix material contained in the housing enveloping the array of elongated diffusion mimicking members. The housing is made of a material whose magnetic susceptibility substantially matches that of the cerebrospinal mimic matrix material.
摘要翻译：这里公开的是脑脊液扩散体，其包括壳体，该壳体的形状和尺寸被配置为在一个或多个预选姿势中插入到磁共振线圈中。脚手架支撑结构安装在所述壳体的内部和支撑在支撑阵列上的多个细长扩散模拟构件。细长的扩散模拟构件被固定到支架支撑结构上，使得细长的扩散模拟构件在基本上模拟生物体中脑脊髓扩散纤维束的3维排列所需的方向上延伸; 以及用于消除基于分辨率偏差，角度精度评估，扩散速率校准和质量保证图像引用的模块。每个细长扩散模拟构件包括可以沿着细长扩散模拟构件扩散的水性组分。幻影包括包含在壳体中的脑脊液组织模拟基质材料，其包围细长的扩散模拟构件阵列。壳体由其磁化率基本上与脑脊液模拟基质材料的磁化率相匹配的材料制成。

2. 发明申请

WO2016134436A1 SYSTEM AND METHOD FOR DELTA RELAXATION ENHANCED MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译： DELTA松弛增强磁共振成像系统与方法
公开(公告)号：WO2016134436A1
公开(公告)日：2016-09-01
申请号：PCT/CA2015/000106
申请日：2015-02-23
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PANTHER, Alexander Gyles , PIRON, Cameron Anthony , STAINSBY, Jeff Alan , HARRIS, Chad Tyler
发明人： PANTHER, Alexander Gyles , PIRON, Cameron Anthony , STAINSBY, Jeff Alan , HARRIS, Chad Tyler
IPC分类号： G01R33/54 , G01R33/46 , G01R33/56
CPC分类号： G01R33/445 , A61B5/00 , A61B5/05 , G01R33/5602 , G01R33/56518
摘要： A delta-relaxation magnetic resonance imaging (DREMR) system is provided. The system includes a main field magnet and field shifting coils. A main magnetic field with a strength B0 can be generated using the main filed magnet and the strength B0 of the main magnetic field can be varied through the use of the field-shifting coils. The DREMR system can be used to perform signal acquisition based on a pulse sequence for acquiring at least one of T2*-weighted signals imaging; MR spectroscopy signals; saturation imaging signals and MR signals for fingerprinting. The MR signal acquisition can be augmented by varying the strength B0 of the main magnetic field for at least a portion of the pulse sequence used to acquire the MR signal.
摘要翻译：提供了一种Δ-松弛磁共振成像（DREMR）系统。该系统包括一个主磁场和磁场移动线圈。可以使用主磁体产生具有强度B0的主磁场，并且可以通过使用励磁线圈来改变主磁场的强度B0。 DREMR系统可以用于基于用于获取T2 *加权信号成像中的至少一个的脉冲序列执行信号采集; MR光谱信号; 饱和成像信号和MR信号进行指纹识别。可以通过改变用于获取MR信号的脉冲序列的至少一部分来改变主磁场的强度B0来增强MR信号采集。

3. 发明申请

WO2017060753A1 METHOD, SYSTEM AND APPARATUS FOR IMAGE-GUIDED INSERTION OF IMPLANT DEVICES 审中-公开
标题翻译：用于图像引导的植入装置的方法，系统和装置
公开(公告)号：WO2017060753A1
公开(公告)日：2017-04-13
申请号：PCT/IB2015/057643
申请日：2015-10-06
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , STAINSBY, Jeff Alan , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , PIRON, Cameron Anthony
发明人： STAINSBY, Jeff Alan , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , PIRON, Cameron Anthony
IPC分类号： A61B5/055 , G01R33/56 , G01R33/563 , A61N1/36
CPC分类号： A61B5/055 , G01R33/50 , G01R33/5608 , G01R33/56341
摘要： A method of imaging an implant device in a computing device is provided. The computing device includes a processor interconnected with a memory and a display. The method includes, at the processor: obtaining a first magnetic resonance (MR) image of a patient tissue, the first MR image containing a first magnetic field strength indicator; responsive to the implant device being inserted in the patient tissue, obtaining a second MR image of the patient tissue, the second MR image containing a second magnetic field strength indicator smaller than the first magnetic field strength indicator; registering the second MR image with the first MR image; generating a composite image from the first MR image and the second MR image; and presenting the composite image on the display.
摘要翻译：提供了一种在计算设备中成像植入装置的方法。计算设备包括与存储器和显示器互连的处理器。该方法包括：在处理器处：获得患者组织的第一磁共振（MR）图像，所述第一MR图像包含第一磁场强度指示符; 响应于所述植入装置被插入患者组织中，获得患者组织的第二MR图像，所述第二MR图像包含小于所述第一磁场强度指示器的第二磁场强度指示器; 用第一MR图像注册第二MR图像; 从所述第一MR图像和所述第二MR图像生成合成图像; 并在显示器上呈现合成图像。

4. 发明申请

WO2016142744A1 SYSTEM AND METHOD FOR IMAGING MACROPHAGE ACTIVITY USING DELTA RELAXATION ENHANCED MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：使用DELTA放松增强磁共振成像来成像宏块活动的系统和方法
公开(公告)号：WO2016142744A1
公开(公告)日：2016-09-15
申请号：PCT/IB2015/051762
申请日：2015-03-11
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PIRON, Cameron Anthony , HARRIS, Chad Tyler , STAINSBY, Jeff Alan , PANTHER, Alexander Gyles
发明人： PIRON, Cameron Anthony , HARRIS, Chad Tyler , STAINSBY, Jeff Alan , PANTHER, Alexander Gyles
IPC分类号： G01R33/483 , A61B5/055 , G01R33/56
CPC分类号： A61B5/414 , A61B5/055 , A61K49/101 , G01R33/445 , G01R33/4806 , G01R33/50 , G01R33/5601
摘要： A magnetic resonance imaging (MRI) system is provided for imaging immune response of soft tissue to therapy by, prior to therapy, administering a contrast agent to the soft tissue; imaging a region of interest using delta relaxation enhanced magnetic resonance (DREMR) to define a functional section; selectively sampling local cells in the functional section; conducting immuno-assay analysis on the sampled local cells; and following therapy, further imaging said region of interest using DREMR to assess immune response of said cells to therapy.
摘要翻译：提供磁共振成像（MRI）系统，用于通过在治疗之前对软组织施用造影剂来对软组织的免疫应答进行成像; 使用Δ弛豫增强磁共振（DREMR）成像感兴趣区域以限定功能区段; 选择性地对功能部分中的局部细胞进行取样; 对取样的局部细胞进行免疫分析; 并且随后的治疗，使用DREMR进一步成像所述感兴趣区域以评估所述细胞对治疗的免疫应答。

5. 发明申请

WO2016181182A1 MAGNETIC RESONANCE VISIBLE LABELS AND MARKERS FOR ENCODING INFORMATION 审中-公开
标题翻译：磁共振可视标签和标记编码信息
公开(公告)号：WO2016181182A1
公开(公告)日：2016-11-17
申请号：PCT/IB2015/053396
申请日：2015-05-08
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.
发明人： DYER, Kelly Noel , STAINSBY, Jeff Alan , KERINS, Fergal
IPC分类号： A61B19/00
CPC分类号： A61B5/055 , A61B90/39 , A61B90/90 , A61B90/94 , A61B90/96 , A61B2090/3933 , A61B2090/3954 , A61B2562/08 , G01R33/58
摘要： Systems and methods for manufacturing and using magnetic resonance ("MR") visible labels or markers to encode information unique to the subject or object being imaged by a magnetic resonance imaging ("MRI") system are provided. The use of such MR-visible labels or markers enables unique information associated with the subject or object being imaged to be encoded into the images of the subject or object. This information can be used to anonymize protected health information ("PHI"); to provide detailed information about a surgical simulation device, quality assurance phantom, or the like; to provide spatial orientation and registration information; or so on.
摘要翻译：提供了用于制造和使用磁共振（“MR”）可见标签或标记来编码由磁共振成像（“MRI”）系统成像的被摄体或物体特有的信息的系统和方法。使用这样的MR-可见标签或标记使与被成像对象或物体相关联的唯一信息能被编码成被摄体或物体的图像。该信息可用于匿名保护健康信息（“PHI”）; 提供关于手术模拟装置，质量保证幻影等的详细信息; 提供空间方向和注册信息; 等等。

6. 发明申请

WO2017125790A1 SYSTEMS AND METHODS FOR MAGNETIC FIELD-DEPENDENT RELAXOMETRY USING MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：使用磁共振成像进行磁场随机放松测量的系统和方法
公开(公告)号：WO2017125790A1
公开(公告)日：2017-07-27
申请号：PCT/IB2016/050341
申请日：2016-01-22
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.
发明人： HARRIS, Chad Tyler , PANTHER, Alexander Gyles , STAINSBY, Jeff Alan , DESCHENES, David Mark , BEATTY, Philip J.
IPC分类号： G01R33/50
CPC分类号： G01R33/50 , G01R33/3804 , G01R33/3815 , G01R33/445
摘要： Systems and methods for magnetic field-dependent relaxometry using magnetic resonance imaging ("MRI"] are provided. Relaxation parameters, including longitudinal relaxation time ("Tl") and transverse relaxation time ("T2"), are estimated from magnetic resonance signal data acquired at multiple different magnetic field strengths using the same MRI system. By measuring these relaxation parameters as a function of magnetic field strength, Tl dispersion data, T2 dispersion data, or both, are generated. Based on this dispersion data, quantitative physiological parameters can be estimated. As one example, iron content can be estimated from T2 dispersion data.
摘要翻译：提供了用于使用磁共振成像（“MRI”）的磁场依赖性松弛测量法的系统和方法。包括纵向弛豫时间（“T1”）和横向弛豫时间（“ T2分散数据或两者），通过测量作为磁场强度的函数的这些松弛参数，根据在多个不同磁场强度下采集的磁共振信号数据来估计T1分散数据，T2分散数据或两者根据这个分散数据，可以估计出定量的生理参数，例如，可以从T2分散数据估算铁含量。

7. 发明申请

WO2016162734A1 SHIMMING COILS FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的线圈
公开(公告)号：WO2016162734A1
公开(公告)日：2016-10-13
申请号：PCT/IB2015/052628
申请日：2015-04-10
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.
发明人： HARRIS, Chad Tyler , BEATTY, Phillip J. , PANTHER, Alexander Gyles , STAINSBY, Jeff Alan , DESCHENES, David Mark
IPC分类号： G01R33/3875
CPC分类号： G01R33/3875 , G01R33/385 , G01R33/543
摘要： A method for operating a magnetic resonance imaging (MRI) system that includes: accessing data indicating a first region for imaging a portion of a subject, the portion being placed in a main magnet of the MRI system and the main magnet generating a magnetic field; selecting, from a group of available shimming coils, a first subset of shimming coils arranged and configured such that, when the shimming coils in the first subset are driven, a homogeneity of the magnetic field at the first region is increased; and driving the shimming coils in the selected first subset of shimming coils without driving other shimming coils in the group of available shimming coils such that the homogeneity of the magnetic field at the first region increases relative to the homogeneity of the magnetic field at the first region when the shimming coils of the selected first subset are not driven.
摘要翻译：一种用于操作磁共振成像（MRI）系统的方法，包括：访问指示用于对被摄体的一部分进行成像的第一区域的数据，该部分被放置在MRI系统的主磁体中，并且主磁体产生磁场; 从一组可用的匀场线圈中选择排列和配置的第一子级的匀场线圈，使得当第一子集中的匀场线圈被驱动时，第一区域处的磁场的均匀性增加; 以及驱动所选择的调整线圈的第一子集中的匀场线圈，而不驱动可用匀场线圈组中的其他匀场线圈，使得第一区域的磁场的均匀性相对于第一区域的磁场的均匀性增加当所选择的第一子集的匀场线圈未被驱动时。

8. 发明申请

WO2017153805A1 REDUCING MAGNETIC FIELD INSTABILITIES CAUSED BY OSCILLATIONS OF A MECHANICAL CRYOCOOLER IN MAGNETIC RESONANCE SYSTEMS 审中-公开
标题翻译：减小磁共振系统中机械热电偶的振荡引起的磁场不稳定性
公开(公告)号：WO2017153805A1
公开(公告)日：2017-09-14
申请号：PCT/IB2016/051344
申请日：2016-03-09
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.
发明人： HARRIS, Chad Tyler , BINDSEIL, Geron Andre , PANTHER, Alexander Gyles , BEATTY, Philip J. , STAINSBY, Jeff Alan
IPC分类号： G01R33/38 , A61B5/055 , G01R33/28 , G01R33/3815 , G01R33/44 , H01F6/04
摘要： Described here are systems and methods for mitigating or otherwise removing the effects of short-term magnetic field instabilities caused by oscillations of the cold head in a cryogen-free magnet system used for magnetic resonance systems, such as magnetic resonance imaging ("MRI") systems, nuclear magnetic resonance ("NMR") systems, or the like.
摘要翻译：这里描述的是用于减轻或以其他方式消除由用于磁共振系统的无致冷剂磁体系统中的冷头的振荡引起的短期磁场不稳定性的影响的系统和方法，所述磁共振系统例如磁共振成像（“MRI”）系统，核磁共振（“NMR”）系统等。

9. 发明申请

WO2016142747A1 OPERATION OF THE MAGNET OF A MAGNETIC RESONANCE IMAGING (MRI) SYSTEM 审中-公开
标题翻译：磁共振成像（MRI）系统磁铁的操作
公开(公告)号：WO2016142747A1
公开(公告)日：2016-09-15
申请号：PCT/IB2015/051775
申请日：2015-03-11
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.
发明人： PIRON, Cameron Anthony , HARRIS, Chad Tyler , STAINSBY, Jeff Alan , PANTHER, Alexander Gyles , SELA, Gal
IPC分类号： A61B5/055
CPC分类号： G01R33/288 , A61B5/0033 , A61B5/055 , A61B2560/0266 , A61B2560/0276 , A61B2562/0223
摘要： Some implementations provide a method for safe operation of a magnetic resonance imaging (MRI) system, the method including: determining, at least in part by using a sensor device, location information that indicates a location of an MR- incompatible object relative to the MRI system, the MRI system generating a polarizing magnetic field for imaging a subject; based on the determined location information, determining, by a control unit associated with the MRI system, that the MR-incompatible object poses an operational hazard to the MRI system; and in response to determining that the MR-incompatible object poses an operational hazard to the MRI system, reducing, by the control unit, a strength of the polarizing magnetic field.
摘要翻译：一些实施方案提供了一种用于磁共振成像（MRI）系统的安全操作的方法，所述方法包括：至少部分地通过使用传感器装置来确定指示MR不相容对象相对于MRI的位置的位置信息系统，MRI系统产生用于成像对象的偏振磁场; 基于所确定的位置信息，通过与所述MRI系统相关联的控制单元确定所述MR不相容对象对所述MRI系统造成操作危险; 并且响应于确定MR不相容的对象对MRI系统造成操作危险，由控制单元减少极化磁场的强度。

10. 发明申请

WO2018011617A1 ADAPTIVE SHIM COILS FOR MR IMAGING 审中-公开
标题翻译：用于MR成像的自适应线圈
公开(公告)号：WO2018011617A1
公开(公告)日：2018-01-18
申请号：PCT/IB2016/054140
申请日：2016-07-11
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.
发明人： STAINSBY, Jeff Alan , HARRIS, Chad Tyler
IPC分类号： G01R33/3875 , A61B5/055 , G01R33/20 , G01R33/32 , G01R33/38 , G01R33/385
摘要： Some implementations provide a system that includes: a housing having a bore in which a subject to be image is placed; a main magnet configured to generate a volume of magnetic field within the bore, the volume of magnetic field having inhomogeneity below a defined threshold; one or more gradient coils configured to linearly vary the volume of magnetic field as a function of spatial location; one or more pulse generating coils configured to generate and apply radio frequency (RF) pulses to the volume of magnetic field in sequence to scan the portion of the subject; one or more shim gradient coils configured to perturb a spatial distribution of the linearly varying volume of magnetic field; and a control unit configured to operate the gradient coils, pulse generating coils, and shim gradient coils such that only the user-defined region within the volume of magnetic field is imaged.
摘要翻译：一些实施方式提供了一种系统，该系统包括：具有孔的壳体，放置待成像的对象的孔; 主磁体，其被配置成在所述孔内产生磁场体积，所述磁体体积具有低于限定的阈值的不均匀性; 一个或多个梯度线圈，其被配置为根据空间位置线性地改变磁场的体积; 一个或多个脉冲生成线圈，其被配置为依次生成射频（RF）脉冲并将其施加到所述磁场的体积以扫描所述对象的所述部分; 一个或多个匀场梯度线圈，其被配置成扰动所述线性变化的磁场体积的空间分布; 以及控制单元，其被配置为操作梯度线圈，脉冲生成线圈和匀场梯度线圈，使得仅磁场体积内的用户限定的区域被成像。

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