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1. 发明申请

WO2009128944A3 COATING SYSTEMS FOR THE CONTROLLED DELIVERY OF HYDROPHILIC BIOACTIVE AGENTS 审中-公开
标题翻译：用于控制输送水解生物剂的涂料体系
公开(公告)号：WO2009128944A3
公开(公告)日：2010-08-05
申请号：PCT/US2009002418
申请日：2009-04-17
申请人： SURMODICS INC , CHAPPA RALPH A , HERGENROTHER ROBERT , WADMAN SHANNON A , WORMUTH KLAUS R
发明人： CHAPPA RALPH A , HERGENROTHER ROBERT , WADMAN SHANNON A , WORMUTH KLAUS R
IPC分类号： A61L27/34 , A61L27/54
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/232 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/608 , A61L2420/08 , C08L31/04
摘要： Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
摘要翻译：描述了用于例如从可植入医疗装置控制递送亲水生物活性剂的涂层系统。本发明的涂层体系包括（a）含有一种或多种亲水性生物活性剂的聚合物底涂层; 和（b）包含聚（乙烯 - 共 - 乙酸乙烯酯）共聚物的洗脱控制面漆层。亲水性生物活性剂的洗脱速度可以通过改变洗脱控制面漆层中的乙酸乙烯酯浓度来控制。

2. 发明申请

WO2008088593A2 ADDITIVES AND METHODS FOR ENHANCING ACTIVE AGENT ELUTION KINETICS 审中-公开
标题翻译：添加剂和增强活性剂溶液动力学的方法
公开(公告)号：WO2008088593A2
公开(公告)日：2008-07-24
申请号：PCT/US2007/079704
申请日：2007-09-27
申请人： SURMODICS, INC. , CHAPPA, Ralph, A.
发明人： CHAPPA, Ralph, A.
CPC分类号： A61K31/56 , A61K9/0024 , A61K9/0048 , A61K47/32 , A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/602 , C08L39/06 , C08L33/10 , C08L29/04
摘要： The present invention relates to methods and additives for increasing active agent elution rates from elution control coatings and elution control coatings including the same. In an embodiment the invention includes an elution control coating comprising a polymeric matrix and at least about 0.1 wt. % of an additive dispersed within the polymeric matrix. The additive can include polyvinylpyrrolidone or a copolymer thereof. An active agent can be dispersed within the polymeric matrix, the active agent having limited solubility in water. Embodiments of the invention also include a method of forming an elution control coating with accelerated release kinetics. Other embodiments are also included herein.
摘要翻译：本发明涉及用于增加洗脱控制涂层和包括其的洗脱控制涂层的活性剂洗脱速率的方法和添加剂。在一个实施方案中，本发明包括洗脱控制涂层，其包含聚合物基质和至少约0.1wt。％的添加剂分散在聚合物基质内。添加剂可以包括聚乙烯吡咯烷酮或其共聚物。活性剂可以分散在聚合物基质内，活性剂在水中的溶解度有限。本发明的实施方案还包括形成具有加速释放动力学的洗脱控制涂层的方法。本文还包括其它实施例。

3. 发明申请

WO2006022854A1 METHOD FOR DEPOSITING A POLYMERIC COATING ON A SUBSTRATE 审中-公开
标题翻译：在基材上沉积聚合物涂层的方法
公开(公告)号：WO2006022854A1
公开(公告)日：2006-03-02
申请号：PCT/US2005/008802
申请日：2005-03-16
申请人： SURMODICS, INC. , CHAPPA, Ralph, A.
发明人： CHAPPA, Ralph, A.
IPC分类号： B05D7/24
CPC分类号： A61L29/085 , A61L27/34 , A61L31/10 , A61L2420/02 , B05D1/60 , B05D3/0218 , B05D2202/15 , C08L65/04
摘要： The present application relates to a method for vapor depositing a polymeric coating onto a substrate. In an embodiment, the invention is a method for applying a polymer coating to a substrate comprising performing a bake-out cycle with a chemical vapor deposition system and performing a deposition cycle with the chemical vapor deposition system.
摘要翻译：本申请涉及将聚合物涂层气相沉积到基底上的方法。在一个实施方案中，本发明是一种将聚合物涂层施加到基底上的方法，包括用化学气相沉积系统进行烘烤循环并且与化学气相沉积系统一起进行沉积循环。

4. 发明申请

WO2005097223A1 COMPOSITION AND METHOD FOR PREPARING BIOCOMPATIBLE SURFACES 审中-公开
标题翻译：用于制备生物化学表面的组合物和方法
公开(公告)号：WO2005097223A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/009908
申请日：2005-03-25
申请人： SURMODICS, INC. , STUCKE, Sean, M. , CHAPPA, Ralph, A. , CHINN, Joseph, A. , ANDERSON, Aron, B.
发明人： STUCKE, Sean, M. , CHAPPA, Ralph, A. , CHINN, Joseph, A. , ANDERSON, Aron, B.
IPC分类号： A61L29/08
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L33/0011 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608 , C08L33/10 , C08L29/04 , C08L39/06
摘要： The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
摘要翻译：本发明提供了用于向医疗制品提供生物相容性表面的方法和组合物。特别地，本发明提供具有肝素活性的生物相容性涂层。在一些方面，本发明的生物相容性涂层能够释放生物活性剂。可以使用生物稳定或可生物降解的聚合物材料和光反应性基团形成涂层。本发明还提供了通过进行生物相容性涂料组合物的预辐射来提高含生物活性剂的涂层的质量的方法。

5. 发明申请

WO2005097222A1 PROCESS AND SYSTEMS FOR BIOCOMPATIBLE SURFACES 审中-公开
标题翻译：生物可溶性表面的过程和系统
公开(公告)号：WO2005097222A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010127
申请日：2005-03-25
申请人： SURMODICS, INC. , STUCKE, Sean, M. , CHAPPA, Ralph, A. , CHINN, Joseph, A.
发明人： STUCKE, Sean, M. , CHAPPA, Ralph, A. , CHINN, Joseph, A.
IPC分类号： A61L29/08
CPC分类号： A61K31/4745 , A61K31/727 , A61L31/10 , A61L31/16 , A61L33/0029 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608
摘要： The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity that are able to release a bioactive agent, wherein the coatings are formed using biostable or biodegradable polymeric material and photoreactive groups.
摘要翻译：本发明提供了用于向医疗制品提供生物相容性表面的方法和组合物。特别地，本发明提供具有能够释放生物活性剂的肝素活性的生物相容性涂层，其中使用生物稳定或可生物降解的聚合物材料和光反应性基团形成涂层。

6. 发明申请

WO2004020012A1 RETENTION COATINGS FOR DELIVERY SYSTEMS 审中-公开
标题翻译：用于输送系统的保持涂层
公开(公告)号：WO2004020012A1
公开(公告)日：2004-03-11
申请号：PCT/US2003/026604
申请日：2003-08-25
申请人： SURMODICS, INC. , STUCKE, Sean, M. , LINDSOE, Kimberly, K., M. , CHAPPA, Ralph, A. , SWAN, Dale, G.
发明人： STUCKE, Sean, M. , LINDSOE, Kimberly, K., M. , CHAPPA, Ralph, A. , SWAN, Dale, G.
IPC分类号： A61L27/34
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/258 , A61L2300/404 , A61L2300/406 , A61L2300/606 , C08L71/02
摘要： A coating composition, in both its uncrosslinked and crosslinked forms, for use in increasing the static friction of a surface of a delivery system comprising a medical device having a surface in contact with the surface of a delivery component, the static friction of the surface being increased in an amount sufficient to substantially maintain the position of the medical device on the delivery component against forces asserted on the delivery system as it navigates through a vessel of the body. The delivery system may comprise a balloon catheter as the delivery component and a stent as the medical device. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, optionally a photoderivatized monomer, and a hydrophilic monomer such as (meth)acrylamide.
摘要翻译：一种涂料组合物，以其未交联和交联的形式，用于增加递送系统的表面的静摩擦力，其包括具有与输送组分表面接触的表面的医疗装置，表面的静摩擦力增加的量足以基本上保持医疗装置在输送部件上的位置，抵抗在输送系统导航通过身体的血管时所断言的力。输送系统可以包括作为输送部件的气囊导管和作为医疗装置的支架。组合物包括聚醚单体，例如烷氧基聚（亚烷基二醇），含羧酸的单体，例如（甲基）丙烯酸，任选的光衍生单体和亲水性单体如（甲基）丙烯酰胺。

7. 发明申请

WO2012096787A1 DOUBLE WALL CATHETER FOR DELIVERING THERAPEUTIC AGENT 审中-公开
标题翻译：用于输送治疗剂的双壁导管
公开(公告)号：WO2012096787A1
公开(公告)日：2012-07-19
申请号：PCT/US2011/067722
申请日：2011-12-29
申请人： SURMODICS, INC. , CHAPPA, Ralph, A.
发明人： CHAPPA, Ralph, A.
IPC分类号： A61M25/10 , A61L29/08
CPC分类号： A61M25/1011 , A61L29/085 , A61L29/16 , A61L2300/00 , A61M2025/1013 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： The present invention relates to a catheter assembly (10) that can deliver a therapeutic composition. The catheter assembly can include an outer balloon (30) with openings (36) for releasing the therapeutic composition. When the catheter assembly is in its contracted state, the openings are closed, and the assembly retains the therapeutic composition. When the catheter assembly is in its dilated state, the openings are open, and the therapeutic composition is released. The present invention also includes methods of making and using such a catheter assembly.
摘要翻译：本发明涉及可递送治疗组合物的导管组件（10）。导管组件可包括具有释放治疗组合物的开口（36）的外球囊（30）。当导管组件处于收缩状态时，开口关闭，并且组件保持治疗组合物。当导管组件处于其扩张状态时，开口是开放的，并且治疗组合物被释放。本发明还包括制造和使用这种导管组件的方法。

8. 发明申请

WO2012058274A2 COATINGS AND METHODS FOR CONTROLLED ELUTION OF HYDROPHILIC ACTIVE AGENTS 审中-公开
标题翻译：亲水性活性剂受控排放的涂层和方法
公开(公告)号：WO2012058274A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/057826
申请日：2011-10-26
申请人： CHAPPA, Ralph, A. , BURKSTRAND, Michael, J. , BABCOCK, David, E. , SURMODICS, INC.
发明人： CHAPPA, Ralph, A. , BURKSTRAND, Michael, J. , BABCOCK, David, E.
IPC分类号： A61L27/34 , A61L31/10
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2420/02 , C08L31/04
摘要： Embodiments of the invention include multi-layer coatings and methods for controlling the elution of hydrophilic active agents. In an embodiment, the invention includes a medical device including a substrate, a primer polymer layer disposed on the substrate, an expandable layer disposed on the primer polymer layer, and a hydrophilic active agent dispersed within the expandable layer. In an embodiment, the invention includes a method of forming a medical device including depositing a primer layer onto a substrate, the primer layer comprising a primer polymer. The method can further include depositing an expandable layer onto the primer layer, the expandable layer including an expandable polymer, and a hydrophilic active agent. The expandable layer can be deposited with a solvent that is effective to solvate both the expandable polymer and the primer polymer. Other embodiments are also included herein.
摘要翻译：本发明的实施方案包括用于控制亲水性活性剂洗脱的多层涂层和方法。在一个实施方案中，本发明包括医疗装置，其包括基底，设置在基底上的底漆聚合物层，设置在底漆聚合物层上的可膨胀层以及分散在可膨胀层内的亲水性活性剂。在一个实施方案中，本发明包括一种形成医疗装置的方法，该方法包括将底漆层沉积到基底上，该底漆层包含底漆聚合物。该方法可以进一步包括将可膨胀层沉积到底层上，可膨胀层包括可膨胀聚合物和亲水活性剂。可膨胀层可以用有效溶解可膨胀聚合物和底层聚合物的溶剂沉积。其他实施例也包括在本文中。

9. 发明申请

WO2010129328A2 DEVICES AND METHODS FOR DELIVERY OF BIOACTIVE AGENTS 审中-公开
标题翻译：用于递送生物剂的装置和方法
公开(公告)号：WO2010129328A2
公开(公告)日：2010-11-11
申请号：PCT/US2010/032741
申请日：2010-04-28
申请人： SURMODICS, INC. , CHAPPA, Ralph A. , BACH, Andrew G.
发明人： CHAPPA, Ralph A. , BACH, Andrew G.
IPC分类号： A61L29/08
CPC分类号： A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/60
摘要： Embodiments of the invention include bioactive agent eluting devices. In an embodiment the invention includes a bioactive agent delivery device including a substrate, a hydrophilic polymer disposed on the substrate, and a substantially amorphous bioactive agent disposed on the surface of the hydrophilic polymer. In an embodiment, the invention includes a method of making a bioactive agent delivery device including depositing a hydrophilic polymer on a substrate forming a hydrophilic surface and depositing a substantially amorphous bioactive agent on the hydrophilic surface. In an embodiment, the invention includes a bioactive agent-eluting catheter including a catheter shaft and an expandable balloon disposed on the catheter shaft. Other embodiments are included herein.
摘要翻译：本发明的实施方案包括生物活性剂洗脱装置。在一个实施方案中，本发明包括生物活性剂递送装置，其包括基底，设置在基底上的亲水性聚合物和设置在亲水性聚合物表面上的基本无定形的生物活性剂。在一个实施方案中，本发明包括制备生物活性剂递送装置的方法，包括在形成亲水表面的基材上沉积亲水性聚合物，并在亲水表面上沉积基本无定形的生物活性剂。在一个实施方案中，本发明包括生物活性剂洗脱导管，其包括导管轴和布置在导管轴上的可膨胀气囊。其他实施例包括在本文中。

10. 发明申请

WO2009132214A1 COATING APPLICATION SYSTEM WITH SHAPED MANDREL 审中-公开
标题翻译：涂层应用系统与形状的MANDREL
公开(公告)号：WO2009132214A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041575
申请日：2009-04-23
申请人： SURMODICS, INC. , CHAPPA, Ralph, A. , ARPS, James
发明人： CHAPPA, Ralph, A. , ARPS, James
IPC分类号： B05B13/02
CPC分类号： A61F2/82 , A61F2240/001 , B05B13/0242 , B05B13/0442
摘要： The invention relates to systems and methods for applying coatings to devices. In an embodiment, the invention includes a coating apparatus including a mandrel having a lengthwise axis and an exterior surface, the exterior surface of the mandrel defining a plurality of channels disposed parallel to the lengthwise axis, the mandrel configured to rotate around the lengthwise axis; and a spray head configured to direct a stream of material at the mandrel. In an embodiment the invention includes a method of applying a coating to a medical device. Other embodiments are also included herein.
摘要翻译：本发明涉及将涂料涂覆到装置上的系统和方法。在一个实施例中，本发明包括涂覆设备，其包括具有纵向轴线和外表面的心轴，心轴的外表面限定平行于纵向轴线设置的多个通道，心轴构造成围绕纵向轴线旋转; 以及喷头，其配置成在心轴处引导材料流。在一个实施方案中，本发明包括将涂层施加到医疗装置的方法。本文还包括其它实施例。

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