专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2011167551A Controlled release bioactive agent delivery device 有权
标题翻译：控制释放生物剂递送装置
公开(公告)号：JP2011167551A
公开(公告)日：2011-09-01
申请号：JP2011116262
申请日：2011-05-24
申请人： Surmodics Inc , サーモディクス,インコーポレイティド
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61M37/00 , A61K9/00 , A61K31/58 , A61K47/32 , A61P27/02
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： PROBLEM TO BE SOLVED: To provide a delivery device for controlled delivery of one or more bioactive agents to a treatment site within body. SOLUTION: The invention relates to a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition including a first polymer, a second polymer, and a bioactive agent in contact with a surface of the body member. In the device, the first polymer comprises polyalkyl(meth)acrylic acid, aromatic poly(meth)acrylic acid, or a combination of polyalkyl(meth)acrylic acid and aromatic poly(meth)acrylic acid, and the second polymer comprises ethylene-vinyl acetic acid copolymer. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于将一种或多种生物活性剂控制递送到体内治疗部位的递送装置。解决方案：本发明涉及一种控制释放生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中至少一部分身体成员偏离延伸方向; 以及包含第一聚合物，第二聚合物和与本体构件的表面接触的生物活性剂的聚合物涂覆组合物。在该装置中，第一聚合物包括聚（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸或聚烷基（甲基）丙烯酸和芳族聚（甲基）丙烯酸的组合），第二聚合物包括乙烯 - 乙烯基乙酸共聚物。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2011025247A Water-soluble coating agent having initiator group and coating method 有权
标题翻译：具有发动机组的水溶性涂料和涂料方法
公开(公告)号：JP2011025247A
公开(公告)日：2011-02-10
申请号：JP2010229101
申请日：2010-10-08
申请人： Surmodics Inc , サーモディクス,インコーポレイティド
发明人： SWAN DALE G , AMOS RICHARD A , EVERSON TERRENCE P , CHUDZIK STEPHEN J , CHAPPA RALPH A , STUCKE SEAN M , DUQUETTE PETER H
IPC分类号： B05D7/24 , C09D4/00 , C09D5/00
摘要： PROBLEM TO BE SOLVED: To provide a reagent and a method which are used for improving initiation of photopolymerization to grow a polymer from a support surface.
SOLUTION: A polymer layer is formed on the support surface by using a coating agent and a polymeric compound. The coating agent provides a photoreactivity group which is applied to adhere the coating agent to the support surface so that the polymer layer is formed on the support surface, and a photoreactivity group which remains as unadhered to the support surface, and therefore is applied to act as a photoinitiator for activating the polymeric compound.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于改善光聚合起始以从支撑表面生长聚合物的试剂和方法。解决方案：通过使用涂覆剂和聚合物，在载体表面上形成聚合物层。涂布剂提供了一种光反应性基团，其被用于将涂覆剂粘附到载体表面上，使得聚合物层形成在载体表面上，以及保持不依赖于载体表面的光反应性基团，因此被应用于作用作为用于活化聚合物的光引发剂。版权所有（C）2011，JPO＆INPIT

3. 发明申请

WO2004098565A3 IMPLANTABLE CONTROLLED RELEASE BIOACTIVE AGENT DELIVERY DEVICE 审中-公开
标题翻译：可植入控制释放生物体递送装置
公开(公告)号：WO2004098565A3
公开(公告)日：2005-03-03
申请号：PCT/US2004013327
申请日：2004-04-29
申请人： SURMODICS INC , ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61K9/00 , A61K31/58
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides the use of said composition for the manufacture of a medicament for delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
摘要翻译：本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物包含（甲基）丙烯酸烷基酯，（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸酯，）丙烯酸酯或聚（甲基）丙烯酸烷基酯和芳族聚（甲基）丙烯酸酯的组合，其中第二聚合物包括聚（乙烯 - 共 - 乙酸乙烯酯）。本发明还提供了所述组合物用于制备用于以控制释放方式将生物活性剂递送至患者的药物以及制备受控释放生物活性剂递送装置的方法的用途。

4. 发明申请

WO2009128944A3 COATING SYSTEMS FOR THE CONTROLLED DELIVERY OF HYDROPHILIC BIOACTIVE AGENTS 审中-公开
标题翻译：用于控制输送水解生物剂的涂料体系
公开(公告)号：WO2009128944A3
公开(公告)日：2010-08-05
申请号：PCT/US2009002418
申请日：2009-04-17
申请人： SURMODICS INC , CHAPPA RALPH A , HERGENROTHER ROBERT , WADMAN SHANNON A , WORMUTH KLAUS R
发明人： CHAPPA RALPH A , HERGENROTHER ROBERT , WADMAN SHANNON A , WORMUTH KLAUS R
IPC分类号： A61L27/34 , A61L27/54
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/232 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/608 , A61L2420/08 , C08L31/04
摘要： Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
摘要翻译：描述了用于例如从可植入医疗装置控制递送亲水生物活性剂的涂层系统。本发明的涂层体系包括（a）含有一种或多种亲水性生物活性剂的聚合物底涂层; 和（b）包含聚（乙烯 - 共 - 乙酸乙烯酯）共聚物的洗脱控制面漆层。亲水性生物活性剂的洗脱速度可以通过改变洗脱控制面漆层中的乙酸乙烯酯浓度来控制。

5. 发明专利

CA2760187C DEVICES AND METHODS FOR DELIVERY OF BIOACTIVE AGENTS 未知
公开(公告)号：CA2760187C
公开(公告)日：2018-01-02
申请号：CA2760187
申请日：2010-04-28
申请人： SURMODICS INC
发明人： CHAPPA RALPH A , BACH ANDREW G
IPC分类号： A61L29/08 , A61F2/958 , A61L29/16
摘要： Embodiments of the invention include bioactive agent eluting devices. In an embodiment the invention includes a bioactive agent delivery device including a substrate, a hydrophilic polymer disposed on the substrate, and a substantially amorphous bioactive agent disposed on the surface of the hydrophilic polymer. In an embodiment, the invention includes a method of making a bioactive agent delivery device including depositing a hydrophilic polymer on a substrate forming a hydrophilic surface and depositing a substantially amorphous bioactive agent on the hydrophilic surface. In an embodiment, the invention includes a bioactive agent-eluting catheter including a catheter shaft and an expandable balloon disposed on the catheter shaft. Other embodiments are included herein.

6. 发明专利

CR20140589A APARATO Y MÉTODO PARA RECUBRIR CATÉTERES CON GLOBO 未知
公开(公告)号：CR20140589A
公开(公告)日：2015-02-24
申请号：CR20140589
申请日：2014-12-17
申请人： SURMODICS INC
发明人： CHAPPA RALPH A , BACH ANDREW G , MACGREGOR MARK
IPC分类号： B05B13/04
摘要： Realizaciones de la invención incluyen un aparato y métodos para recubrir dispositivos médicos que eluyen fármaco.

7. 发明专利

CA2803095A1 CATHETER ASSEMBLY 未知
公开(公告)号：CA2803095A1
公开(公告)日：2012-01-05
申请号：CA2803095
申请日：2011-06-30
申请人： SURMODICS INC
发明人： CHAPPA RALPH A
IPC分类号： A61M25/10 , A61F2/958
摘要： A catheter assembly includes an expandable and collapsible structure (12) having an outer surface (22). The expandable and collapsible structure is adapted to expand between a contracted state and a dilated state. A coating (32) is disposed on the outer surface of the expandable and collapsible structure. The coating includes a bioactive agent. A sleeve (14) is disposed over the coating. The sleeve is adapted to expand between a compressed state and an enlarged state and to return to the compressed state. The sleeve defines a plurality of openings (150) in the compressed state. An outer diameter of the coating is less than an outer diameter of the sleeve when the expandable and collapsible structure is in the contracted state and greater than the outer diameter of the sleeve when the expandable and collapsible structure is in the dilated state.

8. 发明专利

DE602004028638D1 System zur kontrollierten Freisetzung eines bioaktiven Wirkstoffs im hinteren Bereich des Auges 未知
公开(公告)号：DE602004028638D1
公开(公告)日：2010-09-23
申请号：DE602004028638
申请日：2004-04-29
申请人： SURMODICS INC
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61K9/00 , A61K31/58

9. 发明专利

AU2005229667B2 Controlled release bioactive agent delivery device 未知
公开(公告)号：AU2005229667B2
公开(公告)日：2009-09-10
申请号：AU2005229667
申请日：2005-11-02
申请人： SURMODICS INC
发明人： VARNER SIGNE E , CHAPPA RALPH A , JUAN EUGENE DE , ANDERSON ARON B , SHEN BYRON C , LAWIN LAURIE R
IPC分类号： A61K9/00 , A61K31/58

10. 发明专利

AT359129T 未知
公开(公告)号：AT359129T
公开(公告)日：2007-05-15
申请号：AT04711809
申请日：2004-02-17
申请人： SURMODICS INC
发明人： CARLSON MARK F , PORTER STEVEN J , STUCKE SEAN M , CHAPPA RALPH A
IPC分类号： B05C3/109 , B05C9/14 , B05D1/18 , B05D3/06 , A61L31/00
摘要： Described herein is a method for coating an object with a polymer layer. The method includes contacting the object with a first solution comprising a non-polymeric grafting initiator comprising at least one photoinitiator group capable of generating a free radical active species upon absorption of electromagnetic energy, wherein the photoinitiator group is selected from the group consisting of an initiator that is insoluble in polar solvent; and a negatively charged initiator; irradiating the first solution and the object, resulting in the grafting initiator binding to the object; removing the first solution; contacting the object with a second solution comprising a polymerizable monomer having at least one free-radical polymerizable group; and irradiating the second solution and the object, wherein the non-polymeric grafting initiator acts as a photoinitiator for a free-radical polymerization reaction.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式