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1. 发明申请

WO2016174497A1 SYSTEM AND METHOD FOR IMAGE WARP CORRECTION FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的图像温度校正的系统和方法
公开(公告)号：WO2016174497A1
公开(公告)日：2016-11-03
申请号：PCT/IB2015/053059
申请日：2015-04-27
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , BEATTY, Phillip J.
发明人： PANTHER, Alexander Gyles , HARRIS, Chad Tyler , BEATTY, Phillip J.
IPC分类号： G01R33/565
CPC分类号： G01R33/56572 , G01R33/385 , G01R33/4818 , G01R33/4822
摘要： A method of correcting warping of an acquired image in an MRI system, caused by non- linearities in gradient field profiles of gradient coils is set forth, comprising a) constructing a computer model representing conducting pathways for each gradient coil in said MRI system; b) calculating a predicted magnetic field at each point in space for each said gradient coil in said model; c) measuring actual magnetic field at each point in space for each said gradient coil in said MRI system; d) verifying accuracy of said model by comparing said predicted magnetic field to said actual magnetic field at each said point in space and in the event said model is not accurate then repeating a) – d), and in the event said model is accurate then; constructing a distortion map for mapping coordinates in real space to coordinates in warped space of said acquired image based on deviations of said predicted magnetic field from linearity; and unwarping said warping of the acquired image using said distortion map.
摘要翻译：提出了一种校正由梯度线圈的梯度场分布中的非线性引起的MRI系统中获得的图像的翘曲的方法，包括：a）构建表示所述MRI系统中每个梯度线圈的导电路径的计算机模型; b）在所述模型中计算每个所述梯度线圈的每个空间点处的预测磁场; c）测量所述MRI系统中每个所述梯度线圈的每个空间点处的实际磁场; d）通过将所述预测磁场与空间中的每个所述点处的所述实际磁场进行比较并且在所述模型不准确然后重复a）至d）的情况下验证所述模型的精确度，并且在所述模型是准确的情况下 ; 根据所述预测磁场的偏离线性，构造用于将实空间中的坐标映射到所述获取图像的翘曲空间中的坐标的失真图; 并且使用所述失真图来不理想所获取的图像的所述翘曲。

2. 发明申请

WO2016134436A1 SYSTEM AND METHOD FOR DELTA RELAXATION ENHANCED MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译： DELTA松弛增强磁共振成像系统与方法
公开(公告)号：WO2016134436A1
公开(公告)日：2016-09-01
申请号：PCT/CA2015/000106
申请日：2015-02-23
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PANTHER, Alexander Gyles , PIRON, Cameron Anthony , STAINSBY, Jeff Alan , HARRIS, Chad Tyler
发明人： PANTHER, Alexander Gyles , PIRON, Cameron Anthony , STAINSBY, Jeff Alan , HARRIS, Chad Tyler
IPC分类号： G01R33/54 , G01R33/46 , G01R33/56
CPC分类号： G01R33/445 , A61B5/00 , A61B5/05 , G01R33/5602 , G01R33/56518
摘要： A delta-relaxation magnetic resonance imaging (DREMR) system is provided. The system includes a main field magnet and field shifting coils. A main magnetic field with a strength B0 can be generated using the main filed magnet and the strength B0 of the main magnetic field can be varied through the use of the field-shifting coils. The DREMR system can be used to perform signal acquisition based on a pulse sequence for acquiring at least one of T2*-weighted signals imaging; MR spectroscopy signals; saturation imaging signals and MR signals for fingerprinting. The MR signal acquisition can be augmented by varying the strength B0 of the main magnetic field for at least a portion of the pulse sequence used to acquire the MR signal.
摘要翻译：提供了一种Δ-松弛磁共振成像（DREMR）系统。该系统包括一个主磁场和磁场移动线圈。可以使用主磁体产生具有强度B0的主磁场，并且可以通过使用励磁线圈来改变主磁场的强度B0。 DREMR系统可以用于基于用于获取T2 *加权信号成像中的至少一个的脉冲序列执行信号采集; MR光谱信号; 饱和成像信号和MR信号进行指纹识别。可以通过改变用于获取MR信号的脉冲序列的至少一部分来改变主磁场的强度B0来增强MR信号采集。

3. 发明申请

WO2016041047A1 SYSTEM AND METHOD FOR MAGNETIC RESONANCE IMAGE ACQUISITION 审中-公开
标题翻译：用于磁共振图像获取的系统和方法
公开(公告)号：WO2016041047A1
公开(公告)日：2016-03-24
申请号：PCT/CA2014/000692
申请日：2014-09-15
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PIRON, Cameron , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , MCFADYEN, Steve
发明人： PIRON, Cameron , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , MCFADYEN, Steve
IPC分类号： G01R33/54 , G01R33/561 , H03M1/12
CPC分类号： G01R33/4625 , A61B5/055 , G01R33/3621 , G01R33/4608 , G01R33/4616 , G01R33/54 , G01R33/565 , H03M1/183
摘要： A method of data acquisition at a magnetic resonance imaging (MRI) system is provided. The system receives at least a portion of raw data for an image, and detects anomalies in the portion of raw data received. When anomalies are detected, the system can correct those anomalies dynamically, without waiting for a new scan to be ordered. The system can attempt to scan the offending portion of the raw data, either upon detection of the anomaly or at some point during the scan. The system can also correct anomalies using digital correction methods based on expected values. The anomalies can be detected based on variations from thresholds, masks and expected values all of which can be obtained using one of the ongoing scan, previously performed scans and apriori information relating to the type of scan being performed.
摘要翻译：提供了一种在磁共振成像（MRI）系统中进行数据采集的方法。系统接收图像的原始数据的至少一部分，并且检测接收的原始数据的部分中的异常。当检测到异常时，系统可以动态地纠正这些异常，而不需要等待新的扫描。系统可以在检测到异常时或扫描期间的某个时刻尝试扫描原始数据的违规部分。该系统还可以使用基于预期值的数字校正方法来校正异常。可以基于来自阈值，掩模和期望值的变化来检测异常，所有这些都可以使用正在进行的扫描，先前执行的扫描之一和与所执行的扫描类型有关的先验信息来获得。

4. 发明申请

WO2017060753A1 METHOD, SYSTEM AND APPARATUS FOR IMAGE-GUIDED INSERTION OF IMPLANT DEVICES 审中-公开
标题翻译：用于图像引导的植入装置的方法，系统和装置
公开(公告)号：WO2017060753A1
公开(公告)日：2017-04-13
申请号：PCT/IB2015/057643
申请日：2015-10-06
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , STAINSBY, Jeff Alan , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , PIRON, Cameron Anthony
发明人： STAINSBY, Jeff Alan , PANTHER, Alexander Gyles , HARRIS, Chad Tyler , PIRON, Cameron Anthony
IPC分类号： A61B5/055 , G01R33/56 , G01R33/563 , A61N1/36
CPC分类号： A61B5/055 , G01R33/50 , G01R33/5608 , G01R33/56341
摘要： A method of imaging an implant device in a computing device is provided. The computing device includes a processor interconnected with a memory and a display. The method includes, at the processor: obtaining a first magnetic resonance (MR) image of a patient tissue, the first MR image containing a first magnetic field strength indicator; responsive to the implant device being inserted in the patient tissue, obtaining a second MR image of the patient tissue, the second MR image containing a second magnetic field strength indicator smaller than the first magnetic field strength indicator; registering the second MR image with the first MR image; generating a composite image from the first MR image and the second MR image; and presenting the composite image on the display.
摘要翻译：提供了一种在计算设备中成像植入装置的方法。计算设备包括与存储器和显示器互连的处理器。该方法包括：在处理器处：获得患者组织的第一磁共振（MR）图像，所述第一MR图像包含第一磁场强度指示符; 响应于所述植入装置被插入患者组织中，获得患者组织的第二MR图像，所述第二MR图像包含小于所述第一磁场强度指示器的第二磁场强度指示器; 用第一MR图像注册第二MR图像; 从所述第一MR图像和所述第二MR图像生成合成图像; 并在显示器上呈现合成图像。

5. 发明申请

WO2016174498A1 ADAPTIVE ELECTROMAGNET FOR HIGH PERFORMANCE MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于高性能磁共振成像的自适应电磁铁
公开(公告)号：WO2016174498A1
公开(公告)日：2016-11-03
申请号：PCT/IB2015/053062
申请日：2015-04-27
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , HARRIS, Chad Tyler , PANTHER, Alexander Gyles , MCFADYEN, Stephen B.e.
发明人： HARRIS, Chad Tyler , PANTHER, Alexander Gyles , MCFADYEN, Stephen B.e.
IPC分类号： G01R33/385 , G01R33/387
CPC分类号： G01R33/381 , G01R33/3664 , G01R33/385 , G01R33/3875 , G01R33/4833 , G01R33/543 , H01F7/064
摘要： A method of configuring a conducting grid of elements interconnected at intersecting nodes by switches is described. The method includes: constructing a background grid by connection of centroids of the cell shape of the conducting grid; identifying a subset of elements in the background grid that intersect the smooth pattern of loops; identifying a subset of elements in the conducting grid that intersect the subset of elements in the background grid; the subset of elements in the conducting grid forming a discretized pattern of loops representing the smooth pattern of loops; for each of the discretized pattern of loops identifying current-in and current-out nodes; altering the on-off state of individual switches in accordance with the discretized pattern of loops; opening the switch between each respective pair of current-in and current out nodes; and applying power to the conducting grid via at least one pair of the input and output current nodes such that the current flow through the elements generates the magnetic field profile.
摘要翻译：描述了通过交换机在交叉节点处互连的元件的导电栅格的配置方法。该方法包括：通过连接导电栅格的单元格形状的质心来构建背景网格; 识别背景网格中与循环平滑模式相交的元素的子集; 识别导电网格中与背景网格中的元素子集相交的元素的子集; 导电栅格中的元素的子集形成表示环的平滑图案的环的离散模式; 对于每个离散的模式的环路识别电流输入和电流输出节点; 根据循环的离散模式改变各个开关的开关状态; 在每个相应的一对电流输入和当前输出节点之间打开开关; 以及经由至少一对所述输入和输出电流节点向所述导电栅格施加电力，使得通过所述元件的电流产生所述磁场分布。

6. 发明申请

WO2016142744A1 SYSTEM AND METHOD FOR IMAGING MACROPHAGE ACTIVITY USING DELTA RELAXATION ENHANCED MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：使用DELTA放松增强磁共振成像来成像宏块活动的系统和方法
公开(公告)号：WO2016142744A1
公开(公告)日：2016-09-15
申请号：PCT/IB2015/051762
申请日：2015-03-11
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PIRON, Cameron Anthony , HARRIS, Chad Tyler , STAINSBY, Jeff Alan , PANTHER, Alexander Gyles
发明人： PIRON, Cameron Anthony , HARRIS, Chad Tyler , STAINSBY, Jeff Alan , PANTHER, Alexander Gyles
IPC分类号： G01R33/483 , A61B5/055 , G01R33/56
CPC分类号： A61B5/414 , A61B5/055 , A61K49/101 , G01R33/445 , G01R33/4806 , G01R33/50 , G01R33/5601
摘要： A magnetic resonance imaging (MRI) system is provided for imaging immune response of soft tissue to therapy by, prior to therapy, administering a contrast agent to the soft tissue; imaging a region of interest using delta relaxation enhanced magnetic resonance (DREMR) to define a functional section; selectively sampling local cells in the functional section; conducting immuno-assay analysis on the sampled local cells; and following therapy, further imaging said region of interest using DREMR to assess immune response of said cells to therapy.
摘要翻译：提供磁共振成像（MRI）系统，用于通过在治疗之前对软组织施用造影剂来对软组织的免疫应答进行成像; 使用Δ弛豫增强磁共振（DREMR）成像感兴趣区域以限定功能区段; 选择性地对功能部分中的局部细胞进行取样; 对取样的局部细胞进行免疫分析; 并且随后的治疗，使用DREMR进一步成像所述感兴趣区域以评估所述细胞对治疗的免疫应答。

7. 发明申请

WO2017130025A1 HEAD COIL SYSTEM AND METHODS FOR ENHANCING AND/OR OPTIMIZING MRI 审中-公开
标题翻译：头线圈系统和用于增强和/或优化MRI的方法
公开(公告)号：WO2017130025A1
公开(公告)日：2017-08-03
申请号：PCT/IB2016/050407
申请日：2016-01-27
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , LAU, William Wai-Leung , PANTHER, Alexander Gyles , THEVATHASAN, Gilbert , MORREALE, Mark Tullio
发明人： LAU, William Wai-Leung , PANTHER, Alexander Gyles , THEVATHASAN, Gilbert , MORREALE, Mark Tullio
IPC分类号： A61B5/055 , A61B90/00
CPC分类号： G01R33/34046 , A61B90/14 , A61B90/16 , A61B2090/374 , G01R33/34084
摘要： Optionally adjustable head coil system and methods for enhancing and/or optimizing magnetic resonance imaging, involving a housing, the housing having at least one portion, the at least one portion having a lower portion, an upper portion, and opposing side portions, each at least one portion optionally in movable relation to any other portion for facilitating adjustability, each at least one portion configured to accommodate at least one radio-frequency coil, and the upper and lower portions each optionally configured to overlap and engage the opposing side portions for facilitating decoupling the at least one radio-frequency coil, and a tongue portion optionally in movable relation to any other portion for facilitating adjustability, engageable with the lower portion, and fixably couple-able with a transporter.
摘要翻译：可选地，可调节的头部线圈系统和用于增强和/或优化磁共振成像的方法包括壳体，所述壳体具有至少一个部分，所述至少一个部分具有下部，上部和相对的侧面部分，每个至少一个部分可选地与任何其他部分可移动地相关联以便于调节，每个至少一个部分构造成容纳至少一个射频线圈，并且上部和下部各自可选地配置成重叠并接合相对的侧面部分，以便于将至少一个射频线圈和舌片部分解耦，舌片部分可选地与任何其他部分可移动地相关，以便于可调节性，可与下部接合并且可固定地与传送器耦合。 / p>

8. 发明申请

WO2017011892A1 SYSTEM AND METHOD FOR MAPPING NAVIGATION SPACE TO PATIENT SPACE IN A MEDICAL PROCEDURE 审中-公开
标题翻译：用于在医疗过程中将导航空间映射到患者空间的系统和方法
公开(公告)号：WO2017011892A1
公开(公告)日：2017-01-26
申请号：PCT/CA2015/050677
申请日：2015-07-21
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , SELA, Gal , LUI, Dorothy , PANTHER, Alexander Gyles , DYER, Kelly Noel
发明人： SELA, Gal , LUI, Dorothy , PANTHER, Alexander Gyles , DYER, Kelly Noel
IPC分类号： A61B19/00 , G06F19/00 , A61B6/03 , A61B5/055 , A61B8/13
CPC分类号： A61B5/055 , A61B5/064 , A61B34/20 , A61B2034/2055 , A61B2034/2068 , A61B2090/363 , A61B2576/00 , G06F19/00 , G06T7/33 , G06T2207/10004 , G06T2207/10072 , G06T2207/20101
摘要： A medical navigation system is provided for registering a patient for a medical procedure with the medical navigation system using fiducial markers. The fiducial markers are placed on the patient prior to a 3D scan and the fiducial markers each have a target for use with a tracking system. The medical navigation system comprises a 3D scanner, a tracking system, a display, and a controller electrically coupled to the 3D scanner, the tracking system, and the display. The controller has a processor coupled to a memory. The controller is configured to: receive 3D scan data generated by the 3D scanner representative of a 3D scan of at least a portion of the patient, the 3D scan including the fiducial markers visible by the 3D scanner; load from the memory saved medical image data, the saved medical data including preoperative image data saved during a previous scan of at least a portion of the patient; receive position data from the tracking system based on the target for each of the fiducial markers; and perform a transformation mapping to create a single unified virtual coordinate space based on the 3D scan data, the position data, and the medical image data, and updating registration data of the medical navigation system based on the transformation mapping.
摘要翻译：提供医疗导航系统，用于使用基准标记物向医疗导航系统登记用于医疗程序的患者。在3D扫描之前，将基准标记放置在患者身上，并且基准标记各自具有用于跟踪系统的目标。医疗导航系统包括3D扫描器，跟踪系统，显示器和电耦合到3D扫描器，跟踪系统和显示器的控制器。控制器具有耦合到存储器的处理器。控制器被配置为：接收由3D扫描仪生成的3D扫描数据，3D扫描器代表患者的至少一部分的3D扫描，3D扫描包括由3D扫描器可见的基准标记; 来自存储器的加载保存的医学图像数据，所保存的医学数据包括在患者的至少一部分的先前扫描期间保存的术前图像数据; 基于每个基准标记的目标从跟踪系统接收位置数据; 并且基于3D扫描数据，位置数据和医学图像数据执行变换映射以创建单个统一虚拟坐标空间，以及基于变换映射来更新医疗导航系统的注册数据。

9. 发明申请

WO2017033043A1 A MEDICAL IMAGING SYSTEM FOR ILLUMINATING TISSUE SAMPLES USING THREE-DIMENSIONAL STRUCTURED ILLUMINATION MICROSCOPY 审中-公开
标题翻译：一种使用三维结构照明显微镜照射组织样本的医学成像系统
公开(公告)号：WO2017033043A1
公开(公告)日：2017-03-02
申请号：PCT/IB2015/056405
申请日：2015-08-24
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , BAI, Yanhui , WOOD, Michael Frank Gunter , MAK, Siu Wai Jacky , YUWARAJ, Murugathas , PANTHER, Alexander Gyles
发明人： BAI, Yanhui , WOOD, Michael Frank Gunter , MAK, Siu Wai Jacky , YUWARAJ, Murugathas , PANTHER, Alexander Gyles
IPC分类号： A61B19/00 , A61B1/05 , A61B1/06 , A61B5/00 , H04N13/02 , H04N5/335
CPC分类号： A61B34/20 , A61B1/00045 , A61B1/00188 , A61B1/05 , A61B1/06 , A61B5/0071 , A61B5/062 , A61B5/064 , A61B5/4064 , A61B17/34 , A61B90/20 , A61B90/30 , A61B90/361 , A61B2034/2055 , A61B2090/309 , A61B2505/05 , G01B11/25 , G02B21/0012 , G02B21/0052 , G02B21/0064 , G02B21/008 , G02B21/025 , G02B21/04 , G02B21/06 , G02B21/361 , G02B23/2415 , G02B23/2484 , G02B27/30 , H04N5/335 , H04N13/254 , H04N2213/001
摘要： A medical imaging system for illuminating tissue samples using three-dimensional structured illumination microscopy in port-based surgery is provided. The system comprises: an image sensor; a mirror device; zoom optics; a light modulator; a processor; and collimating optics configured to convey one or more images from the modulator to the mirror, the mirror configured to convey the images to the zoom optics, the zoom optics configured: to convey the image(s) from the mirror to a tissue sample; and convey one or more resulting images, formed by the image(s) illuminating the sample, back to the mirror, which conveys the resulting image(s) from the zoom optics to the image sensor, and, the processor configured to control the modulator to form the image(s), the image(s) including at least one pattern selected to interact with the sample to generate different depth information in each of resulting image(s).
摘要翻译：提供了一种用于在基于口腔的手术中使用三维结构照明显微镜照射组织样本的医学成像系统。该系统包括：图像传感器; 镜子装置; 变焦光学; 光调制器处理器以及准直光学器件，被配置为将一个或多个图像从所述调制器传送到所述反射镜，所述镜被配置为将所述图像传送到所述变焦光学器件，所述变焦光学器件被配置为：将所述图像从所述反射镜传送到组织样本; 并且将由照射样品的图像形成的一个或多个所得到的图像传回到反射镜，所述反射镜将所得到的图像从变焦光学器件传送到图像传感器，以及配置成控制调制器的处理器以形成图像，所述图像包括被选择为与样本交互的至少一个图案，以在每个所得图像中生成不同的深度信息。

10. 发明申请

WO2017017498A1 METHOD, SYSTEM AND APPARATUS FOR ADJUSTING IMAGE DATA TO COMPENSATE FOR MODALITY-INDUCED DISTORTION 审中-公开
标题翻译：用于调整图像数据以补偿模态诱发失真的方法，系统和装置
公开(公告)号：WO2017017498A1
公开(公告)日：2017-02-02
申请号：PCT/IB2015/055728
申请日：2015-07-29
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , SELA, Gal , CHEN, Sean Jy-shyang , ALEXANDER, Simon Kenley , PANTHER, Alexander Gyles
发明人： SELA, Gal , CHEN, Sean Jy-shyang , ALEXANDER, Simon Kenley , PANTHER, Alexander Gyles
IPC分类号： G06T3/00 , A61B5/055 , G06T15/08
CPC分类号： G06T19/20 , A61B5/0064 , A61B5/055 , A61B6/00 , A61B6/032 , A61B6/5247 , A61B8/5261 , A61B2576/00 , G06T7/344 , G06T15/08 , G06T2207/10081 , G06T2207/10088 , G06T2207/30016
摘要： A method of generating adjusted image data to compensate for modality-induced distortion includes, at a processor: receiving a three-dimensional image captured with a first imaging modality and including (i) distorted surface image data depicting a surface of an object and (ii) distorted volume image data depicting a 5 volume of the object; extracting the distorted surface image data from the three- dimensional image; receiving reference surface image data captured with a second imaging modality and depicting the surface of the object; determining a surface transformation for registering the distorted surface image data with the reference surface image data; determining a volume transformation informed by 10 the surface transformation; generating an adjusted three-dimensional image by applying the volume transformation to the three-dimensional image; and storing the adjusted three-dimensional image in the memory.
摘要翻译：一种产生调整图像数据以补偿形态诱发失真的方法包括：在处理器处：接收用第一成像模态捕获的三维图像，并且包括（i）描绘对象表面的失真表面图像数据，）扭曲了描绘5个物体体积的图像数据; 从三维图像提取失真的表面图像数据; 接收利用第二成像模式捕获的参考表面图像数据并描绘所述物体的表面; 确定用参考表面图像数据登记失真的表面图像数据的表面变换; 确定通过10表面变换通知的体积变换; 通过对三维图像应用体积变换来生成调整后的三维图像; 并将调整后的三维图像存储在存储器中。

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