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1. 发明专利

JP2011167551A Controlled release bioactive agent delivery device 有权
标题翻译：控制释放生物剂递送装置
公开(公告)号：JP2011167551A
公开(公告)日：2011-09-01
申请号：JP2011116262
申请日：2011-05-24
申请人： Surmodics Inc , サーモディクス,インコーポレイティド
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61M37/00 , A61K9/00 , A61K31/58 , A61K47/32 , A61P27/02
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： PROBLEM TO BE SOLVED: To provide a delivery device for controlled delivery of one or more bioactive agents to a treatment site within body. SOLUTION: The invention relates to a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition including a first polymer, a second polymer, and a bioactive agent in contact with a surface of the body member. In the device, the first polymer comprises polyalkyl(meth)acrylic acid, aromatic poly(meth)acrylic acid, or a combination of polyalkyl(meth)acrylic acid and aromatic poly(meth)acrylic acid, and the second polymer comprises ethylene-vinyl acetic acid copolymer. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于将一种或多种生物活性剂控制递送到体内治疗部位的递送装置。解决方案：本发明涉及一种控制释放生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中至少一部分身体成员偏离延伸方向; 以及包含第一聚合物，第二聚合物和与本体构件的表面接触的生物活性剂的聚合物涂覆组合物。在该装置中，第一聚合物包括聚（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸或聚烷基（甲基）丙烯酸和芳族聚（甲基）丙烯酸的组合），第二聚合物包括乙烯 - 乙烯基乙酸共聚物。版权所有（C）2011，JPO＆INPIT

2. 发明专利

AU2004237774B2 Implantable controlled release bioactive agent delivery device 未知
公开(公告)号：AU2004237774B2
公开(公告)日：2009-09-10
申请号：AU2004237774
申请日：2004-04-29
申请人： SURMODICS INC
发明人： SHEN BYRON C , JUAN EUGENE DE , CHAPPA RALPH A , ANDERSON ARON B , LAWIN LAURIE R , VARNER SIGNE E
IPC分类号： A61K9/00 , A61K31/58
摘要： The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.

3. 发明专利

DE602004028638D1 System zur kontrollierten Freisetzung eines bioaktiven Wirkstoffs im hinteren Bereich des Auges 未知
公开(公告)号：DE602004028638D1
公开(公告)日：2010-09-23
申请号：DE602004028638
申请日：2004-04-29
申请人： SURMODICS INC
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61K9/00 , A61K31/58

4. 发明专利

AU2005229667B2 Controlled release bioactive agent delivery device 未知
公开(公告)号：AU2005229667B2
公开(公告)日：2009-09-10
申请号：AU2005229667
申请日：2005-11-02
申请人： SURMODICS INC
发明人： VARNER SIGNE E , CHAPPA RALPH A , JUAN EUGENE DE , ANDERSON ARON B , SHEN BYRON C , LAWIN LAURIE R
IPC分类号： A61K9/00 , A61K31/58

5. 发明专利

AU2004237774A1 Implantable controlled release bioactive agent delivery device 未知
公开(公告)号：AU2004237774A1
公开(公告)日：2004-11-18
申请号：AU2004237774
申请日：2004-04-29
申请人： SURMODICS INC
发明人： SHEN BYRON C , JUAN EUGENE DE , CHAPPA RALPH A , ANDERSON ARON B , LAWIN LAURIE R , VARNER SIGNE E
IPC分类号： A61K9/00 , A61K31/58
摘要： The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.

6. 发明专利

CA2524271C CONTROLLED RELEASE BIOACTIVE AGENT DELIVERY DEVICE 未知
公开(公告)号：CA2524271C
公开(公告)日：2012-09-04
申请号：CA2524271
申请日：2004-04-29
申请人： SURMODICS INC
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61K9/00 , A61K31/58
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides the use of said composition for the manufacture of a medicament for delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.

7. 发明专利

AT476960T 未知
公开(公告)号：AT476960T
公开(公告)日：2010-08-15
申请号：AT05025475
申请日：2004-04-29
申请人： SURMODICS INC
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61K9/00 , A61K31/58
摘要： The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.

8. 发明专利

CA2524271A1 IMPLANTABLE CONTROLLED RELEASE BIOACTIVE AGENT DELIVERY DEVICE 未知
公开(公告)号：CA2524271A1
公开(公告)日：2004-11-18
申请号：CA2524271
申请日：2004-04-29
申请人： SURMODICS INC
发明人： LAWIN LAURIE R , VARNER SIGNE E , DE JUAN EUGENE , SHEN BYRON C , ANDERSON ARON B , CHAPPA RALPH A
IPC分类号： A61K9/00 , A61K31/58
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body membe r, the polymeric coated composition including a first polymer, a second polymer , and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides the use of said composition for the manufacture of a medicament for delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery devi ce.

9. 发明申请

WO2004098565A3 IMPLANTABLE CONTROLLED RELEASE BIOACTIVE AGENT DELIVERY DEVICE 审中-公开
标题翻译：可植入控制释放生物体递送装置
公开(公告)号：WO2004098565A3
公开(公告)日：2005-03-03
申请号：PCT/US2004013327
申请日：2004-04-29
申请人： SURMODICS INC , ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61K9/00 , A61K31/58
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides the use of said composition for the manufacture of a medicament for delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
摘要翻译：本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物包含（甲基）丙烯酸烷基酯，（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸酯，）丙烯酸酯或聚（甲基）丙烯酸烷基酯和芳族聚（甲基）丙烯酸酯的组合，其中第二聚合物包括聚（乙烯 - 共 - 乙酸乙烯酯）。本发明还提供了所述组合物用于制备用于以控制释放方式将生物活性剂递送至患者的药物以及制备受控释放生物活性剂递送装置的方法的用途。

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