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1. 发明专利

JP2011167551A Controlled release bioactive agent delivery device 有权
标题翻译：控制释放生物剂递送装置
公开(公告)号：JP2011167551A
公开(公告)日：2011-09-01
申请号：JP2011116262
申请日：2011-05-24
申请人： Surmodics Inc , サーモディクス,インコーポレイティド
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61M37/00 , A61K9/00 , A61K31/58 , A61K47/32 , A61P27/02
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： PROBLEM TO BE SOLVED: To provide a delivery device for controlled delivery of one or more bioactive agents to a treatment site within body. SOLUTION: The invention relates to a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition including a first polymer, a second polymer, and a bioactive agent in contact with a surface of the body member. In the device, the first polymer comprises polyalkyl(meth)acrylic acid, aromatic poly(meth)acrylic acid, or a combination of polyalkyl(meth)acrylic acid and aromatic poly(meth)acrylic acid, and the second polymer comprises ethylene-vinyl acetic acid copolymer. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于将一种或多种生物活性剂控制递送到体内治疗部位的递送装置。解决方案：本发明涉及一种控制释放生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中至少一部分身体成员偏离延伸方向; 以及包含第一聚合物，第二聚合物和与本体构件的表面接触的生物活性剂的聚合物涂覆组合物。在该装置中，第一聚合物包括聚（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸或聚烷基（甲基）丙烯酸和芳族聚（甲基）丙烯酸的组合），第二聚合物包括乙烯 - 乙烯基乙酸共聚物。版权所有（C）2011，JPO＆INPIT

2. 发明专利

CA2490233C BIOACTIVE AGENT RELEASE COATING AND CONTROLLED HUMIDITY METHOD 未知
公开(公告)号：CA2490233C
公开(公告)日：2011-10-25
申请号：CA2490233
申请日：2003-06-18
申请人： SURMODICS INC
发明人： CHAPPA RALPH A , HERGENROTHER ROBERT W , ANDERSON ARON B , TRAN LINH V , LAWIN LAURIE R , OFSTEAD RONALD F
IPC分类号： A61L27/34 , A61L29/00 , A61F2/82 , A61F2/84 , A61L17/00 , A61L27/00 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16
摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

3. 发明专利

CA2503831A1 BARRIERS FOR BIOACTIVE AGENT-CONTAINING POLYMERIC COATINGS 未知
公开(公告)号：CA2503831A1
公开(公告)日：2004-06-24
申请号：CA2503831
申请日：2003-12-05
申请人： SURMODICS INC
发明人： LAWIN LAURIE R , BOUCHA-RAYLE MICHELLE C , KLOKE TIMOTHY M
IPC分类号： A61K9/22 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
摘要： A barrier adapted to be positioned between a first surface provided in the form of a polymeric, bioactive agent-containing coating upon a medical devic e, and a second surface provided by another material positioned in apposition, and preferably moveable apposition, to the first surface. The barrier, as provided by block copolymers or photoderivatized polymers, provides protecti on to the polymeric composition from mechanical damage and/or delamination duri ng fabrication, storage, delivery or deployment, and/or residence of the device within the body. A combination that includes a medical device, such as a stent, and another device, such as a surrounding sheath or internal expandab le balloon, between which is positioned a barrier of the type described.

4. 发明专利

AU2003247553A1 BIOACTIVE AGENT RELEASE COATING WITH AROMATIC POLY(METH)ACRYLATES 未知
公开(公告)号：AU2003247553A1
公开(公告)日：2003-12-31
申请号：AU2003247553
申请日：2003-06-18
申请人： SURMODICS INC
发明人： HERGENROTHER ROBERT W , ANDERSON ARON B , TRAN LINH V , LAWIN LAURIE R , OFSTEAD RONALD F , CHAPPA RALPH A
IPC分类号： A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L27/26 , A61L29/04
摘要： A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

5. 发明专利

AU2003245547A1 BIOACTIVE AGENT RELEASE COATING AND CONTROLLED HUMIDITY METHOD 未知
公开(公告)号：AU2003245547A1
公开(公告)日：2003-12-31
申请号：AU2003245547
申请日：2003-06-18
申请人： SURMODICS INC
发明人： CHAPPA RALPH A , HERGENROTHER ROBERT W , ANDERSON ARON B , TRAN LINH V , LAWIN LAURIE R , OFSTEAD RONALD F
IPC分类号： A61L29/00 , A61F2/82 , A61F2/84 , A61L17/00 , A61L27/00 , A61L29/08 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16 , A61L27/34 , A61L27/54
摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

6. 发明专利

DE60328607D1 未知
公开(公告)号：DE60328607D1
公开(公告)日：2009-09-10
申请号：DE60328607
申请日：2003-06-18
申请人： SURMODICS INC
发明人： CHAPPA RALPH A , HERGENROTHER ROBERT W , ANDERSON ARON B , TRAN LINH V , LAWIN LAURIE R , OFSTEAD RONALD F
IPC分类号： A61L27/34 , A61L29/00 , A61F2/82 , A61F2/84 , A61L17/00 , A61L27/00 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16
摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

7. 发明专利

AU2004237774A1 Implantable controlled release bioactive agent delivery device 未知
公开(公告)号：AU2004237774A1
公开(公告)日：2004-11-18
申请号：AU2004237774
申请日：2004-04-29
申请人： SURMODICS INC
发明人： SHEN BYRON C , JUAN EUGENE DE , CHAPPA RALPH A , ANDERSON ARON B , LAWIN LAURIE R , VARNER SIGNE E
IPC分类号： A61K9/00 , A61K31/58
摘要： The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.

8. 发明专利

AU2003251570A1 METHOD AND SYSTEM FOR PROVIDING BIOACTIVE AGENT RELEASE COATING 未知
公开(公告)号：AU2003251570A1
公开(公告)日：2003-12-31
申请号：AU2003251570
申请日：2003-06-18
申请人： SURMODICS INC
发明人： CHUDZIK STEPHEN J , KLOKE TIMOTHY M , LAWIN LAURIE R , OFSTEAD RONALD F , CHAPPA RALPH A , HERGENROTHER ROBERT W , ANDERSON ARON B , TRAN LINH V
IPC分类号： A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L27/34 , A61L27/54
摘要： A composition for bioactive agent release in vivo. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).

9. 发明专利

CA2490238A1 BIOACTIVE AGENT RELEASE COATING WITH AROMATIC POLY(METH)ACRYLATES 未知
公开(公告)号：CA2490238A1
公开(公告)日：2003-12-24
申请号：CA2490238
申请日：2003-06-18
申请人： SURMODICS INC
发明人： LAWIN LAURIE R , TRAN LINH V , ANDERSON ARON B , HERGENROTHER ROBERT W , OFSTEAD RONALD F , CHAPPA RALPH A
IPC分类号： A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L27/26 , A61L29/04
摘要： A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medica l devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

10. 发明专利

CA2524271C CONTROLLED RELEASE BIOACTIVE AGENT DELIVERY DEVICE 未知
公开(公告)号：CA2524271C
公开(公告)日：2012-09-04
申请号：CA2524271
申请日：2004-04-29
申请人： SURMODICS INC
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61K9/00 , A61K31/58
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides the use of said composition for the manufacture of a medicament for delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.

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