专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006120433A1 IMPROVED POLYMERASES 审中-公开
标题翻译：改进的聚合物
公开(公告)号：WO2006120433A1
公开(公告)日：2006-11-16
申请号：PCT/GB2006/001700
申请日：2006-05-10
申请人： SOLEXA LIMITED , OST, Tobias, William, Barr , SMITH, Geoffrey, Paul , BALASUBRAMANIAN, Shankar , RIGATTI, Roberto , SANCHES, Raquel, Maria
发明人： OST, Tobias, William, Barr , SMITH, Geoffrey, Paul , BALASUBRAMANIAN, Shankar , RIGATTI, Roberto , SANCHES, Raquel, Maria
IPC分类号： C12N9/12
CPC分类号： C12N9/1252 , C12Q1/686 , C12Y207/07007
摘要： Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.
摘要翻译：修饰的DNA聚合酶对DNA具有亲和力，使得聚合酶具有在每个反应循环中将一个或多个核苷酸并入到多个单独的DNA模板中的能力。聚合酶能够在每个反应循环中形成增加数量的生产性聚合酶-DNA复合物。修饰的聚合酶可用于许多DNA测序应用，特别是在簇阵列的上下文中。

2. 发明申请

WO2004050916A1 RECOVERY OF ORIGINAL TEMPLATE 审中-公开
标题翻译：原始模板的恢复
公开(公告)号：WO2004050916A1
公开(公告)日：2004-06-17
申请号：PCT/GB2003/005266
申请日：2003-12-02
申请人： SOLEXA LIMITED , GORMLEY, Niall , BALASUBRAMANIAN, Shankar
发明人： GORMLEY, Niall , BALASUBRAMANIAN, Shankar
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2525/301 , C12Q2521/301 , C12Q2521/313
摘要： The present invention relates to methods for regenerating a single-stranded nucleic acid template following its conversion to a double-stranded product, e.g., during a polymerase reaction, and also to regenerating a hairpin or anchoring sequence by removal of the template and its synthesized complement, by design of enzyme restriction sites into the hairpin or anchoring sequence.
摘要翻译：本发明涉及在转化成双链产物之后，例如在聚合酶反应期间再生单链核酸模板的方法，还涉及通过除去模板及其合成的补体来再生发夹或锚定序列通过将酶限制性位点设计到发夹或锚定序列中。

3. 发明申请

WO2003048387A2 LABELLED NUCLEOTIDES 审中-公开
标题翻译：标记的核苷酸
公开(公告)号：WO2003048387A2
公开(公告)日：2003-06-12
申请号：PCT/GB2002/005474
申请日：2002-12-04
申请人： SOLEXA LIMITED , BALASUBRAMANIAN, Shankar , BARNES, Colin , LIU, Xiaohai , SWERDLOW, Harold
发明人： BALASUBRAMANIAN, Shankar , BARNES, Colin , LIU, Xiaohai , SWERDLOW, Harold
IPC分类号： C12Q1/68
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
摘要翻译：公开了核苷和核苷酸，其通过可切割的接头基团与可检测标记相连。

4. 发明申请

WO2013017853A2 METHODS FOR DETECTION OF NUCLEOTIDE MODIFICATION 审中-公开
标题翻译：检测核型修饰的方法
公开(公告)号：WO2013017853A2
公开(公告)日：2013-02-07
申请号：PCT/GB2012/051819
申请日：2012-07-27
申请人： CAMBRIDGE EPIGENETIX LIMITED , BOOTH, Michael, John , BALASUBRAMANIAN, Shankar
发明人： BOOTH, Michael, John , BALASUBRAMANIAN, Shankar
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C01G55/002 , C07H1/00 , C07H21/02 , C07H21/04 , C12Q1/6806 , C12Q1/6827 , C12Q2600/154 , C12Q2523/115 , C12Q2523/125
摘要： This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidising or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidised or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.
摘要翻译：本发明涉及在样本核苷酸序列中鉴定与胞嘧啶（C）不同的修饰胞嘧啶残基如5-甲基胞嘧啶（5mC），5-羟甲基胞嘧啶（5hmC）和5-甲酰胞嘧啶（5fC）。方法可以包括氧化或还原包含样品核苷酸序列的多核苷酸的第一部分; 用亚硫酸氢盐处理氧化或还原的第一部分和第二部分多核苷酸; 在步骤ii）和iii）之后对群体的第一和第二部分中的多核苷酸进行测序以分别产生第一和第二核苷酸序列; 识别与样品核苷酸序列中的胞嘧啶残基相对应的第一和第二核苷酸序列中的残基。这些方法可能是有用的，例如在基因组DNA和/或RNA的分析中。

5. 发明申请

WO2009059023A3 PREPARATION OF PRECISELY CONTROLLED THIN FILM NANOCOMPOSITE OF CARBON NANOTUBES AND BIOMATERIALS 审中-公开
公开(公告)号：WO2009059023A3
公开(公告)日：2009-05-07
申请号：PCT/US2008/081819
申请日：2008-10-30
申请人： AUBURN UNIVERSITY , DAVIS, Virginia, A. , SIMONIAN, Aleksandr, L. , NEPAL, Dhriti , BALASUBRAMANIAN, Shankar
发明人： DAVIS, Virginia, A. , SIMONIAN, Aleksandr, L. , NEPAL, Dhriti , BALASUBRAMANIAN, Shankar
IPC分类号： A01P1/00 , A01N37/46 , A01N57/16 , A01N25/10 , C01B31/02
摘要： Disclosed are nanocomposite materials comprising multiple layers of biomolecules bound to aligned carbon nanotubes. The thickness of each of the layers may be precisely controlled using a layer-by-layer assembly technique.

6. 发明申请

WO2008114009A1 10H-BENZO(G)PTERDINE-2,4-DIONE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译： 10H-BENZO（G）Pterdine-2,4-Dione化合物治疗增殖性疾病
公开(公告)号：WO2008114009A1
公开(公告)日：2008-09-25
申请号：PCT/GB2008/000962
申请日：2008-03-18
申请人： CAMBRIDGE ENTERPRISE LTD. , BALASUBRAMANIAN, Shankar , BEJUGAM, Mallesham
发明人： BALASUBRAMANIAN, Shankar , BEJUGAM, Mallesham
IPC分类号： C07D475/14 , A61K31/519
CPC分类号： C07D475/14
摘要： This invention pertains generally to the field of G-quadruplex ligands, and more particularly, to certain 10H-benzo[g]pteridine-2,4-dione compounds ("BPD compounds"), as described herein, which, inter alia , (selectively) bind (and stabilize) G-quadruplexes. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to (selectively) bind (and stabilize) G-quadruplexes, to inhibit telomerase, to regulate cell proliferation, and in the treatment of proliferative disorders, such as cancer. Formula (I):
摘要翻译：本发明一般涉及G-四链体配体领域，更具体地涉及如本文所述的某些10H-苯并[g]蝶啶-2,4-二酮化合物（“BPD化合物”），其特别包括（选择性地）绑定（并稳定）G-四极杆。本发明还涉及包含这种化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途（选择性地）结合（并稳定）G-四链体，抑制端粒酶调节细胞增殖，以及治疗增殖性疾病如癌症。式（I）：

7. 发明申请

WO2011015829A1 MODULATION OF MIRNA ACTIVITY 审中-公开
标题翻译：米拉活动的调节
公开(公告)号：WO2011015829A1
公开(公告)日：2011-02-10
申请号：PCT/GB2010/001492
申请日：2010-08-06
申请人： CAMBRIDGE ENTERPRISE LIMITED , MISKA, Eric , LEHRBACH, Nic , ARMISEN-GARRIDO, Javier , BALASUBRAMANIAN, Shankar
发明人： MISKA, Eric , LEHRBACH, Nic , ARMISEN-GARRIDO, Javier , BALASUBRAMANIAN, Shankar
IPC分类号： C12Q1/48
CPC分类号： C12Q1/485 , G01N33/573 , G01N2333/9125 , G01N2500/02
摘要： Provided is a method of identifying a compound which modulates miRNA activity comprising (i) determining the ability of a test compound to alter the polyuridylation activity of a ZCCHC polypeptide wherein a test compound which alters the polyuridylation activity is useful in modulating miRNA activity; or (ii) determining the ability of a test compound to alter the binding of a ZCCHC polypeptide to a LIN28 polypeptide, wherein a test compound which alters said binding may be useful in modulating miRNA activity; or (iii) determining the ability of a test compound to bind to a ZCCHC polypeptide, wherein a test compound which binds to the ZCCHC polypeptide may be useful in modulating miRNA activity.
摘要翻译：提供了鉴定调节miRNA活性的化合物的方法，其包括（i）测定测试化合物改变ZCCHC多肽的多聚尿苷酸化活性的能力，其中改变多聚尿苷酸化活性的测试化合物可用于调节miRNA活性; 或（ii）测定测试化合物改变ZCCHC多肽与LIN28多肽的结合的能力，其中改变所述结合的测试化合物可用于调节miRNA活性; 或（iii）测定测试化合物结合ZCCHC多肽的能力，其中与ZCCHC多肽结合的测试化合物可用于调节miRNA活性。

8. 发明申请

WO2008009942A1 HETEROAROMATIC-BASED PEPTIDE MACROCYCLES AS G-QUADRUPLEX LIGANDS 审中-公开
标题翻译：作为G-QUADRUPLEX LIGANDS的基于异种基团的肽
公开(公告)号：WO2008009942A1
公开(公告)日：2008-01-24
申请号：PCT/GB2007/002734
申请日：2007-07-19
申请人： CAMBRIDGE ENTERPRISE LTD. , BALASUBRAMANIAN, Shankar , JANTOS, Katja , LADAME, Sylvain
发明人： BALASUBRAMANIAN, Shankar , JANTOS, Katja , LADAME, Sylvain
IPC分类号： C07K5/12 , A61P35/00
CPC分类号： A61K38/12 , C07D498/22 , Y02A50/395
摘要： This invention pertains generally to the field of G-quadruplex ligands, and more particularly, to certain heteroaromatic-based peptide macrocycles (HBPMs) of the following formula which, inter alia , (selectively) bind (and stabilize) G-quadruplexes formula (I): wherein: n is independently 0 or 1; each of Het 1 , Het 2 , Het 3 , and Het 4 if present, is independently a heteroaromatic 5-membered ring having exactly one ring heteroatom or exactly two ring heteroatoms, wherein each of said ring heteroatoms is independently selected from: nitrogen, oxygen, and sulphur (e.g., oxazole-di-yl and thiazole-di-yl); and is independently unsubstituted or substituted; each of R C1 , R C2 , R C3 , and R C4 is independently -H or a ring-carbon subsituent; and each of R N1 , R N2 , R N3 , and R N4 is independently -H or a ring-nitrogen subsituent. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to (selectively) bind (and stabilize) G-quadruplexes, to inhibit telomerase, to regulate cell proliferation, and in the treatment of proliferative conditions, such as cancer.
摘要翻译：本发明一般涉及G-四链体配体领域，更具体地说涉及下列通式的某些基于杂芳基的肽大环化合物（HBPM），其特别是（选择性地）结合（并稳定）G-四链体配方（I ）：其中：n独立地为0或1; Het 2，Het 3，Het 3，Het 4和Het 4如果存在，独立地是杂芳族5 其中每个所述环杂原子独立地选自：氮，氧和硫（例如恶唑二基和噻唑二基）;其中每个环杂原子具有一个环杂原子或正好两个环杂原子。并且独立地是未取代的或取代的; R C1，R C2和R C4各自独立地为-H或环 - 碳取代; 并且R“N”，“N”，“N”和“R”中的每一个独立地是-H或环 - 氮取代。本发明还涉及包含这种化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途（选择性地）结合（并稳定）G-四链体，抑制端粒酶调节细胞增殖，和治疗增生性疾病如癌症。

9. 发明申请

WO2002061126A2 THE PREPARATION OF POLYNUCLEOTIDE ARRAYS 审中-公开
标题翻译：多核苷酸阵列的制备
公开(公告)号：WO2002061126A2
公开(公告)日：2002-08-08
申请号：PCT/GB2002/000438
申请日：2002-01-30
申请人： SOLEXA LTD. , BARNES, Colin , BALASUBRAMANIAN, Shankar , KLENERMAN, David , OSBORNE, Mark, Allen
发明人： BARNES, Colin , BALASUBRAMANIAN, Shankar , KLENERMAN, David , OSBORNE, Mark, Allen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C12Q2525/301 , C40B40/06 , C12Q2565/507 , C12Q2565/107 , C12Q2525/197 , C12Q2565/619
摘要： A device comprising an array of molecules immobilised on a solid surface is disclosed, wherein the array has a high density of relatively short molecules and relatively long polynucleotides immobilised on the surface of a solid support, wherein the polynucleotides are at a density that permits individual resolution of those parts thereof that extend beyond the relatively short molecules.
摘要翻译：公开了一种包含固定在固体表面上的分子阵列的装置，其中所述阵列具有固定在固体支持物表面上的相对较短分子的高密度和相对长的多核苷酸，其中所述多核苷酸处于允许单独分辨的密度的那些部分延伸超过相对短的分子。

10. 发明申请

WO2012106384A2 NANO/MICROSCALE VEHICLES FOR CAPTURE AND ISOLATION OF TARGET BIOMOLECULES AND LIVING ORGANISMS 审中-公开
标题翻译：用于捕获和分离目标生物分子和生物有机体的纳诺/微型车辆
公开(公告)号：WO2012106384A2
公开(公告)日：2012-08-09
申请号：PCT/US2012/023410
申请日：2012-01-31
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , WANG, Joseph , BALASUBRAMANIAN, Shankar , KAGAN, Daniel , CAMPUZANO-RUIZ, Susana
发明人： WANG, Joseph , BALASUBRAMANIAN, Shankar , KAGAN, Daniel , CAMPUZANO-RUIZ, Susana
IPC分类号： G01N33/53 , G01N33/543 , C12Q1/68
CPC分类号： C12Q1/6806 , B01D15/3885 , B01J20/22 , B01J20/32 , B01J2220/4812 , C12M1/268 , C12Q1/6834 , G01N1/10 , G01N33/54313 , G01N33/5436 , G01N33/54393 , G01N33/544
摘要： Techniques, systems, devices and materials are disclosed for capturing, isolating and transporting target biomolecules and living organisms. In one aspect, a device includes a tube structured to include a large opening and a small opening that are on opposite ends of the tube, and a tube body connecting the openings and having a cross section spatially reducing in size from the large opening to the small opening, in which the tube includes a layered wall including an inner layer having a catalyst material that is reactive with a fuel fluid to produce bubbles exiting the tube from the large opening to propel the tube to move in the fuel fluid and an external layer formed of a material capable of being functionalized, and a molecular layer functionalized onto the external layer of the tube and structured to attach to a targeted molecule in the fuel fluid.
摘要翻译：公开了用于捕获，分离和转运靶生物分子和活生物体的技术，系统，装置和材料。在一个方面，一种装置包括构造成包括在该管的相对端上的大开口和小开口的管，以及连接开口并具有空间尺寸从大开口至小开口，其中管包括层状壁，其包括具有催化剂材料的内层，催化剂材料与燃料流体反应，以从大开口产生离开管的气泡，以推动管在燃料流体中移动和外部层由能够官能化的材料形成，以及分子层，其功能化在管的外层上并被构造成附着到燃料流体中的目标分子上。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式